<article>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#article10_03_12_2354239</id>
	<title>Hunting Disease Origins By Whole-Genome Sequencing</title>
	<author>timothy</author>
	<datestamp>1268395440000</datestamp>
	<htmltext>ChocSnorfler writes <i>"James Lupski, a physician-scientist who suffers from a neurological disorder called Charcot-Marie-Tooth, has been searching for the genetic cause of his disease for more than 25 years. Late last year, he <a href="http://www.technologyreview.com/biomedicine/24720/?ref=rss">finally found it &mdash; by sequencing his entire genome</a>. While a number of human genome sequences have been published to date, Lupski's research is the first to show how whole-genome sequencing can be used to identify the genetic cause of an individual's disease."</i></htmltext>
<tokenext>ChocSnorfler writes " James Lupski , a physician-scientist who suffers from a neurological disorder called Charcot-Marie-Tooth , has been searching for the genetic cause of his disease for more than 25 years .
Late last year , he finally found it    by sequencing his entire genome .
While a number of human genome sequences have been published to date , Lupski 's research is the first to show how whole-genome sequencing can be used to identify the genetic cause of an individual 's disease .
"</tokentext>
<sentencetext>ChocSnorfler writes "James Lupski, a physician-scientist who suffers from a neurological disorder called Charcot-Marie-Tooth, has been searching for the genetic cause of his disease for more than 25 years.
Late last year, he finally found it — by sequencing his entire genome.
While a number of human genome sequences have been published to date, Lupski's research is the first to show how whole-genome sequencing can be used to identify the genetic cause of an individual's disease.
"</sentencetext>
</article>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31459420</id>
	<title>DIY</title>
	<author>pablodiazgutierrez</author>
	<datestamp>1268400660000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>This brings the phrase "do it yourself" to a whole new level.</p></htmltext>
<tokenext>This brings the phrase " do it yourself " to a whole new level .</tokentext>
<sentencetext>This brings the phrase "do it yourself" to a whole new level.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31460600</id>
	<title>Re:Can of Worms?</title>
	<author>jamesh</author>
	<datestamp>1268408160000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p><div class="quote"><p>I think even the most coldhearted persons must admit that your genetic makeup is something you cannot influence and which a caring society should insure you from.</p></div><p>I agree with that. Knowing that you might carry a defective gene, you can make a decision about if you are going to have kids or not though. I don't have an answer for this, but if you are aware that there is an x\% chance of passing on some serious defect to your children, where x is above some magic threshold, should you expect a caring society to insure your family anyway? Taking it another step further, if mandatory genetic scanning[1] of your unborn child shows that has some serious defect, what should happen if you choose to proceed with the pregnancy?</p><p>These are all things we need to have a think about because the technology to do it will be around sooner or later and it's a fairly safe bet that the insurance companies will try and push legislation in their favour.</p><p>[1] yes I know this doesn't exist yet, and without some magic answer to the questions above it probably shouldn't, but it raises an uncomfortable issue.</p></div>
	</htmltext>
<tokenext>I think even the most coldhearted persons must admit that your genetic makeup is something you can not influence and which a caring society should insure you from.I agree with that .
Knowing that you might carry a defective gene , you can make a decision about if you are going to have kids or not though .
I do n't have an answer for this , but if you are aware that there is an x \ % chance of passing on some serious defect to your children , where x is above some magic threshold , should you expect a caring society to insure your family anyway ?
Taking it another step further , if mandatory genetic scanning [ 1 ] of your unborn child shows that has some serious defect , what should happen if you choose to proceed with the pregnancy ? These are all things we need to have a think about because the technology to do it will be around sooner or later and it 's a fairly safe bet that the insurance companies will try and push legislation in their favour .
[ 1 ] yes I know this does n't exist yet , and without some magic answer to the questions above it probably should n't , but it raises an uncomfortable issue .</tokentext>
<sentencetext>I think even the most coldhearted persons must admit that your genetic makeup is something you cannot influence and which a caring society should insure you from.I agree with that.
Knowing that you might carry a defective gene, you can make a decision about if you are going to have kids or not though.
I don't have an answer for this, but if you are aware that there is an x\% chance of passing on some serious defect to your children, where x is above some magic threshold, should you expect a caring society to insure your family anyway?
Taking it another step further, if mandatory genetic scanning[1] of your unborn child shows that has some serious defect, what should happen if you choose to proceed with the pregnancy?These are all things we need to have a think about because the technology to do it will be around sooner or later and it's a fairly safe bet that the insurance companies will try and push legislation in their favour.
[1] yes I know this doesn't exist yet, and without some magic answer to the questions above it probably shouldn't, but it raises an uncomfortable issue.
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31459358</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31459858</id>
	<title>Re:Can of Worms?</title>
	<author>Anonymous</author>
	<datestamp>1268402880000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p><div class="quote"><p>I think even the most coldhearted persons must admit that your genetic makeup is something you cannot influence</p></div><p>True.</p><p><div class="quote"><p>and which a caring society should insure you from.</p></div><p>Not true.  Who said anything about a caring society?  We have plenty of racists who think people should be responsible for uncontrollable traits, and racism has a stigma.  This has no great social baggage.  There are shitloads of people who think you're ability to receive healthcare should be just like your ability to receive a commodity like cars or toys, and if you need something special, that's your problem.  If you die?  Tough luck.</p></div>
	</htmltext>
<tokenext>I think even the most coldhearted persons must admit that your genetic makeup is something you can not influenceTrue.and which a caring society should insure you from.Not true .
Who said anything about a caring society ?
We have plenty of racists who think people should be responsible for uncontrollable traits , and racism has a stigma .
This has no great social baggage .
There are shitloads of people who think you 're ability to receive healthcare should be just like your ability to receive a commodity like cars or toys , and if you need something special , that 's your problem .
If you die ?
Tough luck .</tokentext>
<sentencetext>I think even the most coldhearted persons must admit that your genetic makeup is something you cannot influenceTrue.and which a caring society should insure you from.Not true.
Who said anything about a caring society?
We have plenty of racists who think people should be responsible for uncontrollable traits, and racism has a stigma.
This has no great social baggage.
There are shitloads of people who think you're ability to receive healthcare should be just like your ability to receive a commodity like cars or toys, and if you need something special, that's your problem.
If you die?
Tough luck.
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31459358</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31469830</id>
	<title>Re:Can of Worms?</title>
	<author>wawadave</author>
	<datestamp>1268502420000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext>So far with wetware hacking we are at the scriptkiddy level.
Any genetic hacking has been cutting out a sequence and splicing it in. Copy paste.</htmltext>
<tokenext>So far with wetware hacking we are at the scriptkiddy level .
Any genetic hacking has been cutting out a sequence and splicing it in .
Copy paste .</tokentext>
<sentencetext>So far with wetware hacking we are at the scriptkiddy level.
Any genetic hacking has been cutting out a sequence and splicing it in.
Copy paste.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31459358</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31459216</id>
	<title>Re:Can of Worms?</title>
	<author>WillDraven</author>
	<datestamp>1268399880000</datestamp>
	<modclass>Insightful</modclass>
	<modscore>3</modscore>
	<htmltext><p>Maybe not yet, but it sure is hard to begin fixing something before you know why it's broken.</p></htmltext>
<tokenext>Maybe not yet , but it sure is hard to begin fixing something before you know why it 's broken .</tokentext>
<sentencetext>Maybe not yet, but it sure is hard to begin fixing something before you know why it's broken.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31459060</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31459358</id>
	<title>Re:Can of Worms?</title>
	<author>Anonymous</author>
	<datestamp>1268400480000</datestamp>
	<modclass>Informativ</modclass>
	<modscore>2</modscore>
	<htmltext><p><div class="quote"><p>genetic discrimination</p></div><p>I think even the most coldhearted persons must admit that your genetic makeup is something you cannot influence and which a caring society should insure you from. I don't see much of a problem there, especially since you can point at <i>everyone</i> and ask them with a sharp eye: "Are you sure you don't carry some expensive genetic screwup which can only be fixed by a $250,000 individual cure?"</p><p><div class="quote"><p>Plus, even then is there much we -can- do if we figure out something is genetic?</p></div><p>Well, if you can derive how e.g. a protein folded wrong you might be able to find a drug which fixes that by attaching to that protein and shutting it down.
</p><p>
A more megalomaniac idea would be gene therapy: Inserting a retrovirus with a second strand of DNA into the cell.<br>
That DNA could code for a correct protein sequence. Or, if the original protein sequence is harmful and needs to be suppressed, it could code for interfering RNA, i.e. RNA which intercepts the DNA's RNA and thus disables protein translation. Ah, <b>wetware hacking</b>!</p></div>
	</htmltext>
<tokenext>genetic discriminationI think even the most coldhearted persons must admit that your genetic makeup is something you can not influence and which a caring society should insure you from .
I do n't see much of a problem there , especially since you can point at everyone and ask them with a sharp eye : " Are you sure you do n't carry some expensive genetic screwup which can only be fixed by a $ 250,000 individual cure ?
" Plus , even then is there much we -can- do if we figure out something is genetic ? Well , if you can derive how e.g .
a protein folded wrong you might be able to find a drug which fixes that by attaching to that protein and shutting it down .
A more megalomaniac idea would be gene therapy : Inserting a retrovirus with a second strand of DNA into the cell .
That DNA could code for a correct protein sequence .
Or , if the original protein sequence is harmful and needs to be suppressed , it could code for interfering RNA , i.e .
RNA which intercepts the DNA 's RNA and thus disables protein translation .
Ah , wetware hacking !</tokentext>
<sentencetext>genetic discriminationI think even the most coldhearted persons must admit that your genetic makeup is something you cannot influence and which a caring society should insure you from.
I don't see much of a problem there, especially since you can point at everyone and ask them with a sharp eye: "Are you sure you don't carry some expensive genetic screwup which can only be fixed by a $250,000 individual cure?
"Plus, even then is there much we -can- do if we figure out something is genetic?Well, if you can derive how e.g.
a protein folded wrong you might be able to find a drug which fixes that by attaching to that protein and shutting it down.
A more megalomaniac idea would be gene therapy: Inserting a retrovirus with a second strand of DNA into the cell.
That DNA could code for a correct protein sequence.
Or, if the original protein sequence is harmful and needs to be suppressed, it could code for interfering RNA, i.e.
RNA which intercepts the DNA's RNA and thus disables protein translation.
Ah, wetware hacking!
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31459060</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31471586</id>
	<title>Re:Can of Worms?</title>
	<author>Anonymous</author>
	<datestamp>1268575260000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>Have you been watching Gattaca, too?</p></htmltext>
<tokenext>Have you been watching Gattaca , too ?</tokentext>
<sentencetext>Have you been watching Gattaca, too?</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31459060</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31460544</id>
	<title>Re:Can of Worms?</title>
	<author>FatdogHaiku</author>
	<datestamp>1268407740000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p><div class="quote"><p>With every advancement in figuring out genetic diseases, I can't help but think that the combination of this plus drug testing will lead to genetic discrimination, or at least defamation.

