<article>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#article10_03_24_2232241</id>
	<title>First Anti-Cancer Nanoparticle Trial On Humans a Success</title>
	<author>samzenpus</author>
	<datestamp>1269432960000</datestamp>
	<htmltext>An anonymous reader writes <i>"Nanoparticles have been able to <a href="http://gizmodo.com/5501103/this-is-the-future-of-the-fight-against-cancer">disable cancerous cells in living human bodies</a> for the first time. The results are perfect so far, killing tumors with no side effects whatsoever. Mark Davis, <a href="http://media.caltech.edu/press\_releases/13334">project leader at CalTech</a>, says that 'it sneaks in, evades the immune system, delivers the siRNA, and the disassembled components exit out.' Truly amazing."</i></htmltext>
<tokenext>An anonymous reader writes " Nanoparticles have been able to disable cancerous cells in living human bodies for the first time .
The results are perfect so far , killing tumors with no side effects whatsoever .
Mark Davis , project leader at CalTech , says that 'it sneaks in , evades the immune system , delivers the siRNA , and the disassembled components exit out .
' Truly amazing .
"</tokentext>
<sentencetext>An anonymous reader writes "Nanoparticles have been able to disable cancerous cells in living human bodies for the first time.
The results are perfect so far, killing tumors with no side effects whatsoever.
Mark Davis, project leader at CalTech, says that 'it sneaks in, evades the immune system, delivers the siRNA, and the disassembled components exit out.
' Truly amazing.
"</sentencetext>
</article>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31607354</id>
	<title>Re:Not just cancer!</title>
	<author>Anonymous</author>
	<datestamp>1269453600000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p><div class="quote"><p>Now we just need to figure out how to change people's DNA on the fly.</p></div><p>I think I saw Jeff Goldblum do that in a movie once...</p></div>
	</htmltext>
<tokenext>Now we just need to figure out how to change people 's DNA on the fly.I think I saw Jeff Goldblum do that in a movie once.. .</tokentext>
<sentencetext>Now we just need to figure out how to change people's DNA on the fly.I think I saw Jeff Goldblum do that in a movie once...
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31605834</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606842</id>
	<title>Re:Artificial virus</title>
	<author>Anonymous</author>
	<datestamp>1269446400000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p><div class="quote"><p>I can see what could go right: stealthily delivering an array of genetic changes to women to turn them all into beautiful, bisexual nymphomaniacs.</p></div><p>...who brew beer.</p></div>
	</htmltext>
<tokenext>I can see what could go right : stealthily delivering an array of genetic changes to women to turn them all into beautiful , bisexual nymphomaniacs....who brew beer .</tokentext>
<sentencetext>I can see what could go right: stealthily delivering an array of genetic changes to women to turn them all into beautiful, bisexual nymphomaniacs....who brew beer.
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606018</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31608894</id>
	<title>real article</title>
	<author>cinnamon colbert</author>
	<datestamp>1269522540000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>this url takes you to the real article <br>
<a href="http://www.nature.com/nature/journal/vaop/ncurrent/full/nature08956.html" title="nature.com">http://www.nature.com/nature/journal/vaop/ncurrent/full/nature08956.html</a> [nature.com] <br>

As a scientist who works in biotech, I am amazed at how credulous slashdot is about biotech stuff; i guess it is because most<nobr> <wbr></nobr>/.s are not biologists, so they don't understand how far from a treatment this sort of thing is;
This is great science, and an important step forward, but it is a long, long way from an FDA approved treatment.</htmltext>
<tokenext>this url takes you to the real article http : //www.nature.com/nature/journal/vaop/ncurrent/full/nature08956.html [ nature.com ] As a scientist who works in biotech , I am amazed at how credulous slashdot is about biotech stuff ; i guess it is because most /.s are not biologists , so they do n't understand how far from a treatment this sort of thing is ; This is great science , and an important step forward , but it is a long , long way from an FDA approved treatment .</tokentext>
<sentencetext>this url takes you to the real article 
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature08956.html [nature.com] 

As a scientist who works in biotech, I am amazed at how credulous slashdot is about biotech stuff; i guess it is because most /.s are not biologists, so they don't understand how far from a treatment this sort of thing is;
This is great science, and an important step forward, but it is a long, long way from an FDA approved treatment.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31613224</id>
	<title>Now, see the video</title>
	<author>forgot\_my\_username</author>
	<datestamp>1269540360000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>I have two videos (stolen..... er... borrowed from youtube) that show how siRNA works and protein synthesis.... as a little refresher.<br>
the link is : <a href="http://www.allvoices.com/contributed-news/5471722-cancer-zapped-with-nanoparticles-in-humans" title="allvoices.com" rel="nofollow">siRNA + Protein Synthesis, with article attached<nobr> <wbr></nobr>:P</a> [allvoices.com]</htmltext>
<tokenext>I have two videos ( stolen..... er... borrowed from youtube ) that show how siRNA works and protein synthesis.... as a little refresher .
the link is : siRNA + Protein Synthesis , with article attached : P [ allvoices.com ]</tokentext>
<sentencetext>I have two videos (stolen..... er... borrowed from youtube) that show how siRNA works and protein synthesis.... as a little refresher.
the link is : siRNA + Protein Synthesis, with article attached :P [allvoices.com]</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606180</id>
	<title>Re:Isn't this...</title>
	<author>erroneus</author>
	<datestamp>1269439680000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>It also goes to show how a carefully engineered nano-particle can be used to kill people in a rather covert way.  CSI probably doesn't yet have a way to detect this stuff.</p></htmltext>
<tokenext>It also goes to show how a carefully engineered nano-particle can be used to kill people in a rather covert way .
CSI probably does n't yet have a way to detect this stuff .</tokentext>
<sentencetext>It also goes to show how a carefully engineered nano-particle can be used to kill people in a rather covert way.
CSI probably doesn't yet have a way to detect this stuff.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31605812</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31611764</id>
	<title>Pasedena builds Cure for Cancer!</title>
	<author>Anonymous</author>
	<datestamp>1269535860000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>When does the +1 happiness in all cities kick in?<nobr> <wbr></nobr>:D</p></htmltext>
<tokenext>When does the + 1 happiness in all cities kick in ?
: D</tokentext>
<sentencetext>When does the +1 happiness in all cities kick in?
:D</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31607146</id>
	<title>Re:Isn't this...</title>
	<author>AmigaMMC</author>
	<datestamp>1269449580000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>Yeah sure, and one morning we wake up and we are Borg.</htmltext>
<tokenext>Yeah sure , and one morning we wake up and we are Borg .</tokentext>
<sentencetext>Yeah sure, and one morning we wake up and we are Borg.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31605812</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606224</id>
	<title>The good.. and bad?</title>
	<author>EkriirkE</author>
	<datestamp>1269440160000</datestamp>
	<modclass>Troll</modclass>
	<modscore>0</modscore>
	<htmltext><p><div class="quote"><p>What's so exciting is that virtually any gene can be targeted now. Every protein now is druggable.</p></div><p>&lt;tinfoilhat&gt;<br>
This has potential as an anti GATACA, making people more subservient, less/non violent.  What's to stop [controlling body] from slipping in some extra alterations alongside the cancer stopper?
<br>&lt;/tinfoilhat&gt;</p></div>
	</htmltext>
<tokenext>What 's so exciting is that virtually any gene can be targeted now .
Every protein now is druggable .
This has potential as an anti GATACA , making people more subservient , less/non violent .
What 's to stop [ controlling body ] from slipping in some extra alterations alongside the cancer stopper ?</tokentext>
<sentencetext>What's so exciting is that virtually any gene can be targeted now.
Every protein now is druggable.
This has potential as an anti GATACA, making people more subservient, less/non violent.
What's to stop [controlling body] from slipping in some extra alterations alongside the cancer stopper?

	</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31607324</id>
	<title>Immortality anyone?</title>
	<author>Raystonn</author>
	<datestamp>1269452820000</datestamp>
	<modclass>Interestin</modclass>
	<modscore>2</modscore>
	<htmltext>Wonderful.  Now that we can destroy cancer cells, where can I sign up to have my telemeres refreshed?  I'm not getting any younger here... yet.</htmltext>
<tokenext>Wonderful .
Now that we can destroy cancer cells , where can I sign up to have my telemeres refreshed ?
I 'm not getting any younger here... yet .</tokentext>
<sentencetext>Wonderful.
Now that we can destroy cancer cells, where can I sign up to have my telemeres refreshed?
I'm not getting any younger here... yet.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31607122</id>
	<title>Re:Not just cancer!</title>
	<author>Anonymous</author>
	<datestamp>1269449220000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p><div class="quote"><p>From comments on TFA, "The Lab" writes: "a science editor would be more capable of pointing out what is really exciting here, which is the ability to stop cells from producing a given protein."</p><p>I think the cancer aspect is great (if it works) but this has potential for curing a whole host of diseases.</p><p>Now we just need to figure out how to change people's DNA on the fly.</p></div><p>Why, so that we have a bunch of crazed splicers running around, building underwater cities and kidnapping our children?</p></div>
	</htmltext>
<tokenext>From comments on TFA , " The Lab " writes : " a science editor would be more capable of pointing out what is really exciting here , which is the ability to stop cells from producing a given protein .
" I think the cancer aspect is great ( if it works ) but this has potential for curing a whole host of diseases.Now we just need to figure out how to change people 's DNA on the fly.Why , so that we have a bunch of crazed splicers running around , building underwater cities and kidnapping our children ?</tokentext>
<sentencetext>From comments on TFA, "The Lab" writes: "a science editor would be more capable of pointing out what is really exciting here, which is the ability to stop cells from producing a given protein.
"I think the cancer aspect is great (if it works) but this has potential for curing a whole host of diseases.Now we just need to figure out how to change people's DNA on the fly.Why, so that we have a bunch of crazed splicers running around, building underwater cities and kidnapping our children?
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31605834</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606618</id>
	<title>Re:Isn't this...</title>
	<author>nacturation</author>
	<datestamp>1269444000000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p><div class="quote"><p>The basis of I Am Legend (the movie) was the modification of a virus to selectively treat cancer. Unless these "nano-bots" learn to replicate themselves, I think we'll be alright.</p></div><p>To prevent that, we'll simply engineer them with a lysine deficiency.</p></div>
	</htmltext>
<tokenext>The basis of I Am Legend ( the movie ) was the modification of a virus to selectively treat cancer .
Unless these " nano-bots " learn to replicate themselves , I think we 'll be alright.To prevent that , we 'll simply engineer them with a lysine deficiency .</tokentext>
<sentencetext>The basis of I Am Legend (the movie) was the modification of a virus to selectively treat cancer.
Unless these "nano-bots" learn to replicate themselves, I think we'll be alright.To prevent that, we'll simply engineer them with a lysine deficiency.
