<article>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#article10_03_17_1425241</id>
	<title>Scientists Demonstrate Mammalian Tissue Regeneration</title>
	<author>Soulskill</author>
	<datestamp>1268838120000</datestamp>
	<htmltext>telomerewhythere writes <i>"A quest that began over a decade ago with a chance observation has reached a milestone: the identification of a gene that may regulate regeneration in mammals. The absence of this single gene, called p21, <a href="http://www.sciencedaily.com/releases/2010/03/100315161913.htm">confers a healing potential in mice</a> long thought to have been lost through evolution and reserved for creatures like flatworms, sponges, and some species of salamander. 'Unlike typical mammals, which heal wounds by forming a scar, these mice begin by forming a blastema, a structure associated with rapid cell growth and de-differentiation as seen in amphibians. According to the Wistar researchers, the loss of p21 causes the cells of these mice to behave more like embryonic stem cells than adult mammalian cells, and their findings provide solid evidence to link tissue regeneration to the control of cell division. "Much like a newt that has lost a limb, these mice will replace missing or damaged tissue with healthy tissue that lacks any sign of scarring," said the project's lead scientist.' Here is the <a href="http://www.pnas.org/content/early/2010/03/08/1000830107">academic paper</a> for those with <em>PNAS</em> access."</i></htmltext>
<tokenext>telomerewhythere writes " A quest that began over a decade ago with a chance observation has reached a milestone : the identification of a gene that may regulate regeneration in mammals .
The absence of this single gene , called p21 , confers a healing potential in mice long thought to have been lost through evolution and reserved for creatures like flatworms , sponges , and some species of salamander .
'Unlike typical mammals , which heal wounds by forming a scar , these mice begin by forming a blastema , a structure associated with rapid cell growth and de-differentiation as seen in amphibians .
According to the Wistar researchers , the loss of p21 causes the cells of these mice to behave more like embryonic stem cells than adult mammalian cells , and their findings provide solid evidence to link tissue regeneration to the control of cell division .
" Much like a newt that has lost a limb , these mice will replace missing or damaged tissue with healthy tissue that lacks any sign of scarring , " said the project 's lead scientist .
' Here is the academic paper for those with PNAS access .
"</tokentext>
<sentencetext>telomerewhythere writes "A quest that began over a decade ago with a chance observation has reached a milestone: the identification of a gene that may regulate regeneration in mammals.
The absence of this single gene, called p21, confers a healing potential in mice long thought to have been lost through evolution and reserved for creatures like flatworms, sponges, and some species of salamander.
'Unlike typical mammals, which heal wounds by forming a scar, these mice begin by forming a blastema, a structure associated with rapid cell growth and de-differentiation as seen in amphibians.
According to the Wistar researchers, the loss of p21 causes the cells of these mice to behave more like embryonic stem cells than adult mammalian cells, and their findings provide solid evidence to link tissue regeneration to the control of cell division.
"Much like a newt that has lost a limb, these mice will replace missing or damaged tissue with healthy tissue that lacks any sign of scarring," said the project's lead scientist.
' Here is the academic paper for those with PNAS access.
"</sentencetext>
</article>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31511716</id>
	<title>Re:All very nice stuff, but...</title>
	<author>Mindcontrolled</author>
	<datestamp>1268851440000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>A live fix in the sense of gene therapy is *maybe* possible for example by targeted insertion of a retrovirus into the gene coding for p21. However, such gene therapy methods have not worked very well so far. It is especially problematic to target a majority of somatic cells. Most gene therapy trials so far were aimed at hematopoetic stem cells in bone marrow, which can be extracted and treated ex vivo. This would not work in this case, so at the moment, I don't see a very promising way to do it. An alternative to gene therapy would be a targeted inhibitor. p21 works, amongst others, by inhibiting the working of certain enzymes responsible for cell cycle progression - the cyclin dependent kinases (CDK). One could possibly try to find a small molecule that blocks the interaction of p21 with those CDKs or other proteins affected by p21. You would have to take that medication constantly to retain the regenerative function of p21 blockage. To my knowledge, no such molecule is known as of yet, but I am out of that field for a while.</htmltext>
<tokenext>A live fix in the sense of gene therapy is * maybe * possible for example by targeted insertion of a retrovirus into the gene coding for p21 .
However , such gene therapy methods have not worked very well so far .
It is especially problematic to target a majority of somatic cells .
Most gene therapy trials so far were aimed at hematopoetic stem cells in bone marrow , which can be extracted and treated ex vivo .
This would not work in this case , so at the moment , I do n't see a very promising way to do it .
An alternative to gene therapy would be a targeted inhibitor .
p21 works , amongst others , by inhibiting the working of certain enzymes responsible for cell cycle progression - the cyclin dependent kinases ( CDK ) .
One could possibly try to find a small molecule that blocks the interaction of p21 with those CDKs or other proteins affected by p21 .
You would have to take that medication constantly to retain the regenerative function of p21 blockage .
To my knowledge , no such molecule is known as of yet , but I am out of that field for a while .</tokentext>
<sentencetext>A live fix in the sense of gene therapy is *maybe* possible for example by targeted insertion of a retrovirus into the gene coding for p21.
However, such gene therapy methods have not worked very well so far.
It is especially problematic to target a majority of somatic cells.
Most gene therapy trials so far were aimed at hematopoetic stem cells in bone marrow, which can be extracted and treated ex vivo.
This would not work in this case, so at the moment, I don't see a very promising way to do it.
An alternative to gene therapy would be a targeted inhibitor.
p21 works, amongst others, by inhibiting the working of certain enzymes responsible for cell cycle progression - the cyclin dependent kinases (CDK).
One could possibly try to find a small molecule that blocks the interaction of p21 with those CDKs or other proteins affected by p21.
You would have to take that medication constantly to retain the regenerative function of p21 blockage.
To my knowledge, no such molecule is known as of yet, but I am out of that field for a while.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509180</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31510006</id>
	<title>Re:So</title>
	<author>pablo\_max</author>
	<datestamp>1268846880000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>yeah...what he said.</p></htmltext>
<tokenext>yeah...what he said .</tokentext>
<sentencetext>yeah...what he said.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509134</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509318</id>
	<title>Anyone think about what it's going to feel like?</title>
	<author>Anonymous</author>
	<datestamp>1268844300000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>Losing an appendage and regrowing it? That's gotta sting!</p></htmltext>
<tokenext>Losing an appendage and regrowing it ?
That 's got ta sting !</tokentext>
<sentencetext>Losing an appendage and regrowing it?
That's gotta sting!</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509574</id>
	<title>Re:So</title>
	<author>beelsebob</author>
	<datestamp>1268845260000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>While in general I agree with your statement about not wading into something I don't know about, I'm going to do it anyway<nobr> <wbr></nobr>:P</p><p>p21 was evolved out of mammals, if it's got this wondrous healing ability attached to it, it makes very little sense for it to have not had a *major* impact on the fitness of creatures without it unless it also gives some major benefit by having it present.  I'm not going to claim it protects against cancer, instead merely make a vague statement along the lines of "we'd better watch out carefully when removing something evolution has decided should appear in fit creatures".</p></htmltext>
<tokenext>While in general I agree with your statement about not wading into something I do n't know about , I 'm going to do it anyway : Pp21 was evolved out of mammals , if it 's got this wondrous healing ability attached to it , it makes very little sense for it to have not had a * major * impact on the fitness of creatures without it unless it also gives some major benefit by having it present .
I 'm not going to claim it protects against cancer , instead merely make a vague statement along the lines of " we 'd better watch out carefully when removing something evolution has decided should appear in fit creatures " .</tokentext>
<sentencetext>While in general I agree with your statement about not wading into something I don't know about, I'm going to do it anyway :Pp21 was evolved out of mammals, if it's got this wondrous healing ability attached to it, it makes very little sense for it to have not had a *major* impact on the fitness of creatures without it unless it also gives some major benefit by having it present.
I'm not going to claim it protects against cancer, instead merely make a vague statement along the lines of "we'd better watch out carefully when removing something evolution has decided should appear in fit creatures".</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509134</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31508876</id>
	<title>Degeneration</title>
	<author>Anonymous</author>
	<datestamp>1268842440000</datestamp>
	<modclass>Funny</modclass>
	<modscore>2</modscore>
	<htmltext><p>You know this discussion will degenerate into how this can be applied to growing a longer penis.</p></htmltext>
<tokenext>You know this discussion will degenerate into how this can be applied to growing a longer penis .</tokentext>
<sentencetext>You know this discussion will degenerate into how this can be applied to growing a longer penis.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31510264</id>
	<title>I have access to a PNAS...</title>
	<author>zero\_out</author>
	<datestamp>1268847600000</datestamp>
	<modclass>Funny</modclass>
	<modscore>4</modscore>
	<htmltext><p><div class="quote"><p>Here is the academic paper for those with PNAS access.</p></div><p>I have access to a PNAS.  Sometimes I let my wife have access to it, too.</p></div>
	</htmltext>
<tokenext>Here is the academic paper for those with PNAS access.I have access to a PNAS .
Sometimes I let my wife have access to it , too .</tokentext>
<sentencetext>Here is the academic paper for those with PNAS access.I have access to a PNAS.
Sometimes I let my wife have access to it, too.
	</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509204</id>
	<title>What's the downside?</title>
	<author>Biotech9</author>
	<datestamp>1268843760000</datestamp>
	<modclass>Informativ</modclass>
	<modscore>4</modscore>
	<htmltext><p>A lot of people are asking why evolution has taken away our regenerative capacities, and are guessing what the downside of this regeneration is.</p><p>P21 is involved with anti-cancer. It arrests the cell cycle when DNA damage occurs, allowing the damage to be repaired (so mistakes are not carried forward into new generations). Or if the damage is too severe, the cell is made senescent (they lose the ability to reproduce and instead lead out a gentle retirement, performing their normal job until they just die of old age)</p><p>P21 knockout mice show a lot of carcinomas and P21 is also up-regulated by and works to remedy excessive oxidative stress. It's very unlikely this research is going to lead to a pill that knocks out P21 and lets us grow limbs back. It will <i>only</i> lead to a greater understanding of how our pathways work.</p></htmltext>
<tokenext>A lot of people are asking why evolution has taken away our regenerative capacities , and are guessing what the downside of this regeneration is.P21 is involved with anti-cancer .
It arrests the cell cycle when DNA damage occurs , allowing the damage to be repaired ( so mistakes are not carried forward into new generations ) .
Or if the damage is too severe , the cell is made senescent ( they lose the ability to reproduce and instead lead out a gentle retirement , performing their normal job until they just die of old age ) P21 knockout mice show a lot of carcinomas and P21 is also up-regulated by and works to remedy excessive oxidative stress .
It 's very unlikely this research is going to lead to a pill that knocks out P21 and lets us grow limbs back .
It will only lead to a greater understanding of how our pathways work .</tokentext>
<sentencetext>A lot of people are asking why evolution has taken away our regenerative capacities, and are guessing what the downside of this regeneration is.P21 is involved with anti-cancer.
It arrests the cell cycle when DNA damage occurs, allowing the damage to be repaired (so mistakes are not carried forward into new generations).
Or if the damage is too severe, the cell is made senescent (they lose the ability to reproduce and instead lead out a gentle retirement, performing their normal job until they just die of old age)P21 knockout mice show a lot of carcinomas and P21 is also up-regulated by and works to remedy excessive oxidative stress.
It's very unlikely this research is going to lead to a pill that knocks out P21 and lets us grow limbs back.
It will only lead to a greater understanding of how our pathways work.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31508844</id>
	<title>I for one...</title>
	<author>trurl7</author>
	<datestamp>1268842260000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>...welcome our new, non-scarring, regenerating....</p><p>too easy, forget it.</p></htmltext>
<tokenext>...welcome our new , non-scarring , regenerating....too easy , forget it .</tokentext>
<sentencetext>...welcome our new, non-scarring, regenerating....too easy, forget it.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31511012</id>
	<title>hold your regenerating troll-horses</title>
	<author>bzdyelnik</author>
	<datestamp>1268849580000</datestamp>
	<modclass>Informativ</modclass>
	<modscore>2</modscore>
	<htmltext>The wikipedia entry for p21 (http://en.wikipedia.org/wiki/P21) is somewhat misleading about its relationship with cancer.

For a good review, see:

<a href="http://journals.cambridge.org/action/displayFulltext?type=1&amp;fid=1919868&amp;jid=ERM&amp;volumeId=10&amp;issueId=-1&amp;aid=1919860" title="cambridge.org" rel="nofollow">http://journals.cambridge.org/action/displayFulltext?type=1&amp;fid=1919868&amp;jid=ERM&amp;volumeId=10&amp;issueId=-1&amp;aid=1919860</a> [cambridge.org]

Excerpt:

"However, p21-null mice were found to
be more susceptible to chemically induced
tumours of the skin (Ref. 94) and colon
(Ref. 95), and following irradiation they
displayed increased tumourigenesis and
metastases (Ref. 96). In addition, using different
mouse strains, others have found that p21-null
mice exhibit spontaneous tumour formation in
the background of other genetic knockouts,
such as Muc22/2 (lacking mucin 2) (Ref. 97)
and Apc1638/2 (carrying a mutant allele of the
adenomatosis polyposis coli gene) (Ref. 98).
Furthermore, subsequent to the initial
description of p21-null mice, investigators have
found that p21-null mice bred on a 129Sv/
C57BL6 50:50 background did in fact develop
spontaneous tumours at an average age of 16
months (Ref. 99). Collectively, these mouse
studies demonstrated the importance of p21 in
mediating the G1 checkpoint, and its ability to
function as a tumour suppressor."</htmltext>
<tokenext>The wikipedia entry for p21 ( http : //en.wikipedia.org/wiki/P21 ) is somewhat misleading about its relationship with cancer .
For a good review , see : http : //journals.cambridge.org/action/displayFulltext ? type = 1&amp;fid = 1919868&amp;jid = ERM&amp;volumeId = 10&amp;issueId = -1&amp;aid = 1919860 [ cambridge.org ] Excerpt : " However , p21-null mice were found to be more susceptible to chemically induced tumours of the skin ( Ref .
94 ) and colon ( Ref .
95 ) , and following irradiation they displayed increased tumourigenesis and metastases ( Ref .
96 ) . In addition , using different mouse strains , others have found that p21-null mice exhibit spontaneous tumour formation in the background of other genetic knockouts , such as Muc22/2 ( lacking mucin 2 ) ( Ref .
97 ) and Apc1638/2 ( carrying a mutant allele of the adenomatosis polyposis coli gene ) ( Ref .
98 ) . Furthermore , subsequent to the initial description of p21-null mice , investigators have found that p21-null mice bred on a 129Sv/ C57BL6 50 : 50 background did in fact develop spontaneous tumours at an average age of 16 months ( Ref .
99 ) . Collectively , these mouse studies demonstrated the importance of p21 in mediating the G1 checkpoint , and its ability to function as a tumour suppressor .
"</tokentext>
<sentencetext>The wikipedia entry for p21 (http://en.wikipedia.org/wiki/P21) is somewhat misleading about its relationship with cancer.
For a good review, see:

http://journals.cambridge.org/action/displayFulltext?type=1&amp;fid=1919868&amp;jid=ERM&amp;volumeId=10&amp;issueId=-1&amp;aid=1919860 [cambridge.org]