<br> <br>

Plus, even then is there much we -can- do if we figure out something is genetic?</p></div><p>That seems to be a really short sighted view. Once you find the major problems and prevent people with those from passing the "bad data" on to their children the burden on both the family and society drops off sharply. True, there may at first be some people that can't bred with certain other people, or maybe even should not bred at all... I would think that if gene therapy is going to benefit us it would be easiest to apply at the  "one egg, one sperm" level rather than trying to modify a complete human...<br> <br>Centuries of domestication in animals has shown us that with enough time we can express desired results. Nothing is perfect at first, as I'm sure the people that died trying to domesticate cattle would attest. It doesn't mean we should not try to improve the conditions under which we exist.</p></div>
	</htmltext>
<tokenext>With every advancement in figuring out genetic diseases , I ca n't help but think that the combination of this plus drug testing will lead to genetic discrimination , or at least defamation .
Plus , even then is there much we -can- do if we figure out something is genetic ? That seems to be a really short sighted view .
Once you find the major problems and prevent people with those from passing the " bad data " on to their children the burden on both the family and society drops off sharply .
True , there may at first be some people that ca n't bred with certain other people , or maybe even should not bred at all... I would think that if gene therapy is going to benefit us it would be easiest to apply at the " one egg , one sperm " level rather than trying to modify a complete human... Centuries of domestication in animals has shown us that with enough time we can express desired results .
Nothing is perfect at first , as I 'm sure the people that died trying to domesticate cattle would attest .
It does n't mean we should not try to improve the conditions under which we exist .</tokentext>
<sentencetext>With every advancement in figuring out genetic diseases, I can't help but think that the combination of this plus drug testing will lead to genetic discrimination, or at least defamation.
Plus, even then is there much we -can- do if we figure out something is genetic?That seems to be a really short sighted view.
Once you find the major problems and prevent people with those from passing the "bad data" on to their children the burden on both the family and society drops off sharply.
True, there may at first be some people that can't bred with certain other people, or maybe even should not bred at all... I would think that if gene therapy is going to benefit us it would be easiest to apply at the  "one egg, one sperm" level rather than trying to modify a complete human... Centuries of domestication in animals has shown us that with enough time we can express desired results.
Nothing is perfect at first, as I'm sure the people that died trying to domesticate cattle would attest.
It doesn't mean we should not try to improve the conditions under which we exist.
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31459060</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31459268</id>
	<title>Re:scary part of TFA</title>
	<author>Anonymous</author>
	<datestamp>1268400060000</datestamp>
	<modclass>Insightful</modclass>
	<modscore>1</modscore>
	<htmltext><p>So instead of changing the corrupt health care system, you want to ban life-saving technologies? Get back to your third-world shithole. Americant.</p></htmltext>
<tokenext>So instead of changing the corrupt health care system , you want to ban life-saving technologies ?
Get back to your third-world shithole .
Americant .</tokentext>
<sentencetext>So instead of changing the corrupt health care system, you want to ban life-saving technologies?
Get back to your third-world shithole.
Americant.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31459198</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31461206</id>
	<title>Re:Can of Worms?</title>
	<author>im\_thatoneguy</author>
	<datestamp>1268412540000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p><div class="quote"><p>With every advancement in figuring out genetic diseases, I can't help but think that the combination of this plus drug testing will lead to genetic discrimination, or at least defamation.<br>Plus, even then is there much we -can- do if we figure out something is genetic?</p></div><p>That would certainly be the pessimistic outlook.  One which could easily be legislated away with a ban on discrimination.</p><p>The positive outlook would be that instead of discriminating or paying for expensive therapies we could actually... you know... fix the defects or find more effective treatments which cost less to develop.</p></div>
	</htmltext>
<tokenext>With every advancement in figuring out genetic diseases , I ca n't help but think that the combination of this plus drug testing will lead to genetic discrimination , or at least defamation.Plus , even then is there much we -can- do if we figure out something is genetic ? That would certainly be the pessimistic outlook .
One which could easily be legislated away with a ban on discrimination.The positive outlook would be that instead of discriminating or paying for expensive therapies we could actually... you know... fix the defects or find more effective treatments which cost less to develop .</tokentext>
<sentencetext>With every advancement in figuring out genetic diseases, I can't help but think that the combination of this plus drug testing will lead to genetic discrimination, or at least defamation.Plus, even then is there much we -can- do if we figure out something is genetic?That would certainly be the pessimistic outlook.
One which could easily be legislated away with a ban on discrimination.The positive outlook would be that instead of discriminating or paying for expensive therapies we could actually... you know... fix the defects or find more effective treatments which cost less to develop.
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31459060</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31459198</id>
	<title>scary part of TFA</title>
	<author>Anonymous</author>
	<datestamp>1268399820000</datestamp>
	<modclass>Insightful</modclass>
	<modscore>1</modscore>
	<htmltext><blockquote><div><p>But cost-wise, personal genomes may not be far off. For example, Bird at the University of Washington says that a comprehensive genetic screen for inherited nerve diseases costs about $15,000. Researchers estimate that Lupski's genome cost about $50,000. And Complete Genomics, a startup in California that sequenced the family in Hood's study, will soon offer bulk sequencing services for about $20,000 a genome, with a $5,000 price tag not far behind.</p></div></blockquote><p>How long before sequencing becomes part of a routine physical exam, and having the disease-prone genes becomes a pre-existing condition for health insurance purposes?</p></div>
	</htmltext>
<tokenext>But cost-wise , personal genomes may not be far off .
For example , Bird at the University of Washington says that a comprehensive genetic screen for inherited nerve diseases costs about $ 15,000 .
Researchers estimate that Lupski 's genome cost about $ 50,000 .
And Complete Genomics , a startup in California that sequenced the family in Hood 's study , will soon offer bulk sequencing services for about $ 20,000 a genome , with a $ 5,000 price tag not far behind.How long before sequencing becomes part of a routine physical exam , and having the disease-prone genes becomes a pre-existing condition for health insurance purposes ?</tokentext>
<sentencetext>But cost-wise, personal genomes may not be far off.
For example, Bird at the University of Washington says that a comprehensive genetic screen for inherited nerve diseases costs about $15,000.
Researchers estimate that Lupski's genome cost about $50,000.
And Complete Genomics, a startup in California that sequenced the family in Hood's study, will soon offer bulk sequencing services for about $20,000 a genome, with a $5,000 price tag not far behind.How long before sequencing becomes part of a routine physical exam, and having the disease-prone genes becomes a pre-existing condition for health insurance purposes?
	</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31462842</id>
	<title>OCPD is far worse than Schizoaffective Disorder</title>
	<author>MichaelCrawford</author>
	<datestamp>1268479140000</datestamp>
	<modclass>Interestin</modclass>
	<modscore>1</modscore>
	<htmltext>One wouldn't think so - and I certainly didn't myself at first - because the symptoms of Bipolar Type Schizoaffective Disorder are so obvious, severe and quite commonly life-threatening: visual and auditory hallucinations, paranoia and delusions - in my case, I am constantly pursued by a shadowy law enforcement agency that I can see but you cannot.  I call them The Thought Police, because they are the police inside my head, but ironically just knowing that you're paranoid doesn't make the paranoia go away.  I fear The Thought Police like nothing else, because they come not to arrest me, but to kill me.<p>

A symptom called "Flat Affect:" makes it nearly impossible to express emotion in any normal kind of way.  It's not that I don't experience emotion - I very definitely do - but I am unable to show my feelings outwardly.  My expression is always wooden, a poker face.  It makes it very, very difficult to connect with other people, especially the opposite sex.</p><p>

My most prevalent schizoaffective symptom is depression which is often profound and can be suicidal.  I also experience a profoundly euphoric state called mania.  One might think that it's not so bad because it is actually a very happy, joyful feeling, it is actually the worst of the schizoaffective symptoms because when I am manic, I am utterly and completely out of touch with reality.  I am like a bull in a china shop.  When I am manic, it is a matter for the police - lots and lots and lots of police.</p><p>

But all of this pales in comparison with my Obsessive Compulsive Personality Disorder.  One reason is that I understood from the very beginning that my schizoaffective disorder was bad and just why it was bad, so I was able to work from the very beginning to overcome it.  But I had been in psytherapeutic and psychiatric treatment for twenty-four years before I was finally able to understand just how destructive my OCPD had been, not just to me, but to everyone that I cared about.</p><p>

Simply being crazy is not so bad.  There are many ways to cope, many ways to get by.  What really is bad is to be crazy, yet completely unaware of it,  Thus it was with me and my Obsessive Compulsive Personality.</p><p>

I would be very grateful if you would read this short essay, it is just five pages or so:</p><ul>
<li> <a href="http://www.geometricvisions.com/ocpd/damnation.html" title="geometricvisions.com">A Special Kind of Crazy</a> [geometricvisions.com]</li>
</ul><p>

Kuro5hin's undermyne said of me:</p><blockquote><div><p>You, sir are a special kind of crazy. They may even name a type of crazy after you.
People will no longer be called "odd" when they are batshit, self destructive crazy. They will be called "ogg".</p></div> </blockquote><p>

I am grateful for all of your kind understanding.</p></div>
	</htmltext>
<tokenext>One would n't think so - and I certainly did n't myself at first - because the symptoms of Bipolar Type Schizoaffective Disorder are so obvious , severe and quite commonly life-threatening : visual and auditory hallucinations , paranoia and delusions - in my case , I am constantly pursued by a shadowy law enforcement agency that I can see but you can not .
I call them The Thought Police , because they are the police inside my head , but ironically just knowing that you 're paranoid does n't make the paranoia go away .
I fear The Thought Police like nothing else , because they come not to arrest me , but to kill me .
A symptom called " Flat Affect : " makes it nearly impossible to express emotion in any normal kind of way .
It 's not that I do n't experience emotion - I very definitely do - but I am unable to show my feelings outwardly .
My expression is always wooden , a poker face .
It makes it very , very difficult to connect with other people , especially the opposite sex .
My most prevalent schizoaffective symptom is depression which is often profound and can be suicidal .
I also experience a profoundly euphoric state called mania .
One might think that it 's not so bad because it is actually a very happy , joyful feeling , it is actually the worst of the schizoaffective symptoms because when I am manic , I am utterly and completely out of touch with reality .
I am like a bull in a china shop .
When I am manic , it is a matter for the police - lots and lots and lots of police .
But all of this pales in comparison with my Obsessive Compulsive Personality Disorder .
One reason is that I understood from the very beginning that my schizoaffective disorder was bad and just why it was bad , so I was able to work from the very beginning to overcome it .
But I had been in psytherapeutic and psychiatric treatment for twenty-four years before I was finally able to understand just how destructive my OCPD had been , not just to me , but to everyone that I cared about .
Simply being crazy is not so bad .
There are many ways to cope , many ways to get by .
What really is bad is to be crazy , yet completely unaware of it , Thus it was with me and my Obsessive Compulsive Personality .
I would be very grateful if you would read this short essay , it is just five pages or so : A Special Kind of Crazy [ geometricvisions.com ] Kuro5hin 's undermyne said of me : You , sir are a special kind of crazy .
They may even name a type of crazy after you .
People will no longer be called " odd " when they are batshit , self destructive crazy .
They will be called " ogg " .
I am grateful for all of your kind understanding .</tokentext>
<sentencetext>One wouldn't think so - and I certainly didn't myself at first - because the symptoms of Bipolar Type Schizoaffective Disorder are so obvious, severe and quite commonly life-threatening: visual and auditory hallucinations, paranoia and delusions - in my case, I am constantly pursued by a shadowy law enforcement agency that I can see but you cannot.
I call them The Thought Police, because they are the police inside my head, but ironically just knowing that you're paranoid doesn't make the paranoia go away.
I fear The Thought Police like nothing else, because they come not to arrest me, but to kill me.
A symptom called "Flat Affect:" makes it nearly impossible to express emotion in any normal kind of way.
It's not that I don't experience emotion - I very definitely do - but I am unable to show my feelings outwardly.
My expression is always wooden, a poker face.
It makes it very, very difficult to connect with other people, especially the opposite sex.
My most prevalent schizoaffective symptom is depression which is often profound and can be suicidal.
I also experience a profoundly euphoric state called mania.
One might think that it's not so bad because it is actually a very happy, joyful feeling, it is actually the worst of the schizoaffective symptoms because when I am manic, I am utterly and completely out of touch with reality.
I am like a bull in a china shop.
When I am manic, it is a matter for the police - lots and lots and lots of police.
But all of this pales in comparison with my Obsessive Compulsive Personality Disorder.
One reason is that I understood from the very beginning that my schizoaffective disorder was bad and just why it was bad, so I was able to work from the very beginning to overcome it.
But I had been in psytherapeutic and psychiatric treatment for twenty-four years before I was finally able to understand just how destructive my OCPD had been, not just to me, but to everyone that I cared about.
Simply being crazy is not so bad.
There are many ways to cope, many ways to get by.
What really is bad is to be crazy, yet completely unaware of it,  Thus it was with me and my Obsessive Compulsive Personality.
I would be very grateful if you would read this short essay, it is just five pages or so:
 A Special Kind of Crazy [geometricvisions.com]