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31605812</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606032</id>
	<title>Eternal LIfe</title>
	<author>Anonymous</author>
	<datestamp>1269438660000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>Now how let's reprogram them to repair the body</p><p>Phase I Weapon X program</p></htmltext>
<tokenext>Now how let 's reprogram them to repair the bodyPhase I Weapon X program</tokentext>
<sentencetext>Now how let's reprogram them to repair the bodyPhase I Weapon X program</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31623080</id>
	<title>Nanoparticles and Transferrin receptor</title>
	<author>drkim</author>
	<datestamp>1269595800000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>Nanoparticles and Transferrin receptor, Simplified diagram:
<br>
<a href="http://cache.gawker.com/assets/images/comment/4/2010/03/a24330d4c386a394de94deac3aeb8e7a/original.png" title="gawker.com" rel="nofollow">http://cache.gawker.com/assets/images/comment/4/2010/03/a24330d4c386a394de94deac3aeb8e7a/original.png</a> [gawker.com]</htmltext>
<tokenext>Nanoparticles and Transferrin receptor , Simplified diagram : http : //cache.gawker.com/assets/images/comment/4/2010/03/a24330d4c386a394de94deac3aeb8e7a/original.png [ gawker.com ]</tokentext>
<sentencetext>Nanoparticles and Transferrin receptor, Simplified diagram:

http://cache.gawker.com/assets/images/comment/4/2010/03/a24330d4c386a394de94deac3aeb8e7a/original.png [gawker.com]</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31605922</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31610594</id>
	<title>I am living in the future!</title>
	<author>Buzz\_Litebeer</author>
	<datestamp>1269532080000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>Seriously, every day when I realize I am living in a near future science fiction novel I become a bit happier.</p><p>I am just glad we have avoided the need for blade runners... so far.</p></htmltext>
<tokenext>Seriously , every day when I realize I am living in a near future science fiction novel I become a bit happier.I am just glad we have avoided the need for blade runners... so far .</tokentext>
<sentencetext>Seriously, every day when I realize I am living in a near future science fiction novel I become a bit happier.I am just glad we have avoided the need for blade runners... so far.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606840</id>
	<title>Re:Then take a statistics class</title>
	<author>TubeSteak</author>
	<datestamp>1269446340000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p><div class="quote"><p>You can achieve quite a lot when your sample is well selected.</p></div><p>Sure, but "n = 15" just means "more study needed"<br>By the time they get to phase 3 trials, their sample size will be a lot bigger.<br>Which, btw,  is what makes clinical trials so expensive.</p></div>
	</htmltext>
<tokenext>You can achieve quite a lot when your sample is well selected.Sure , but " n = 15 " just means " more study needed " By the time they get to phase 3 trials , their sample size will be a lot bigger.Which , btw , is what makes clinical trials so expensive .</tokentext>
<sentencetext>You can achieve quite a lot when your sample is well selected.Sure, but "n = 15" just means "more study needed"By the time they get to phase 3 trials, their sample size will be a lot bigger.Which, btw,  is what makes clinical trials so expensive.
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31605896</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31615578</id>
	<title>Re:Artificial virus</title>
	<author>Anonymous</author>
	<datestamp>1269547680000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>I can see what could go right: stealthily delivering an array of genetic changes to women to turn them all into beautiful, bisexual nymphomaniacs <b>with bad eyesight</b>.</p><p>fixed</p></htmltext>
<tokenext>I can see what could go right : stealthily delivering an array of genetic changes to women to turn them all into beautiful , bisexual nymphomaniacs with bad eyesight.fixed</tokentext>
<sentencetext>I can see what could go right: stealthily delivering an array of genetic changes to women to turn them all into beautiful, bisexual nymphomaniacs with bad eyesight.fixed</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606018</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31607208</id>
	<title>Re:Then take a statistics class</title>
	<author>Anonymous</author>
	<datestamp>1269450600000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>I really wish they'd require a common sense class along side that statistics class so people like you would stop making statements like that.</p><p>Theory is not reality.  The universe in which any sample size is usable as long as it has perfect distribution is the same one that contains Santa Clause and the Easter Bunny.</p></htmltext>
<tokenext>I really wish they 'd require a common sense class along side that statistics class so people like you would stop making statements like that.Theory is not reality .
The universe in which any sample size is usable as long as it has perfect distribution is the same one that contains Santa Clause and the Easter Bunny .</tokentext>
<sentencetext>I really wish they'd require a common sense class along side that statistics class so people like you would stop making statements like that.Theory is not reality.
The universe in which any sample size is usable as long as it has perfect distribution is the same one that contains Santa Clause and the Easter Bunny.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31605896</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606652</id>
	<title>Re:Isn't this...</title>
	<author>nacturation</author>
	<datestamp>1269444300000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p><div class="quote"><p>It also goes to show how a carefully engineered nano-particle can be used to kill people in a rather covert way.</p></div><p> <a href="http://memory-alpha.org/en/wiki/Yuta" title="memory-alpha.org">Parthos, a la Yuta!</a> [memory-alpha.org]</p></div>
	</htmltext>
<tokenext>It also goes to show how a carefully engineered nano-particle can be used to kill people in a rather covert way .
Parthos , a la Yuta !
[ memory-alpha.org ]</tokentext>
<sentencetext>It also goes to show how a carefully engineered nano-particle can be used to kill people in a rather covert way.
Parthos, a la Yuta!
[memory-alpha.org]
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606180</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606452</id>
	<title>This was already posted on /. 2 days ago!</title>
	<author>Vapor8</author>
	<datestamp>1269442080000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>Must be a slow evening; this article was posted 2 days ago here on<nobr> <wbr></nobr>/.</p><p><a href="http://science.slashdot.org/story/10/03/22/175200/RNA-Loaded-Nanoparticles-Fight-Cancer?art\_pos=1" title="slashdot.org" rel="nofollow">http://science.slashdot.org/story/10/03/22/175200/RNA-Loaded-Nanoparticles-Fight-Cancer?art\_pos=1</a> [slashdot.org]</p></htmltext>
<tokenext>Must be a slow evening ; this article was posted 2 days ago here on /.http : //science.slashdot.org/story/10/03/22/175200/RNA-Loaded-Nanoparticles-Fight-Cancer ? art \ _pos = 1 [ slashdot.org ]</tokentext>
<sentencetext>Must be a slow evening; this article was posted 2 days ago here on /.http://science.slashdot.org/story/10/03/22/175200/RNA-Loaded-Nanoparticles-Fight-Cancer?art\_pos=1 [slashdot.org]</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31607230</id>
	<title>Re:Not just cancer!</title>
	<author>QBasicer</author>
	<datestamp>1269451020000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>We can't even apply a lot of updates (like a new kernel) that easily without a reboot, how can we expect to do it to something vastly more complicated like a living organism?</htmltext>
<tokenext>We ca n't even apply a lot of updates ( like a new kernel ) that easily without a reboot , how can we expect to do it to something vastly more complicated like a living organism ?</tokentext>
<sentencetext>We can't even apply a lot of updates (like a new kernel) that easily without a reboot, how can we expect to do it to something vastly more complicated like a living organism?</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31605834</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31610012</id>
	<title>Re:Too small a sample size</title>
	<author>Leafheart</author>
	<datestamp>1269529200000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p><div class="quote"><p>These trials are <b>placebo-controlled</b>, randomized, double-blind studies (the hallmark of research). Statistical analysis then allows you to determine if the therapy was effective in improving outcomes.</p></div><p>You know, I know it is necessary to have the control group, and more important to not have them be know. But in case of diseases like cancer, it must be a bloody hellish thing to be one of the placebo users.</p></div>
	</htmltext>
<tokenext>These trials are placebo-controlled , randomized , double-blind studies ( the hallmark of research ) .
Statistical analysis then allows you to determine if the therapy was effective in improving outcomes.You know , I know it is necessary to have the control group , and more important to not have them be know .
But in case of diseases like cancer , it must be a bloody hellish thing to be one of the placebo users .</tokentext>
<sentencetext>These trials are placebo-controlled, randomized, double-blind studies (the hallmark of research).
Statistical analysis then allows you to determine if the therapy was effective in improving outcomes.You know, I know it is necessary to have the control group, and more important to not have them be know.
But in case of diseases like cancer, it must be a bloody hellish thing to be one of the placebo users.
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606192</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606620</id>
	<title>The perfect eugenics tool?</title>
	<author>vell0cet</author>
	<datestamp>1269444000000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>This is awesome... except... they say that they can target any gene and protein.  This would make a very useful weapon if you wanted to target a specific genotype.  Say a particular family.  Wasn't that an episode of ST:TNG?</htmltext>
<tokenext>This is awesome... except... they say that they can target any gene and protein .
This would make a very useful weapon if you wanted to target a specific genotype .
Say a particular family .
Was n't that an episode of ST : TNG ?</tokentext>
<sentencetext>This is awesome... except... they say that they can target any gene and protein.
This would make a very useful weapon if you wanted to target a specific genotype.
Say a particular family.
Wasn't that an episode of ST:TNG?</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31605800</id>
	<title>cool</title>
	<author>Anonymous</author>
	<datestamp>1269437220000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>Now they just need to test it on more cancer patients.</p></htmltext>
<tokenext>Now they just need to test it on more cancer patients .</tokentext>
<sentencetext>Now they just need to test it on more cancer patients.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606192</id>
	<title>Re:Too small a sample size</title>
	<author>Anonymous</author>
	<datestamp>1269439860000</datestamp>
	<modclass>Informativ</modclass>
	<modscore>5</modscore>
	<htmltext><p><div class="quote"><p>  I cannot see anything meaningful coming from such a small sample size. It has potential but obviously much more research is needed.</p></div><p>You can't just jump from rats to tens of thousands of humans. That's why the sample size is 15. That's why it's a Phase I trial. There are four phases of clinical pharmaceutical testing that follow preclinical (animals, in vitro, etc.) testing. Phase I normally tests a treatment in healthy humans in order to see the negative effects of the treatment (this is not necessarily the case in cancer treatments because all cancer treatments have significant negative effects). Phase I trials are only a couple dozen people, max. Successful Phase I trials allow for Phase II trials. These usually have one or two hundred people with the disease the therapy is intended to treat. In Phase II, they are mainly gathering pharmacokinetic data (half life, metabolism, volume of distribution, etc.). Phase III is where you start to see the trials you're clamoring for. These are typically done in several thousand patients, all with the disease in question. These trials are placebo-controlled, randomized, double-blind studies (the hallmark of research). Statistical analysis then allows you to determine if the therapy was effective in improving outcomes. If so, the drug goes to the FDA. 30 days later, it is officially on the market. Phase IV studies begin here, and continue perpetually. They are called post-marketing surveillance, and they study long-term effects (because previous trials are not long enough to do this), as well as very rare adverse effects (where the sample size in previous trials may have been too small to correctly detect the progressive multifocal leukoencephalopathy that occurs in 0.1\% of patients treated).

</p><p>So don't claim the study size wasn't big enough - it wasn't supposed to be. Phase III trials are what you want. Phase I and II trials are of no interest to anyone outside of health professions, really.</p></div>
	</htmltext>
<tokenext>I can not see anything meaningful coming from such a small sample size .
It has potential but obviously much more research is needed.You ca n't just jump from rats to tens of thousands of humans .
That 's why the sample size is 15 .
That 's why it 's a Phase I trial .
There are four phases of clinical pharmaceutical testing that follow preclinical ( animals , in vitro , etc .
) testing .