Excerpt:

"However, p21-null mice were found to
be more susceptible to chemically induced
tumours of the skin (Ref.
94) and colon
(Ref.
95), and following irradiation they
displayed increased tumourigenesis and
metastases (Ref.
96). In addition, using different
mouse strains, others have found that p21-null
mice exhibit spontaneous tumour formation in
the background of other genetic knockouts,
such as Muc22/2 (lacking mucin 2) (Ref.
97)
and Apc1638/2 (carrying a mutant allele of the
adenomatosis polyposis coli gene) (Ref.
98).
Furthermore, subsequent to the initial
description of p21-null mice, investigators have
found that p21-null mice bred on a 129Sv/
C57BL6 50:50 background did in fact develop
spontaneous tumours at an average age of 16
months (Ref.
99). Collectively, these mouse
studies demonstrated the importance of p21 in
mediating the G1 checkpoint, and its ability to
function as a tumour suppressor.
"</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31512516</id>
	<title>But the book didn't say!</title>
	<author>Anonymous</author>
	<datestamp>1268853660000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>So, how does the God book explain how all of this is working?  Is this still all part of the design?</p></htmltext>
<tokenext>So , how does the God book explain how all of this is working ?
Is this still all part of the design ?</tokentext>
<sentencetext>So, how does the God book explain how all of this is working?
Is this still all part of the design?</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31512866</id>
	<title>Re:What's the downside?</title>
	<author>radtea</author>
	<datestamp>1268854680000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p><div class="quote"><p>P21 knockout mice show a lot of carcinomas</p></div><p>The article claims that there is no increase observed.</p><p>The overwhelmingly likely factor in regeneration vs scaring is that the warm-blooded creatures scar, cold-blooded creatures regenerate (more or less).  There are pretty obvious reasons why a creature that needs a fairly constant supply of food would be selected for a healing mechanism that works very quickly, as opposed to one that works slowly but restores more complete functionality.</p><p>Because evolution is an elaborative process, it is likely that scaring came about by repurposing genes that control regeneration in other species (there's a lab at the University of Ottawa working on this, I believe--can't recall who.)  Therefore creatures that scar don't regenerate, but have a latent ability to do so with a little tweaking.</p></div>
	</htmltext>
<tokenext>P21 knockout mice show a lot of carcinomasThe article claims that there is no increase observed.The overwhelmingly likely factor in regeneration vs scaring is that the warm-blooded creatures scar , cold-blooded creatures regenerate ( more or less ) .
There are pretty obvious reasons why a creature that needs a fairly constant supply of food would be selected for a healing mechanism that works very quickly , as opposed to one that works slowly but restores more complete functionality.Because evolution is an elaborative process , it is likely that scaring came about by repurposing genes that control regeneration in other species ( there 's a lab at the University of Ottawa working on this , I believe--ca n't recall who .
) Therefore creatures that scar do n't regenerate , but have a latent ability to do so with a little tweaking .</tokentext>
<sentencetext>P21 knockout mice show a lot of carcinomasThe article claims that there is no increase observed.The overwhelmingly likely factor in regeneration vs scaring is that the warm-blooded creatures scar, cold-blooded creatures regenerate (more or less).
There are pretty obvious reasons why a creature that needs a fairly constant supply of food would be selected for a healing mechanism that works very quickly, as opposed to one that works slowly but restores more complete functionality.Because evolution is an elaborative process, it is likely that scaring came about by repurposing genes that control regeneration in other species (there's a lab at the University of Ottawa working on this, I believe--can't recall who.
)  Therefore creatures that scar don't regenerate, but have a latent ability to do so with a little tweaking.
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509204</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509880</id>
	<title>Promissing but...</title>
	<author>Corson</author>
	<datestamp>1268846460000</datestamp>
	<modclass>Informativ</modclass>
	<modscore>2</modscore>
	<htmltext>It is unlikely that a process so complex as mammalian tissue regeneration be controlled by a single gene. Moreover, p21 mutations have been associated with cancers. Which brings forth another question: why is it that only "lower" organisms (and mammalian fetuses) are capable of scar-less tissue regeneration? The answer is yet to be discovered but it is very likely that evolution had to stroke a balance between cancer control and tissue regeneration. It won't be easy to figure out "the way back" to regeneration, or even to avoid the risks of such a path.</htmltext>
<tokenext>It is unlikely that a process so complex as mammalian tissue regeneration be controlled by a single gene .
Moreover , p21 mutations have been associated with cancers .
Which brings forth another question : why is it that only " lower " organisms ( and mammalian fetuses ) are capable of scar-less tissue regeneration ?
The answer is yet to be discovered but it is very likely that evolution had to stroke a balance between cancer control and tissue regeneration .
It wo n't be easy to figure out " the way back " to regeneration , or even to avoid the risks of such a path .</tokentext>
<sentencetext>It is unlikely that a process so complex as mammalian tissue regeneration be controlled by a single gene.
Moreover, p21 mutations have been associated with cancers.
Which brings forth another question: why is it that only "lower" organisms (and mammalian fetuses) are capable of scar-less tissue regeneration?
The answer is yet to be discovered but it is very likely that evolution had to stroke a balance between cancer control and tissue regeneration.
It won't be easy to figure out "the way back" to regeneration, or even to avoid the risks of such a path.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509448</id>
	<title>Re:Be careful when fooling Mother Nature</title>
	<author>Securityemo</author>
	<datestamp>1268844780000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>We're all concerned and cautious, but where would we be in science and technology without enthusiasm and dreaming? Nobody's just going to start toggling DNA markers and associated cell machinery in humans without lots of testing on lower lifeforms - unless, of course, the human subject has nothing to lose.</htmltext>
<tokenext>We 're all concerned and cautious , but where would we be in science and technology without enthusiasm and dreaming ?
Nobody 's just going to start toggling DNA markers and associated cell machinery in humans without lots of testing on lower lifeforms - unless , of course , the human subject has nothing to lose .</tokentext>
<sentencetext>We're all concerned and cautious, but where would we be in science and technology without enthusiasm and dreaming?
Nobody's just going to start toggling DNA markers and associated cell machinery in humans without lots of testing on lower lifeforms - unless, of course, the human subject has nothing to lose.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509060</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31518296</id>
	<title>Re:Now I can finally start my restaurant...</title>
	<author>Valdrax</author>
	<datestamp>1268839440000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p><div class="quote"><p>Now I can finally start my restaurant (which specializes in mouse-tail delicacies) without PETA breathing down my neck. "Look: it's growing back!" Mouse-tail soup anyone?</p></div><p>Not really.  If vegans oppose milking cows and harvesting honey, then cutting pieces off living animals, waiting for them to regrow, and then cutting more off again is just *may* be a bit less acceptable.</p></div>
	</htmltext>
<tokenext>Now I can finally start my restaurant ( which specializes in mouse-tail delicacies ) without PETA breathing down my neck .
" Look : it 's growing back !
" Mouse-tail soup anyone ? Not really .
If vegans oppose milking cows and harvesting honey , then cutting pieces off living animals , waiting for them to regrow , and then cutting more off again is just * may * be a bit less acceptable .</tokentext>
<sentencetext>Now I can finally start my restaurant (which specializes in mouse-tail delicacies) without PETA breathing down my neck.
"Look: it's growing back!
" Mouse-tail soup anyone?Not really.
If vegans oppose milking cows and harvesting honey, then cutting pieces off living animals, waiting for them to regrow, and then cutting more off again is just *may* be a bit less acceptable.
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31508792</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31510306</id>
	<title>Re:So</title>
	<author>misfit815</author>
	<datestamp>1268847660000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>Forget Wolverine. this has Dr. Curt Connors / Lizard written all over it.</p></htmltext>
<tokenext>Forget Wolverine .
this has Dr. Curt Connors / Lizard written all over it .</tokentext>
<sentencetext>Forget Wolverine.
this has Dr. Curt Connors / Lizard written all over it.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31508764</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31511700</id>
	<title>Re:So</title>
	<author>pseudorand</author>
	<datestamp>1268851380000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>I was thinking more like <a href="http://en.wikipedia.org/wiki/Zaphod\_Beeblebrox" title="wikipedia.org">Zaphod Beeblebrox</a> [wikipedia.org].</htmltext>
<tokenext>I was thinking more like Zaphod Beeblebrox [ wikipedia.org ] .</tokentext>
<sentencetext>I was thinking more like Zaphod Beeblebrox [wikipedia.org].</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31508764</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509624</id>
	<title>Re:It will be interesting to see...</title>
	<author>AceJohnny</author>
	<datestamp>1268845500000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><blockquote><div><p>you'll 'regenerate' yourself entirely full of tumors by age 20.</p></div></blockquote><p>The article states: <i>"In these mice without p21, we do see the expected increase in DNA damage, but surprisingly no increase in cancer has been reported."</i></p><p>Also, I suggest other<nobr> <wbr></nobr>/.ers read the article. It is high quality, not a random blog post.</p></div>
	</htmltext>
<tokenext>you 'll 'regenerate ' yourself entirely full of tumors by age 20.The article states : " In these mice without p21 , we do see the expected increase in DNA damage , but surprisingly no increase in cancer has been reported .
" Also , I suggest other /.ers read the article .
It is high quality , not a random blog post .</tokentext>
<sentencetext>you'll 'regenerate' yourself entirely full of tumors by age 20.The article states: "In these mice without p21, we do see the expected increase in DNA damage, but surprisingly no increase in cancer has been reported.
"Also, I suggest other /.ers read the article.
It is high quality, not a random blog post.
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31508960</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31513698</id>
	<title>Re:Degeneration</title>
	<author>Anonymous</author>
	<datestamp>1268857560000</datestamp>
	<modclass>Interestin</modclass>
	<modscore>1</modscore>
	<htmltext><p>Uh, if this actually DID allow penis modification, the researchers should lead with such knowledge.  They'd have all the funding they'd ever need from self-conscious males looking to score an extra inch or five (or perhaps, on a slightly less vain note, to reverse a likely non-consensual circumcision).  I'm not trying to be funny; people routinely pony up big time for sex-related investments -- setting aside investments directly involved in the procurement of and enhancement of sex, there's cosmetic surgery, clothes, cars...</p><p>I propose that if some scientists would make an effort to double the length of (or regrow) a mouse's schlong instead of fiddling with its tail, they'd be sure to get extra public attention, and the increased funding that would follow would ultimately be beneficial in other, more relevant areas.</p></htmltext>
<tokenext>Uh , if this actually DID allow penis modification , the researchers should lead with such knowledge .
They 'd have all the funding they 'd ever need from self-conscious males looking to score an extra inch or five ( or perhaps , on a slightly less vain note , to reverse a likely non-consensual circumcision ) .
I 'm not trying to be funny ; people routinely pony up big time for sex-related investments -- setting aside investments directly involved in the procurement of and enhancement of sex , there 's cosmetic surgery , clothes , cars...I propose that if some scientists would make an effort to double the length of ( or regrow ) a mouse 's schlong instead of fiddling with its tail , they 'd be sure to get extra public attention , and the increased funding that would follow would ultimately be beneficial in other , more relevant areas .</tokentext>
<sentencetext>Uh, if this actually DID allow penis modification, the researchers should lead with such knowledge.
They'd have all the funding they'd ever need from self-conscious males looking to score an extra inch or five (or perhaps, on a slightly less vain note, to reverse a likely non-consensual circumcision).
I'm not trying to be funny; people routinely pony up big time for sex-related investments -- setting aside investments directly involved in the procurement of and enhancement of sex, there's cosmetic surgery, clothes, cars...I propose that if some scientists would make an effort to double the length of (or regrow) a mouse's schlong instead of fiddling with its tail, they'd be sure to get extra public attention, and the increased funding that would follow would ultimately be beneficial in other, more relevant areas.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31508876</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31524612</id>
	<title>Re:One important question remains:</title>
	<author>compro01</author>
	<datestamp>1268935680000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>1. Energy requirements - Regrowing an entire appendage is not cheap and warm blooded mammals already have high basic energy requirements compared to the cold blooded creatures where regeneration does take place.  Being able to regrow an arm doesn't help much if it increases your energy requirements so much that it results in you starving to death in the meantime.</p><p>2. Basic survival rate - Prior to modern medicine (antibiotics in particular, which were only discovered about 80 years ago, which is practically yesterday in evolutionary scales), the odds of surviving an injury that resulted in the loss of a limb was very low.  Not much point in being able to regrow a limb if you'll die from infection before that.  Just closing up the hole with scar tissue is a lot faster (especially with far more common more minor injuries), leaving that much less time for infection to set in.</p></htmltext>
<tokenext>1 .
Energy requirements - Regrowing an entire appendage is not cheap and warm blooded mammals already have high basic energy requirements compared to the cold blooded creatures where regeneration does take place .
Being able to regrow an arm does n't help much if it increases your energy requirements so much that it results in you starving to death in the meantime.2 .
Basic survival rate - Prior to modern medicine ( antibiotics in particular , which were only discovered about 80 years ago , which is practically yesterday in evolutionary scales ) , the odds of surviving an injury that resulted in the loss of a limb was very low .
Not much point in being able to regrow a limb if you 'll die from infection before that .
Just closing up the hole with scar tissue is a lot faster ( especially with far more common more minor injuries ) , leaving that much less time for infection to set in .</tokentext>
<sentencetext>1.
Energy requirements - Regrowing an entire appendage is not cheap and warm blooded mammals already have high basic energy requirements compared to the cold blooded creatures where regeneration does take place.
Being able to regrow an arm doesn't help much if it increases your energy requirements so much that it results in you starving to death in the meantime.2.
Basic survival rate - Prior to modern medicine (antibiotics in particular, which were only discovered about 80 years ago, which is practically yesterday in evolutionary scales), the odds of surviving an injury that resulted in the loss of a limb was very low.
Not much point in being able to regrow a limb if you'll die from infection before that.
Just closing up the hole with scar tissue is a lot faster (especially with far more common more minor injuries), leaving that much less time for infection to set in.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31510000</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31514374</id>
	<title>How many studies are no longer valid?</title>
	<author>BobMcD</author>
	<datestamp>1268817060000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p><div class="quote"><p>As it turned out, p21 knockout mice had already been created, were readily available, and widely used in many studies.</p></div><p>How many studies showing that 'X leaves no lasting damage' are now no longer valid because they were tested on regenerating mice???</p></div>
	</htmltext>
<tokenext>As it turned out , p21 knockout mice had already been created , were readily available , and widely used in many studies.How many studies showing that 'X leaves no lasting damage ' are now no longer valid because they were tested on regenerating mice ? ?
?</tokentext>
<sentencetext>As it turned out, p21 knockout mice had already been created, were readily available, and widely used in many studies.How many studies showing that 'X leaves no lasting damage' are now no longer valid because they were tested on regenerating mice??
?
	</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509400</id>
	<title>Re:It will be interesting to see...</title>
	<author>Tom Boz</author>
	<datestamp>1268844600000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>I think it's more the extra energy costs that led to using scarring rather than regeneration.  It's my understanding (having taken 1 biomaterials class) that scarring is also a relatively useful response in most situations; that is, it usually is a sub-par solution to the problem, but since it works the same everywhere on the body, that's an advantage.  It can also happen far more quickly than regeneration, I would assume.  Either way, this will be an interesting development to follow - who knows what side effects we'll find?!</htmltext>
<tokenext>I think it 's more the extra energy costs that led to using scarring rather than regeneration .
It 's my understanding ( having taken 1 biomaterials class ) that scarring is also a relatively useful response in most situations ; that is , it usually is a sub-par solution to the problem , but since it works the same everywhere on the body , that 's an advantage .
It can also happen far more quickly than regeneration , I would assume .
Either way , this will be an interesting development to follow - who knows what side effects we 'll find ?
!</tokentext>
<sentencetext>I think it's more the extra energy costs that led to using scarring rather than regeneration.
It's my understanding (having taken 1 biomaterials class) that scarring is also a relatively useful response in most situations; that is, it usually is a sub-par solution to the problem, but since it works the same everywhere on the body, that's an advantage.
It can also happen far more quickly than regeneration, I would assume.
Either way, this will be an interesting development to follow - who knows what side effects we'll find?
!</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31508960</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509536</id>
	<title>Re:Be careful when fooling Mother Nature</title>
	<author>zwei2stein</author>
	<datestamp>1268845140000</datestamp>
	<modclass>Interestin</modclass>
	<modscore>2</modscore>
	<htmltext><p>Any form of health care is dangerous this way.</p><p>Consider this: we can (and do) save many children with birth defects, often we are succesfull enough so that they can leard normal life (and even be oblivious to any issues). Problem is that some of theese defects are hereditary. Guess what? Next generation is worse off as far as ratio of defects is concerned.</p><p>We obviously will never do "sparta" thing and kill of children society finds undesirable. Nor will anyone with genetic defect be prevented from having children. Neither is civilized resolution or would be even remotelly popular (would you want to risk your child falling victim to it? noone would.)</p><p>Anyway, I would not worry about this particular medical advance. This regeneration propably caused cancer if it got out of controll (cancer with nondiversified cells as medium is quite scarry).</p></htmltext>
<tokenext>Any form of health care is dangerous this way.Consider this : we can ( and do ) save many children with birth defects , often we are succesfull enough so that they can leard normal life ( and even be oblivious to any issues ) .
Problem is that some of theese defects are hereditary .
Guess what ?
Next generation is worse off as far as ratio of defects is concerned.We obviously will never do " sparta " thing and kill of children society finds undesirable .