Kuro5hin's undermyne said of me:You, sir are a special kind of crazy.
They may even name a type of crazy after you.
People will no longer be called "odd" when they are batshit, self destructive crazy.
They will be called "ogg".
I am grateful for all of your kind understanding.
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31460894</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31460112</id>
	<title>Re:scary part of TFA</title>
	<author>virtualXTC</author>
	<datestamp>1268404800000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>Less than 3 yrs before it's feasible; more than 7 due to public backlash.</htmltext>
<tokenext>Less than 3 yrs before it 's feasible ; more than 7 due to public backlash .</tokentext>
<sentencetext>Less than 3 yrs before it's feasible; more than 7 due to public backlash.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31459198</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31460006</id>
	<title>Re:Can of Worms?</title>
	<author>Scrameustache</author>
	<datestamp>1268404080000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p><div class="quote"><p><div class="quote"><p>genetic discrimination</p></div><p>I think even the most coldhearted persons must admit that your genetic makeup is something you cannot influence</p></div><p>Tell that to my lump of thorium!</p></div>
	</htmltext>
<tokenext>genetic discriminationI think even the most coldhearted persons must admit that your genetic makeup is something you can not influenceTell that to my lump of thorium !</tokentext>
<sentencetext>genetic discriminationI think even the most coldhearted persons must admit that your genetic makeup is something you cannot influenceTell that to my lump of thorium!
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31459358</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31459990</id>
	<title>Re:Can of Worms?</title>
	<author>virtualXTC</author>
	<datestamp>1268403960000</datestamp>
	<modclass>Informativ</modclass>
	<modscore>2</modscore>
	<htmltext><p><div class="quote"><p>With every advancement in figuring out genetic diseases, I can't help but think that the combination of this plus drug testing will lead to genetic discrimination, or at least defamation.

Plus, even then is there much we -can- do if we figure out something is genetic?</p></div><p>Sad you were modded flamebait for voicing honest concerns.  Good thing you were the FP.<br>
<br>
Genetic discrimination is already illegal in the US.<br>
<br>
Understanding that a disease is genetic DOES allow us to do something.  Take <a href="http://en.wikipedia.org/wiki/Glycogen\_storage\_disease\_type\_II" title="wikipedia.org" rel="nofollow">pompe disease</a> [wikipedia.org] for instance, there are now 2 possible ways of treating it that we were able to derrive from our genetic understanding.  The first, and most obvious; make the protein that is deficient in the patients with the disease and administer it to them.  The second; now that we know the cause of the disease, find a small molecule that restores function to the mutated protein (or potentially further up stream: allows the mRNA to fold properly).</p></div>
	</htmltext>
<tokenext>With every advancement in figuring out genetic diseases , I ca n't help but think that the combination of this plus drug testing will lead to genetic discrimination , or at least defamation .
Plus , even then is there much we -can- do if we figure out something is genetic ? Sad you were modded flamebait for voicing honest concerns .
Good thing you were the FP .
Genetic discrimination is already illegal in the US .
Understanding that a disease is genetic DOES allow us to do something .
Take pompe disease [ wikipedia.org ] for instance , there are now 2 possible ways of treating it that we were able to derrive from our genetic understanding .
The first , and most obvious ; make the protein that is deficient in the patients with the disease and administer it to them .
The second ; now that we know the cause of the disease , find a small molecule that restores function to the mutated protein ( or potentially further up stream : allows the mRNA to fold properly ) .</tokentext>
<sentencetext>With every advancement in figuring out genetic diseases, I can't help but think that the combination of this plus drug testing will lead to genetic discrimination, or at least defamation.
Plus, even then is there much we -can- do if we figure out something is genetic?Sad you were modded flamebait for voicing honest concerns.
Good thing you were the FP.
Genetic discrimination is already illegal in the US.
Understanding that a disease is genetic DOES allow us to do something.
Take pompe disease [wikipedia.org] for instance, there are now 2 possible ways of treating it that we were able to derrive from our genetic understanding.
The first, and most obvious; make the protein that is deficient in the patients with the disease and administer it to them.
The second; now that we know the cause of the disease, find a small molecule that restores function to the mutated protein (or potentially further up stream: allows the mRNA to fold properly).
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31459060</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31461604</id>
	<title>Re:Can of Worms?</title>
	<author>repapetilto</author>
	<datestamp>1268416740000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>Genetic disorders occur because of either over- or under-activity of whatever protein is encoded by the mutant gene. Once the gene is discovered it is possible to figure out the characteristics of the protein it encodes and treat with drugs that can counter the over activity by inhibiting the protein or counter the underactivity by mimicking or stimulating the protein.</p></htmltext>
<tokenext>Genetic disorders occur because of either over- or under-activity of whatever protein is encoded by the mutant gene .
Once the gene is discovered it is possible to figure out the characteristics of the protein it encodes and treat with drugs that can counter the over activity by inhibiting the protein or counter the underactivity by mimicking or stimulating the protein .</tokentext>
<sentencetext>Genetic disorders occur because of either over- or under-activity of whatever protein is encoded by the mutant gene.
Once the gene is discovered it is possible to figure out the characteristics of the protein it encodes and treat with drugs that can counter the over activity by inhibiting the protein or counter the underactivity by mimicking or stimulating the protein.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31459060</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31492232</id>
	<title>Re:Ambiguous parsing</title>
	<author>qatarmark</author>
	<datestamp>1268678520000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>yes what is it exactly by the ways guys have you ever tried this webiste , it's online companies and business directory with great search engine, <a href="http://www.qatarmark.com/qatar-business/search-qatar-companies/" title="qatarmark.com" rel="nofollow">http://www.qatarmark.com/qatar-business/search-qatar-companies/</a> [qatarmark.com]

Regards</htmltext>
<tokenext>yes what is it exactly by the ways guys have you ever tried this webiste , it 's online companies and business directory with great search engine , http : //www.qatarmark.com/qatar-business/search-qatar-companies/ [ qatarmark.com ] Regards</tokentext>
<sentencetext>yes what is it exactly by the ways guys have you ever tried this webiste , it's online companies and business directory with great search engine, http://www.qatarmark.com/qatar-business/search-qatar-companies/ [qatarmark.com]

Regards</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31459454</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31459060</id>
	<title>Can of Worms?</title>
	<author>Darkness404</author>
	<datestamp>1268399280000</datestamp>
	<modclass>None</modclass>
	<modscore>2</modscore>
	<htmltext>With every advancement in figuring out genetic diseases, I can't help but think that the combination of this plus drug testing will lead to genetic discrimination, or at least defamation. <br> <br>