Phase I normally tests a treatment in healthy humans in order to see the negative effects of the treatment ( this is not necessarily the case in cancer treatments because all cancer treatments have significant negative effects ) .
Phase I trials are only a couple dozen people , max .
Successful Phase I trials allow for Phase II trials .
These usually have one or two hundred people with the disease the therapy is intended to treat .
In Phase II , they are mainly gathering pharmacokinetic data ( half life , metabolism , volume of distribution , etc. ) .
Phase III is where you start to see the trials you 're clamoring for .
These are typically done in several thousand patients , all with the disease in question .
These trials are placebo-controlled , randomized , double-blind studies ( the hallmark of research ) .
Statistical analysis then allows you to determine if the therapy was effective in improving outcomes .
If so , the drug goes to the FDA .
30 days later , it is officially on the market .
Phase IV studies begin here , and continue perpetually .
They are called post-marketing surveillance , and they study long-term effects ( because previous trials are not long enough to do this ) , as well as very rare adverse effects ( where the sample size in previous trials may have been too small to correctly detect the progressive multifocal leukoencephalopathy that occurs in 0.1 \ % of patients treated ) .
So do n't claim the study size was n't big enough - it was n't supposed to be .
Phase III trials are what you want .
Phase I and II trials are of no interest to anyone outside of health professions , really .</tokentext>
<sentencetext>  I cannot see anything meaningful coming from such a small sample size.
It has potential but obviously much more research is needed.You can't just jump from rats to tens of thousands of humans.
That's why the sample size is 15.
That's why it's a Phase I trial.
There are four phases of clinical pharmaceutical testing that follow preclinical (animals, in vitro, etc.
) testing.
Phase I normally tests a treatment in healthy humans in order to see the negative effects of the treatment (this is not necessarily the case in cancer treatments because all cancer treatments have significant negative effects).
Phase I trials are only a couple dozen people, max.
Successful Phase I trials allow for Phase II trials.
These usually have one or two hundred people with the disease the therapy is intended to treat.
In Phase II, they are mainly gathering pharmacokinetic data (half life, metabolism, volume of distribution, etc.).
Phase III is where you start to see the trials you're clamoring for.
These are typically done in several thousand patients, all with the disease in question.
These trials are placebo-controlled, randomized, double-blind studies (the hallmark of research).
Statistical analysis then allows you to determine if the therapy was effective in improving outcomes.
If so, the drug goes to the FDA.
30 days later, it is officially on the market.
Phase IV studies begin here, and continue perpetually.
They are called post-marketing surveillance, and they study long-term effects (because previous trials are not long enough to do this), as well as very rare adverse effects (where the sample size in previous trials may have been too small to correctly detect the progressive multifocal leukoencephalopathy that occurs in 0.1\% of patients treated).
So don't claim the study size wasn't big enough - it wasn't supposed to be.
Phase III trials are what you want.
Phase I and II trials are of no interest to anyone outside of health professions, really.
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31605794</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31607130</id>
	<title>Re:Too small a sample size</title>
	<author>BenVis</author>
	<datestamp>1269449400000</datestamp>
	<modclass>Interestin</modclass>
	<modscore>3</modscore>
	<htmltext><p>Thanks for the overview of the clinical trials procedure.  You clearly know a lot about it.  One thing I wanted to point out is that while placebo-controlled designs are probably the most reliable, in many contexts (including a cancer treatment) it would be unethical to give patients a placebo (i.e. a treatment expected to do nothing) rather than a treatment that might actually help them.
</p><p>Basically, if there is a treatment that is known to be at least somewhat effective, that's your control rather than a placebo.  It might be that the definition of placebo has shifted to include any standard non-experimental treatment, but that would be news to me.</p></htmltext>
<tokenext>Thanks for the overview of the clinical trials procedure .
You clearly know a lot about it .
One thing I wanted to point out is that while placebo-controlled designs are probably the most reliable , in many contexts ( including a cancer treatment ) it would be unethical to give patients a placebo ( i.e .
a treatment expected to do nothing ) rather than a treatment that might actually help them .
Basically , if there is a treatment that is known to be at least somewhat effective , that 's your control rather than a placebo .
It might be that the definition of placebo has shifted to include any standard non-experimental treatment , but that would be news to me .</tokentext>
<sentencetext>Thanks for the overview of the clinical trials procedure.
You clearly know a lot about it.
One thing I wanted to point out is that while placebo-controlled designs are probably the most reliable, in many contexts (including a cancer treatment) it would be unethical to give patients a placebo (i.e.
a treatment expected to do nothing) rather than a treatment that might actually help them.
Basically, if there is a treatment that is known to be at least somewhat effective, that's your control rather than a placebo.
It might be that the definition of placebo has shifted to include any standard non-experimental treatment, but that would be news to me.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606192</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31605936</id>
	<title>Re:Not just cancer!</title>
	<author>Anonymous</author>
	<datestamp>1269438000000</datestamp>
	<modclass>Interestin</modclass>
	<modscore>4</modscore>
	<htmltext><p>RNAi is an ancient anti-viral defense mechanism found in everything from plants to humans.  That said, I agree.  Any disease that is caused by the production of a given protein could in principle be treated using a derivative of this RNAi nanoparticle technology.<br>
&nbsp; </p><blockquote><div><p>Now we just need to figure out how to change people's DNA on the fly</p></div></blockquote><p> Viruses come close to this, it is just a matter of expanding what they can do (eg. enlarging their payload) and reducing the incidence of side effects like severe immune reactions.</p></div>
	</htmltext>
<tokenext>RNAi is an ancient anti-viral defense mechanism found in everything from plants to humans .
That said , I agree .
Any disease that is caused by the production of a given protein could in principle be treated using a derivative of this RNAi nanoparticle technology .
  Now we just need to figure out how to change people 's DNA on the fly Viruses come close to this , it is just a matter of expanding what they can do ( eg .
enlarging their payload ) and reducing the incidence of side effects like severe immune reactions .</tokentext>
<sentencetext>RNAi is an ancient anti-viral defense mechanism found in everything from plants to humans.
That said, I agree.
Any disease that is caused by the production of a given protein could in principle be treated using a derivative of this RNAi nanoparticle technology.
  Now we just need to figure out how to change people's DNA on the fly Viruses come close to this, it is just a matter of expanding what they can do (eg.
enlarging their payload) and reducing the incidence of side effects like severe immune reactions.
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31605834</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31607758</id>
	<title>Re:Too small a sample size</title>
	<author>Anonymous</author>
	<datestamp>1269460680000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p> <em>I cannot see anything meaningful coming from such a small sample size. It has potential but obviously much more research is needed.</em> </p><p>You say it's not meaningful but it has potential? Exactly on what basis are you asserting that it shows potential, then? Clairvoyance?</p><p>Would people please read some basic fucking statistics before making stupid comments about sample size? Is a sample size of 15 significant? That depends on what the observed variance was, what the best estimates of the priors are, and quite a few other factors. If I observe 15 random people in a hick town in the American West, and I see that they are all white, am I surprised? No. If I flip a coin 15 times in a row and it comes up heads each time, am I surprised? Yes. That's because <i>situations fucking differ from each other</i>, and they can't be compared solely in terms of sample size.</p><p>Beyond that, it was probably next to impossible simply to <i>assemble</i> a suitable sample of 15 patients -- should the lack of trial candidates stand in our way of advancing medicine? How about you apply a few fucking statistical tests to the actual data and parameters before spewing garbage about sample size?</p></htmltext>
<tokenext>I can not see anything meaningful coming from such a small sample size .
It has potential but obviously much more research is needed .
You say it 's not meaningful but it has potential ?
Exactly on what basis are you asserting that it shows potential , then ?
Clairvoyance ? Would people please read some basic fucking statistics before making stupid comments about sample size ?
Is a sample size of 15 significant ?
That depends on what the observed variance was , what the best estimates of the priors are , and quite a few other factors .
If I observe 15 random people in a hick town in the American West , and I see that they are all white , am I surprised ?
No. If I flip a coin 15 times in a row and it comes up heads each time , am I surprised ?
Yes. That 's because situations fucking differ from each other , and they ca n't be compared solely in terms of sample size.Beyond that , it was probably next to impossible simply to assemble a suitable sample of 15 patients -- should the lack of trial candidates stand in our way of advancing medicine ?
How about you apply a few fucking statistical tests to the actual data and parameters before spewing garbage about sample size ?</tokentext>
<sentencetext> I cannot see anything meaningful coming from such a small sample size.
It has potential but obviously much more research is needed.
You say it's not meaningful but it has potential?
Exactly on what basis are you asserting that it shows potential, then?
Clairvoyance?Would people please read some basic fucking statistics before making stupid comments about sample size?
Is a sample size of 15 significant?
That depends on what the observed variance was, what the best estimates of the priors are, and quite a few other factors.
If I observe 15 random people in a hick town in the American West, and I see that they are all white, am I surprised?
No. If I flip a coin 15 times in a row and it comes up heads each time, am I surprised?
Yes. That's because situations fucking differ from each other, and they can't be compared solely in terms of sample size.Beyond that, it was probably next to impossible simply to assemble a suitable sample of 15 patients -- should the lack of trial candidates stand in our way of advancing medicine?
How about you apply a few fucking statistical tests to the actual data and parameters before spewing garbage about sample size?</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31605794</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31617880</id>
	<title>Re:Not just cancer!</title>
	<author>Anonymous</author>
	<datestamp>1269512580000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p><div class="quote"><p>I think the cancer aspect is great (if it works) but this has potential for curing a whole host of diseases.</p></div><p>It also opens the door to very scary non-medical uses. If it can target cancer cells, it can also target healthy cells. From the sound of it, it may also be possible to target specific genetic traits. Something like this would make genocide a significantly easier undertaking since there would be no need to identify targets, just dispense indiscriminately and allow the nanoparticles to perform the identification.</p><p>You can bet that if this technology is being developed as a way to cure diseases, it's is also being developed somewhere in a weaponized form.</p></div>
	</htmltext>
<tokenext>I think the cancer aspect is great ( if it works ) but this has potential for curing a whole host of diseases.It also opens the door to very scary non-medical uses .
If it can target cancer cells , it can also target healthy cells .
From the sound of it , it may also be possible to target specific genetic traits .
Something like this would make genocide a significantly easier undertaking since there would be no need to identify targets , just dispense indiscriminately and allow the nanoparticles to perform the identification.You can bet that if this technology is being developed as a way to cure diseases , it 's is also being developed somewhere in a weaponized form .</tokentext>
<sentencetext>I think the cancer aspect is great (if it works) but this has potential for curing a whole host of diseases.It also opens the door to very scary non-medical uses.
If it can target cancer cells, it can also target healthy cells.
From the sound of it, it may also be possible to target specific genetic traits.
Something like this would make genocide a significantly easier undertaking since there would be no need to identify targets, just dispense indiscriminately and allow the nanoparticles to perform the identification.You can bet that if this technology is being developed as a way to cure diseases, it's is also being developed somewhere in a weaponized form.
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31605834</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31612848</id>
	<title>Re:Not just cancer!</title>
	<author>dzCepheus</author>
	<datestamp>1269539040000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p><div class="quote"><p>Now we just need to figure out how to change people's DNA on the fly.</p></div><p>On the fly?