Nor will anyone with genetic defect be prevented from having children .
Neither is civilized resolution or would be even remotelly popular ( would you want to risk your child falling victim to it ?
noone would .
) Anyway , I would not worry about this particular medical advance .
This regeneration propably caused cancer if it got out of controll ( cancer with nondiversified cells as medium is quite scarry ) .</tokentext>
<sentencetext>Any form of health care is dangerous this way.Consider this: we can (and do) save many children with birth defects, often we are succesfull enough so that they can leard normal life (and even be oblivious to any issues).
Problem is that some of theese defects are hereditary.
Guess what?
Next generation is worse off as far as ratio of defects is concerned.We obviously will never do "sparta" thing and kill of children society finds undesirable.
Nor will anyone with genetic defect be prevented from having children.
Neither is civilized resolution or would be even remotelly popular (would you want to risk your child falling victim to it?
noone would.
)Anyway, I would not worry about this particular medical advance.
This regeneration propably caused cancer if it got out of controll (cancer with nondiversified cells as medium is quite scarry).</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509060</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31518112</id>
	<title>Re:It will be interesting to see...</title>
	<author>moortak</author>
	<datestamp>1268837760000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>It could be that quick scarring to heal a wound was a better deal for survival than a slow regrowth.  In a world with sufficient food, sterile wound dressings, and antibiotics regeneration would be clearly better.  It might not have been for the protomammal.</htmltext>
<tokenext>It could be that quick scarring to heal a wound was a better deal for survival than a slow regrowth .
In a world with sufficient food , sterile wound dressings , and antibiotics regeneration would be clearly better .
It might not have been for the protomammal .</tokentext>
<sentencetext>It could be that quick scarring to heal a wound was a better deal for survival than a slow regrowth.
In a world with sufficient food, sterile wound dressings, and antibiotics regeneration would be clearly better.
It might not have been for the protomammal.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31508960</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509090</id>
	<title>Highlander?</title>
	<author>Anonymous</author>
	<datestamp>1268843220000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>Then the  immortals are just humans with p21 expressed?</p></htmltext>
<tokenext>Then the immortals are just humans with p21 expressed ?</tokentext>
<sentencetext>Then the  immortals are just humans with p21 expressed?</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31510262</id>
	<title>Re:So</title>
	<author>Syberz</author>
	<datestamp>1268847600000</datestamp>
	<modclass>Funny</modclass>
	<modscore>2</modscore>
	<htmltext><p><div class="quote"><p>I have a feeling you should know something about the subject before weighing in.</p></div><p>You sir are hanging out on the wrong internets.</p></div>
	</htmltext>
<tokenext>I have a feeling you should know something about the subject before weighing in.You sir are hanging out on the wrong internets .</tokentext>
<sentencetext>I have a feeling you should know something about the subject before weighing in.You sir are hanging out on the wrong internets.
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509134</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31508818</id>
	<title>Re:So</title>
	<author>Anonymous</author>
	<datestamp>1268842140000</datestamp>
	<modclass>Interestin</modclass>
	<modscore>0</modscore>
	<htmltext><p>I have a feeling this causes cancer, eventually...</p></htmltext>
<tokenext>I have a feeling this causes cancer , eventually.. .</tokentext>
<sentencetext>I have a feeling this causes cancer, eventually...</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31508764</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509058</id>
	<title>Re:It will be interesting to see...</title>
	<author>Zeros</author>
	<datestamp>1268843160000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>The problem is you can only regenerate 12 times.</htmltext>
<tokenext>The problem is you can only regenerate 12 times .</tokentext>
<sentencetext>The problem is you can only regenerate 12 times.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31508960</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31511360</id>
	<title>Re:Be careful when fooling Mother Nature</title>
	<author>Anonymous</author>
	<datestamp>1268850480000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>Well, since we don't know for sure, lets carefully give it a go and see what happens.  We can try carefully a few times, and study the results, learning and improving as we go.  Or we could go the American way, let some company step out into the unknown whole-hog, create a huge unforseen disaster (there has to be a disaster), and if it could also include explosions, earthquakes and frogs raining from the sky, that would be a nice touch.  Then have the American government ban all access and incarcerate anyone experimenting or studying this, storing even promising results in some giant secret government warehouse somewhere (see the last scene in Raiders of the Lost Ark for a reference).</p></htmltext>
<tokenext>Well , since we do n't know for sure , lets carefully give it a go and see what happens .
We can try carefully a few times , and study the results , learning and improving as we go .
Or we could go the American way , let some company step out into the unknown whole-hog , create a huge unforseen disaster ( there has to be a disaster ) , and if it could also include explosions , earthquakes and frogs raining from the sky , that would be a nice touch .
Then have the American government ban all access and incarcerate anyone experimenting or studying this , storing even promising results in some giant secret government warehouse somewhere ( see the last scene in Raiders of the Lost Ark for a reference ) .</tokentext>
<sentencetext>Well, since we don't know for sure, lets carefully give it a go and see what happens.
We can try carefully a few times, and study the results, learning and improving as we go.
Or we could go the American way, let some company step out into the unknown whole-hog, create a huge unforseen disaster (there has to be a disaster), and if it could also include explosions, earthquakes and frogs raining from the sky, that would be a nice touch.
Then have the American government ban all access and incarcerate anyone experimenting or studying this, storing even promising results in some giant secret government warehouse somewhere (see the last scene in Raiders of the Lost Ark for a reference).</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509060</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31513268</id>
	<title>Re:Now I can finally start my restaurant...</title>
	<author>Anonymous</author>
	<datestamp>1268856120000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>I love animals...they taste great!</p></htmltext>
<tokenext>I love animals...they taste great !</tokentext>
<sentencetext>I love animals...they taste great!</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31508792</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509374</id>
	<title>Re:Now I can finally start my restaurant...</title>
	<author>Anonymous</author>
	<datestamp>1268844480000</datestamp>
	<modclass>Interestin</modclass>
	<modscore>2</modscore>
	<htmltext><p>Of course PETA believes any sort of servitude by animals is the same as slavery.  They'll never be happy.  After all, if they ever got everything they wanted they'd have to find something useful to do with their lives.</p></htmltext>
<tokenext>Of course PETA believes any sort of servitude by animals is the same as slavery .
They 'll never be happy .
After all , if they ever got everything they wanted they 'd have to find something useful to do with their lives .</tokentext>
<sentencetext>Of course PETA believes any sort of servitude by animals is the same as slavery.
They'll never be happy.
After all, if they ever got everything they wanted they'd have to find something useful to do with their lives.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31508792</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31514708</id>
	<title>Regeneration Miracle</title>
	<author>imess</author>
	<datestamp>1268818200000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>Quite off topic, but I don't remember any Jesus-regenerated-a-limb miracles in the Bible, or are there?</p></htmltext>
<tokenext>Quite off topic , but I do n't remember any Jesus-regenerated-a-limb miracles in the Bible , or are there ?</tokentext>
<sentencetext>Quite off topic, but I don't remember any Jesus-regenerated-a-limb miracles in the Bible, or are there?</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509070</id>
	<title>Re:It will be interesting to see...</title>
	<author>bcmm</author>
	<datestamp>1268843160000</datestamp>
	<modclass>Insightful</modclass>
	<modscore>4</modscore>
	<htmltext>Scarring is much faster, and probably carries a lower risk of infection for creatures that don't have access to medical care.</htmltext>
<tokenext>Scarring is much faster , and probably carries a lower risk of infection for creatures that do n't have access to medical care .</tokentext>
<sentencetext>Scarring is much faster, and probably carries a lower risk of infection for creatures that don't have access to medical care.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31508960</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509388</id>
	<title>Re:So</title>
	<author>Drakkenmensch</author>
	<datestamp>1268844540000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>As long as p53 remains correctly active and functional, p21 inhibition has a potential to become a major cure treatment for a variety of ailments, from third degree burns to diabetes... up to any number of currently untreatable problems. Such a promising cure could possibly be upgraded, research pending, to a magic bullet vaccine status.</htmltext>
<tokenext>As long as p53 remains correctly active and functional , p21 inhibition has a potential to become a major cure treatment for a variety of ailments , from third degree burns to diabetes... up to any number of currently untreatable problems .
Such a promising cure could possibly be upgraded , research pending , to a magic bullet vaccine status .</tokentext>
<sentencetext>As long as p53 remains correctly active and functional, p21 inhibition has a potential to become a major cure treatment for a variety of ailments, from third degree burns to diabetes... up to any number of currently untreatable problems.
Such a promising cure could possibly be upgraded, research pending, to a magic bullet vaccine status.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509134</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31512558</id>
	<title>Re:Degeneration</title>
	<author>joocemann</author>
	<datestamp>1268853780000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p><div class="quote"><p>You know this discussion will degenerate into how this can be applied to growing a longer penis.</p></div><p>Ironically, you were the first...</p></div>
	</htmltext>
<tokenext>You know this discussion will degenerate into how this can be applied to growing a longer penis.Ironically , you were the first.. .</tokentext>
<sentencetext>You know this discussion will degenerate into how this can be applied to growing a longer penis.Ironically, you were the first...
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31508876</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31508954</id>
	<title>very probably this will cause cancer</title>
	<author>Anonymous</author>
	<datestamp>1268842740000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>Because cancer happens when cells start to divide much faster</p></htmltext>
<tokenext>Because cancer happens when cells start to divide much faster</tokentext>
<sentencetext>Because cancer happens when cells start to divide much faster</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509286</id>
	<title>Re:Be careful when fooling Mother Nature</title>
	<author>Anonymous</author>
	<datestamp>1268844180000</datestamp>
	<modclass>Insightful</modclass>
	<modscore>3</modscore>
	<htmltext><p>I  can  think of a couple reasons why this feature may have been dropped.  nutrition (regrowing something is a hell of a lot more resource intensive than just closing the hole) and infection prevention (just closing the hole is a lot faster than regrowing something, so less chance of it getting infected).  Both of these were relevant considerations very recently and evolution is pretty slow.</p></htmltext>
<tokenext>I can think of a couple reasons why this feature may have been dropped .
nutrition ( regrowing something is a hell of a lot more resource intensive than just closing the hole ) and infection prevention ( just closing the hole is a lot faster than regrowing something , so less chance of it getting infected ) .
Both of these were relevant considerations very recently and evolution is pretty slow .</tokentext>
<sentencetext>I  can  think of a couple reasons why this feature may have been dropped.
nutrition (regrowing something is a hell of a lot more resource intensive than just closing the hole) and infection prevention (just closing the hole is a lot faster than regrowing something, so less chance of it getting infected).
Both of these were relevant considerations very recently and evolution is pretty slow.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509060</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509934</id>
	<title>Re:Be careful when fooling Mother Nature</title>
	<author>IndustrialComplex</author>
	<datestamp>1268846640000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p><i>Nature does things for a reason</i></p><p>Actually, no it doesn't.</p></htmltext>
<tokenext>Nature does things for a reasonActually , no it does n't .</tokentext>
<sentencetext>Nature does things for a reasonActually, no it doesn't.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509060</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509458</id>
	<title>Re:Be careful when fooling Mother Nature</title>
	<author>Anonymous</author>
	<datestamp>1268844780000</datestamp>
	<modclass>Insightful</modclass>
	<modscore>2</modscore>
	<htmltext><p>Sure anyone with even a vague knowledge of evolution and basic highschool genetics will worry, but as long as they make vague promises like bigger dicks, hair regrowth and weight loss pills, they won't have any problems.</p></htmltext>
<tokenext>Sure anyone with even a vague knowledge of evolution and basic highschool genetics will worry , but as long as they make vague promises like bigger dicks , hair regrowth and weight loss pills , they wo n't have any problems .</tokentext>
<sentencetext>Sure anyone with even a vague knowledge of evolution and basic highschool genetics will worry, but as long as they make vague promises like bigger dicks, hair regrowth and weight loss pills, they won't have any problems.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509060</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509510</id>
	<title>Re:What's the downside?</title>
	<author>Chris Burke</author>
	<datestamp>1268845020000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p><i>Or if the damage is too severe, the cell is made senescent (they lose the ability to reproduce and instead lead out a gentle retirement, performing their normal job until they just die of old age)</i></p><p>I just heard one of my P21-arrested liver cells audibly scoff at that "gentle retirement" bit.<nobr> <wbr></nobr>:)</p></htmltext>
<tokenext>Or if the damage is too severe , the cell is made senescent ( they lose the ability to reproduce and instead lead out a gentle retirement , performing their normal job until they just die of old age ) I just heard one of my P21-arrested liver cells audibly scoff at that " gentle retirement " bit .
: )</tokentext>
<sentencetext>Or if the damage is too severe, the cell is made senescent (they lose the ability to reproduce and instead lead out a gentle retirement, performing their normal job until they just die of old age)I just heard one of my P21-arrested liver cells audibly scoff at that "gentle retirement" bit.
:)</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509204</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31510870</id>
	<title>Re:It will be interesting to see...</title>
	<author>Anonymous</author>
	<datestamp>1268849160000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>I agree, but I'm interested in whether there's more to it. Our ancestors must've already been eating foods that contained vitamin C, for synthesis of it to be irrelevant.</p><p>It's loss might even be the result of long term feedback and tolerance the body developed in response to having several times more than normal. The body's cells don't distinguish whether it's coming from an internal or external source, it just responds to it like an overproduction problem.</p><p>From what I know, vitamin C has a very low level of toxicity. If other mammals are more sensitive to it than us (for the same concentration, worse effect), it may suggest our ancestors were really adapting to having too much.</p><p>Then the loss of the trait for vitamin C synthesis, and inhibiting toxicity would've had selective pressures.</p><p>It'd be interesting to find out if this is plausible. Other mammals being more sensitive would only hint at a possible link, but does somebody here know offhand if they are?</p></htmltext>
<tokenext>I agree , but I 'm interested in whether there 's more to it .
Our ancestors must 've already been eating foods that contained vitamin C , for synthesis of it to be irrelevant.It 's loss might even be the result of long term feedback and tolerance the body developed in response to having several times more than normal .
The body 's cells do n't distinguish whether it 's coming from an internal or external source , it just responds to it like an overproduction problem.From what I know , vitamin C has a very low level of toxicity .
If other mammals are more sensitive to it than us ( for the same concentration , worse effect ) , it may suggest our ancestors were really adapting to having too much.Then the loss of the trait for vitamin C synthesis , and inhibiting toxicity would 've had selective pressures.It 'd be interesting to find out if this is plausible .
Other mammals being more sensitive would only hint at a possible link , but does somebody here know offhand if they are ?</tokentext>
<sentencetext>I agree, but I'm interested in whether there's more to it.
Our ancestors must've already been eating foods that contained vitamin C, for synthesis of it to be irrelevant.It's loss might even be the result of long term feedback and tolerance the body developed in response to having several times more than normal.
The body's cells don't distinguish whether it's coming from an internal or external source, it just responds to it like an overproduction problem.From what I know, vitamin C has a very low level of toxicity.
If other mammals are more sensitive to it than us (for the same concentration, worse effect), it may suggest our ancestors were really adapting to having too much.Then the loss of the trait for vitamin C synthesis, and inhibiting toxicity would've had selective pressures.It'd be interesting to find out if this is plausible.
Other mammals being more sensitive would only hint at a possible link, but does somebody here know offhand if they are?</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509336</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509178</id>
	<title>Why was that gene there?</title>
	<author>gmuslera</author>
	<datestamp>1268843700000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>Somewhat not being able to regenerate (or something deeply related with that) gave us an evolutionary advantage. Is pretty tempting to just make pills to turn that off, but what will be the cost? Don't think that you will fall into not being able to get older or make new memories, but still stinks to too good to be true.</htmltext>
<tokenext>Somewhat not being able to regenerate ( or something deeply related with that ) gave us an evolutionary advantage .
Is pretty tempting to just make pills to turn that off , but what will be the cost ?
Do n't think that you will fall into not being able to get older or make new memories , but still stinks to too good to be true .</tokentext>
<sentencetext>Somewhat not being able to regenerate (or something deeply related with that) gave us an evolutionary advantage.
Is pretty tempting to just make pills to turn that off, but what will be the cost?
Don't think that you will fall into not being able to get older or make new memories, but still stinks to too good to be true.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509336</id>
	<title>Re:It will be interesting to see...</title>
	<author>Spatial</author>
	<datestamp>1268844360000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p><div class="quote"><p>One would(perhaps naively) assume that regeneration is an obvious survival advantage, and that losing regenerative capabilities would be a handicap. That being so, one would tend to suspect that an anti-regeneration gene would be fairly strongly selected against. Since this gene is, in fact, rampant in mammals, one is led to the suspicion that there must be some sort of upside.</p></div><p>We can't synthesise vitamin C either, but there's no benefit to that.  Almost all other animals can synthesise it, but we get scurvy and die unless we ingest it.<br> <br>