Plus, even then is there much we -can- do if we figure out something is genetic?</htmltext>
<tokenext>With every advancement in figuring out genetic diseases , I ca n't help but think that the combination of this plus drug testing will lead to genetic discrimination , or at least defamation .
Plus , even then is there much we -can- do if we figure out something is genetic ?</tokentext>
<sentencetext>With every advancement in figuring out genetic diseases, I can't help but think that the combination of this plus drug testing will lead to genetic discrimination, or at least defamation.
Plus, even then is there much we -can- do if we figure out something is genetic?</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31460762</id>
	<title>Re:Can of Worms?</title>
	<author>Anonymous</author>
	<datestamp>1268409360000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>That's the most boring, predictable, and utterly BORING thing I've heard anyone say.</p></htmltext>
<tokenext>That 's the most boring , predictable , and utterly BORING thing I 've heard anyone say .</tokentext>
<sentencetext>That's the most boring, predictable, and utterly BORING thing I've heard anyone say.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31459060</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31460060</id>
	<title>Re:Can of Worms?</title>
	<author>Anonymous</author>
	<datestamp>1268404380000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p><div class="quote"><p>I think even the most coldhearted persons must admit that your genetic makeup is something you cannot influence and which a caring society should insure you from. I don't see much of a problem there, especially since you can point at everyone and ask them with a sharp eye: "Are you sure you don't carry some expensive genetic screwup which can only be fixed by a $250,000 individual cure?"</p></div><p>Tell that to someone with Turner's syndrome when they're trying to get insurance.</p></div>
	</htmltext>
<tokenext>I think even the most coldhearted persons must admit that your genetic makeup is something you can not influence and which a caring society should insure you from .
I do n't see much of a problem there , especially since you can point at everyone and ask them with a sharp eye : " Are you sure you do n't carry some expensive genetic screwup which can only be fixed by a $ 250,000 individual cure ?
" Tell that to someone with Turner 's syndrome when they 're trying to get insurance .</tokentext>
<sentencetext>I think even the most coldhearted persons must admit that your genetic makeup is something you cannot influence and which a caring society should insure you from.
I don't see much of a problem there, especially since you can point at everyone and ask them with a sharp eye: "Are you sure you don't carry some expensive genetic screwup which can only be fixed by a $250,000 individual cure?
"Tell that to someone with Turner's syndrome when they're trying to get insurance.
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31459358</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31459454</id>
	<title>Ambiguous parsing</title>
	<author>Anonymous</author>
	<datestamp>1268400780000</datestamp>
	<modclass>Interestin</modclass>
	<modscore>2</modscore>
	<htmltext><p>What's this <i>Hunting disease</i> they talk about?</p></htmltext>
<tokenext>What 's this Hunting disease they talk about ?</tokentext>
<sentencetext>What's this Hunting disease they talk about?</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31461386</id>
	<title>Re:Can of Worms?</title>
	<author>dAzED1</author>
	<datestamp>1268414220000</datestamp>
	<modclass>Interestin</modclass>
	<modscore>2</modscore>
	<htmltext><p>genetic testing allowed me to know that I do indeed have a genetic disorder that causes a lack of an enzyme involved in the processing of l-dopa, causing me to frequently not have enough dopamine in my brain...giving me dopa-responsive dystonia, treated via the same thing Parkinson's suffers use (sinemet).</p><p>That being the case...I'm going to genetically discriminate myself, and get a vasectomy.  I'd never wish this upon a child...not when we've since figured out that my father's lifetime non-drug-responsive hypertension is because of the same problem, just presenting differently.  Do you have a genetic disorder?  Unless you're part of the target audience, don't speak for us<nobr> <wbr></nobr>;)</p></htmltext>
<tokenext>genetic testing allowed me to know that I do indeed have a genetic disorder that causes a lack of an enzyme involved in the processing of l-dopa , causing me to frequently not have enough dopamine in my brain...giving me dopa-responsive dystonia , treated via the same thing Parkinson 's suffers use ( sinemet ) .That being the case...I 'm going to genetically discriminate myself , and get a vasectomy .
I 'd never wish this upon a child...not when we 've since figured out that my father 's lifetime non-drug-responsive hypertension is because of the same problem , just presenting differently .
Do you have a genetic disorder ?
Unless you 're part of the target audience , do n't speak for us ; )</tokentext>
<sentencetext>genetic testing allowed me to know that I do indeed have a genetic disorder that causes a lack of an enzyme involved in the processing of l-dopa, causing me to frequently not have enough dopamine in my brain...giving me dopa-responsive dystonia, treated via the same thing Parkinson's suffers use (sinemet).That being the case...I'm going to genetically discriminate myself, and get a vasectomy.
I'd never wish this upon a child...not when we've since figured out that my father's lifetime non-drug-responsive hypertension is because of the same problem, just presenting differently.
Do you have a genetic disorder?
Unless you're part of the target audience, don't speak for us ;)</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31459060</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31460050</id>
	<title>Re:Can of Worms?</title>
	<author>moogied</author>
	<datestamp>1268404320000</datestamp>
	<modclass>Informativ</modclass>
	<modscore>2</modscore>
	<htmltext>Wow, I don't often to get to use the same post twice.. but uh, they passed a law making genetic discrimination illegal in America.</htmltext>
<tokenext>Wow , I do n't often to get to use the same post twice.. but uh , they passed a law making genetic discrimination illegal in America .</tokentext>
<sentencetext>Wow, I don't often to get to use the same post twice.. but uh, they passed a law making genetic discrimination illegal in America.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31459060</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31460004</id>
	<title>The more interesting ones...</title>
	<author>Hurricane78</author>
	<datestamp>1268404020000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>...will be those they expect to find in the genes, but won&rsquo;t. Like many of those so-called &ldquo;age-related&rdquo; diseases. Because then they have to admit it&rsquo;s caused by the environment. Like the actually food-related group.</p></htmltext>
<tokenext>...will be those they expect to find in the genes , but won    t .
Like many of those so-called    age-related    diseases .
Because then they have to admit it    s caused by the environment .
Like the actually food-related group .</tokentext>
<sentencetext>...will be those they expect to find in the genes, but won’t.
Like many of those so-called “age-related” diseases.
Because then they have to admit it’s caused by the environment.
Like the actually food-related group.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31462304</id>
	<title>Worms are for fish and birds</title>
	<author>nido</author>
	<datestamp>1268512020000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>Humans use their minds to recognize traps. There aren't a lot of us who know how to avoid the 'genetics' hook, but it <i>is</i> possible...</p><p><div class="quote"><p>I think even the most coldhearted persons must admit that your genetic makeup is something you cannot influence</p> </div><p>I may be the most coldhearted person you'll never meet (the man who used to train mercenaries said I missed my true calling), and I do a damn good job of influencing my genes.</p><p><a href="http://discovermagazine.com/2006/nov/cover" title="discovermagazine.com">DNA Is Not Destiny</a> [discovermagazine.com] (Discover Magazine)<br><a href="http://www.time.com/time/health/article/0,8599,1951968,00.html" title="time.com">Why Your DNA Isn't Your Destiny</a> [time.com](Time Magazine)</p><p>Why do some people with the "bad gene" develop a given disease, while other people do not?  Epigenetics FTW!<nobr> <wbr></nobr>:)</p><p>Eat right, productively deal with your stress, <a href="http://slashdot.org/comments.pl?sid=1572902&amp;cid=31376758" title="slashdot.org">balance your nervous system</a> [slashdot.org], indulge in creativity, etc, and you won't have to worry about your genes.</p></div>
	</htmltext>
<tokenext>Humans use their minds to recognize traps .
There are n't a lot of us who know how to avoid the 'genetics ' hook , but it is possible...I think even the most coldhearted persons must admit that your genetic makeup is something you can not influence I may be the most coldhearted person you 'll never meet ( the man who used to train mercenaries said I missed my true calling ) , and I do a damn good job of influencing my genes.DNA Is Not Destiny [ discovermagazine.com ] ( Discover Magazine ) Why Your DNA Is n't Your Destiny [ time.com ] ( Time Magazine ) Why do some people with the " bad gene " develop a given disease , while other people do not ?
Epigenetics FTW !
: ) Eat right , productively deal with your stress , balance your nervous system [ slashdot.org ] , indulge in creativity , etc , and you wo n't have to worry about your genes .</tokentext>
<sentencetext>Humans use their minds to recognize traps.
There aren't a lot of us who know how to avoid the 'genetics' hook, but it is possible...I think even the most coldhearted persons must admit that your genetic makeup is something you cannot influence I may be the most coldhearted person you'll never meet (the man who used to train mercenaries said I missed my true calling), and I do a damn good job of influencing my genes.DNA Is Not Destiny [discovermagazine.com] (Discover Magazine)Why Your DNA Isn't Your Destiny [time.com](Time Magazine)Why do some people with the "bad gene" develop a given disease, while other people do not?
Epigenetics FTW!
:)Eat right, productively deal with your stress, balance your nervous system [slashdot.org], indulge in creativity, etc, and you won't have to worry about your genes.
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31459358</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31460134</id>
	<title>Re:Can of Worms?</title>
	<author>Xipe66</author>
	<datestamp>1268404920000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>Wow, how quaintly naive.</p></htmltext>
<tokenext>Wow , how quaintly naive .</tokentext>
<sentencetext>Wow, how quaintly naive.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31459358</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31461686</id>
	<title>Re:I'd like to offer my genome for sequencing</title>
	<author>Anonymous</author>
	<datestamp>1268417580000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>Personal Genome Project: http://www.personalgenomes.org/</p><p>looking for 100,000...</p></htmltext>
<tokenext>Personal Genome Project : http : //www.personalgenomes.org/looking for 100,000.. .</tokentext>
<sentencetext>Personal Genome Project: http://www.personalgenomes.org/looking for 100,000...</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31460894</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31459998</id>
	<title>Re:Can of Worms?</title>
	<author>benjamindees</author>
	<datestamp>1268404020000</datestamp>
	<modclass>Flamebait</modclass>
	<modscore>0</modscore>
	<htmltext><p><div class="quote"><p>your genetic makeup is something you cannot influence and which a caring society should insure you from</p></div><p><div class="quote"><p>$250,000</p></div><p>So, it's not enough that I have to pay for your economic failures, now.</p><p>I get to pay for your genetic defects as well?</p></div>
	</htmltext>
<tokenext>your genetic makeup is something you can not influence and which a caring society should insure you from $ 250,000So , it 's not enough that I have to pay for your economic failures , now.I get to pay for your genetic defects as well ?</tokentext>
<sentencetext>your genetic makeup is something you cannot influence and which a caring society should insure you from$250,000So, it's not enough that I have to pay for your economic failures, now.I get to pay for your genetic defects as well?
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31459358</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31460454</id>
	<title>Re:scary part of TFA</title>
	<author>jeff4747</author>
	<datestamp>1268406900000</datestamp>
	<modclass>Interestin</modclass>
	<modscore>2</modscore>
	<htmltext><blockquote><div><p>How long before sequencing becomes part of a routine physical exam, and having the disease-prone genes becomes a pre-existing condition for health insurance purposes?</p></div></blockquote><p>That depends.</p><p>If the Democrats manage to pass health care reform, there will no longer be any "pre-existing conditions" so the question is moot.</p><p>If the Republicans manage to stop health care reform, it'll take 10 minutes.</p><p>(Actually there's a law against using genetic tests to set insurance rates, but I wanted to get a little snark in)</p></div>
	</htmltext>
<tokenext>How long before sequencing becomes part of a routine physical exam , and having the disease-prone genes becomes a pre-existing condition for health insurance purposes ? That depends.If the Democrats manage to pass health care reform , there will no longer be any " pre-existing conditions " so the question is moot.If the Republicans manage to stop health care reform , it 'll take 10 minutes .
( Actually there 's a law against using genetic tests to set insurance rates , but I wanted to get a little snark in )</tokentext>
<sentencetext>How long before sequencing becomes part of a routine physical exam, and having the disease-prone genes becomes a pre-existing condition for health insurance purposes?That depends.If the Democrats manage to pass health care reform, there will no longer be any "pre-existing conditions" so the question is moot.If the Republicans manage to stop health care reform, it'll take 10 minutes.
(Actually there's a law against using genetic tests to set insurance rates, but I wanted to get a little snark in)
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31459198</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31460394</id>
	<title>Re:Can of Worms?</title>
	<author>Daniel Dvorkin</author>
	<datestamp>1268406360000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>Genetic discrimination is a worry, of course, but the risk of it is far outweighed by the benefits which understanding the role of genetics in human health offers.  And the <a href="http://www.genome.gov/24519851" title="genome.gov">Genetic Information Nondiscrimination Act (GINA)</a> [genome.gov] is actually a pretty good law.</p><p>As for the medical usefulness of genetics<nobr> <wbr></nobr>... warfarin (Coumadin) is one of the most widely used clot-busting drugs in the world, and IIRC <a href="http://content.nejm.org/cgi/content/short/360/8/753" title="nejm.org">this</a> [nejm.org] has now been incorporated into the dosage guidelines.  It isn't quite the same as actually curing a genetic disease, of course, but it is an important advance which has the potential to save a lot of lives.</p></htmltext>
<tokenext>Genetic discrimination is a worry , of course , but the risk of it is far outweighed by the benefits which understanding the role of genetics in human health offers .
And the Genetic Information Nondiscrimination Act ( GINA ) [ genome.gov ] is actually a pretty good law.As for the medical usefulness of genetics ... warfarin ( Coumadin ) is one of the most widely used clot-busting drugs in the world , and IIRC this [ nejm.org ] has now been incorporated into the dosage guidelines .
It is n't quite the same as actually curing a genetic disease , of course , but it is an important advance which has the potential to save a lot of lives .</tokentext>
<sentencetext>Genetic discrimination is a worry, of course, but the risk of it is far outweighed by the benefits which understanding the role of genetics in human health offers.
And the Genetic Information Nondiscrimination Act (GINA) [genome.gov] is actually a pretty good law.As for the medical usefulness of genetics ... warfarin (Coumadin) is one of the most widely used clot-busting drugs in the world, and IIRC this [nejm.org] has now been incorporated into the dosage guidelines.
It isn't quite the same as actually curing a genetic disease, of course, but it is an important advance which has the potential to save a lot of lives.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31459060</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31461496</id>
	<title>Re:Ambiguous parsing</title>
	<author>sjames</author>
	<datestamp>1268415720000</datestamp>
	<modclass>Funny</modclass>
	<modscore>3</modscore>
	<htmltext><p>Also known as <a href="http://en.wikipedia.org/wiki/Dick\_Cheney\_hunting\_incident" title="wikipedia.org">"Cheney's disease"</a> [wikipedia.org] </p></htmltext>
<tokenext>Also known as " Cheney 's disease " [ wikipedia.org ]</tokentext>
<sentencetext>Also known as "Cheney's disease" [wikipedia.org] </sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31459454</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31460370</id>
	<title>Re:Can of Worms?</title>
	<author>baKanale</author>
	<datestamp>1268406240000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><blockquote><div><blockquote><div><p>genetic discrimination</p></div></blockquote><p>I think even the most coldhearted persons must admit that your genetic makeup is something you cannot influence...</p></div></blockquote><p>