<i>"What am I working on? Uhh... I'm working on something that will change the world, and human life as we know it."</i> - Seth Brundle, The Fly</p></div>
	</htmltext>
<tokenext>Now we just need to figure out how to change people 's DNA on the fly.On the fly ?
" What am I working on ?
Uhh... I 'm working on something that will change the world , and human life as we know it .
" - Seth Brundle , The Fly</tokentext>
<sentencetext>Now we just need to figure out how to change people's DNA on the fly.On the fly?
"What am I working on?
Uhh... I'm working on something that will change the world, and human life as we know it.
" - Seth Brundle, The Fly
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31605834</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31625428</id>
	<title>Reminds me of Acts of The Apostles</title>
	<author>jsundman</author>
	<datestamp>1269615120000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><a href="http://slashdot.org/books/00/05/09/1543222.shtml" title="slashdot.org" rel="nofollow">http://slashdot.org/books/00/05/09/1543222.shtml</a> [slashdot.org]

yes, it's by me. But it's still germane, I think.</htmltext>
<tokenext>http : //slashdot.org/books/00/05/09/1543222.shtml [ slashdot.org ] yes , it 's by me .
But it 's still germane , I think .</tokentext>
<sentencetext>http://slashdot.org/books/00/05/09/1543222.shtml [slashdot.org]

yes, it's by me.
But it's still germane, I think.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606558</id>
	<title>The first?  Hardly...</title>
	<author>Anonymous</author>
	<datestamp>1269443340000</datestamp>
	<modclass>Informativ</modclass>
	<modscore>2</modscore>
	<htmltext><a href="http://www.abraxisbio.com/" title="abraxisbio.com">Abraxis BioScience</a> [abraxisbio.com] is a fully integrated biotechnology company dedicated to delivering progressive therapeutics and core technologies that offer patients and medical professionals safer and more effective treatments for cancer and other critical illnesses. The Abraxis portfolio includes the world's first and only protein-based nanoparticle chemotherapeutic compound (ABRAXANE) which is based on its proprietary tumor targeting system known as the nab(TM) Technology platform. From the discovery and research phase to development and commercialization, Abraxis BioScience is committed to rapidly enriching the company's pipeline and accelerating the delivery of breakthrough therapies that will transform the lives of the patients who need them.<p>.</p><p>

Abraxis has been around for, literally, years.</p></htmltext>
<tokenext>Abraxis BioScience [ abraxisbio.com ] is a fully integrated biotechnology company dedicated to delivering progressive therapeutics and core technologies that offer patients and medical professionals safer and more effective treatments for cancer and other critical illnesses .
The Abraxis portfolio includes the world 's first and only protein-based nanoparticle chemotherapeutic compound ( ABRAXANE ) which is based on its proprietary tumor targeting system known as the nab ( TM ) Technology platform .
From the discovery and research phase to development and commercialization , Abraxis BioScience is committed to rapidly enriching the company 's pipeline and accelerating the delivery of breakthrough therapies that will transform the lives of the patients who need them. . Abraxis has been around for , literally , years .</tokentext>
<sentencetext>Abraxis BioScience [abraxisbio.com] is a fully integrated biotechnology company dedicated to delivering progressive therapeutics and core technologies that offer patients and medical professionals safer and more effective treatments for cancer and other critical illnesses.
The Abraxis portfolio includes the world's first and only protein-based nanoparticle chemotherapeutic compound (ABRAXANE) which is based on its proprietary tumor targeting system known as the nab(TM) Technology platform.
From the discovery and research phase to development and commercialization, Abraxis BioScience is committed to rapidly enriching the company's pipeline and accelerating the delivery of breakthrough therapies that will transform the lives of the patients who need them..

Abraxis has been around for, literally, years.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31605812</id>
	<title>Re:Isn't this...</title>
	<author>Anonymous</author>
	<datestamp>1269437280000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>The basis of I Am Legend (the movie) was the modification of a virus to selectively treat cancer. Unless these "nano-bots" learn to replicate themselves, I think we'll be alright.</htmltext>
<tokenext>The basis of I Am Legend ( the movie ) was the modification of a virus to selectively treat cancer .
Unless these " nano-bots " learn to replicate themselves , I think we 'll be alright .</tokentext>
<sentencetext>The basis of I Am Legend (the movie) was the modification of a virus to selectively treat cancer.
Unless these "nano-bots" learn to replicate themselves, I think we'll be alright.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31605748</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606960</id>
	<title>Re:Isn't this...</title>
	<author>Anonymous</author>
	<datestamp>1269447540000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p><div class="quote"><p>The basis of I Am Legend (the movie) was the modification of a virus to selectively treat cancer. Unless these "nano-bots" learn to replicate themselves, I think we'll be alright.</p></div><p>don't let wil wheaton anywhere near them!</p></div>
	</htmltext>
<tokenext>The basis of I Am Legend ( the movie ) was the modification of a virus to selectively treat cancer .
Unless these " nano-bots " learn to replicate themselves , I think we 'll be alright.do n't let wil wheaton anywhere near them !</tokentext>
<sentencetext>The basis of I Am Legend (the movie) was the modification of a virus to selectively treat cancer.
Unless these "nano-bots" learn to replicate themselves, I think we'll be alright.don't let wil wheaton anywhere near them!
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31605812</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606314</id>
	<title>Re:Too small a sample size</title>
	<author>forgot\_my\_username</author>
	<datestamp>1269440940000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>It may be a small sample size, but man this is cool stuff.<br>
From TFA, the siRNA can stop any mRNA produced protein.<br>
Eventually, this could be huge for treatments of diseases and conditions associated with mutated proteins.<br>
Before, they had the siRNA, but no real way to deliver them.<br>
So, this is a double wammy!<br>
<br>
<br>
<a href="http://www.allvoices.com/contributed-news/5471722-cancer-zapped-with-nanoparticles-in-humans" title="allvoices.com" rel="nofollow">There is a story with a video about this and siRNA</a> [allvoices.com] <br>
<br>
In fairness, I wrote the story, and found the video... but it I think it is very cool.</htmltext>
<tokenext>It may be a small sample size , but man this is cool stuff .
From TFA , the siRNA can stop any mRNA produced protein .
Eventually , this could be huge for treatments of diseases and conditions associated with mutated proteins .
Before , they had the siRNA , but no real way to deliver them .
So , this is a double wammy !
There is a story with a video about this and siRNA [ allvoices.com ] In fairness , I wrote the story , and found the video... but it I think it is very cool .</tokentext>
<sentencetext>It may be a small sample size, but man this is cool stuff.
From TFA, the siRNA can stop any mRNA produced protein.
Eventually, this could be huge for treatments of diseases and conditions associated with mutated proteins.
Before, they had the siRNA, but no real way to deliver them.
So, this is a double wammy!
There is a story with a video about this and siRNA [allvoices.com] 

In fairness, I wrote the story, and found the video... but it I think it is very cool.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31605794</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606824</id>
	<title>Hey, let's celebrate:</title>
	<author>mcneely.mike</author>
	<datestamp>1269446220000</datestamp>
	<modclass>Funny</modclass>
	<modscore>2</modscore>
	<htmltext>Break out the cuban cigars and pass me a diet Pepsi... sure you can smoke 'em if you got em!
Cancer, smancer.... i eat urea formaldehyde foam insulation for breakfast!</htmltext>
<tokenext>Break out the cuban cigars and pass me a diet Pepsi... sure you can smoke 'em if you got em !
Cancer , smancer.... i eat urea formaldehyde foam insulation for breakfast !</tokentext>
<sentencetext>Break out the cuban cigars and pass me a diet Pepsi... sure you can smoke 'em if you got em!
Cancer, smancer.... i eat urea formaldehyde foam insulation for breakfast!</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31608230</id>
	<title>/b/</title>
	<author>Anonymous</author>
	<datestamp>1269511980000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>Does this mean<nobr> <wbr></nobr>/b/ will finally become good again?</p></htmltext>
<tokenext>Does this mean /b/ will finally become good again ?</tokentext>
<sentencetext>Does this mean /b/ will finally become good again?</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31605896</id>
	<title>Then take a statistics class</title>
	<author>Anonymous</author>
	<datestamp>1269437820000</datestamp>
	<modclass>Informativ</modclass>
	<modscore>4</modscore>
	<htmltext><p>As long as the subjects have the same distribution as the population, this sample can be considered representative of the population.  This means that they didn't pick 15 terminal patients and didn't pick 15 100\%-survival-rate patients.  You can achieve quite a lot when your sample is well selected.</p></htmltext>
<tokenext>As long as the subjects have the same distribution as the population , this sample can be considered representative of the population .
This means that they did n't pick 15 terminal patients and did n't pick 15 100 \ % -survival-rate patients .
You can achieve quite a lot when your sample is well selected .</tokentext>
<sentencetext>As long as the subjects have the same distribution as the population, this sample can be considered representative of the population.
This means that they didn't pick 15 terminal patients and didn't pick 15 100\%-survival-rate patients.
You can achieve quite a lot when your sample is well selected.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31605794</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31605834</id>
	<title>Not just cancer!</title>
	<author>Anonymous</author>
	<datestamp>1269437400000</datestamp>
	<modclass>Informativ</modclass>
	<modscore>5</modscore>
	<htmltext><p>From comments on TFA, "The Lab" writes: "a science editor would be more capable of pointing out what is really exciting here, which is the ability to stop cells from producing a given protein."</p><p>I think the cancer aspect is great (if it works) but this has potential for curing a whole host of diseases.</p><p>Now we just need to figure out how to change people's DNA on the fly.</p></htmltext>
<tokenext>From comments on TFA , " The Lab " writes : " a science editor would be more capable of pointing out what is really exciting here , which is the ability to stop cells from producing a given protein .
" I think the cancer aspect is great ( if it works ) but this has potential for curing a whole host of diseases.Now we just need to figure out how to change people 's DNA on the fly .</tokentext>
<sentencetext>From comments on TFA, "The Lab" writes: "a science editor would be more capable of pointing out what is really exciting here, which is the ability to stop cells from producing a given protein.
"I think the cancer aspect is great (if it works) but this has potential for curing a whole host of diseases.Now we just need to figure out how to change people's DNA on the fly.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31621666</id>
	<title>Re:Not just cancer!</title>
	<author>Anonymous</author>
	<datestamp>1269534900000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>Cant' be done, really. At least not in any effective way.</p><p>Consider: Every single cell has a full copy of the inherited DNA (with the exception of erythrocytes and certain WBC's). How can the DNA in every cell be changed? Even viroids that might be recruited for some such process tend to be cell-type specific. Indeed. it is because cells carry unique markers that allows the body's various processes to recognize them. That said, perhaps it is sufficient to target cells of a particular organ for modification, but we are still a long way off, even for that. And I'm<nobr> <wbr></nobr>/assuming/ that all the background work preparing to do such a thing can all be done. One has to know a myriad complex details, not only about how a possible genetic alteration itself will work, but all the tangential effects it is certain to cause.</p><p><div class="quote"><p>Now we just need to figure out how to change people's DNA on the fly.</p></div></div>
	</htmltext>
<tokenext>Cant ' be done , really .