If it doesn't kill you before you can reproduce, and it doesn't make you infertile, it can be passed on.  We lack that ability because one of our ancestors lacked it, but survived and reproduced regardless.<br> <br>

Because of that low standard for selection, it's relatively easy for a trait to be irrelevant to the selection process, good or bad.</p></div>
	</htmltext>
<tokenext>One would ( perhaps naively ) assume that regeneration is an obvious survival advantage , and that losing regenerative capabilities would be a handicap .
That being so , one would tend to suspect that an anti-regeneration gene would be fairly strongly selected against .
Since this gene is , in fact , rampant in mammals , one is led to the suspicion that there must be some sort of upside.We ca n't synthesise vitamin C either , but there 's no benefit to that .
Almost all other animals can synthesise it , but we get scurvy and die unless we ingest it .
If it does n't kill you before you can reproduce , and it does n't make you infertile , it can be passed on .
We lack that ability because one of our ancestors lacked it , but survived and reproduced regardless .
Because of that low standard for selection , it 's relatively easy for a trait to be irrelevant to the selection process , good or bad .</tokentext>
<sentencetext>One would(perhaps naively) assume that regeneration is an obvious survival advantage, and that losing regenerative capabilities would be a handicap.
That being so, one would tend to suspect that an anti-regeneration gene would be fairly strongly selected against.
Since this gene is, in fact, rampant in mammals, one is led to the suspicion that there must be some sort of upside.We can't synthesise vitamin C either, but there's no benefit to that.
Almost all other animals can synthesise it, but we get scurvy and die unless we ingest it.
If it doesn't kill you before you can reproduce, and it doesn't make you infertile, it can be passed on.
We lack that ability because one of our ancestors lacked it, but survived and reproduced regardless.
Because of that low standard for selection, it's relatively easy for a trait to be irrelevant to the selection process, good or bad.
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31508960</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31508962</id>
	<title>Which way first?</title>
	<author>spaceman375</author>
	<datestamp>1268842740000</datestamp>
	<modclass>Insightful</modclass>
	<modscore>3</modscore>
	<htmltext><p>The next step is to make some p21 specific RNA interference molecules and shut it down in an adult, non-regenerative mouse. Then clip its ear and see what happens.<br>Since it also increases apoptosis, would this make a good diet pill?</p></htmltext>
<tokenext>The next step is to make some p21 specific RNA interference molecules and shut it down in an adult , non-regenerative mouse .
Then clip its ear and see what happens.Since it also increases apoptosis , would this make a good diet pill ?</tokentext>
<sentencetext>The next step is to make some p21 specific RNA interference molecules and shut it down in an adult, non-regenerative mouse.
Then clip its ear and see what happens.Since it also increases apoptosis, would this make a good diet pill?</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509004</id>
	<title>Re:So</title>
	<author>Exitar</author>
	<datestamp>1268842920000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>Nope. Rat-Man.</p></htmltext>
<tokenext>Nope .
Rat-Man .</tokentext>
<sentencetext>Nope.
Rat-Man.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31508764</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509190</id>
	<title>Oh yes!</title>
	<author>Anonymous</author>
	<datestamp>1268843700000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>What the fuck? Lady Gaga is kind of hot. I know she has a penis, but if I could have sex with her and Beyonce...well butter my ass and call me a homo.</p></htmltext>
<tokenext>What the fuck ?
Lady Gaga is kind of hot .
I know she has a penis , but if I could have sex with her and Beyonce...well butter my ass and call me a homo .</tokentext>
<sentencetext>What the fuck?
Lady Gaga is kind of hot.
I know she has a penis, but if I could have sex with her and Beyonce...well butter my ass and call me a homo.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31508976</id>
	<title>Pythonic...</title>
	<author>fuzzyfuzzyfungus</author>
	<datestamp>1268842860000</datestamp>
	<modclass>Redundant</modclass>
	<modscore>1</modscore>
	<htmltext>"She turned me into a newt!"... "I regenerated!".</htmltext>
<tokenext>" She turned me into a newt ! " .. .
" I regenerated !
" .</tokentext>
<sentencetext>"She turned me into a newt!"...
"I regenerated!
".</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509840</id>
	<title>Re:So</title>
	<author>icannotthinkofaname</author>
	<datestamp>1268846280000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>Actually, my first thought was that if I can regenerate, then all I'm missing is a TARDIS.</p><p>brb, off to find some TARDIS coral so I can grow my own TARDIS.</p></htmltext>
<tokenext>Actually , my first thought was that if I can regenerate , then all I 'm missing is a TARDIS.brb , off to find some TARDIS coral so I can grow my own TARDIS .</tokentext>
<sentencetext>Actually, my first thought was that if I can regenerate, then all I'm missing is a TARDIS.brb, off to find some TARDIS coral so I can grow my own TARDIS.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31508764</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509868</id>
	<title>I don't know anything beyond high school biology.</title>
	<author>calibre-not-output</author>
	<datestamp>1268846400000</datestamp>
	<modclass>Insightful</modclass>
	<modscore>2</modscore>
	<htmltext>But this still makes me giddy for the future of Medicine.</htmltext>
<tokenext>But this still makes me giddy for the future of Medicine .</tokentext>
<sentencetext>But this still makes me giddy for the future of Medicine.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31508764</id>
	<title>So</title>
	<author>Anonymous</author>
	<datestamp>1268841840000</datestamp>
	<modclass>Funny</modclass>
	<modscore>4</modscore>
	<htmltext><p>We can all be Wolverine now?  Cool!</p></htmltext>
<tokenext>We can all be Wolverine now ?
Cool !</tokentext>
<sentencetext>We can all be Wolverine now?
Cool!</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509654</id>
	<title>Re:So</title>
	<author>Scubaraf</author>
	<datestamp>1268845560000</datestamp>
	<modclass>Interestin</modclass>
	<modscore>3</modscore>
	<htmltext>The cancer concern is a legitimate one. These p21 knockouts are lab mice kept in clean conditions. They may not develop cancers in a three year span, but that demonstrates little about the oncogenic potential in humans.
<br> <br>
I'm assuming there is some evolutionary reason for curtailing a vigorous healing response. It maybe to reduce the cancer rate, but it could just as simply be something else very important - regulation of immune response for example.
<br> <br>
One potentially useful experiment would be to challenge these mice with carcinogen (like ENU) and see what their cancer rate is compared to controls. Alternatively, you could use genetic means (insertion of oncogenes or mating to mice with knocked out tumor suppressor genes) to see if the cancers they develop are more aggressive or more likely to metastasize.