Coldhearted persons discriminate all the time based on something as arbitrary as the color of a person's skin, a trait encoded in your genetic makeup with you cannot influence.  And that's not even when they stand to make money off of it, either.</p></div>
	</htmltext>
<tokenext>genetic discriminationI think even the most coldhearted persons must admit that your genetic makeup is something you can not influence.. . Coldhearted persons discriminate all the time based on something as arbitrary as the color of a person 's skin , a trait encoded in your genetic makeup with you can not influence .
And that 's not even when they stand to make money off of it , either .</tokentext>
<sentencetext>genetic discriminationI think even the most coldhearted persons must admit that your genetic makeup is something you cannot influence...

Coldhearted persons discriminate all the time based on something as arbitrary as the color of a person's skin, a trait encoded in your genetic makeup with you cannot influence.
And that's not even when they stand to make money off of it, either.
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31459358</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31460448</id>
	<title>Re:scary part of TFA</title>
	<author>Daniel Dvorkin</author>
	<datestamp>1268406840000</datestamp>
	<modclass>Insightful</modclass>
	<modscore>2</modscore>
	<htmltext><p>People in the sequencing biz talk about the "thousand dollar genome" as kind of the magic number, and the consensus is that we can expect to get there in five years or so.  At that point, yes, it will be a routine part of everyone's medical record.  As for discrimination, the best we can do is guard against it; the <a href="http://www.genome.gov/24519851" title="genome.gov">Genetic Information Nondiscrimination Act (GINA)</a> [genome.gov] is a very good start.  There is no way in hell that we are going to turn our backs on the enormous medical potential of cheap, nearly universal sequencing because of fears cobbled together -- as most anti-genetics rants seem to be -- out of massive ignorance and half-remembered ideas picked up from Frankenstein, Jurassic Park, and Gattaca.</p></htmltext>
<tokenext>People in the sequencing biz talk about the " thousand dollar genome " as kind of the magic number , and the consensus is that we can expect to get there in five years or so .
At that point , yes , it will be a routine part of everyone 's medical record .
As for discrimination , the best we can do is guard against it ; the Genetic Information Nondiscrimination Act ( GINA ) [ genome.gov ] is a very good start .
There is no way in hell that we are going to turn our backs on the enormous medical potential of cheap , nearly universal sequencing because of fears cobbled together -- as most anti-genetics rants seem to be -- out of massive ignorance and half-remembered ideas picked up from Frankenstein , Jurassic Park , and Gattaca .</tokentext>
<sentencetext>People in the sequencing biz talk about the "thousand dollar genome" as kind of the magic number, and the consensus is that we can expect to get there in five years or so.
At that point, yes, it will be a routine part of everyone's medical record.
As for discrimination, the best we can do is guard against it; the Genetic Information Nondiscrimination Act (GINA) [genome.gov] is a very good start.
There is no way in hell that we are going to turn our backs on the enormous medical potential of cheap, nearly universal sequencing because of fears cobbled together -- as most anti-genetics rants seem to be -- out of massive ignorance and half-remembered ideas picked up from Frankenstein, Jurassic Park, and Gattaca.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31459198</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31461248</id>
	<title>Re:Can of Worms?</title>
	<author>pnewhook</author>
	<datestamp>1268412900000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>No.  But I can see the day when a child with a genetic disease can sue his parents because given this technology they *should have known* offspring could inherit problems, therefore it is their actions can be considered willful harm.
</p><p>Unless of course we build a rocket and fire all the lawyers into the sun.</p></htmltext>
<tokenext>No .
But I can see the day when a child with a genetic disease can sue his parents because given this technology they * should have known * offspring could inherit problems , therefore it is their actions can be considered willful harm .
Unless of course we build a rocket and fire all the lawyers into the sun .</tokentext>
<sentencetext>No.
But I can see the day when a child with a genetic disease can sue his parents because given this technology they *should have known* offspring could inherit problems, therefore it is their actions can be considered willful harm.
Unless of course we build a rocket and fire all the lawyers into the sun.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31459060</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31462564</id>
	<title>Re:the</title>
	<author>acheron12</author>
	<datestamp>1268473560000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p><div class="quote"><p>However after what was probably not a trivial expense, at the end of the day he went home knowing that, well, he had Charcot-Marie-Tooth disease. Er yeah, but he already knew that.</p></div><p>Yeah, but this wasn't a medical test, it was a scientific test. The goal was not to diagnose but to further basic research.</p></div>
	</htmltext>
<tokenext>However after what was probably not a trivial expense , at the end of the day he went home knowing that , well , he had Charcot-Marie-Tooth disease .
Er yeah , but he already knew that.Yeah , but this was n't a medical test , it was a scientific test .
The goal was not to diagnose but to further basic research .</tokentext>
<sentencetext>However after what was probably not a trivial expense, at the end of the day he went home knowing that, well, he had Charcot-Marie-Tooth disease.
Er yeah, but he already knew that.Yeah, but this wasn't a medical test, it was a scientific test.
The goal was not to diagnose but to further basic research.
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31461186</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31460502</id>
	<title>Compatible</title>
	<author>Anonymous</author>
	<datestamp>1268407200000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>Don't we share 99\% of our DNA with monkeys? People share 70\% DNA with bananas. I guess all that sharing makes us compatible.</p></htmltext>
<tokenext>Do n't we share 99 \ % of our DNA with monkeys ?
People share 70 \ % DNA with bananas .
I guess all that sharing makes us compatible .</tokentext>
<sentencetext>Don't we share 99\% of our DNA with monkeys?
People share 70\% DNA with bananas.
I guess all that sharing makes us compatible.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31461350</id>
	<title>Speaking as an insider</title>
	<author>dorpus</author>
	<datestamp>1268413920000</datestamp>
	<modclass>Informativ</modclass>
	<modscore>2</modscore>
	<htmltext><p>I'm getting my PhD in a statistical genetics program.</p><p>The quality of "newly discovered genes" in the literature is very, very poor.  Any scientific "discovery" should be replicated by other researchers, but that is not being done.  Negative results rarely get published.  Since we have tens of thousands of genes, one can find any number of genes that have a "significant association" with a given condition.</p><p>In reality, many diseases are known to have multiple origins.  The same disease could be caused by entirely different genes in different people.  And that's assuming it is a genetic condition, as opposed to other causes.  Researchers have spent decades looking for genes that cause diabetes, but there is increasing evidence that diabetes is really caused by viral infections.  In particular, type I diabetes was assumed to be genetic, but there is a fairly large amount of evidence that it is caused by viruses such as Coxsackie B4.  The incidence of type 1 diabetes is increasing throughout the world, which cannot be explained by genetics.</p><p>To dispel a couple of other myths, genetic diseases are not always recessive.  Many of them are dominant.  Also, "bad" genes do not always get selected out of the gene pool; diseases that cause problems later in life, such as Alzheimer's, heart disease, Huntington's, happen after reproductive age and so there is no selection pressure.</p></htmltext>
<tokenext>I 'm getting my PhD in a statistical genetics program.The quality of " newly discovered genes " in the literature is very , very poor .
Any scientific " discovery " should be replicated by other researchers , but that is not being done .
Negative results rarely get published .
Since we have tens of thousands of genes , one can find any number of genes that have a " significant association " with a given condition.In reality , many diseases are known to have multiple origins .
The same disease could be caused by entirely different genes in different people .
And that 's assuming it is a genetic condition , as opposed to other causes .
Researchers have spent decades looking for genes that cause diabetes , but there is increasing evidence that diabetes is really caused by viral infections .
In particular , type I diabetes was assumed to be genetic , but there is a fairly large amount of evidence that it is caused by viruses such as Coxsackie B4 .
The incidence of type 1 diabetes is increasing throughout the world , which can not be explained by genetics.To dispel a couple of other myths , genetic diseases are not always recessive .
Many of them are dominant .
Also , " bad " genes do not always get selected out of the gene pool ; diseases that cause problems later in life , such as Alzheimer 's , heart disease , Huntington 's , happen after reproductive age and so there is no selection pressure .</tokentext>
<sentencetext>I'm getting my PhD in a statistical genetics program.The quality of "newly discovered genes" in the literature is very, very poor.
Any scientific "discovery" should be replicated by other researchers, but that is not being done.
Negative results rarely get published.
Since we have tens of thousands of genes, one can find any number of genes that have a "significant association" with a given condition.In reality, many diseases are known to have multiple origins.
The same disease could be caused by entirely different genes in different people.
And that's assuming it is a genetic condition, as opposed to other causes.
Researchers have spent decades looking for genes that cause diabetes, but there is increasing evidence that diabetes is really caused by viral infections.
In particular, type I diabetes was assumed to be genetic, but there is a fairly large amount of evidence that it is caused by viruses such as Coxsackie B4.
The incidence of type 1 diabetes is increasing throughout the world, which cannot be explained by genetics.To dispel a couple of other myths, genetic diseases are not always recessive.
Many of them are dominant.
Also, "bad" genes do not always get selected out of the gene pool; diseases that cause problems later in life, such as Alzheimer's, heart disease, Huntington's, happen after reproductive age and so there is no selection pressure.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31459320</id>
	<title>Re:scary part of TFA</title>
	<author>pclminion</author>
	<datestamp>1268400300000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>I don't think the problem is limited to gene sequencing. For instance, here in Oregon the insurance companies are required to provide coverage for certain types of smoking cessation treatment. However, you'd have to be an idiot to take them up on their offer, because as soon as you do, they know you are a smoker and will certainly jack your rates through the stratosphere. I wouldn't be surprised if the insurance companies actually backed that law.</htmltext>
<tokenext>I do n't think the problem is limited to gene sequencing .
For instance , here in Oregon the insurance companies are required to provide coverage for certain types of smoking cessation treatment .
However , you 'd have to be an idiot to take them up on their offer , because as soon as you do , they know you are a smoker and will certainly jack your rates through the stratosphere .
I would n't be surprised if the insurance companies actually backed that law .</tokentext>
<sentencetext>I don't think the problem is limited to gene sequencing.
For instance, here in Oregon the insurance companies are required to provide coverage for certain types of smoking cessation treatment.
However, you'd have to be an idiot to take them up on their offer, because as soon as you do, they know you are a smoker and will certainly jack your rates through the stratosphere.
I wouldn't be surprised if the insurance companies actually backed that law.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31459198</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31460068</id>
	<title>Re:scary part of TFA</title>
	<author>Idiomatick</author>
	<datestamp>1268404440000</datestamp>
	<modclass>Insightful</modclass>
	<modscore>2</modscore>
	<htmltext>Yeah, itd suck to have drugs individually tailored to your genes. They'd work like, way better. Plus you could get information on maldies that you might come across. Hell you may be able to work pre-emptively to avoid getting them.<br> <br>Honestly there are tons of reasons why this is a GOOD THING.</htmltext>
<tokenext>Yeah , itd suck to have drugs individually tailored to your genes .
They 'd work like , way better .
Plus you could get information on maldies that you might come across .
Hell you may be able to work pre-emptively to avoid getting them .
Honestly there are tons of reasons why this is a GOOD THING .</tokentext>
<sentencetext>Yeah, itd suck to have drugs individually tailored to your genes.
They'd work like, way better.
Plus you could get information on maldies that you might come across.
Hell you may be able to work pre-emptively to avoid getting them.
Honestly there are tons of reasons why this is a GOOD THING.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31459198</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31461186</id>
	<title>the</title>
	<author>Dunbal</author>
	<datestamp>1268412420000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>First rule of medicine (well no, not really, it's probably down there around number 87) is "Thou shalt not brute force medicine".</p><p>Of course looking at medical shows, no wonder the public believes that the medical art consists of rattling off possible diagnoses at random and running tests until a magical positive result is found. And good for Dr. Lupski if he found a genetic cause for his disease. However after what was probably not a trivial expense, at the end of the day he went home knowing that, well, he had Charcot-Marie-Tooth disease. Er yeah, but he already knew that.</p><p>Above putative rule #87 is another rule: If a particular test will not change your diagnosis if it gives a positive (or negative) result, don't do the test. Because tests use up limited resources like paper, reagents, labs, money and time. And especially the patient (or his insurer) usually doesn't have an unlimited supply of these things. While as a doctor I could theoretically order every test in the world to rule out that the stuff oozing out of your nose is not caused by anything other than the common cold (cerebro-spinal fluid leaks, anyone?), the ART of being a doctor is making the RIGHT diagnosis and ordering the minimum RIGHT tests to confirm that diagnosis.</p><p>This is something that the medical community has forgotten, somewhere along the way through technological progress (read - lots of neat toys to play with) and defensive medicine (I did the tests so if I get sued I can prove that I thought of this). Of course going out and getting your whole genome sequenced will make lots of biotech companies very very happy. Of course once in a while someone somewhere will discover some condition they never knew they had. However firstly if it's in your genes there's not much you can do about it anyway except in very rare cases, and secondly exactly how much will this cost again? Maybe when the $5 genome sequencing is available this could be an option for mass screening, but for now - please, let's use some common sense. Especially when the costs of doing something like this are born by OTHER people - like in insurance or state run health care scenarios.</p><p>Just because you CAN do something doesn't necessarily mean you SHOULD do something. But hey, I'm just an aging family doctor, what do I know.</p></htmltext>
<tokenext>First rule of medicine ( well no , not really , it 's probably down there around number 87 ) is " Thou shalt not brute force medicine " .Of course looking at medical shows , no wonder the public believes that the medical art consists of rattling off possible diagnoses at random and running tests until a magical positive result is found .
And good for Dr. Lupski if he found a genetic cause for his disease .
However after what was probably not a trivial expense , at the end of the day he went home knowing that , well , he had Charcot-Marie-Tooth disease .
Er yeah , but he already knew that.Above putative rule # 87 is another rule : If a particular test will not change your diagnosis if it gives a positive ( or negative ) result , do n't do the test .
Because tests use up limited resources like paper , reagents , labs , money and time .
And especially the patient ( or his insurer ) usually does n't have an unlimited supply of these things .
While as a doctor I could theoretically order every test in the world to rule out that the stuff oozing out of your nose is not caused by anything other than the common cold ( cerebro-spinal fluid leaks , anyone ?
) , the ART of being a doctor is making the RIGHT diagnosis and ordering the minimum RIGHT tests to confirm that diagnosis.This is something that the medical community has forgotten , somewhere along the way through technological progress ( read - lots of neat toys to play with ) and defensive medicine ( I did the tests so if I get sued I can prove that I thought of this ) .
Of course going out and getting your whole genome sequenced will make lots of biotech companies very very happy .
Of course once in a while someone somewhere will discover some condition they never knew they had .
However firstly if it 's in your genes there 's not much you can do about it anyway except in very rare cases , and secondly exactly how much will this cost again ?
Maybe when the $ 5 genome sequencing is available this could be an option for mass screening , but for now - please , let 's use some common sense .
Especially when the costs of doing something like this are born by OTHER people - like in insurance or state run health care scenarios.Just because you CAN do something does n't necessarily mean you SHOULD do something .
But hey , I 'm just an aging family doctor , what do I know .</tokentext>
<sentencetext>First rule of medicine (well no, not really, it's probably down there around number 87) is "Thou shalt not brute force medicine".Of course looking at medical shows, no wonder the public believes that the medical art consists of rattling off possible diagnoses at random and running tests until a magical positive result is found.
And good for Dr. Lupski if he found a genetic cause for his disease.
However after what was probably not a trivial expense, at the end of the day he went home knowing that, well, he had Charcot-Marie-Tooth disease.
Er yeah, but he already knew that.Above putative rule #87 is another rule: If a particular test will not change your diagnosis if it gives a positive (or negative) result, don't do the test.
Because tests use up limited resources like paper, reagents, labs, money and time.
And especially the patient (or his insurer) usually doesn't have an unlimited supply of these things.
While as a doctor I could theoretically order every test in the world to rule out that the stuff oozing out of your nose is not caused by anything other than the common cold (cerebro-spinal fluid leaks, anyone?
), the ART of being a doctor is making the RIGHT diagnosis and ordering the minimum RIGHT tests to confirm that diagnosis.This is something that the medical community has forgotten, somewhere along the way through technological progress (read - lots of neat toys to play with) and defensive medicine (I did the tests so if I get sued I can prove that I thought of this).
Of course going out and getting your whole genome sequenced will make lots of biotech companies very very happy.
Of course once in a while someone somewhere will discover some condition they never knew they had.
However firstly if it's in your genes there's not much you can do about it anyway except in very rare cases, and secondly exactly how much will this cost again?
Maybe when the $5 genome sequencing is available this could be an option for mass screening, but for now - please, let's use some common sense.
Especially when the costs of doing something like this are born by OTHER people - like in insurance or state run health care scenarios.Just because you CAN do something doesn't necessarily mean you SHOULD do something.
But hey, I'm just an aging family doctor, what do I know.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31460894</id>
	<title>I'd like to offer my genome for sequencing</title>
	<author>Anonymous</author>
	<datestamp>1268410200000</datestamp>
	<modclass>Interestin</modclass>
	<modscore>3</modscore>
	<htmltext>If anyone can make a credible offer to sequence my genome, drop me a line at mdcrawford at gmail dot com and I'll arrange for you to get a sample of my DNA.  I will gladly sign an informed consent that would permit you to release the lot of it publicly - you need not be concerned about issues of confidentiality.  Really I would prefer it that way.<p>