At least not in any effective way.Consider : Every single cell has a full copy of the inherited DNA ( with the exception of erythrocytes and certain WBC 's ) .
How can the DNA in every cell be changed ?
Even viroids that might be recruited for some such process tend to be cell-type specific .
Indeed. it is because cells carry unique markers that allows the body 's various processes to recognize them .
That said , perhaps it is sufficient to target cells of a particular organ for modification , but we are still a long way off , even for that .
And I 'm /assuming/ that all the background work preparing to do such a thing can all be done .
One has to know a myriad complex details , not only about how a possible genetic alteration itself will work , but all the tangential effects it is certain to cause.Now we just need to figure out how to change people 's DNA on the fly .</tokentext>
<sentencetext>Cant' be done, really.
At least not in any effective way.Consider: Every single cell has a full copy of the inherited DNA (with the exception of erythrocytes and certain WBC's).
How can the DNA in every cell be changed?
Even viroids that might be recruited for some such process tend to be cell-type specific.
Indeed. it is because cells carry unique markers that allows the body's various processes to recognize them.
That said, perhaps it is sufficient to target cells of a particular organ for modification, but we are still a long way off, even for that.
And I'm /assuming/ that all the background work preparing to do such a thing can all be done.
One has to know a myriad complex details, not only about how a possible genetic alteration itself will work, but all the tangential effects it is certain to cause.Now we just need to figure out how to change people's DNA on the fly.
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31605834</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606858</id>
	<title>Hopefully this works on Metastatic cancer</title>
	<author>NotSoHeavyD3</author>
	<datestamp>1269446580000</datestamp>
	<modclass>Interestin</modclass>
	<modscore>2</modscore>
	<htmltext>Since currently if you have metastasis most of the time it's incurable.(If you're lucky you'll just be a chronic cancer victim.)</htmltext>
<tokenext>Since currently if you have metastasis most of the time it 's incurable .
( If you 're lucky you 'll just be a chronic cancer victim .
)</tokentext>
<sentencetext>Since currently if you have metastasis most of the time it's incurable.
(If you're lucky you'll just be a chronic cancer victim.
)</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606730</id>
	<title>Re:Targetting</title>
	<author>wxwz</author>
	<datestamp>1269445320000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>The technique being applied is that of RNA interference (RNAi) which was awarded the Nobel prize in 2006. There's a good layman's introduction to it over at <a href="http://www.pbs.org/wgbh/nova/sciencenow/3210/02.html" title="pbs.org" rel="nofollow">PBS</a> [pbs.org].
<br> <br>
For a more in-depth introduction, Craig Mello, who was co-recipient of the Nobel Prize gave a <a href="http://video.google.com/videoplay?docid=-7104884525024111858#" title="google.com" rel="nofollow">Google tech-talk</a> [google.com].</htmltext>
<tokenext>The technique being applied is that of RNA interference ( RNAi ) which was awarded the Nobel prize in 2006 .
There 's a good layman 's introduction to it over at PBS [ pbs.org ] .
For a more in-depth introduction , Craig Mello , who was co-recipient of the Nobel Prize gave a Google tech-talk [ google.com ] .</tokentext>
<sentencetext>The technique being applied is that of RNA interference (RNAi) which was awarded the Nobel prize in 2006.
There's a good layman's introduction to it over at PBS [pbs.org].
For a more in-depth introduction, Craig Mello, who was co-recipient of the Nobel Prize gave a Google tech-talk [google.com].</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31605786</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31610734</id>
	<title>Why are we "testing" this?</title>
	<author>Trailer Trash</author>
	<datestamp>1269532620000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>Seriously.  What's the worst that it's going to do to a person?  Kill him?</p><p>Well, guess what?  They have cancer.</p><p>Geeze, get this in everybody who has cancer right now.</p></htmltext>
<tokenext>Seriously .
What 's the worst that it 's going to do to a person ?
Kill him ? Well , guess what ?
They have cancer.Geeze , get this in everybody who has cancer right now .</tokentext>
<sentencetext>Seriously.
What's the worst that it's going to do to a person?
Kill him?Well, guess what?
They have cancer.Geeze, get this in everybody who has cancer right now.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606692</id>
	<title>Re:Isn't this...</title>
	<author>cmiller173</author>
	<datestamp>1269444720000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>I hear the "blood brain barrier" is pretty vital.  I wonder if there is something common to all cells that could be a target marker...  I'm thinking along the lines of what happened to the senator in the second x-men movie, make all the cells lose cohesion.  and wear galoshes.</htmltext>
<tokenext>I hear the " blood brain barrier " is pretty vital .
I wonder if there is something common to all cells that could be a target marker... I 'm thinking along the lines of what happened to the senator in the second x-men movie , make all the cells lose cohesion .
and wear galoshes .</tokentext>
<sentencetext>I hear the "blood brain barrier" is pretty vital.
I wonder if there is something common to all cells that could be a target marker...  I'm thinking along the lines of what happened to the senator in the second x-men movie, make all the cells lose cohesion.
and wear galoshes.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606330</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606628</id>
	<title>Re:The good.. and bad?</title>
	<author>Anarki2004</author>
	<datestamp>1269444000000</datestamp>
	<modclass>None</modclass>
	<modscore>2</modscore>
	<htmltext>That's what fluoride is for, silly!</htmltext>
<tokenext>That 's what fluoride is for , silly !</tokentext>
<sentencetext>That's what fluoride is for, silly!</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606224</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31607026</id>
	<title>Re:Not just cancer!</title>
	<author>Hurricane78</author>
	<datestamp>1269448200000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>Done. Take a normal virus, remove its dna, replace it with your replacing fragment, and inject it into the body.<br>I&rsquo;m simplyfiying things here, but that&rsquo;s it.<br>I&rsquo;ve read about some team doing it, about 5 years ago.</p></htmltext>
<tokenext>Done .
Take a normal virus , remove its dna , replace it with your replacing fragment , and inject it into the body.I    m simplyfiying things here , but that    s it.I    ve read about some team doing it , about 5 years ago .</tokentext>
<sentencetext>Done.
Take a normal virus, remove its dna, replace it with your replacing fragment, and inject it into the body.I’m simplyfiying things here, but that’s it.I’ve read about some team doing it, about 5 years ago.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31605834</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31608584</id>
	<title>Re:The first? Hardly...</title>
	<author>Anonymous</author>
	<datestamp>1269518040000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>Sanjay Gupta is their senior vice president</p></htmltext>
<tokenext>Sanjay Gupta is their senior vice president</tokentext>
<sentencetext>Sanjay Gupta is their senior vice president</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606558</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31607296</id>
	<title>More technical article</title>
	<author>syncopated</author>
	<datestamp>1269452400000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><a href="http://www.rsc.org/chemistryworld/News/2010/March/21031001.asp" title="rsc.org" rel="nofollow">http://www.rsc.org/chemistryworld/News/2010/March/21031001.asp</a> [rsc.org]</htmltext>
<tokenext>http : //www.rsc.org/chemistryworld/News/2010/March/21031001.asp [ rsc.org ]</tokentext>
<sentencetext>http://www.rsc.org/chemistryworld/News/2010/March/21031001.asp [rsc.org]</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31607090</id>
	<title>Simply Awesome</title>
	<author>The Yuckinator</author>
	<datestamp>1269448800000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>Smoke 'em if you've got 'em!</p></htmltext>
<tokenext>Smoke 'em if you 've got 'em !</tokentext>
<sentencetext>Smoke 'em if you've got 'em!</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606336</id>
	<title>Re:Not just cancer!</title>
	<author>snowgirl</author>
	<datestamp>1269441060000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p><div class="quote"><p>From comments on TFA, "The Lab" writes: "a science editor would be more capable of pointing out what is really exciting here, which is the ability to stop cells from producing a given protein."</p><p>I think the cancer aspect is great (if it works) but this has potential for curing a whole host of diseases.</p><p>Now we just need to figure out how to change people's DNA on the fly.</p></div><p>Does this mean that we could make the body START to produce a protein?  Like... to fix the human dependency of Vitamin C in our diets?</p><p>I know I mentioned this one time on slashdot before, but it'd be super cool to fix us to being like every other animal on Earth (except Guinea Pigs) and make our own Vitamin C...</p></div>
	</htmltext>
<tokenext>From comments on TFA , " The Lab " writes : " a science editor would be more capable of pointing out what is really exciting here , which is the ability to stop cells from producing a given protein .
" I think the cancer aspect is great ( if it works ) but this has potential for curing a whole host of diseases.Now we just need to figure out how to change people 's DNA on the fly.Does this mean that we could make the body START to produce a protein ?
Like... to fix the human dependency of Vitamin C in our diets ? I know I mentioned this one time on slashdot before , but it 'd be super cool to fix us to being like every other animal on Earth ( except Guinea Pigs ) and make our own Vitamin C.. .</tokentext>
<sentencetext>From comments on TFA, "The Lab" writes: "a science editor would be more capable of pointing out what is really exciting here, which is the ability to stop cells from producing a given protein.
"I think the cancer aspect is great (if it works) but this has potential for curing a whole host of diseases.Now we just need to figure out how to change people's DNA on the fly.Does this mean that we could make the body START to produce a protein?
Like... to fix the human dependency of Vitamin C in our diets?I know I mentioned this one time on slashdot before, but it'd be super cool to fix us to being like every other animal on Earth (except Guinea Pigs) and make our own Vitamin C...