In any case, this is a very cool finding.</htmltext>
<tokenext>The cancer concern is a legitimate one .
These p21 knockouts are lab mice kept in clean conditions .
They may not develop cancers in a three year span , but that demonstrates little about the oncogenic potential in humans .
I 'm assuming there is some evolutionary reason for curtailing a vigorous healing response .
It maybe to reduce the cancer rate , but it could just as simply be something else very important - regulation of immune response for example .
One potentially useful experiment would be to challenge these mice with carcinogen ( like ENU ) and see what their cancer rate is compared to controls .
Alternatively , you could use genetic means ( insertion of oncogenes or mating to mice with knocked out tumor suppressor genes ) to see if the cancers they develop are more aggressive or more likely to metastasize .
In any case , this is a very cool finding .</tokentext>
<sentencetext>The cancer concern is a legitimate one.
These p21 knockouts are lab mice kept in clean conditions.
They may not develop cancers in a three year span, but that demonstrates little about the oncogenic potential in humans.
I'm assuming there is some evolutionary reason for curtailing a vigorous healing response.
It maybe to reduce the cancer rate, but it could just as simply be something else very important - regulation of immune response for example.
One potentially useful experiment would be to challenge these mice with carcinogen (like ENU) and see what their cancer rate is compared to controls.
Alternatively, you could use genetic means (insertion of oncogenes or mating to mice with knocked out tumor suppressor genes) to see if the cancers they develop are more aggressive or more likely to metastasize.
In any case, this is a very cool finding.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509134</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509180</id>
	<title>All very nice stuff, but...</title>
	<author>Nihiltres</author>
	<datestamp>1268843700000</datestamp>
	<modclass>Interestin</modclass>
	<modscore>2</modscore>
	<htmltext><p>...in practice, do we have the technology to knock this gene out in humans? That's the key thing. Either you have to engineer every human to have the gene before birth, or you have to do a live fix. And a live fix has all sorts of complications.</p><p>Of course, I'm completely ignoring potential side effects. This is best if you imagine a drug for it being advertised: "Regrowitol may cause side effects including cancer, accessory limbs, mutation into evil lizard creature..."</p><p>We're living in the future, sure. But we don't have all the cheat codes for reality yet.</p></htmltext>
<tokenext>...in practice , do we have the technology to knock this gene out in humans ?
That 's the key thing .
Either you have to engineer every human to have the gene before birth , or you have to do a live fix .
And a live fix has all sorts of complications.Of course , I 'm completely ignoring potential side effects .
This is best if you imagine a drug for it being advertised : " Regrowitol may cause side effects including cancer , accessory limbs , mutation into evil lizard creature... " We 're living in the future , sure .
But we do n't have all the cheat codes for reality yet .</tokentext>
<sentencetext>...in practice, do we have the technology to knock this gene out in humans?
That's the key thing.
Either you have to engineer every human to have the gene before birth, or you have to do a live fix.
And a live fix has all sorts of complications.Of course, I'm completely ignoring potential side effects.
This is best if you imagine a drug for it being advertised: "Regrowitol may cause side effects including cancer, accessory limbs, mutation into evil lizard creature..."We're living in the future, sure.
But we don't have all the cheat codes for reality yet.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31513186</id>
	<title>Re:So</title>
	<author>Anonymous</author>
	<datestamp>1268855760000</datestamp>
	<modclass>Funny</modclass>
	<modscore>1</modscore>
	<htmltext><p>Not only that, but consider the anti-aging possibilities:</p><p>1. Get old<br>2. Sequentially, &amp; repeat:<br>
&nbsp; &nbsp; &nbsp; a. Amputate old body segments<br>
&nbsp; &nbsp; &nbsp; b. <b> <i>Scream like a motherfucker</i></b> <br>
&nbsp; &nbsp; &nbsp; c. Regenerate yer parts with that "factory fresh" smell<br>3. ???<br>4. Profit!</p><p>Don't worry about your brain, you can do one hemisphere at a time.  And remember, corporate ownership of popular culture means all your important memories are already stored in the cloud!</p></htmltext>
<tokenext>Not only that , but consider the anti-aging possibilities : 1 .
Get old2 .
Sequentially , &amp; repeat :       a. Amputate old body segments       b. Scream like a motherfucker       c. Regenerate yer parts with that " factory fresh " smell3 .
? ? ? 4. Profit ! Do n't worry about your brain , you can do one hemisphere at a time .
And remember , corporate ownership of popular culture means all your important memories are already stored in the cloud !</tokentext>
<sentencetext>Not only that, but consider the anti-aging possibilities:1.
Get old2.
Sequentially, &amp; repeat:
      a. Amputate old body segments
      b.  Scream like a motherfucker 
      c. Regenerate yer parts with that "factory fresh" smell3.
???4. Profit!Don't worry about your brain, you can do one hemisphere at a time.
And remember, corporate ownership of popular culture means all your important memories are already stored in the cloud!</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31508764</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31516948</id>
	<title>Especially useful</title>
	<author>el cisne</author>
	<datestamp>1268828700000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>See: John Wayne Bobbit</htmltext>
<tokenext>See : John Wayne Bobbit</tokentext>
<sentencetext>See: John Wayne Bobbit</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31514510</id>
	<title>Re:Now I can finally start my restaurant...</title>
	<author>jellomizer</author>
	<datestamp>1268817540000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>The problem is groups like PETA group together way to many ideals and try to get them all enforced. If they just focused on an area they could probably get better progress done.</p><p>Lets just say Fur Coats... You could probably lot of people to support you on that.<br>Then you say to join our group you can't eat meat then you will loose members. Then you say you can't eat milk and eggs... You loose more.  Then you say you can't have pets you loose even more...</p><p>So what you end up with is a small group of people who are very like minded... The good it makes them easy to manage but in general rather ineffective overall.</p></htmltext>
<tokenext>The problem is groups like PETA group together way to many ideals and try to get them all enforced .
If they just focused on an area they could probably get better progress done.Lets just say Fur Coats... You could probably lot of people to support you on that.Then you say to join our group you ca n't eat meat then you will loose members .
Then you say you ca n't eat milk and eggs... You loose more .
Then you say you ca n't have pets you loose even more...So what you end up with is a small group of people who are very like minded... The good it makes them easy to manage but in general rather ineffective overall .</tokentext>
<sentencetext>The problem is groups like PETA group together way to many ideals and try to get them all enforced.
If they just focused on an area they could probably get better progress done.Lets just say Fur Coats... You could probably lot of people to support you on that.Then you say to join our group you can't eat meat then you will loose members.
Then you say you can't eat milk and eggs... You loose more.
Then you say you can't have pets you loose even more...So what you end up with is a small group of people who are very like minded... The good it makes them easy to manage but in general rather ineffective overall.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509374</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509410</id>
	<title>Re:It will be interesting to see...</title>
	<author>Scrameustache</author>
	<datestamp>1268844600000</datestamp>
	<modclass>Insightful</modclass>
	<modscore>2</modscore>
	<htmltext><p><div class="quote"><p>What the side effects are. One would(perhaps naively) assume that regeneration is an obvious survival advantage, and that losing regenerative capabilities would be a handicap. That being so, one would tend to suspect that an anti-regeneration gene would be fairly strongly selected against. Since this gene is, in fact, rampant in mammals, one is led to the suspicion that there must be some sort of upside.<br>Is it something more or less irrelevant to modern humans(at least those wealthy enough to ever be genetically engineered), something like "without any sort of medical care, most serious injuries were fatal before regeneration could occur, so the extra energy costs weren't worth it", or is it some kicker of the "Well, without a whole bunch of other adaptations possessed by certain amphibians and creepy-crawlies, you'll 'regenerate' yourself entirely full of tumors by age 20." flavor?</p></div><p>Well, FTFA: <i>"In normal cells, p21 acts like a brake to block cell cycle progression in the event of DNA damage, preventing the cells from dividing and potentially becoming cancerous," Heber-Katz said. "In these mice without p21, <b>we do see the expected increase in DNA damage, but surprisingly no increase in cancer has been reported</b>."<br>In fact, the researchers saw an increase in apoptosis in MRL mice -- also known as programmed cell death -- the cell's self-destruct mechanism that is often switched on when DNA has been damaged. According to Heber-Katz, this is exactly the sort of behavior seen in naturally regenerative creatures.</i></p><p>Maybe this gene was like the scaffolding you build before building an arch, and now that we have evolved the rest of the cancer-fighting-arch, we can remove the p21 scaffolding.<br>Or maybe this will end up like thalidomide. I say we proceed with cautious optimism.</p></div>
	</htmltext>
<tokenext>What the side effects are .
One would ( perhaps naively ) assume that regeneration is an obvious survival advantage , and that losing regenerative capabilities would be a handicap .
That being so , one would tend to suspect that an anti-regeneration gene would be fairly strongly selected against .
Since this gene is , in fact , rampant in mammals , one is led to the suspicion that there must be some sort of upside.Is it something more or less irrelevant to modern humans ( at least those wealthy enough to ever be genetically engineered ) , something like " without any sort of medical care , most serious injuries were fatal before regeneration could occur , so the extra energy costs were n't worth it " , or is it some kicker of the " Well , without a whole bunch of other adaptations possessed by certain amphibians and creepy-crawlies , you 'll 'regenerate ' yourself entirely full of tumors by age 20 .
" flavor ? Well , FTFA : " In normal cells , p21 acts like a brake to block cell cycle progression in the event of DNA damage , preventing the cells from dividing and potentially becoming cancerous , " Heber-Katz said .
" In these mice without p21 , we do see the expected increase in DNA damage , but surprisingly no increase in cancer has been reported .
" In fact , the researchers saw an increase in apoptosis in MRL mice -- also known as programmed cell death -- the cell 's self-destruct mechanism that is often switched on when DNA has been damaged .
According to Heber-Katz , this is exactly the sort of behavior seen in naturally regenerative creatures.Maybe this gene was like the scaffolding you build before building an arch , and now that we have evolved the rest of the cancer-fighting-arch , we can remove the p21 scaffolding.Or maybe this will end up like thalidomide .
I say we proceed with cautious optimism .</tokentext>
<sentencetext>What the side effects are.
One would(perhaps naively) assume that regeneration is an obvious survival advantage, and that losing regenerative capabilities would be a handicap.
That being so, one would tend to suspect that an anti-regeneration gene would be fairly strongly selected against.
Since this gene is, in fact, rampant in mammals, one is led to the suspicion that there must be some sort of upside.Is it something more or less irrelevant to modern humans(at least those wealthy enough to ever be genetically engineered), something like "without any sort of medical care, most serious injuries were fatal before regeneration could occur, so the extra energy costs weren't worth it", or is it some kicker of the "Well, without a whole bunch of other adaptations possessed by certain amphibians and creepy-crawlies, you'll 'regenerate' yourself entirely full of tumors by age 20.
" flavor?Well, FTFA: "In normal cells, p21 acts like a brake to block cell cycle progression in the event of DNA damage, preventing the cells from dividing and potentially becoming cancerous," Heber-Katz said.
"In these mice without p21, we do see the expected increase in DNA damage, but surprisingly no increase in cancer has been reported.
"In fact, the researchers saw an increase in apoptosis in MRL mice -- also known as programmed cell death -- the cell's self-destruct mechanism that is often switched on when DNA has been damaged.
According to Heber-Katz, this is exactly the sort of behavior seen in naturally regenerative creatures.Maybe this gene was like the scaffolding you build before building an arch, and now that we have evolved the rest of the cancer-fighting-arch, we can remove the p21 scaffolding.Or maybe this will end up like thalidomide.
I say we proceed with cautious optimism.
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31508960</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31520328</id>
	<title>Re:Now I can finally start my restaurant...</title>
	<author>Anonymous</author>
	<datestamp>1268908860000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>You should have more sympathy for cats.  Think of them as 'land kittens'.</p></htmltext>
<tokenext>You should have more sympathy for cats .
Think of them as 'land kittens' .</tokentext>
<sentencetext>You should have more sympathy for cats.
Think of them as 'land kittens'.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509862</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31511740</id>
	<title>We are the borg</title>
	<author>Anonymous</author>
	<datestamp>1268851500000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>Resistance is futile..!</p><p>I wonder when we will be able to grow hearts, livers and other replacement organs, like brains for some people.</p><p>But really, has a single mouse, cow, pig, chicken, or amphebian benefitted from this branch of research?</p></htmltext>
<tokenext>Resistance is futile.. ! I wonder when we will be able to grow hearts , livers and other replacement organs , like brains for some people.But really , has a single mouse , cow , pig , chicken , or amphebian benefitted from this branch of research ?</tokentext>
<sentencetext>Resistance is futile..!I wonder when we will be able to grow hearts, livers and other replacement organs, like brains for some people.But really, has a single mouse, cow, pig, chicken, or amphebian benefitted from this branch of research?</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509394</id>
	<title>PNAS</title>
	<author>Anonymous</author>
	<datestamp>1268844540000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>Be careful how you pronounce this.</p></htmltext>
<tokenext>Be careful how you pronounce this .</tokentext>
<sentencetext>Be careful how you pronounce this.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509054</id>
	<title>Re:Now I can finally start my restaurant...</title>
	<author>Bakkster</author>
	<datestamp>1268843100000</datestamp>
	<modclass>Funny</modclass>
	<modscore>2</modscore>
	<htmltext><p>"Waiter, there's a blastema in my soup."</p></htmltext>
<tokenext>" Waiter , there 's a blastema in my soup .
"</tokentext>
<sentencetext>"Waiter, there's a blastema in my soup.
"</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31508792</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31510272</id>
	<title>Where is the Evolutionary Advantage?</title>
	<author>Roger W Moore</author>
	<datestamp>1268847600000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>Presumably in the past there must have been some evolutionary advantage to developing scars rather than regrowing a new limb. It is possible that this might not be a factor that helps us now. For example perhaps it allowed more rapid recovery from a serious wound whereas now, with hospitals and modern medicine, a more complete recovery would be an advantage over speed. However until we have some idea what the advantage was/is it would be wise to proceed with some caution.</htmltext>
<tokenext>Presumably in the past there must have been some evolutionary advantage to developing scars rather than regrowing a new limb .
It is possible that this might not be a factor that helps us now .
For example perhaps it allowed more rapid recovery from a serious wound whereas now , with hospitals and modern medicine , a more complete recovery would be an advantage over speed .
However until we have some idea what the advantage was/is it would be wise to proceed with some caution .</tokentext>
<sentencetext>Presumably in the past there must have been some evolutionary advantage to developing scars rather than regrowing a new limb.
It is possible that this might not be a factor that helps us now.
For example perhaps it allowed more rapid recovery from a serious wound whereas now, with hospitals and modern medicine, a more complete recovery would be an advantage over speed.
However until we have some idea what the advantage was/is it would be wise to proceed with some caution.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509134</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509522</id>
	<title>Re:Be careful when fooling Mother Nature</title>
	<author>The End Of Days</author>
	<datestamp>1268845080000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p><div class="quote"><p>Darwinism is cruel.</p></div><p>Darwinism is a description of natural processes. Cruelty requires intent, and there is no evidence of intent in the underlying processes, never mind the description of those same.</p><p><div class="quote"><p>Nature does things for a reason.</p></div><p>Again, there is no evidence of this point of view.</p><p>I'm not sure how you got modded up.  I can only assume the intelligent design folks somehow got points today.</p></div>
	</htmltext>
<tokenext>Darwinism is cruel.Darwinism is a description of natural processes .
Cruelty requires intent , and there is no evidence of intent in the underlying processes , never mind the description of those same.Nature does things for a reason.Again , there is no evidence of this point of view.I 'm not sure how you got modded up .
I can only assume the intelligent design folks somehow got points today .</tokentext>
<sentencetext>Darwinism is cruel.Darwinism is a description of natural processes.
Cruelty requires intent, and there is no evidence of intent in the underlying processes, never mind the description of those same.Nature does things for a reason.Again, there is no evidence of this point of view.I'm not sure how you got modded up.
I can only assume the intelligent design folks somehow got points today.
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509060</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509908</id>
	<title>Re:Now I can finally start my restaurant...</title>
	<author>nomoreunusednickname</author>
	<datestamp>1268846520000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>Add to your menu: frog legs, ox tail soup, chicken wings, various ears and tongues... all sustainably grown *drool*</htmltext>
<tokenext>Add to your menu : frog legs , ox tail soup , chicken wings , various ears and tongues... all sustainably grown * drool *</tokentext>
<sentencetext>Add to your menu: frog legs, ox tail soup, chicken wings, various ears and tongues... all sustainably grown *drool*</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31508792</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31508960</id>
	<title>It will be interesting to see...</title>
	<author>fuzzyfuzzyfungus</author>
	<datestamp>1268842740000</datestamp>
	<modclass>Insightful</modclass>
	<modscore>5</modscore>
	<htmltext>What the side effects are. One would(perhaps naively) assume that regeneration is an obvious survival advantage, and that losing regenerative capabilities would be a handicap. That being so, one would tend to suspect that an anti-regeneration gene would be fairly strongly selected against. Since this gene is, in fact, rampant in mammals, one is led to the suspicion that there must be some sort of upside.<br> <br>