I have two distinctly different mental illnesses, a neurological condition that affects my brain, and a circadian rhythm disorder that more or less makes it impossible for me to hold any kind of nine-to-five job.</p><p>

I have Bipolar-Type Schizoaffective Disorder, which is just like being Schizophrenic and Manic Depressive at the same time.  That was diagnosed in 1985.  I also have Obsessive-Compulsive Personality Disorder.  That's quite a different thing than the more well-known Obsessive Compulsive Disorder (OCPD vs OCD).  I was told of the diagnosis in 1994 but I have reason to believe the diagnosis was made long before, but my therapist chose to wait many years to give me the bad news.</p><p>

  The neurological condition is Attention Deficit Hyperactivity Disorder.  I got that diagnosis in 2008.  ADHD isn't taken very seriously by a lot of people, with some believing that it's not a real illness.  It's no joking matter: I got the diagnosis in a psychiatric hospital where I committed myself rather than go off the Golden Gate Bridge as a result of my profound inability to focus on my work.  I had been begging all manner of medical and mental health practitioners for help with it for ten years, but none of them had the first clue as to how to help me.  It was only the shrink in 2008 who was able to make a real difference.</p><p>

My circadian rhythm disorder is Delayed Sleep Phase Syndrome.  It is the main reason I am a software engineer - my degree is in Physics, and not Computer Science.  When I noticed that many of my programmer friends worked at night, I figured that being a coder would be the only way I would ever be able to hold a real job.  All of my life I have slept during the day and stayed up all night.  My mother said I was this way even when I was a newborn in the hospital.</p><p>

My reason for wanting my genome sequenced is not at all to help myself, but to help others with my conditions.  Besides understanding my various illnesses, I also want the medical community to figure out why I have done so well despite what would normally be a profound disability:</p><p>

It is very, very rare for someone with Schizoaffective Disorder to live independently, let alone hold any kind of real job.  I have a degree in Physics and have been a coder for twenty-two years.  But most who share my diagnosis have to live off the disability check, be cared for by their families, spend their lives in institutions, or survive somehow on the streets, tormented by despair and madness.</p><p>

There was a time when I was so hopelessly in the grip of my delusions that when God Almighty Himself sent me visions in the sky, I would photograph them.  But when the pictures came back from the developer without my visions in them, I figured it was due to my inexperience as a photographer and not because those hallucinations were the products of my own demented imagination.</p><p>

My hope is that by having my genome sequenced, I might not only ease the sufferring of others, but prevent a lot of otherwise needless suicides.</p><p>