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31605834</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606584</id>
	<title>Re:Too small a sample size</title>
	<author>Benbrizzi</author>
	<datestamp>1269443580000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><a href="http://www.phdcomics.com/comics.php?f=1174" title="phdcomics.com" rel="nofollow">Obligatory PhD comic</a> [phdcomics.com]</htmltext>
<tokenext>Obligatory PhD comic [ phdcomics.com ]</tokentext>
<sentencetext>Obligatory PhD comic [phdcomics.com]</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31605794</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31607052</id>
	<title>It is spelled Caltech NOT CalTech</title>
	<author>Anonymous</author>
	<datestamp>1269448500000</datestamp>
	<modclass>Informativ</modclass>
	<modscore>3</modscore>
	<htmltext><p><a href="http://media.caltech.edu/press\_releases/13334" title="caltech.edu" rel="nofollow">http://media.caltech.edu/press\_releases/13334</a> [caltech.edu]</p><p>If you cannot spell Caltech properly - please turn in your nerd card.</p></htmltext>
<tokenext>http : //media.caltech.edu/press \ _releases/13334 [ caltech.edu ] If you can not spell Caltech properly - please turn in your nerd card .</tokentext>
<sentencetext>http://media.caltech.edu/press\_releases/13334 [caltech.edu]If you cannot spell Caltech properly - please turn in your nerd card.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606588</id>
	<title>Re:Isn't this...</title>
	<author>Anonymous</author>
	<datestamp>1269443640000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>I believe that is the plot to  cowboy bebop the move</p></htmltext>
<tokenext>I believe that is the plot to cowboy bebop the move</tokentext>
<sentencetext>I believe that is the plot to  cowboy bebop the move</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606180</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31615958</id>
	<title>Breaking News</title>
	<author>earlymon</author>
	<datestamp>1269549000000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>Possible Cancer Cure Announced!</p><p>Slashdotters Transform Announcement into Wanton Pleas for Women!</p><p>Film at 11.</p></htmltext>
<tokenext>Possible Cancer Cure Announced ! Slashdotters Transform Announcement into Wanton Pleas for Women ! Film at 11 .</tokentext>
<sentencetext>Possible Cancer Cure Announced!Slashdotters Transform Announcement into Wanton Pleas for Women!Film at 11.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606018</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31605842</id>
	<title>Re:Targetting</title>
	<author>newcastlejon</author>
	<datestamp>1269437460000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>The same way that so-called "targeted" painkillers work: they don't.</p><p>Every time I see that damn Nurofen advert I cringe</p><p><div class="quote"><p> In addition, Davis and his colleagues were able to show that the higher the nanoparticle dose administered to the patient, the higher the number of particles found inside the tumor cells&mdash;the first example of this kind of dose-dependent response using targeted nanoparticles.</p></div><p>Either I'm missing something <i>really</i> important or this is the biggest 'Well, Duh!' moment I've had this year</p></div>
	</htmltext>
<tokenext>The same way that so-called " targeted " painkillers work : they do n't.Every time I see that damn Nurofen advert I cringe In addition , Davis and his colleagues were able to show that the higher the nanoparticle dose administered to the patient , the higher the number of particles found inside the tumor cells    the first example of this kind of dose-dependent response using targeted nanoparticles.Either I 'm missing something really important or this is the biggest 'Well , Duh !
' moment I 've had this year</tokentext>
<sentencetext>The same way that so-called "targeted" painkillers work: they don't.Every time I see that damn Nurofen advert I cringe In addition, Davis and his colleagues were able to show that the higher the nanoparticle dose administered to the patient, the higher the number of particles found inside the tumor cells—the first example of this kind of dose-dependent response using targeted nanoparticles.Either I'm missing something really important or this is the biggest 'Well, Duh!
' moment I've had this year
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31605786</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31608610</id>
	<title>Re:Isn't this...</title>
	<author>KDR\_11k</author>
	<datestamp>1269518340000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>If it is detected it doesn't give you plausible deniability, killer nanobots aren't likely to be produced everywhere. A neat dose of botox would be very deniable, for example.</p></htmltext>
<tokenext>If it is detected it does n't give you plausible deniability , killer nanobots are n't likely to be produced everywhere .
A neat dose of botox would be very deniable , for example .</tokentext>
<sentencetext>If it is detected it doesn't give you plausible deniability, killer nanobots aren't likely to be produced everywhere.
A neat dose of botox would be very deniable, for example.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606180</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606752</id>
	<title>Re:The good.. and bad?</title>
	<author>izomiac</author>
	<datestamp>1269445440000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>Two reasons really.  First, there's no such thing as the "obedience gene", the "selfish gene", the "criminal gene", or the "alcoholic gene", that's the media oversimplifying; it'd be like rewiring a single transistor in your computer and expecting it to add a feature to a specific program.  Second, even if it were scientifically possible, there's no government that could pull it off, it'd be a massive project that'd go way over budget and be discovered when it fail spectacularly.</htmltext>
<tokenext>Two reasons really .
First , there 's no such thing as the " obedience gene " , the " selfish gene " , the " criminal gene " , or the " alcoholic gene " , that 's the media oversimplifying ; it 'd be like rewiring a single transistor in your computer and expecting it to add a feature to a specific program .
Second , even if it were scientifically possible , there 's no government that could pull it off , it 'd be a massive project that 'd go way over budget and be discovered when it fail spectacularly .</tokentext>
<sentencetext>Two reasons really.
First, there's no such thing as the "obedience gene", the "selfish gene", the "criminal gene", or the "alcoholic gene", that's the media oversimplifying; it'd be like rewiring a single transistor in your computer and expecting it to add a feature to a specific program.
Second, even if it were scientifically possible, there's no government that could pull it off, it'd be a massive project that'd go way over budget and be discovered when it fail spectacularly.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606224</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31614894</id>
	<title>Re:Too small a sample size</title>
	<author>Issarlk</author>
	<datestamp>1269545400000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>I wouldn't want to be one of the guys in phase III given placebos to cure his cancer !</htmltext>
<tokenext>I would n't want to be one of the guys in phase III given placebos to cure his cancer !</tokentext>
<sentencetext>I wouldn't want to be one of the guys in phase III given placebos to cure his cancer !</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606192</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31605922</id>
	<title>Re:Targetting</title>
	<author>reverseengineer</author>
	<datestamp>1269437940000</datestamp>
	<modclass>Informativ</modclass>
	<modscore>5</modscore>
	<htmltext>The nanoparticles have a component that attaches to the transferrin receptor on the surface of a cancer cell.  Transferrin receptors are highly abundant on cancer cells because iron (what transferrin carries) is needed for cell division processes.  Coincidentally, this is a fact I learned the first time this story was posted a few days ago.</htmltext>
<tokenext>The nanoparticles have a component that attaches to the transferrin receptor on the surface of a cancer cell .
Transferrin receptors are highly abundant on cancer cells because iron ( what transferrin carries ) is needed for cell division processes .
Coincidentally , this is a fact I learned the first time this story was posted a few days ago .</tokentext>
<sentencetext>The nanoparticles have a component that attaches to the transferrin receptor on the surface of a cancer cell.
Transferrin receptors are highly abundant on cancer cells because iron (what transferrin carries) is needed for cell division processes.
Coincidentally, this is a fact I learned the first time this story was posted a few days ago.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31605786</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31605786</id>
	<title>Targetting</title>
	<author>oldhack</author>
	<datestamp>1269437100000</datestamp>
	<modclass>Interestin</modclass>
	<modscore>2</modscore>
	<htmltext>How do they direct them into tumor cells?</htmltext>
<tokenext>How do they direct them into tumor cells ?</tokentext>
<sentencetext>How do they direct them into tumor cells?</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606330</id>
	<title>Re:Isn't this...</title>
	<author>Trebawa</author>
	<datestamp>1269441000000</datestamp>
	<modclass>Informativ</modclass>
	<modscore>2</modscore>
	<htmltext>You'd have to engineer particles that target a specific vital tissue (and stop thinking "brain", because the blood-brain barrier would block that), and then deliver a piece of siRNA that silences an essential gene for that tissue.  You'd also have to inject enough of these into the person to have this effect.  Still, it could be useful to replace the siRNA entirely with some kind of toxin (it would be nearly undetectable, because it wouldn't linger in the bloodstream).</htmltext>
<tokenext>You 'd have to engineer particles that target a specific vital tissue ( and stop thinking " brain " , because the blood-brain barrier would block that ) , and then deliver a piece of siRNA that silences an essential gene for that tissue .
You 'd also have to inject enough of these into the person to have this effect .
Still , it could be useful to replace the siRNA entirely with some kind of toxin ( it would be nearly undetectable , because it would n't linger in the bloodstream ) .</tokentext>
<sentencetext>You'd have to engineer particles that target a specific vital tissue (and stop thinking "brain", because the blood-brain barrier would block that), and then deliver a piece of siRNA that silences an essential gene for that tissue.
You'd also have to inject enough of these into the person to have this effect.
Still, it could be useful to replace the siRNA entirely with some kind of toxin (it would be nearly undetectable, because it wouldn't linger in the bloodstream).</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606180</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31607198</id>
	<title>No side effects?</title>
	<author>Anonymous</author>
	<datestamp>1269450480000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>I call bullshit on the no side effects. Cancer cells absolutely do not carry big signs saying I AM CANCER, PLS KILL. I'm sure there are ways, like with the transferrin receptors, but cancer is uncontrolled growth. Uncontrolled growth doesn't necessarily produce unique, easily identifiable receptors on the outside. So, you're going to either kill some cells you shouldn't, or let some cancer cells live. It can still improve dramatically on current chemotherapy &amp; radiotherapy, though.</p></htmltext>
<tokenext>I call bullshit on the no side effects .
Cancer cells absolutely do not carry big signs saying I AM CANCER , PLS KILL .
I 'm sure there are ways , like with the transferrin receptors , but cancer is uncontrolled growth .
Uncontrolled growth does n't necessarily produce unique , easily identifiable receptors on the outside .
So , you 're going to either kill some cells you should n't , or let some cancer cells live .
It can still improve dramatically on current chemotherapy &amp; radiotherapy , though .</tokentext>
<sentencetext>I call bullshit on the no side effects.
Cancer cells absolutely do not carry big signs saying I AM CANCER, PLS KILL.
I'm sure there are ways, like with the transferrin receptors, but cancer is uncontrolled growth.
Uncontrolled growth doesn't necessarily produce unique, easily identifiable receptors on the outside.
So, you're going to either kill some cells you shouldn't, or let some cancer cells live.
It can still improve dramatically on current chemotherapy &amp; radiotherapy, though.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31610136</id>
	<title>Obligatory I Am Legend Reference...</title>
	<author>Anonymous</author>
	<datestamp>1269529920000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>Somewhere someone is setting up a secret lab under a nice house in New York just in case...</p></htmltext>
<tokenext>Somewhere someone is setting up a secret lab under a nice house in New York just in case.. .</tokentext>
<sentencetext>Somewhere someone is setting up a secret lab under a nice house in New York just in case...</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31607558</id>
	<title>Maybe we will look back on this time...</title>
	<author>Arancaytar</author>
	<datestamp>1269457080000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>...as the point when the Diamond Age really began.</p><p>This is amazing. The future is going to be pretty cool!</p></htmltext>
<tokenext>...as the point when the Diamond Age really began.This is amazing .
The future is going to be pretty cool !</tokentext>
<sentencetext>...as the point when the Diamond Age really began.This is amazing.
The future is going to be pretty cool!</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606018</id>
	<title>Re:Artificial virus</title>
	<author>Anonymous</author>
	<datestamp>1269438540000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>I can see what could go right: stealthily delivering an array of genetic changes to women to turn them all into beautiful, bisexual nymphomaniacs.</p></htmltext>
<tokenext>I can see what could go right : stealthily delivering an array of genetic changes to women to turn them all into beautiful , bisexual nymphomaniacs .</tokentext>
<sentencetext>I can see what could go right: stealthily delivering an array of genetic changes to women to turn them all into beautiful, bisexual nymphomaniacs.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31605952</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606320</id>
	<title>This is incredible. I hope this is the cure.</title>
	<author>Jackie\_Chan\_Fan</author>
	<datestamp>1269441000000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>Its about time we solve the cancer puzzle.</p></htmltext>
<tokenext>Its about time we solve the cancer puzzle .</tokentext>
<sentencetext>Its about time we solve the cancer puzzle.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31605762</id>
	<title>Finally..</title>
	<author>Anonymous</author>
	<datestamp>1269436860000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>..the time has come.</p></htmltext>
<tokenext>..the time has come .</tokentext>
<sentencetext>..the time has come.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31623098</id>
	<title>Re:Not just cancer!</title>
	<author>drkim</author>
	<datestamp>1269596100000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>Hey!