Is it something more or less irrelevant to modern humans(at least those wealthy enough to ever be genetically engineered), something like "without any sort of medical care, most serious injuries were fatal before regeneration could occur, so the extra energy costs weren't worth it", or is it some kicker of the "Well, without a whole bunch of other adaptations possessed by certain amphibians and creepy-crawlies, you'll 'regenerate' yourself entirely full of tumors by age 20." flavor?</htmltext>
<tokenext>What the side effects are .
One would ( perhaps naively ) assume that regeneration is an obvious survival advantage , and that losing regenerative capabilities would be a handicap .
That being so , one would tend to suspect that an anti-regeneration gene would be fairly strongly selected against .
Since this gene is , in fact , rampant in mammals , one is led to the suspicion that there must be some sort of upside .
Is it something more or less irrelevant to modern humans ( at least those wealthy enough to ever be genetically engineered ) , something like " without any sort of medical care , most serious injuries were fatal before regeneration could occur , so the extra energy costs were n't worth it " , or is it some kicker of the " Well , without a whole bunch of other adaptations possessed by certain amphibians and creepy-crawlies , you 'll 'regenerate ' yourself entirely full of tumors by age 20 .
" flavor ?</tokentext>
<sentencetext>What the side effects are.
One would(perhaps naively) assume that regeneration is an obvious survival advantage, and that losing regenerative capabilities would be a handicap.
That being so, one would tend to suspect that an anti-regeneration gene would be fairly strongly selected against.
Since this gene is, in fact, rampant in mammals, one is led to the suspicion that there must be some sort of upside.
Is it something more or less irrelevant to modern humans(at least those wealthy enough to ever be genetically engineered), something like "without any sort of medical care, most serious injuries were fatal before regeneration could occur, so the extra energy costs weren't worth it", or is it some kicker of the "Well, without a whole bunch of other adaptations possessed by certain amphibians and creepy-crawlies, you'll 'regenerate' yourself entirely full of tumors by age 20.
" flavor?</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509152</id>
	<title>Re:Degeneration</title>
	<author>JavaBear</author>
	<datestamp>1268843580000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p><div class="quote"><p>You know this discussion will degenerate into how this can be applied to growing a longer penis.</p></div><p>No, but spammers are sure to find a way to try and sell that point</p></div>
	</htmltext>
<tokenext>You know this discussion will degenerate into how this can be applied to growing a longer penis.No , but spammers are sure to find a way to try and sell that point</tokentext>
<sentencetext>You know this discussion will degenerate into how this can be applied to growing a longer penis.No, but spammers are sure to find a way to try and sell that point
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31508876</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509862</id>
	<title>Re:Now I can finally start my restaurant...</title>
	<author>Anonymous</author>
	<datestamp>1268846400000</datestamp>
	<modclass>Interestin</modclass>
	<modscore>3</modscore>
	<htmltext><p>The worst part of it is, <a href="http://en.wikipedia.org/wiki/Self-domestication" title="wikipedia.org">science believes that cats 'self domesticated'</a> [wikipedia.org].  If anything, <i>denying</i> humans the right to keep cats as pets is animal abuse, since it is denying them an adaptation they developed themselves.</p><p>Who ever said these people used logic though?</p></htmltext>
<tokenext>The worst part of it is , science believes that cats 'self domesticated ' [ wikipedia.org ] .
If anything , denying humans the right to keep cats as pets is animal abuse , since it is denying them an adaptation they developed themselves.Who ever said these people used logic though ?</tokentext>
<sentencetext>The worst part of it is, science believes that cats 'self domesticated' [wikipedia.org].
If anything, denying humans the right to keep cats as pets is animal abuse, since it is denying them an adaptation they developed themselves.Who ever said these people used logic though?</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509374</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31512938</id>
	<title>Good news for bobbit</title>
	<author>Anonymous</author>
	<datestamp>1268854980000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>Good news for bobbit, he can finally re-grow his <i>PNAS</i>...</p></htmltext>
<tokenext>Good news for bobbit , he can finally re-grow his PNAS.. .</tokentext>
<sentencetext>Good news for bobbit, he can finally re-grow his PNAS...</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509580</id>
	<title>Re:What's the downside?</title>
	<author>Anonymous</author>
	<datestamp>1268845320000</datestamp>
	<modclass>Interestin</modclass>
	<modscore>1</modscore>
	<htmltext><p>Well, it's also useful for medical reasons. If we develop a molecule/protein that counteracts the protein fabricated by p21, we could temporarily get the healing power (for example, to heal damage to internal organs), without giving up the anti-cancer protection. This would be localized, and not too dangerous as the effects are temporary.</p></htmltext>
<tokenext>Well , it 's also useful for medical reasons .
If we develop a molecule/protein that counteracts the protein fabricated by p21 , we could temporarily get the healing power ( for example , to heal damage to internal organs ) , without giving up the anti-cancer protection .
This would be localized , and not too dangerous as the effects are temporary .</tokentext>
<sentencetext>Well, it's also useful for medical reasons.
If we develop a molecule/protein that counteracts the protein fabricated by p21, we could temporarily get the healing power (for example, to heal damage to internal organs), without giving up the anti-cancer protection.
This would be localized, and not too dangerous as the effects are temporary.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509204</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31513464</id>
	<title>The consequence is scary: a world of cheerleaders.</title>
	<author>garompeta</author>
	<datestamp>1268856840000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>If we all agree that the real purpose of reproduction is to perpetuate ourselves for the survival of the species...<p>Then with the eventual eradication of death (or continuous delaying of death) our reproductive function will begin to become a liability for our survival on this planet. (Overpopulating the world, depletion of natural resources, etc...)</p><p> If we achieve perfect regeneration and become almost immortals, are we going destined to live in a sexless world?... is space colonization the answer to this problem? </p><p> Just some food for thought...</p></htmltext>
<tokenext>If we all agree that the real purpose of reproduction is to perpetuate ourselves for the survival of the species...Then with the eventual eradication of death ( or continuous delaying of death ) our reproductive function will begin to become a liability for our survival on this planet .
( Overpopulating the world , depletion of natural resources , etc... ) If we achieve perfect regeneration and become almost immortals , are we going destined to live in a sexless world ? .. .
is space colonization the answer to this problem ?
Just some food for thought.. .</tokentext>
<sentencetext>If we all agree that the real purpose of reproduction is to perpetuate ourselves for the survival of the species...Then with the eventual eradication of death (or continuous delaying of death) our reproductive function will begin to become a liability for our survival on this planet.
(Overpopulating the world, depletion of natural resources, etc...) If we achieve perfect regeneration and become almost immortals, are we going destined to live in a sexless world?...
is space colonization the answer to this problem?
Just some food for thought...</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31518010</id>
	<title>Re:Be careful when fooling Mother Nature</title>
	<author>Anonymous</author>
	<datestamp>1268836980000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p><div class="quote"><p>It nature is so cruel and barbaric, then for what reason did it evolve human beings who feel sympathy, empathy...</p></div><p>As an audience. Obviously nature grew tired of doing it for its own sadistic pleasure, and thought it would be cool to generate an audience who could be shocked and dismayed. (This is anthropomorphism gone wild, of course, but what the heck.)</p></div>
	</htmltext>
<tokenext>It nature is so cruel and barbaric , then for what reason did it evolve human beings who feel sympathy , empathy...As an audience .
Obviously nature grew tired of doing it for its own sadistic pleasure , and thought it would be cool to generate an audience who could be shocked and dismayed .
( This is anthropomorphism gone wild , of course , but what the heck .
)</tokentext>
<sentencetext>It nature is so cruel and barbaric, then for what reason did it evolve human beings who feel sympathy, empathy...As an audience.
Obviously nature grew tired of doing it for its own sadistic pleasure, and thought it would be cool to generate an audience who could be shocked and dismayed.
(This is anthropomorphism gone wild, of course, but what the heck.
)
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509710</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31511788</id>
	<title>Re:Now I can finally start my restaurant...</title>
	<author>flyingfsck</author>
	<datestamp>1268851620000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>Well, doesn't PETA mean People Eating Tasty Animals?</htmltext>
<tokenext>Well , does n't PETA mean People Eating Tasty Animals ?</tokentext>
<sentencetext>Well, doesn't PETA mean People Eating Tasty Animals?</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31508792</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31512838</id>
	<title>Re:Be careful when fooling Mother Nature</title>
	<author>Yamata no Orochi</author>
	<datestamp>1268854620000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>Maybe that has something to do with why they're testing it on mice instead of immediately patenting and having some drug approved by the FDA for human consumption. What are you trying to convince us of?</p></htmltext>
<tokenext>Maybe that has something to do with why they 're testing it on mice instead of immediately patenting and having some drug approved by the FDA for human consumption .
What are you trying to convince us of ?</tokentext>
<sentencetext>Maybe that has something to do with why they're testing it on mice instead of immediately patenting and having some drug approved by the FDA for human consumption.
What are you trying to convince us of?</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509060</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31513930</id>
	<title>Re:So</title>
	<author>Red Flayer</author>
	<datestamp>1268858520000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><blockquote><div><p>I'm not going to claim it protects against cancer, instead merely make a vague statement along the lines of "we'd better watch out carefully when removing something evolution has decided should appear in fit creatures".</p></div></blockquote><p>We already know what the answer is -- why this gene was selected for.  Did you notice that the regeneration resulted in no scar formation?  The answer to the reproductive advantage should be coming clear to you any second, it's obvious really. <br> <br>Chicks dig scars.</p></div>
	</htmltext>
<tokenext>I 'm not going to claim it protects against cancer , instead merely make a vague statement along the lines of " we 'd better watch out carefully when removing something evolution has decided should appear in fit creatures " .We already know what the answer is -- why this gene was selected for .
Did you notice that the regeneration resulted in no scar formation ?
The answer to the reproductive advantage should be coming clear to you any second , it 's obvious really .
Chicks dig scars .</tokentext>
<sentencetext>I'm not going to claim it protects against cancer, instead merely make a vague statement along the lines of "we'd better watch out carefully when removing something evolution has decided should appear in fit creatures".We already know what the answer is -- why this gene was selected for.
Did you notice that the regeneration resulted in no scar formation?
The answer to the reproductive advantage should be coming clear to you any second, it's obvious really.
Chicks dig scars.
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509574</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31510832</id>
	<title>Re:Be careful when fooling Mother Nature</title>
	<author>Anonymous</author>
	<datestamp>1268849040000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>I'm concerned that you're anthropomorphizing nature.</p><p>Nature does not do things for a reason.  Nature is a product of blind cause-and-effect, not of intelligence.</p></htmltext>
<tokenext>I 'm concerned that you 're anthropomorphizing nature.Nature does not do things for a reason .
Nature is a product of blind cause-and-effect , not of intelligence .</tokentext>
<sentencetext>I'm concerned that you're anthropomorphizing nature.Nature does not do things for a reason.
Nature is a product of blind cause-and-effect, not of intelligence.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509060</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509268</id>
	<title>bit3h</title>
	<author>Anonymous</author>
	<datestamp>1268844060000</datestamp>
	<modclass>Troll</modclass>
	<modscore>-1</modscore>
	<htmltext><A HREF="http://goat.cx/" title="goat.cx" rel="nofollow">BSD fanatics? I've the most. Look at sta.ndpoint, I don't the last night of</a> [goat.cx]</htmltext>
<tokenext>BSD fanatics ?
I 've the most .
Look at sta.ndpoint , I do n't the last night of [ goat.cx ]</tokentext>
<sentencetext>BSD fanatics?
I've the most.
Look at sta.ndpoint, I don't the last night of [goat.cx]</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509856</id>
	<title>Re:So</title>
	<author>interkin3tic</author>
	<datestamp>1268846340000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p><div class="quote"><p>We can all be Wolverine now? Cool!</p></div><p>More like <a href="http://en.wikipedia.org/wiki/Deadpool" title="wikipedia.org">Deadpool.</a> [wikipedia.org] </p><p><div class="quote"><p>However, his healing factor results in massive scar tissue causing his appearance to be severely disfigured. An unanticipated side effect of the therapy was a rapid acceleration of cancerous tumors as well, causing them to quickly spread across his entire body as soon as his powers fully activated.</p></div><p>Except without the funny one liners, awesome assasin skills, teleporter, or probably the rivalry with wolverine.  I suppose you could wear the costume though and get in a fight with a real wolverine.</p></div>
	</htmltext>
<tokenext>We can all be Wolverine now ?
Cool ! More like Deadpool .
[ wikipedia.org ] However , his healing factor results in massive scar tissue causing his appearance to be severely disfigured .
An unanticipated side effect of the therapy was a rapid acceleration of cancerous tumors as well , causing them to quickly spread across his entire body as soon as his powers fully activated.Except without the funny one liners , awesome assasin skills , teleporter , or probably the rivalry with wolverine .
I suppose you could wear the costume though and get in a fight with a real wolverine .</tokentext>
<sentencetext>We can all be Wolverine now?
Cool!More like Deadpool.
[wikipedia.org] However, his healing factor results in massive scar tissue causing his appearance to be severely disfigured.
An unanticipated side effect of the therapy was a rapid acceleration of cancerous tumors as well, causing them to quickly spread across his entire body as soon as his powers fully activated.Except without the funny one liners, awesome assasin skills, teleporter, or probably the rivalry with wolverine.
I suppose you could wear the costume though and get in a fight with a real wolverine.
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31508764</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509554</id>
	<title>Re:It will be interesting to see...</title>
	<author>structural\_biologist</author>
	<datestamp>1268845200000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>In the <i>PNAS</i> paper published by the scientists, they noted that the "healer" strains of mice deficient in the p21 protein showed increased signs of DNA damage.  These observations make sense because p21 is a key component of biochemical stress response pathways that, for example, stop a cell from dividing after its DNA has been damaged.</p><p>In fact, p21 is one of the proteins that carries out instructions from the infamous p53 protein (the tumor-suppressor protein commonly referred to as the "Guardian of the Genome" that is mutated in over 50\% of cancers).  So, in terms of applications, disrupting p21 function in order to induce regenerative abilities would be like playing with fire: such a modification would shut down one pathway through which p53 protects cells against cancer.  If one were to think of using this knowledge for regenerative medicine, applications where p21 is temporarily disabled (for example, through transient application of RNA interference) would be better than permanently shutting off the gene.</p><p>Overall, however, this paper produces some nice evidence pointing to DNA damage as an important mechanism in aging.  This is of course known, but it's always nice to see these concepts pop up in fields related to aging.</p></htmltext>
<tokenext>In the PNAS paper published by the scientists , they noted that the " healer " strains of mice deficient in the p21 protein showed increased signs of DNA damage .
These observations make sense because p21 is a key component of biochemical stress response pathways that , for example , stop a cell from dividing after its DNA has been damaged.In fact , p21 is one of the proteins that carries out instructions from the infamous p53 protein ( the tumor-suppressor protein commonly referred to as the " Guardian of the Genome " that is mutated in over 50 \ % of cancers ) .
So , in terms of applications , disrupting p21 function in order to induce regenerative abilities would be like playing with fire : such a modification would shut down one pathway through which p53 protects cells against cancer .
If one were to think of using this knowledge for regenerative medicine , applications where p21 is temporarily disabled ( for example , through transient application of RNA interference ) would be better than permanently shutting off the gene.Overall , however , this paper produces some nice evidence pointing to DNA damage as an important mechanism in aging .
This is of course known , but it 's always nice to see these concepts pop up in fields related to aging .</tokentext>
<sentencetext>In the PNAS paper published by the scientists, they noted that the "healer" strains of mice deficient in the p21 protein showed increased signs of DNA damage.
These observations make sense because p21 is a key component of biochemical stress response pathways that, for example, stop a cell from dividing after its DNA has been damaged.In fact, p21 is one of the proteins that carries out instructions from the infamous p53 protein (the tumor-suppressor protein commonly referred to as the "Guardian of the Genome" that is mutated in over 50\% of cancers).
So, in terms of applications, disrupting p21 function in order to induce regenerative abilities would be like playing with fire: such a modification would shut down one pathway through which p53 protects cells against cancer.
If one were to think of using this knowledge for regenerative medicine, applications where p21 is temporarily disabled (for example, through transient application of RNA interference) would be better than permanently shutting off the gene.Overall, however, this paper produces some nice evidence pointing to DNA damage as an important mechanism in aging.
This is of course known, but it's always nice to see these concepts pop up in fields related to aging.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31508960</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31511906</id>
	<title>Re:Wait, so..</title>
	<author>Mindcontrolled</author>
	<datestamp>1268851920000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>It is not that simple in the field of cellular regulation. The mammalian cell has a complex network of signals and signal processing proteins that control the development of the cell - when it divides, when it dies, when it goes into a resting state. Within such a network, there is no simple "one gene - one trait" relationship. Blocking the p21 gene alters the behaviour of this network in a way that makes regeneration possible in mice. The function of the gene - or rather its product - is to block entry of cells into a certain development phase. It acts as a checkpoint mechanism for development. That is not purely a negative trait as in "loss of regeneration", but can be viewed as positive as in "increased control over cellular development". It is quite hard to slap simple evaluations on such functions. The reason why the system evolved that way may be cancer prevention, it may also be a more fine-grained control over tissue development.</htmltext>
<tokenext>It is not that simple in the field of cellular regulation .
The mammalian cell has a complex network of signals and signal processing proteins that control the development of the cell - when it divides , when it dies , when it goes into a resting state .
Within such a network , there is no simple " one gene - one trait " relationship .
Blocking the p21 gene alters the behaviour of this network in a way that makes regeneration possible in mice .
The function of the gene - or rather its product - is to block entry of cells into a certain development phase .
It acts as a checkpoint mechanism for development .
That is not purely a negative trait as in " loss of regeneration " , but can be viewed as positive as in " increased control over cellular development " .
It is quite hard to slap simple evaluations on such functions .
The reason why the system evolved that way may be cancer prevention , it may also be a more fine-grained control over tissue development .</tokentext>
<sentencetext>It is not that simple in the field of cellular regulation.
The mammalian cell has a complex network of signals and signal processing proteins that control the development of the cell - when it divides, when it dies, when it goes into a resting state.
Within such a network, there is no simple "one gene - one trait" relationship.
Blocking the p21 gene alters the behaviour of this network in a way that makes regeneration possible in mice.
The function of the gene - or rather its product - is to block entry of cells into a certain development phase.
It acts as a checkpoint mechanism for development.
That is not purely a negative trait as in "loss of regeneration", but can be viewed as positive as in "increased control over cellular development".
It is quite hard to slap simple evaluations on such functions.
The reason why the system evolved that way may be cancer prevention, it may also be a more fine-grained control over tissue development.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509476</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509768</id>
	<title>evolution purists</title>
	<author>Anonymous</author>
	<datestamp>1268845980000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>For the evolution purists out there. Don't worry about it. Genetic problems are always self correcting, despite all our efforts to the contrary. Disaster and catastrophe are always around the corner. As a race, we will either be strong enough to survive or smart enough to compensate...or not. After all, if you are a purist, and we go the way of the dinosuar, that it is as it should be, right?</p></htmltext>
<tokenext>For the evolution purists out there .
Do n't worry about it .
Genetic problems are always self correcting , despite all our efforts to the contrary .
Disaster and catastrophe are always around the corner .
As a race , we will either be strong enough to survive or smart enough to compensate...or not .
After all , if you are a purist , and we go the way of the dinosuar , that it is as it should be , right ?</tokentext>
<sentencetext>For the evolution purists out there.
Don't worry about it.
Genetic problems are always self correcting, despite all our efforts to the contrary.
Disaster and catastrophe are always around the corner.
As a race, we will either be strong enough to survive or smart enough to compensate...or not.
After all, if you are a purist, and we go the way of the dinosuar, that it is as it should be, right?</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31510294</id>
	<title>Re:Be careful when fooling Mother Nature</title>
	<author>Rogue974</author>
	<datestamp>1268847660000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>This was already answered on Star Trek Next Generation, Episode Genesis.  Data and Picard come back from chasing a run away torpedo they were testing.  While gone, Dr. Crusher activated a dormant gen in Lt. Barkley so he could naturally fight off an alien flu virus.