I am absolutely serious: mdcrawford at gmail dot com</p></htmltext>
<tokenext>If anyone can make a credible offer to sequence my genome , drop me a line at mdcrawford at gmail dot com and I 'll arrange for you to get a sample of my DNA .
I will gladly sign an informed consent that would permit you to release the lot of it publicly - you need not be concerned about issues of confidentiality .
Really I would prefer it that way .
I have two distinctly different mental illnesses , a neurological condition that affects my brain , and a circadian rhythm disorder that more or less makes it impossible for me to hold any kind of nine-to-five job .
I have Bipolar-Type Schizoaffective Disorder , which is just like being Schizophrenic and Manic Depressive at the same time .
That was diagnosed in 1985 .
I also have Obsessive-Compulsive Personality Disorder .
That 's quite a different thing than the more well-known Obsessive Compulsive Disorder ( OCPD vs OCD ) .
I was told of the diagnosis in 1994 but I have reason to believe the diagnosis was made long before , but my therapist chose to wait many years to give me the bad news .
The neurological condition is Attention Deficit Hyperactivity Disorder .
I got that diagnosis in 2008 .
ADHD is n't taken very seriously by a lot of people , with some believing that it 's not a real illness .
It 's no joking matter : I got the diagnosis in a psychiatric hospital where I committed myself rather than go off the Golden Gate Bridge as a result of my profound inability to focus on my work .
I had been begging all manner of medical and mental health practitioners for help with it for ten years , but none of them had the first clue as to how to help me .
It was only the shrink in 2008 who was able to make a real difference .
My circadian rhythm disorder is Delayed Sleep Phase Syndrome .
It is the main reason I am a software engineer - my degree is in Physics , and not Computer Science .
When I noticed that many of my programmer friends worked at night , I figured that being a coder would be the only way I would ever be able to hold a real job .
All of my life I have slept during the day and stayed up all night .
My mother said I was this way even when I was a newborn in the hospital .
My reason for wanting my genome sequenced is not at all to help myself , but to help others with my conditions .
Besides understanding my various illnesses , I also want the medical community to figure out why I have done so well despite what would normally be a profound disability : It is very , very rare for someone with Schizoaffective Disorder to live independently , let alone hold any kind of real job .
I have a degree in Physics and have been a coder for twenty-two years .
But most who share my diagnosis have to live off the disability check , be cared for by their families , spend their lives in institutions , or survive somehow on the streets , tormented by despair and madness .
There was a time when I was so hopelessly in the grip of my delusions that when God Almighty Himself sent me visions in the sky , I would photograph them .
But when the pictures came back from the developer without my visions in them , I figured it was due to my inexperience as a photographer and not because those hallucinations were the products of my own demented imagination .
My hope is that by having my genome sequenced , I might not only ease the sufferring of others , but prevent a lot of otherwise needless suicides .
I am absolutely serious : mdcrawford at gmail dot com</tokentext>
<sentencetext>If anyone can make a credible offer to sequence my genome, drop me a line at mdcrawford at gmail dot com and I'll arrange for you to get a sample of my DNA.
I will gladly sign an informed consent that would permit you to release the lot of it publicly - you need not be concerned about issues of confidentiality.
Really I would prefer it that way.
I have two distinctly different mental illnesses, a neurological condition that affects my brain, and a circadian rhythm disorder that more or less makes it impossible for me to hold any kind of nine-to-five job.
I have Bipolar-Type Schizoaffective Disorder, which is just like being Schizophrenic and Manic Depressive at the same time.
That was diagnosed in 1985.
I also have Obsessive-Compulsive Personality Disorder.
That's quite a different thing than the more well-known Obsessive Compulsive Disorder (OCPD vs OCD).
I was told of the diagnosis in 1994 but I have reason to believe the diagnosis was made long before, but my therapist chose to wait many years to give me the bad news.
The neurological condition is Attention Deficit Hyperactivity Disorder.
I got that diagnosis in 2008.
ADHD isn't taken very seriously by a lot of people, with some believing that it's not a real illness.
It's no joking matter: I got the diagnosis in a psychiatric hospital where I committed myself rather than go off the Golden Gate Bridge as a result of my profound inability to focus on my work.
I had been begging all manner of medical and mental health practitioners for help with it for ten years, but none of them had the first clue as to how to help me.
It was only the shrink in 2008 who was able to make a real difference.
My circadian rhythm disorder is Delayed Sleep Phase Syndrome.
It is the main reason I am a software engineer - my degree is in Physics, and not Computer Science.
When I noticed that many of my programmer friends worked at night, I figured that being a coder would be the only way I would ever be able to hold a real job.
All of my life I have slept during the day and stayed up all night.
My mother said I was this way even when I was a newborn in the hospital.
My reason for wanting my genome sequenced is not at all to help myself, but to help others with my conditions.
Besides understanding my various illnesses, I also want the medical community to figure out why I have done so well despite what would normally be a profound disability:

It is very, very rare for someone with Schizoaffective Disorder to live independently, let alone hold any kind of real job.
I have a degree in Physics and have been a coder for twenty-two years.
But most who share my diagnosis have to live off the disability check, be cared for by their families, spend their lives in institutions, or survive somehow on the streets, tormented by despair and madness.
There was a time when I was so hopelessly in the grip of my delusions that when God Almighty Himself sent me visions in the sky, I would photograph them.
But when the pictures came back from the developer without my visions in them, I figured it was due to my inexperience as a photographer and not because those hallucinations were the products of my own demented imagination.
My hope is that by having my genome sequenced, I might not only ease the sufferring of others, but prevent a lot of otherwise needless suicides.
I am absolutely serious: mdcrawford at gmail dot com</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31464146</id>
	<title>Looks like someone's working on it...</title>
	<author>ebydav</author>
	<datestamp>1268498280000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>It looks like someone is working on this.  This PubMed link turns up in a Google search of 'gwas Schizoaffective Disorder':  <a href="http://www.ncbi.nlm.nih.gov/pubmed/19839995/" title="nih.gov" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/19839995/</a> [nih.gov].
<p>
They may not be looking at the exact form of the disorder that is affecting you, but at least it's close.  You might want to contact the authors and see what they can do.  The posted article points out that researchers are moving into studying more rare and complex disease forms, so your case might interest them.
</p><p>
GWAS = <a href="http://en.wikipedia.org/wiki/Genome-wide\_association\_study/" title="wikipedia.org" rel="nofollow">http://en.wikipedia.org/wiki/Genome-wide\_association\_study/</a> [wikipedia.org].  I have no idea if they are using the same technology as in the posted article, but it's a very recent study (2009) so it's an active research area.
</p><p>
As an aside, I really feel for you, man.  My mother used to run a care facility for Schizophrenics, so I grew up seeing some of the effects.  They usually did not show symptoms as severe as yours, though now and then there were more complicated clients.  Not a pretty sight, even for those with more "manageable" forms of the disorder.  I can only imagine a case like yours.
</p><p>
Good luck</p></htmltext>
<tokenext>It looks like someone is working on this .
This PubMed link turns up in a Google search of 'gwas Schizoaffective Disorder ' : http : //www.ncbi.nlm.nih.gov/pubmed/19839995/ [ nih.gov ] .
They may not be looking at the exact form of the disorder that is affecting you , but at least it 's close .
You might want to contact the authors and see what they can do .
The posted article points out that researchers are moving into studying more rare and complex disease forms , so your case might interest them .
GWAS = http : //en.wikipedia.org/wiki/Genome-wide \ _association \ _study/ [ wikipedia.org ] .
I have no idea if they are using the same technology as in the posted article , but it 's a very recent study ( 2009 ) so it 's an active research area .
As an aside , I really feel for you , man .
My mother used to run a care facility for Schizophrenics , so I grew up seeing some of the effects .
They usually did not show symptoms as severe as yours , though now and then there were more complicated clients .
Not a pretty sight , even for those with more " manageable " forms of the disorder .
I can only imagine a case like yours .
Good luck</tokentext>
<sentencetext>It looks like someone is working on this.
This PubMed link turns up in a Google search of 'gwas Schizoaffective Disorder':  http://www.ncbi.nlm.nih.gov/pubmed/19839995/ [nih.gov].
They may not be looking at the exact form of the disorder that is affecting you, but at least it's close.
You might want to contact the authors and see what they can do.
The posted article points out that researchers are moving into studying more rare and complex disease forms, so your case might interest them.
GWAS = http://en.wikipedia.org/wiki/Genome-wide\_association\_study/ [wikipedia.org].
I have no idea if they are using the same technology as in the posted article, but it's a very recent study (2009) so it's an active research area.
As an aside, I really feel for you, man.
My mother used to run a care facility for Schizophrenics, so I grew up seeing some of the effects.
They usually did not show symptoms as severe as yours, though now and then there were more complicated clients.
Not a pretty sight, even for those with more "manageable" forms of the disorder.
I can only imagine a case like yours.
Good luck</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31460894</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31460316</id>
	<title>Obviously,</title>
	<author>Anonymous</author>
	<datestamp>1268405940000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>  he uses Gentoo or LFS.</p></htmltext>
<tokenext>he uses Gentoo or LFS .</tokentext>
<sentencetext>  he uses Gentoo or LFS.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31462958</id>
	<title>Re:I'd like to offer my genome for sequencing</title>
	<author>Isaac-1</author>
	<datestamp>1268480880000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>Although not officially diagnosed (I don't see the point of spending a lot of money being diagnosed given the lack of effective treatment), I too show all the symptoms of DSPD, and feel there is likely a genetic component to this problem as my father suffers from what appears to be ASPD, and my son (now in his 20's) also shows many signs of a sleep phase disorder (he has done sleep studies, etc, but as yet with no official detailed results, other than acknowledgement of a problem).  I have been lucky enough to find others who share my sleep patterns if not my exact condition, and have also found ways to cope with my problem while holding down a somewhat regular job.  I sometimes wonder if the internet could possibly bring all of us night dwellers together so we could form our own physical community, one where businesses are open to fit our sleep cycles, one where doctors, dentist, etc. don't demand one shows up for appointments 5 hours before our natural waking times, one where as a parent we don't have to deal with notes from schools about how our children are having problems in classes that occur during the middle of their natural sleep cycle, etc.  Can you imagine it, going to a restaurant while they are serving breakfast and not be half asleep, going to the grocery store and having more than one lane open, aisles not blocked by restockers and boxes, much more importantly other people there that don't look like zombies.</p></htmltext>
<tokenext>Although not officially diagnosed ( I do n't see the point of spending a lot of money being diagnosed given the lack of effective treatment ) , I too show all the symptoms of DSPD , and feel there is likely a genetic component to this problem as my father suffers from what appears to be ASPD , and my son ( now in his 20 's ) also shows many signs of a sleep phase disorder ( he has done sleep studies , etc , but as yet with no official detailed results , other than acknowledgement of a problem ) .
I have been lucky enough to find others who share my sleep patterns if not my exact condition , and have also found ways to cope with my problem while holding down a somewhat regular job .
I sometimes wonder if the internet could possibly bring all of us night dwellers together so we could form our own physical community , one where businesses are open to fit our sleep cycles , one where doctors , dentist , etc .
do n't demand one shows up for appointments 5 hours before our natural waking times , one where as a parent we do n't have to deal with notes from schools about how our children are having problems in classes that occur during the middle of their natural sleep cycle , etc .
Can you imagine it , going to a restaurant while they are serving breakfast and not be half asleep , going to the grocery store and having more than one lane open , aisles not blocked by restockers and boxes , much more importantly other people there that do n't look like zombies .</tokentext>
<sentencetext>Although not officially diagnosed (I don't see the point of spending a lot of money being diagnosed given the lack of effective treatment), I too show all the symptoms of DSPD, and feel there is likely a genetic component to this problem as my father suffers from what appears to be ASPD, and my son (now in his 20's) also shows many signs of a sleep phase disorder (he has done sleep studies, etc, but as yet with no official detailed results, other than acknowledgement of a problem).
I have been lucky enough to find others who share my sleep patterns if not my exact condition, and have also found ways to cope with my problem while holding down a somewhat regular job.
I sometimes wonder if the internet could possibly bring all of us night dwellers together so we could form our own physical community, one where businesses are open to fit our sleep cycles, one where doctors, dentist, etc.
don't demand one shows up for appointments 5 hours before our natural waking times, one where as a parent we don't have to deal with notes from schools about how our children are having problems in classes that occur during the middle of their natural sleep cycle, etc.
Can you imagine it, going to a restaurant while they are serving breakfast and not be half asleep, going to the grocery store and having more than one lane open, aisles not blocked by restockers and boxes, much more importantly other people there that don't look like zombies.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31460894</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31459772</id>
	<title>Here's a similar NYT article</title>
	<author>OBeardedOne</author>
	<datestamp>1268402400000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>Interestingly, this is a very similar article published by the NYT the day before - <a href="http://www.nytimes.com/2010/03/11/health/research/11gene.html?ref=health" title="nytimes.com" rel="nofollow">http://www.nytimes.com/2010/03/11/health/research/11gene.html?ref=health</a> [nytimes.com]</htmltext>
<tokenext>Interestingly , this is a very similar article published by the NYT the day before - http : //www.nytimes.com/2010/03/11/health/research/11gene.html ? ref = health [ nytimes.com ]</tokentext>
<sentencetext>Interestingly, this is a very similar article published by the NYT the day before - http://www.nytimes.com/2010/03/11/health/research/11gene.html?ref=health [nytimes.com]</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31460336</id>
	<title>Re:Can of Worms?</title>
	<author>Anonymous</author>
	<datestamp>1268406000000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p><div class="quote"><p>I think even the most coldhearted persons must admit that your genetic makeup is something you cannot influence and which a caring society should insure you from.</p></div><p>I'd disagree. You aren't being cynical enough. You don't think that there's someone who would say "They're contaminating the gene pool and shouldn't be treated at all!" ?</p></div>
	</htmltext>
<tokenext>I think even the most coldhearted persons must admit that your genetic makeup is something you can not influence and which a caring society should insure you from.I 'd disagree .
You are n't being cynical enough .
You do n't think that there 's someone who would say " They 're contaminating the gene pool and should n't be treated at all !
" ?</tokentext>
<sentencetext>I think even the most coldhearted persons must admit that your genetic makeup is something you cannot influence and which a caring society should insure you from.I'd disagree.
You aren't being cynical enough.
You don't think that there's someone who would say "They're contaminating the gene pool and shouldn't be treated at all!
" ?
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31459358</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31462638</id>
	<title>Re:I'd like to offer my genome for sequencing</title>
	<author>Anonymous</author>
	<datestamp>1268475000000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>You were able to concentrate long enough to type all that?</p></htmltext>
<tokenext>You were able to concentrate long enough to type all that ?</tokentext>
<sentencetext>You were able to concentrate long enough to type all that?</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31460894</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31461412</id>
	<title>Re:Can of Worms?</title>
	<author>sjames</author>
	<datestamp>1268414460000</datestamp>
	<modclass>Interestin</modclass>
	<modscore>2</modscore>
	<htmltext><p><div class="quote"><p>I think even the most coldhearted persons must admit that your genetic makeup is something you cannot influence and which a caring society should insure you from.</p></div><p>The problem is that HR policies don't have hearts at all. The very name Human Resources sounds like a euphemism. Frankly, there are plenty of corporations out there that would happily toss babies into a wood chipper if there was any profit in it.</p></div>
	</htmltext>
<tokenext>I think even the most coldhearted persons must admit that your genetic makeup is something you can not influence and which a caring society should insure you from.The problem is that HR policies do n't have hearts at all .
The very name Human Resources sounds like a euphemism .
Frankly , there are plenty of corporations out there that would happily toss babies into a wood chipper if there was any profit in it .</tokentext>
<sentencetext>I think even the most coldhearted persons must admit that your genetic makeup is something you cannot influence and which a caring society should insure you from.The problem is that HR policies don't have hearts at all.
The very name Human Resources sounds like a euphemism.
Frankly, there are plenty of corporations out there that would happily toss babies into a wood chipper if there was any profit in it.
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31459358</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31459812</id>
	<title>Open Source Genomes?</title>
	<author>Anonymous</author>
	<datestamp>1268402580000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>They've sequenced a lot of diseases but they're keeping them secret because of HIPPA<br>Perhaps it's time to open source genomes so that many eyes can find the interesting stuff.<br>You may have a polymorphism that causes disease and you may not get insurance because of it but you and your children might benefit by a cure found by examining the data.<br>Which is better?</p></htmltext>
<tokenext>They 've sequenced a lot of diseases but they 're keeping them secret because of HIPPAPerhaps it 's time to open source genomes so that many eyes can find the interesting stuff.You may have a polymorphism that causes disease and you may not get insurance because of it but you and your children might benefit by a cure found by examining the data.Which is better ?</tokentext>
<sentencetext>They've sequenced a lot of diseases but they're keeping them secret because of HIPPAPerhaps it's time to open source genomes so that many eyes can find the interesting stuff.You may have a polymorphism that causes disease and you may not get insurance because of it but you and your children might benefit by a cure found by examining the data.Which is better?</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31460732</id>
	<title>Wow!</title>
	<author>hduff</author>
	<datestamp>1268409060000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>My local paper had this story in today's edition. Are they getting better or is Slashdot getting, um, sluggish?</htmltext>
<tokenext>My local paper had this story in today 's edition .
Are they getting better or is Slashdot getting , um , sluggish ?</tokentext>
<sentencetext>My local paper had this story in today's edition.
Are they getting better or is Slashdot getting, um, sluggish?</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31465546</id>
	<title>Re:I'd like to offer my genome for sequencing</title>
	<author>Anonymous</author>
	<datestamp>1268510280000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>you are my favorite internet degenerate, michael crawford</p></htmltext>
<tokenext>you are my favorite internet degenerate , michael crawford</tokentext>
<sentencetext>you are my favorite internet degenerate, michael crawford</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31460894</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31461786</id>
	<title>Re:Can of Worms?</title>
	<author>physburn</author>
	<datestamp>1268418720000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>Well now, there be an easy test, for the disease, but no cure. But in principle finding the gene, does lead
to a cure relavitively easierly. If the broken gene, needs to de activated then the physicians can use
RNA interference to de activate the gene. I the broken gene, is something important missing then in
principle, gene therapy, insertation of an other copy of the gene, using a retrovirus should cure the
disease. I say in principle, neither RNA interference nor Gene therapy a proven technologies yet.
<p>
---
</p><p>
<a href="http://www.feeddistiller.com/blogs/Genetic\%20Engineering/feed.html" title="feeddistiller.com">Genetic Engineering</a> [feeddistiller.com] Feed @ <a href="http://www.feeddistiller.com/" title="feeddistiller.com">Feed Distiller</a> [feeddistiller.com]</p></htmltext>
<tokenext>Well now , there be an easy test , for the disease , but no cure .
But in principle finding the gene , does lead to a cure relavitively easierly .
If the broken gene , needs to de activated then the physicians can use RNA interference to de activate the gene .
I the broken gene , is something important missing then in principle , gene therapy , insertation of an other copy of the gene , using a retrovirus should cure the disease .
I say in principle , neither RNA interference nor Gene therapy a proven technologies yet .
--- Genetic Engineering [ feeddistiller.com ] Feed @ Feed Distiller [ feeddistiller.com ]</tokentext>
<sentencetext>Well now, there be an easy test, for the disease, but no cure.
But in principle finding the gene, does lead
to a cure relavitively easierly.
If the broken gene, needs to de activated then the physicians can use
RNA interference to de activate the gene.
I the broken gene, is something important missing then in
principle, gene therapy, insertation of an other copy of the gene, using a retrovirus should cure the
disease.
I say in principle, neither RNA interference nor Gene therapy a proven technologies yet.
---

Genetic Engineering [feeddistiller.com] Feed @ Feed Distiller [feeddistiller.com]</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31459060</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31460012</id>
	<title>Re:Can of Worms?</title>
	<author>Thng</author>
	<datestamp>1268404080000</datestamp>
	<modclass>Informativ</modclass>
	<modscore>2</modscore>
	<htmltext><a href="http://frwebgate.access.gpo.gov/cgi-bin/getdoc.cgi?dbname=110\_cong\_bills&amp;docid=f:h493eas.txt.pdf" title="gpo.gov">Genetic Information Nondiscrimination Act (GINA)</a> [gpo.gov] <p>

from Newscientist:
"After more than a decade of political debate, GINA bans health insurers from setting premiums or denying coverage based on the results of genetic tests, as long as customers have no pre-existing disease symptoms. It is also aimed to prevent discrimination in employment decisions."
</p><p>
Discrimination still could happen, but there appears to be a bit of a framework to work against it.</p></htmltext>
<tokenext>Genetic Information Nondiscrimination Act ( GINA ) [ gpo.gov ] from Newscientist : " After more than a decade of political debate , GINA bans health insurers from setting premiums or denying coverage based on the results of genetic tests , as long as customers have no pre-existing disease symptoms .
It is also aimed to prevent discrimination in employment decisions .
" Discrimination still could happen , but there appears to be a bit of a framework to work against it .</tokentext>
<sentencetext>Genetic Information Nondiscrimination Act (GINA) [gpo.gov] 

from Newscientist:
"After more than a decade of political debate, GINA bans health insurers from setting premiums or denying coverage based on the results of genetic tests, as long as customers have no pre-existing disease symptoms.
It is also aimed to prevent discrimination in employment decisions.
"

Discrimination still could happen, but there appears to be a bit of a framework to work against it.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31459060</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31459386</id>
	<title>Sequence plus a lot of prior work</title>
	<author>jfengel</author>
	<datestamp>1268400480000</datestamp>
	<modclass>Informativ</modclass>
	<modscore>5</modscore>
	<htmltext><p>Your genome has a lot of differences from the reference genome.  They narrowed down the differences based on a lot of previous work discovering genes linked to the disorder.</p><p>Only then were they able to zero in on precisely what gene in his specific genome caused the problem, and confirm it by testing other family members.</p></htmltext>
<tokenext>Your genome has a lot of differences from the reference genome .
They narrowed down the differences based on a lot of previous work discovering genes linked to the disorder.Only then were they able to zero in on precisely what gene in his specific genome caused the problem , and confirm it by testing other family members .</tokentext>
<sentencetext>Your genome has a lot of differences from the reference genome.
They narrowed down the differences based on a lot of previous work discovering genes linked to the disorder.Only then were they able to zero in on precisely what gene in his specific genome caused the problem, and confirm it by testing other family members.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_12_2354239.31463526</id>
	<title>Dizi izle</title>
	<author>pislick</author>
	<datestamp>1268491140000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><a href="http://www.tvdizi.net/" title="tvdizi.net" rel="nofollow">
dizi izle</a> [tvdizi.net]
<a href="http://www.izlebunu.org/" title="izlebunu.org" rel="nofollow">
video izle</a> [izlebunu.org]
<a href="http://www.linkle.net/" title="linkle.net" rel="nofollow">
linkle</a> [linkle.net] <a href="http://www.surup.net/" title="surup.net" rel="nofollow">
Blog</a> [surup.net]</htmltext>
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