<br>
How could you tell I got DNA all over my fly??!!!</htmltext>
<tokenext>Hey !
How could you tell I got DNA all over my fly ? ? ! !
!</tokentext>
<sentencetext>Hey!
How could you tell I got DNA all over my fly??!!
!</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31605834</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31605748</id>
	<title>Isn't this...</title>
	<author>Anonymous</author>
	<datestamp>1269436740000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>...how "I am Legend" started?</p></htmltext>
<tokenext>...how " I am Legend " started ?</tokentext>
<sentencetext>...how "I am Legend" started?</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31607402</id>
	<title>Is nanotech the new asbestos?</title>
	<author>Anonymous</author>
	<datestamp>1269454500000</datestamp>
	<modclass>Interestin</modclass>
	<modscore>1</modscore>
	<htmltext><p><a href="http://www.lowtechmagazine.com/2008/05/nanotechnolog-1.html" title="lowtechmagazine.com" rel="nofollow">http://www.lowtechmagazine.com/2008/05/nanotechnolog-1.html</a> [lowtechmagazine.com]</p></htmltext>
<tokenext>http : //www.lowtechmagazine.com/2008/05/nanotechnolog-1.html [ lowtechmagazine.com ]</tokentext>
<sentencetext>http://www.lowtechmagazine.com/2008/05/nanotechnolog-1.html [lowtechmagazine.com]</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31607338</id>
	<title>Re:Too small a sample size</title>
	<author>Anonymous</author>
	<datestamp>1269453300000</datestamp>
	<modclass>Interestin</modclass>
	<modscore>1</modscore>
	<htmltext><p>It's kind of morbid to think that a cancer patient would receive a placebo and be told it was a cure.</p></htmltext>
<tokenext>It 's kind of morbid to think that a cancer patient would receive a placebo and be told it was a cure .</tokentext>
<sentencetext>It's kind of morbid to think that a cancer patient would receive a placebo and be told it was a cure.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606192</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31607270</id>
	<title>What could possibly go wrong?</title>
	<author>spmkk</author>
	<datestamp>1269451860000</datestamp>
	<modclass>Insightful</modclass>
	<modscore>2</modscore>
	<htmltext><i>"it sneaks in, evades the immune system..."</i> <br>
<br>
Um, this doesn't catch anyone else as potentially really scary? What else might (now or eventually) sneak in and evade the immune system along with it?<br>
<br>
Not that it's relevant to anything, but Hollywood <a href="http://www.imdb.com/title/tt0480249/" title="imdb.com" rel="nofollow">touched on this subject</a> [imdb.com] a few years ago.</htmltext>
<tokenext>" it sneaks in , evades the immune system... " Um , this does n't catch anyone else as potentially really scary ?
What else might ( now or eventually ) sneak in and evade the immune system along with it ?
Not that it 's relevant to anything , but Hollywood touched on this subject [ imdb.com ] a few years ago .</tokentext>
<sentencetext>"it sneaks in, evades the immune system..." 

Um, this doesn't catch anyone else as potentially really scary?
What else might (now or eventually) sneak in and evade the immune system along with it?
Not that it's relevant to anything, but Hollywood touched on this subject [imdb.com] a few years ago.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606460</id>
	<title>Re:Too small a sample size</title>
	<author>electrons\_are\_brave</author>
	<datestamp>1269442200000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>I know someone going through chemo/radium therapy for an inoperable cancer with a very poor prognosis at the moment, so the side effects would need to be something as dire as a patient explosion or the nanos breeding, mutating and eating us all alive before this would be rejected.</htmltext>
<tokenext>I know someone going through chemo/radium therapy for an inoperable cancer with a very poor prognosis at the moment , so the side effects would need to be something as dire as a patient explosion or the nanos breeding , mutating and eating us all alive before this would be rejected .</tokentext>
<sentencetext>I know someone going through chemo/radium therapy for an inoperable cancer with a very poor prognosis at the moment, so the side effects would need to be something as dire as a patient explosion or the nanos breeding, mutating and eating us all alive before this would be rejected.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31605828</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606260</id>
	<title>Smoke 'em if you got 'em</title>
	<author>mirix</author>
	<datestamp>1269440520000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>No cure for cancer? pfft.</p></htmltext>
<tokenext>No cure for cancer ?
pfft .</tokentext>
<sentencetext>No cure for cancer?
pfft.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606106</id>
	<title>Can we get it to target republicans?</title>
	<author>Anonymous</author>
	<datestamp>1269439200000</datestamp>
	<modclass>Troll</modclass>
	<modscore>0</modscore>
	<htmltext><p>Just wondering....</p></htmltext>
<tokenext>Just wondering... .</tokentext>
<sentencetext>Just wondering....</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31612448</id>
	<title>Nanoselves</title>
	<author>CopaceticOpus</author>
	<datestamp>1269537840000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>This is only the beginning. I'd be surprised if, in the next 20-500 years, we don't all have nano particles in our blood streams which:

<ul>
  <li>Monitor our systems in fine detail, alerting us to conditions very early in their onset</li><li>Target and eliminate cancer and some diseases before they can gain a foothold</li><li>Clear arteries</li><li>Slow or stop effects of aging</li><li>Increase muscle, reduce fat, enhance flexibility, balance hormones</li></ul></htmltext>
<tokenext>This is only the beginning .
I 'd be surprised if , in the next 20-500 years , we do n't all have nano particles in our blood streams which : Monitor our systems in fine detail , alerting us to conditions very early in their onsetTarget and eliminate cancer and some diseases before they can gain a footholdClear arteriesSlow or stop effects of agingIncrease muscle , reduce fat , enhance flexibility , balance hormones</tokentext>
<sentencetext>This is only the beginning.
I'd be surprised if, in the next 20-500 years, we don't all have nano particles in our blood streams which:


  Monitor our systems in fine detail, alerting us to conditions very early in their onsetTarget and eliminate cancer and some diseases before they can gain a footholdClear arteriesSlow or stop effects of agingIncrease muscle, reduce fat, enhance flexibility, balance hormones</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31607464</id>
	<title>Re:The good.. and bad?</title>
	<author>Anonymous</author>
	<datestamp>1269455760000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>You appear to have an allelic variation in your GATTACA there.</p></htmltext>
<tokenext>You appear to have an allelic variation in your GATTACA there .</tokentext>
<sentencetext>You appear to have an allelic variation in your GATTACA there.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606224</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31633182</id>
	<title>No exaggerations here, move along</title>
	<author>Anonymous</author>
	<datestamp>1269601080000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>Nature.com: One person out of 15 showed measurable changes in tumor gene expression.  No side effects observed in this (admittedly small) initial trial.</p><p>Gizmodo: The first trial was a success!  No side effects!</p><p>Slashdot: The results are perfect so far, killing cancer cells with no side effects whatsoever.</p><p>Gotta love teh interwebs!</p></htmltext>
<tokenext>Nature.com : One person out of 15 showed measurable changes in tumor gene expression .
No side effects observed in this ( admittedly small ) initial trial.Gizmodo : The first trial was a success !
No side effects ! Slashdot : The results are perfect so far , killing cancer cells with no side effects whatsoever.Got ta love teh interwebs !</tokentext>
<sentencetext>Nature.com: One person out of 15 showed measurable changes in tumor gene expression.
No side effects observed in this (admittedly small) initial trial.Gizmodo: The first trial was a success!
No side effects!Slashdot: The results are perfect so far, killing cancer cells with no side effects whatsoever.Gotta love teh interwebs!</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606854</id>
	<title>Enjoy it now</title>
	<author>Anonymous</author>
	<datestamp>1269446520000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>We won't have medical advances like this in about 10 years at the rate we're going in the US.</p></htmltext>
<tokenext>We wo n't have medical advances like this in about 10 years at the rate we 're going in the US .</tokentext>
<sentencetext>We won't have medical advances like this in about 10 years at the rate we're going in the US.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31605794</id>
	<title>Too small a sample size</title>
	<author>Meshach</author>
	<datestamp>1269437160000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext>From the <a href="http://www.nature.com/news/2010/100321/full/news.2010.138.html" title="nature.com" rel="nofollow">real article</a> [nature.com] linked from TFA:<blockquote><div><p>The study describes the science behind a phase I trial assessing the safety of the technique in 15 patients.</p></div>
</blockquote><p>
I cannot see anything meaningful coming from such a small sample size.  It has potential but obviously much more research is needed.</p></div>
	</htmltext>
<tokenext>From the real article [ nature.com ] linked from TFA : The study describes the science behind a phase I trial assessing the safety of the technique in 15 patients .
I can not see anything meaningful coming from such a small sample size .
It has potential but obviously much more research is needed .</tokentext>
<sentencetext>From the real article [nature.com] linked from TFA:The study describes the science behind a phase I trial assessing the safety of the technique in 15 patients.
I cannot see anything meaningful coming from such a small sample size.
It has potential but obviously much more research is needed.
	</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606890</id>
	<title>blood brain barrier is not...</title>
	<author>Anonymous</author>
	<datestamp>1269446880000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>...an absolute defense. Make the nano particle small enough, the BBB will be as porous as the Maginot Line.</p></htmltext>
<tokenext>...an absolute defense .
Make the nano particle small enough , the BBB will be as porous as the Maginot Line .</tokentext>
<sentencetext>...an absolute defense.
Make the nano particle small enough, the BBB will be as porous as the Maginot Line.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606330</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31605952</id>
	<title>Artificial virus</title>
	<author>zzyzyx</author>
	<datestamp>1269438120000</datestamp>
	<modclass>Insightful</modclass>
	<modscore>1</modscore>
	<htmltext><p>So, they made an artificial virus that can deliver an RNA payload without triggering the immune system. I don't see what could go wrong!</p></htmltext>
<tokenext>So , they made an artificial virus that can deliver an RNA payload without triggering the immune system .
I do n't see what could go wrong !</tokentext>
<sentencetext>So, they made an artificial virus that can deliver an RNA payload without triggering the immune system.
I don't see what could go wrong!</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31610544</id>
	<title>seti</title>
	<author>hort\_wort</author>
	<datestamp>1269531900000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>So does this mean I can switch back to SETI@Home?  What has the next priority?</p></htmltext>
<tokenext>So does this mean I can switch back to SETI @ Home ?
What has the next priority ?</tokentext>
<sentencetext>So does this mean I can switch back to SETI@Home?
What has the next priority?</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606058</id>
	<title>Re:Targetting</title>
	<author>alexborges</author>
	<datestamp>1269438840000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>BTW, targeted painkillers do not have a funky RNA that attaches to a cell. This babies do.</p></htmltext>
<tokenext>BTW , targeted painkillers do not have a funky RNA that attaches to a cell .
This babies do .</tokentext>
<sentencetext>BTW, targeted painkillers do not have a funky RNA that attaches to a cell.
This babies do.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31605842</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606094</id>
	<title>Hooray!</title>
	<author>Anonymous</author>
	<datestamp>1269439080000</datestamp>
	<modclass>Insightful</modclass>
	<modscore>2</modscore>
	<htmltext><p>This is so much win, I can hardly stand it. And I never thought I'd see the day when they'd be able to find something to kill this cancer trash. We all live in very interesting times.</p></htmltext>
<tokenext>This is so much win , I can hardly stand it .