The newly activated defense went airborne and started activating all of the dormant genes in the entire crew and they all de-evolved to lower forms of life.

So if they proceed, it will activate other things that nature turned off and we will all end up as freaks of nature and some day, hundred of years in the future, the aliens will land and find the remains of our society with the many strange and varied species of monkeys that shouldn't exist and they will wonder were all the people that made the society went to, not realizing we are right there...all those strange looking monkeys that are watching them explore the remains of our cities!

Then they will try and move in and the primitive half-ape-man gone wrong things will attack and there will be mass chaos as battle between primitives and aliens happen and then something close to Dances with Wolves, or Avatar happens!

I followed the advice of your sig and decided to not be dull in my response.</htmltext>
<tokenext>This was already answered on Star Trek Next Generation , Episode Genesis .
Data and Picard come back from chasing a run away torpedo they were testing .
While gone , Dr. Crusher activated a dormant gen in Lt. Barkley so he could naturally fight off an alien flu virus .
The newly activated defense went airborne and started activating all of the dormant genes in the entire crew and they all de-evolved to lower forms of life .
So if they proceed , it will activate other things that nature turned off and we will all end up as freaks of nature and some day , hundred of years in the future , the aliens will land and find the remains of our society with the many strange and varied species of monkeys that should n't exist and they will wonder were all the people that made the society went to , not realizing we are right there...all those strange looking monkeys that are watching them explore the remains of our cities !
Then they will try and move in and the primitive half-ape-man gone wrong things will attack and there will be mass chaos as battle between primitives and aliens happen and then something close to Dances with Wolves , or Avatar happens !
I followed the advice of your sig and decided to not be dull in my response .</tokentext>
<sentencetext>This was already answered on Star Trek Next Generation, Episode Genesis.
Data and Picard come back from chasing a run away torpedo they were testing.
While gone, Dr. Crusher activated a dormant gen in Lt. Barkley so he could naturally fight off an alien flu virus.
The newly activated defense went airborne and started activating all of the dormant genes in the entire crew and they all de-evolved to lower forms of life.
So if they proceed, it will activate other things that nature turned off and we will all end up as freaks of nature and some day, hundred of years in the future, the aliens will land and find the remains of our society with the many strange and varied species of monkeys that shouldn't exist and they will wonder were all the people that made the society went to, not realizing we are right there...all those strange looking monkeys that are watching them explore the remains of our cities!
Then they will try and move in and the primitive half-ape-man gone wrong things will attack and there will be mass chaos as battle between primitives and aliens happen and then something close to Dances with Wolves, or Avatar happens!
I followed the advice of your sig and decided to not be dull in my response.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509060</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509884</id>
	<title>Re:So</title>
	<author>jlebrech</author>
	<datestamp>1268846460000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>or if you cannot switch it off; Benjamin Button!</p></htmltext>
<tokenext>or if you can not switch it off ; Benjamin Button !</tokentext>
<sentencetext>or if you cannot switch it off; Benjamin Button!</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31508764</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31510000</id>
	<title>One important question remains:</title>
	<author>Hurricane78</author>
	<datestamp>1268846880000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>What is the reason that life forms without that ability won the evolutionary war in the first place?<br>What bad could come from that ability? Side-effects?<br>Because I really can&rsquo;t see any downsides.</p><p>Anyone here who is a bit more of an expert than the random coward?<nobr> <wbr></nobr>;)</p></htmltext>
<tokenext>What is the reason that life forms without that ability won the evolutionary war in the first place ? What bad could come from that ability ?
Side-effects ? Because I really can    t see any downsides.Anyone here who is a bit more of an expert than the random coward ?
; )</tokentext>
<sentencetext>What is the reason that life forms without that ability won the evolutionary war in the first place?What bad could come from that ability?
Side-effects?Because I really can’t see any downsides.Anyone here who is a bit more of an expert than the random coward?
;)</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509710</id>
	<title>Re:Be careful when fooling Mother Nature</title>
	<author>lawpoop</author>
	<datestamp>1268845800000</datestamp>
	<modclass>Funny</modclass>
	<modscore>4</modscore>
	<htmltext><p><div class="quote"><p>Darwinism is cruel... Nature does things for a reason.</p></div><p>Narture wants to be anthropomorphized<nobr> <wbr></nobr>;)<br> <br>It nature is so cruel and barbaric, then for what reason did it evolve human beings who feel sympathy, empathy, are able to learn, and practice healing arts?</p></div>
	</htmltext>
<tokenext>Darwinism is cruel... Nature does things for a reason.Narture wants to be anthropomorphized ; ) It nature is so cruel and barbaric , then for what reason did it evolve human beings who feel sympathy , empathy , are able to learn , and practice healing arts ?</tokentext>
<sentencetext>Darwinism is cruel... Nature does things for a reason.Narture wants to be anthropomorphized ;) It nature is so cruel and barbaric, then for what reason did it evolve human beings who feel sympathy, empathy, are able to learn, and practice healing arts?
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509060</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509404</id>
	<title>Why won't God heal amputees?</title>
	<author>Holammer</author>
	<datestamp>1268844600000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>... when science does?

Cheap shots aside, here's hoping that this actually get a practical application that will help people in the future.</htmltext>
<tokenext>... when science does ?
Cheap shots aside , here 's hoping that this actually get a practical application that will help people in the future .</tokentext>
<sentencetext>... when science does?
Cheap shots aside, here's hoping that this actually get a practical application that will help people in the future.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509976</id>
	<title>Darwinism in a social context...</title>
	<author>Xzisted</author>
	<datestamp>1268846760000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>The only reason that mammals with an active p21 gene and the inability to regenerate tissue continued on and p21 suppressed mammals did not is because chicks dig scars.  No perfectly healthy scarless male is going to attract a hot chick who is only interested in the dummy injury prone type.</htmltext>
<tokenext>The only reason that mammals with an active p21 gene and the inability to regenerate tissue continued on and p21 suppressed mammals did not is because chicks dig scars .
No perfectly healthy scarless male is going to attract a hot chick who is only interested in the dummy injury prone type .</tokentext>
<sentencetext>The only reason that mammals with an active p21 gene and the inability to regenerate tissue continued on and p21 suppressed mammals did not is because chicks dig scars.
No perfectly healthy scarless male is going to attract a hot chick who is only interested in the dummy injury prone type.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509060</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31510130</id>
	<title>Other News: Genetically-Modified Spider Disappears</title>
	<author>Anonymous</author>
	<datestamp>1268847180000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>In other news a genetically-modified spider has disappeared from a NYC museum.  The disappearance was noticed after a high school group had gone for a tour through the museum.  Museum personnel explained, that the disappearance should not concern anyone as the spiders cannot reproduce.</p></htmltext>
<tokenext>In other news a genetically-modified spider has disappeared from a NYC museum .
The disappearance was noticed after a high school group had gone for a tour through the museum .
Museum personnel explained , that the disappearance should not concern anyone as the spiders can not reproduce .</tokentext>
<sentencetext>In other news a genetically-modified spider has disappeared from a NYC museum.
The disappearance was noticed after a high school group had gone for a tour through the museum.
Museum personnel explained, that the disappearance should not concern anyone as the spiders cannot reproduce.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31513632</id>
	<title>Re:Be careful when fooling Mother Nature</title>
	<author>Chris Burke</author>
	<datestamp>1268857320000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p><i>Narture wants to be anthropomorphized<nobr> <wbr></nobr>;)</i></p><p><i>It nature is so cruel and barbaric, then for what reason did it evolve human beings who feel sympathy, empathy, are able to learn, and practice healing arts?</i></p><p>You said it yourself:  So that we could anthropomorphize nature!</p></htmltext>
<tokenext>Narture wants to be anthropomorphized ; ) It nature is so cruel and barbaric , then for what reason did it evolve human beings who feel sympathy , empathy , are able to learn , and practice healing arts ? You said it yourself : So that we could anthropomorphize nature !</tokentext>
<sentencetext>Narture wants to be anthropomorphized ;)It nature is so cruel and barbaric, then for what reason did it evolve human beings who feel sympathy, empathy, are able to learn, and practice healing arts?You said it yourself:  So that we could anthropomorphize nature!</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509710</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509762</id>
	<title>Re:Now I can finally start my restaurant...</title>
	<author>thijsh</author>
	<datestamp>1268845980000</datestamp>
	<modclass>Interestin</modclass>
	<modscore>3</modscore>
	<htmltext>Something useful... like ending actual ongoing *human* slavery? Nah... PETA finds it more worthwhile to kill (uhhh 'rescue') some more animals: <a href="http://www.petakillsanimals.com/" title="petakillsanimals.com">http://www.petakillsanimals.com/</a> [petakillsanimals.com].</htmltext>
<tokenext>Something useful... like ending actual ongoing * human * slavery ?
Nah... PETA finds it more worthwhile to kill ( uhhh 'rescue ' ) some more animals : http : //www.petakillsanimals.com/ [ petakillsanimals.com ] .</tokentext>
<sentencetext>Something useful... like ending actual ongoing *human* slavery?
Nah... PETA finds it more worthwhile to kill (uhhh 'rescue') some more animals: http://www.petakillsanimals.com/ [petakillsanimals.com].</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509374</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509294</id>
	<title>Safety switch.</title>
	<author>Anonymous</author>
	<datestamp>1268844180000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>My guess is that while not having this gene results in wonderous regenerative abilities, it'll also increase your chances of developing cancer before the age of 20 by a bajillionfold. Not a problem for mice, but certainly a problem for men.</p></htmltext>
<tokenext>My guess is that while not having this gene results in wonderous regenerative abilities , it 'll also increase your chances of developing cancer before the age of 20 by a bajillionfold .
Not a problem for mice , but certainly a problem for men .</tokentext>
<sentencetext>My guess is that while not having this gene results in wonderous regenerative abilities, it'll also increase your chances of developing cancer before the age of 20 by a bajillionfold.
Not a problem for mice, but certainly a problem for men.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31508846</id>
	<title>So this is what hell will be...</title>
	<author>mtrachtenberg</author>
	<datestamp>1268842260000</datestamp>
	<modclass>Troll</modclass>
	<modscore>0</modscore>
	<htmltext><p>So this is what the religions were talking about when they talked about hell.  Everyone lives forever, one hundred people have all the money, and Sarah Palin is President-for-Life.</p></htmltext>
<tokenext>So this is what the religions were talking about when they talked about hell .
Everyone lives forever , one hundred people have all the money , and Sarah Palin is President-for-Life .</tokentext>
<sentencetext>So this is what the religions were talking about when they talked about hell.
Everyone lives forever, one hundred people have all the money, and Sarah Palin is President-for-Life.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509476</id>
	<title>Wait, so..</title>
	<author>flintmecha</author>
	<datestamp>1268844900000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext>...the expierment involves <i>removing</i> the gene which <i>prohibits</i> the regeneration. <br>