And I never thought I 'd see the day when they 'd be able to find something to kill this cancer trash .
We all live in very interesting times .</tokentext>
<sentencetext>This is so much win, I can hardly stand it.
And I never thought I'd see the day when they'd be able to find something to kill this cancer trash.
We all live in very interesting times.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606844</id>
	<title>Why have there been so many Duplicate stories?</title>
	<author>virtualXTC</author>
	<datestamp>1269446400000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>I swear I've seen 2 duplicate stories a week for the past month or so:
<a href="http://science.slashdot.org/story/10/03/22/175200/RNA-Loaded-Nanoparticles-Fight-Cancer?art\_pos=19" title="slashdot.org" rel="nofollow">http://science.slashdot.org/story/10/03/22/175200/RNA-Loaded-Nanoparticles-Fight-Cancer?art\_pos=19</a> [slashdot.org]</htmltext>
<tokenext>I swear I 've seen 2 duplicate stories a week for the past month or so : http : //science.slashdot.org/story/10/03/22/175200/RNA-Loaded-Nanoparticles-Fight-Cancer ? art \ _pos = 19 [ slashdot.org ]</tokentext>
<sentencetext>I swear I've seen 2 duplicate stories a week for the past month or so:
http://science.slashdot.org/story/10/03/22/175200/RNA-Loaded-Nanoparticles-Fight-Cancer?art\_pos=19 [slashdot.org]</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31609896</id>
	<title>Next stop</title>
	<author>wcrowe</author>
	<datestamp>1269528600000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>Weaponize it.</p></htmltext>
<tokenext>Weaponize it .</tokentext>
<sentencetext>Weaponize it.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31607074</id>
	<title>FDA Approval?</title>
	<author>Anonymous</author>
	<datestamp>1269448680000</datestamp>
	<modclass>Offtopic</modclass>
	<modscore>-1</modscore>
	<htmltext><p>Ok, I'm taking bets on how many people die of cancer while the FDA drags its feet for the next 20 years because there is a slight chance there might be a side effect or two.  I'm putting the over/under at 28,000 slow and painful deaths.</p><p>FDA Mentality, real life example:</p><p>Hey guys, I know that we have hundreds of thousands of Americans dropping dead from obesity related illnesses every year.  Ephedrine is quite effective at helping people manage both their appetites and ability to metabolize fat, but since 6 idiots took way too much of it and killed themselves over the course of 4 years, we're going to ban it entirely.  Enjoy your diabetes and heart attacks, America.</p><p>Incidentally, fuck the FDA.</p></htmltext>
<tokenext>Ok , I 'm taking bets on how many people die of cancer while the FDA drags its feet for the next 20 years because there is a slight chance there might be a side effect or two .
I 'm putting the over/under at 28,000 slow and painful deaths.FDA Mentality , real life example : Hey guys , I know that we have hundreds of thousands of Americans dropping dead from obesity related illnesses every year .
Ephedrine is quite effective at helping people manage both their appetites and ability to metabolize fat , but since 6 idiots took way too much of it and killed themselves over the course of 4 years , we 're going to ban it entirely .
Enjoy your diabetes and heart attacks , America.Incidentally , fuck the FDA .</tokentext>
<sentencetext>Ok, I'm taking bets on how many people die of cancer while the FDA drags its feet for the next 20 years because there is a slight chance there might be a side effect or two.
I'm putting the over/under at 28,000 slow and painful deaths.FDA Mentality, real life example:Hey guys, I know that we have hundreds of thousands of Americans dropping dead from obesity related illnesses every year.
Ephedrine is quite effective at helping people manage both their appetites and ability to metabolize fat, but since 6 idiots took way too much of it and killed themselves over the course of 4 years, we're going to ban it entirely.
Enjoy your diabetes and heart attacks, America.Incidentally, fuck the FDA.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606182</id>
	<title>Re:Not just cancer!</title>
	<author>yabos</author>
	<datestamp>1269439740000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>"Now we just need to figure out how to change people's DNA on the fly."<br> <br>
Apparently all it really takes is a few daily hyposprays to keep the alien DNA at bay and revert your original genome.</htmltext>
<tokenext>" Now we just need to figure out how to change people 's DNA on the fly .
" Apparently all it really takes is a few daily hyposprays to keep the alien DNA at bay and revert your original genome .</tokentext>
<sentencetext>"Now we just need to figure out how to change people's DNA on the fly.
" 
Apparently all it really takes is a few daily hyposprays to keep the alien DNA at bay and revert your original genome.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31605834</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31610124</id>
	<title>Re:Targetting</title>
	<author>David Gerard</author>
	<datestamp>1269529860000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>This is an insanely big deal. The siRNA mechanism got its discoverers a Nobel prize in 2006<nobr> <wbr></nobr>... but if this delivery mechanism works well, it'll warrant a Nobel for these guys too. There are all sorts of therapies that would theoretically zero in on a disease gene and take it out cleanly without side effects (e.g. for AIDS as well as cancers), but with no delivery mechanism - this could be a huge deal on the level of antibiotics.</p></htmltext>
<tokenext>This is an insanely big deal .
The siRNA mechanism got its discoverers a Nobel prize in 2006 ... but if this delivery mechanism works well , it 'll warrant a Nobel for these guys too .
There are all sorts of therapies that would theoretically zero in on a disease gene and take it out cleanly without side effects ( e.g .
for AIDS as well as cancers ) , but with no delivery mechanism - this could be a huge deal on the level of antibiotics .</tokentext>
<sentencetext>This is an insanely big deal.
The siRNA mechanism got its discoverers a Nobel prize in 2006 ... but if this delivery mechanism works well, it'll warrant a Nobel for these guys too.
There are all sorts of therapies that would theoretically zero in on a disease gene and take it out cleanly without side effects (e.g.
for AIDS as well as cancers), but with no delivery mechanism - this could be a huge deal on the level of antibiotics.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31605842</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31607814</id>
	<title>Re:The good.. and bad?</title>
	<author>phorm</author>
	<datestamp>1269549300000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>Or some nutball might come up with a way to target individuals with given genetic backgrounds for termination/sterilization etc. Einstein never anticipated the A-bomb, after all. Hopefully nobody will find a way to mis-use this technology</p></htmltext>
<tokenext>Or some nutball might come up with a way to target individuals with given genetic backgrounds for termination/sterilization etc .
Einstein never anticipated the A-bomb , after all .
Hopefully nobody will find a way to mis-use this technology</tokentext>
<sentencetext>Or some nutball might come up with a way to target individuals with given genetic backgrounds for termination/sterilization etc.
Einstein never anticipated the A-bomb, after all.
Hopefully nobody will find a way to mis-use this technology</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606224</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31607184</id>
	<title>Obama</title>
	<author>Anonymous</author>
	<datestamp>1269450240000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>First universal health care then the cure for cancer!  Yes, Obama can do it all!</p></htmltext>
<tokenext>First universal health care then the cure for cancer !
Yes , Obama can do it all !</tokentext>
<sentencetext>First universal health care then the cure for cancer!
Yes, Obama can do it all!</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606502</id>
	<title>Re:Isn't this...</title>
	<author>fregare</author>
	<datestamp>1269442620000</datestamp>
	<modclass>None</modclass>
	<modscore>-1</modscore>
	<htmltext>Just shine UV light on it.  As I remember on CSI (rarely watch the TUBO) everything is detected with UV.</htmltext>
<tokenext>Just shine UV light on it .
As I remember on CSI ( rarely watch the TUBO ) everything is detected with UV .</tokentext>
<sentencetext>Just shine UV light on it.
As I remember on CSI (rarely watch the TUBO) everything is detected with UV.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606180</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606348</id>
	<title>Re:Not just cancer!</title>
	<author>Trebawa</author>
	<datestamp>1269441180000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>This has enormous potential.  You could target it to pancreatic cells, for example, and knock out a gene that reduces insulin production.  The problem is that this technique can't insert new DNA, so it can't repair the damaged genes that cause a lot of genetic disorders.</htmltext>
<tokenext>This has enormous potential .
You could target it to pancreatic cells , for example , and knock out a gene that reduces insulin production .
The problem is that this technique ca n't insert new DNA , so it ca n't repair the damaged genes that cause a lot of genetic disorders .</tokentext>
<sentencetext>This has enormous potential.
You could target it to pancreatic cells, for example, and knock out a gene that reduces insulin production.
The problem is that this technique can't insert new DNA, so it can't repair the damaged genes that cause a lot of genetic disorders.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31605834</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31605974</id>
	<title>Re:Too small a sample size</title>
	<author>chowdahhead</author>
	<datestamp>1269438240000</datestamp>
	<modclass>Insightful</modclass>
	<modscore>5</modscore>
	<htmltext>It's a phase-I trial, it only confirms safety already established in animal models and kinetics.  Phase-II and phase-III trials, much larger in scale, assess efficacy and optimum dosing.  That will tell us if this can be more effective than traditional chemotherapy (possible) and monoclonal chemotherapy (much more difficult to predict).</htmltext>
<tokenext>It 's a phase-I trial , it only confirms safety already established in animal models and kinetics .
Phase-II and phase-III trials , much larger in scale , assess efficacy and optimum dosing .
That will tell us if this can be more effective than traditional chemotherapy ( possible ) and monoclonal chemotherapy ( much more difficult to predict ) .</tokentext>
<sentencetext>It's a phase-I trial, it only confirms safety already established in animal models and kinetics.
Phase-II and phase-III trials, much larger in scale, assess efficacy and optimum dosing.
That will tell us if this can be more effective than traditional chemotherapy (possible) and monoclonal chemotherapy (much more difficult to predict).</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31605794</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31609164</id>
	<title>Re:The good.. and bad?</title>
	<author>Anonymous</author>
	<datestamp>1269524580000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>Yay! If we find the right genes, we can finally slip some into the water of every tyrant on earth and make them behave like nice, sane people!</p></htmltext>
<tokenext>Yay !
If we find the right genes , we can finally slip some into the water of every tyrant on earth and make them behave like nice , sane people !</tokentext>
<sentencetext>Yay!
If we find the right genes, we can finally slip some into the water of every tyrant on earth and make them behave like nice, sane people!</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31606224</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31605828</id>
	<title>Re:Too small a sample size</title>
	<author>Anonymous</author>
	<datestamp>1269437400000</datestamp>
	<modclass>Informativ</modclass>
	<modscore>4</modscore>
	<htmltext><p>The point of the study is to make sure that people don't explode when the procedure is performed, or for something similarly unpleasant to happen--it's a Phase I study, not a real effectiveness trial.</p></htmltext>
<tokenext>The point of the study is to make sure that people do n't explode when the procedure is performed , or for something similarly unpleasant to happen--it 's a Phase I study , not a real effectiveness trial .</tokentext>
<sentencetext>The point of the study is to make sure that people don't explode when the procedure is performed, or for something similarly unpleasant to happen--it's a Phase I study, not a real effectiveness trial.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_24_2232241.31605794</parent>
</comment>
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