Interesting how that works. I would think the existence of a gene would grant the existence of a trait, not the absence of it. Then again, I'm no biologist. So mammals evolved this gene which prevents tissue regeneration. I wonder why?<br> <br>

Anyway, this is really cool.</htmltext>
<tokenext>...the expierment involves removing the gene which prohibits the regeneration .
Interesting how that works .
I would think the existence of a gene would grant the existence of a trait , not the absence of it .
Then again , I 'm no biologist .
So mammals evolved this gene which prevents tissue regeneration .
I wonder why ?
Anyway , this is really cool .</tokentext>
<sentencetext>...the expierment involves removing the gene which prohibits the regeneration.
Interesting how that works.
I would think the existence of a gene would grant the existence of a trait, not the absence of it.
Then again, I'm no biologist.
So mammals evolved this gene which prevents tissue regeneration.
I wonder why?
Anyway, this is really cool.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509060</id>
	<title>Be careful when fooling Mother Nature</title>
	<author>Anonymous</author>
	<datestamp>1268843160000</datestamp>
	<modclass>Insightful</modclass>
	<modscore>1</modscore>
	<htmltext>This is, obviously, the holy grail for many injuries and holds out immense hope for amputees etc. etc. There's one thing about it that has me concerned. Darwinism is cruel. It causes the weak to fall by the wayside of evolution and the strong to perpetuate the best of the species. Nature does things for a reason. The question in the back of my mind is: if we fool with this, what are the underlying natural reasons for the gene to be turned off? We aught to be taking a very close look at the consequences of turning on this gene before we start trying to fool mother nature. In short, I'm not against it, I'm just concerned and cautious - are you?</htmltext>
<tokenext>This is , obviously , the holy grail for many injuries and holds out immense hope for amputees etc .
etc. There 's one thing about it that has me concerned .
Darwinism is cruel .
It causes the weak to fall by the wayside of evolution and the strong to perpetuate the best of the species .
Nature does things for a reason .
The question in the back of my mind is : if we fool with this , what are the underlying natural reasons for the gene to be turned off ?
We aught to be taking a very close look at the consequences of turning on this gene before we start trying to fool mother nature .
In short , I 'm not against it , I 'm just concerned and cautious - are you ?</tokentext>
<sentencetext>This is, obviously, the holy grail for many injuries and holds out immense hope for amputees etc.
etc. There's one thing about it that has me concerned.
Darwinism is cruel.
It causes the weak to fall by the wayside of evolution and the strong to perpetuate the best of the species.
Nature does things for a reason.
The question in the back of my mind is: if we fool with this, what are the underlying natural reasons for the gene to be turned off?
We aught to be taking a very close look at the consequences of turning on this gene before we start trying to fool mother nature.
In short, I'm not against it, I'm just concerned and cautious - are you?</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509378</id>
	<title>Re:Degeneration</title>
	<author>Chris Burke</author>
	<datestamp>1268844540000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>*Jamaican^W WoW troll voice*</p><p>They say that when you cut off an extremity it regenerates a little bigger.</p><p><i>Don't believe it.</i></p></htmltext>
<tokenext>* Jamaican ^ W WoW troll voice * They say that when you cut off an extremity it regenerates a little bigger.Do n't believe it .</tokentext>
<sentencetext>*Jamaican^W WoW troll voice*They say that when you cut off an extremity it regenerates a little bigger.Don't believe it.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31508876</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509452</id>
	<title>Re:Be careful when fooling Mother Nature</title>
	<author>Scrameustache</author>
	<datestamp>1268844780000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p><div class="quote"><p>the underlying natural reasons for the gene to be turned off? We aught to be taking a very close look at the consequences of turning on this gene</p></div><p>Other way around: <i>The <b>absence</b> of this single gene, called p21, confers a healing potential in mice</i></p></div>
	</htmltext>
<tokenext>the underlying natural reasons for the gene to be turned off ?
We aught to be taking a very close look at the consequences of turning on this geneOther way around : The absence of this single gene , called p21 , confers a healing potential in mice</tokentext>
<sentencetext>the underlying natural reasons for the gene to be turned off?
We aught to be taking a very close look at the consequences of turning on this geneOther way around: The absence of this single gene, called p21, confers a healing potential in mice
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509060</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31515372</id>
	<title>Re:Be careful when fooling Mother Nature</title>
	<author>pclminion</author>
	<datestamp>1268820540000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p> <em>There's one thing about it that has me concerned. Darwinism is cruel. It causes the weak to fall by the wayside of evolution and the strong to perpetuate the best of the species. Nature does things for a reason.</em> </p><p>"Cruel," "weak," "strong," "best," "reason." That's an awful lot of total bullshit.</p><p>Here's one of my favorite analogies. You're driving on a country road in autumn. On either side of the road, there are fallen leaves piled up. On the road itself, there are no leaves. LIKEOHMIGOD. What could have caused this to happen? The answer, obviously, is that any leaf which lies in the road will be blown around by passing cars at random, until it eventually (randomly!) comes to rest on the side of the road, away from the influence of the cars. The result is an ordering of the system. The leaves on the side of the road are stable. The leaves on the road are not stable. Hopefully, you see the insanity of ascribing any sort of willfulness, or distinction between "weak" and "strong" leaves, or try to find any "reason" for it other than simply that the leaves move until they no longer move.</p><p>In this case, the passing cars represent the forces of nature and environment which dictate which organisms survive and which do not survive. When you say that nature is weeding out the weak from the strong, it's like saying that one of the goals of the passing cars is to push all the leaves to the side of the road.</p><p>Now, you're driving down the road and you see a leaf right in the middle. LIKEOHMIGOD-AGAIN! Something terribly deep must be happening here. Something unexpected, like the lack of mammalian regeneration. <i>There must be a good reason for it!</i> The passing cars (nature) must be singling out this leaf as special somehow, and not throwing it to the side of the road!</p><p>The answer turns out to be that the leaf is stuck to the pavement by a piece of chewing gum. Aww, there wasn't any deep meaning after all.</p></htmltext>
<tokenext>There 's one thing about it that has me concerned .
Darwinism is cruel .
It causes the weak to fall by the wayside of evolution and the strong to perpetuate the best of the species .
Nature does things for a reason .
" Cruel , " " weak , " " strong , " " best , " " reason .
" That 's an awful lot of total bullshit.Here 's one of my favorite analogies .
You 're driving on a country road in autumn .
On either side of the road , there are fallen leaves piled up .
On the road itself , there are no leaves .
LIKEOHMIGOD. What could have caused this to happen ?
The answer , obviously , is that any leaf which lies in the road will be blown around by passing cars at random , until it eventually ( randomly !
) comes to rest on the side of the road , away from the influence of the cars .
The result is an ordering of the system .
The leaves on the side of the road are stable .
The leaves on the road are not stable .
Hopefully , you see the insanity of ascribing any sort of willfulness , or distinction between " weak " and " strong " leaves , or try to find any " reason " for it other than simply that the leaves move until they no longer move.In this case , the passing cars represent the forces of nature and environment which dictate which organisms survive and which do not survive .
When you say that nature is weeding out the weak from the strong , it 's like saying that one of the goals of the passing cars is to push all the leaves to the side of the road.Now , you 're driving down the road and you see a leaf right in the middle .
LIKEOHMIGOD-AGAIN ! Something terribly deep must be happening here .
Something unexpected , like the lack of mammalian regeneration .
There must be a good reason for it !
The passing cars ( nature ) must be singling out this leaf as special somehow , and not throwing it to the side of the road ! The answer turns out to be that the leaf is stuck to the pavement by a piece of chewing gum .
Aww , there was n't any deep meaning after all .</tokentext>
<sentencetext> There's one thing about it that has me concerned.
Darwinism is cruel.
It causes the weak to fall by the wayside of evolution and the strong to perpetuate the best of the species.
Nature does things for a reason.
"Cruel," "weak," "strong," "best," "reason.
" That's an awful lot of total bullshit.Here's one of my favorite analogies.
You're driving on a country road in autumn.
On either side of the road, there are fallen leaves piled up.
On the road itself, there are no leaves.
LIKEOHMIGOD. What could have caused this to happen?
The answer, obviously, is that any leaf which lies in the road will be blown around by passing cars at random, until it eventually (randomly!
) comes to rest on the side of the road, away from the influence of the cars.
The result is an ordering of the system.
The leaves on the side of the road are stable.
The leaves on the road are not stable.
Hopefully, you see the insanity of ascribing any sort of willfulness, or distinction between "weak" and "strong" leaves, or try to find any "reason" for it other than simply that the leaves move until they no longer move.In this case, the passing cars represent the forces of nature and environment which dictate which organisms survive and which do not survive.
When you say that nature is weeding out the weak from the strong, it's like saying that one of the goals of the passing cars is to push all the leaves to the side of the road.Now, you're driving down the road and you see a leaf right in the middle.
LIKEOHMIGOD-AGAIN! Something terribly deep must be happening here.
Something unexpected, like the lack of mammalian regeneration.
There must be a good reason for it!
The passing cars (nature) must be singling out this leaf as special somehow, and not throwing it to the side of the road!The answer turns out to be that the leaf is stuck to the pavement by a piece of chewing gum.
Aww, there wasn't any deep meaning after all.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509060</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509354</id>
	<title>Re:Degeneration</title>
	<author>geekoid</author>
	<datestamp>1268844360000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>If by 'larger' you mean 'second', then yes.</p></htmltext>
<tokenext>If by 'larger ' you mean 'second ' , then yes .</tokentext>
<sentencetext>If by 'larger' you mean 'second', then yes.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31508876</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31508792</id>
	<title>Now I can finally start my restaurant...</title>
	<author>Anonymous</author>
	<datestamp>1268842020000</datestamp>
	<modclass>Funny</modclass>
	<modscore>5</modscore>
	<htmltext>Now I can finally start my restaurant (which specializes in mouse-tail delicacies) without PETA breathing down my neck.  "Look:  it's growing back!"  Mouse-tail soup anyone?</htmltext>
<tokenext>Now I can finally start my restaurant ( which specializes in mouse-tail delicacies ) without PETA breathing down my neck .
" Look : it 's growing back !
" Mouse-tail soup anyone ?</tokentext>
<sentencetext>Now I can finally start my restaurant (which specializes in mouse-tail delicacies) without PETA breathing down my neck.
"Look:  it's growing back!
"  Mouse-tail soup anyone?</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31520304</id>
	<title>Can we grow back mouses from tails?</title>
	<author>OMFG it's Rici</author>
	<datestamp>1268908440000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>Can we grow back entire mouses from tails?<nobr> <wbr></nobr>:v</htmltext>
<tokenext>Can we grow back entire mouses from tails ?
: v</tokentext>
<sentencetext>Can we grow back entire mouses from tails?
:v</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509134</id>
	<title>Re:So</title>
	<author>TheMeuge</author>
	<datestamp>1268843460000</datestamp>
	<modclass>Informativ</modclass>
	<modscore>5</modscore>
	<htmltext><p>I have a feeling you should know something about the subject before weighing in.</p><p>p21 knockout mice don't appear to get cancer more than wild-type mice, interestingly enough...</p><p>It's interesting, because p53 is a major regulator of p21 expression, and p21 itself is a major player in regulating cell cycle progression into S-phase, thus controlling cell replication. p53 knockouts, on the other hand, are extremely prone to cancer, as p53 is one of the most important tumor-suppressor genes.</p><p>The paper is interesting because the authors demonstrate that two separate strains of mice that contain a p21 deficiency can both regenerate differentiated tissue (measured by looking at ear-hole closure), supporting the link between p21/cell cycle progression and tissue regeneration. Whether this is of consequence therapeutically is a different story, but I'd be very interested to see the same study repeated in wild-type mice being fed or injected a small molecule p21 inhibitor.</p></htmltext>
<tokenext>I have a feeling you should know something about the subject before weighing in.p21 knockout mice do n't appear to get cancer more than wild-type mice , interestingly enough...It 's interesting , because p53 is a major regulator of p21 expression , and p21 itself is a major player in regulating cell cycle progression into S-phase , thus controlling cell replication .
p53 knockouts , on the other hand , are extremely prone to cancer , as p53 is one of the most important tumor-suppressor genes.The paper is interesting because the authors demonstrate that two separate strains of mice that contain a p21 deficiency can both regenerate differentiated tissue ( measured by looking at ear-hole closure ) , supporting the link between p21/cell cycle progression and tissue regeneration .
Whether this is of consequence therapeutically is a different story , but I 'd be very interested to see the same study repeated in wild-type mice being fed or injected a small molecule p21 inhibitor .</tokentext>
<sentencetext>I have a feeling you should know something about the subject before weighing in.p21 knockout mice don't appear to get cancer more than wild-type mice, interestingly enough...It's interesting, because p53 is a major regulator of p21 expression, and p21 itself is a major player in regulating cell cycle progression into S-phase, thus controlling cell replication.
p53 knockouts, on the other hand, are extremely prone to cancer, as p53 is one of the most important tumor-suppressor genes.The paper is interesting because the authors demonstrate that two separate strains of mice that contain a p21 deficiency can both regenerate differentiated tissue (measured by looking at ear-hole closure), supporting the link between p21/cell cycle progression and tissue regeneration.
Whether this is of consequence therapeutically is a different story, but I'd be very interested to see the same study repeated in wild-type mice being fed or injected a small molecule p21 inhibitor.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31508818</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31509162</id>
	<title>Re:So</title>
	<author>Anonymous</author>
	<datestamp>1268843580000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>I just want to know if the bird on a mans penis has been regenerated yet?</p></htmltext>
<tokenext>I just want to know if the bird on a mans penis has been regenerated yet ?</tokentext>
<sentencetext>I just want to know if the bird on a mans penis has been regenerated yet?</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31508764</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31510176</id>
	<title>Re:So</title>
	<author>Anonymous</author>
	<datestamp>1268847360000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>I will be the Lizard!</p></htmltext>
<tokenext>I will be the Lizard !</tokentext>
<sentencetext>I will be the Lizard!</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_17_1425241.31508764</parent>
</comment>
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