<article>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#article10_03_08_2354226</id>
	<title>AIDS Virus Can Hide In Bone Marrow</title>
	<author>kdawson</author>
	<datestamp>1268052120000</datestamp>
	<htmltext>suraj.sun writes <i>"The <a href="http://www.google.com/hostednews/ap/article/ALeqM5jIzw5TNPc3bTHfHDOrmqk5VNd9rgD9E9UL400">virus that causes AIDS can hide in the bone marrow</a>, avoiding drugs and later awakening to cause illness, according to new research that could point the way toward better treatments for the disease. Dr. Kathleen Collins of the University of Michigan and her colleagues report in this week's edition of the journal <em>Nature</em> Medicine that the HIV virus can infect long-lived bone marrow cells that eventually convert into blood cells. The virus is dormant in the bone marrow cells, she said, but when those progenitor cells develop into blood cells, it can be reactivated and cause renewed infection. The virus kills the new blood cells and then moves on to infect other cells, said. In recent years, drugs have reduced AIDS deaths sharply, but patients need to keep taking the medicines for life or the infection comes back, Dr. Collins said."</i></htmltext>
<tokenext>suraj.sun writes " The virus that causes AIDS can hide in the bone marrow , avoiding drugs and later awakening to cause illness , according to new research that could point the way toward better treatments for the disease .
Dr. Kathleen Collins of the University of Michigan and her colleagues report in this week 's edition of the journal Nature Medicine that the HIV virus can infect long-lived bone marrow cells that eventually convert into blood cells .
The virus is dormant in the bone marrow cells , she said , but when those progenitor cells develop into blood cells , it can be reactivated and cause renewed infection .
The virus kills the new blood cells and then moves on to infect other cells , said .
In recent years , drugs have reduced AIDS deaths sharply , but patients need to keep taking the medicines for life or the infection comes back , Dr. Collins said .
"</tokentext>
<sentencetext>suraj.sun writes "The virus that causes AIDS can hide in the bone marrow, avoiding drugs and later awakening to cause illness, according to new research that could point the way toward better treatments for the disease.
Dr. Kathleen Collins of the University of Michigan and her colleagues report in this week's edition of the journal Nature Medicine that the HIV virus can infect long-lived bone marrow cells that eventually convert into blood cells.
The virus is dormant in the bone marrow cells, she said, but when those progenitor cells develop into blood cells, it can be reactivated and cause renewed infection.
The virus kills the new blood cells and then moves on to infect other cells, said.
In recent years, drugs have reduced AIDS deaths sharply, but patients need to keep taking the medicines for life or the infection comes back, Dr. Collins said.
"</sentencetext>
</article>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31413784</id>
	<title>Regrarding Transplants</title>
	<author>Anonymous</author>
	<datestamp>1268150760000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>France has been doing work on  treating HIV like leukemia, in doing this, a transplant completely cured the person of any trace of HIV. Granted its a VERY expensive and dangerous process so its not  viable for the general populous as a cure. But in 50 years maybe the FDA will actually allow those same tests to be done in the USA. Its sad how  slow our medical system is to accept trials  of solutions to global issues when this  report further  proves what the french doctors have been saying for  15 yrs about the HIV virus and ways to cripple it.</p></htmltext>
<tokenext>France has been doing work on treating HIV like leukemia , in doing this , a transplant completely cured the person of any trace of HIV .
Granted its a VERY expensive and dangerous process so its not viable for the general populous as a cure .
But in 50 years maybe the FDA will actually allow those same tests to be done in the USA .
Its sad how slow our medical system is to accept trials of solutions to global issues when this report further proves what the french doctors have been saying for 15 yrs about the HIV virus and ways to cripple it .</tokentext>
<sentencetext>France has been doing work on  treating HIV like leukemia, in doing this, a transplant completely cured the person of any trace of HIV.
Granted its a VERY expensive and dangerous process so its not  viable for the general populous as a cure.
But in 50 years maybe the FDA will actually allow those same tests to be done in the USA.
Its sad how  slow our medical system is to accept trials  of solutions to global issues when this  report further  proves what the french doctors have been saying for  15 yrs about the HIV virus and ways to cripple it.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31408752</id>
	<title>Re:Uh This is a Surprise?</title>
	<author>thms</author>
	<datestamp>1268058840000</datestamp>
	<modclass>Interestin</modclass>
	<modscore>5</modscore>
	<htmltext><p><div class="quote"><p>you are implying that a virus competely changes your entire genetic make up. and this is simply not the case. it changes cellular dna to instructs those infected cells to mass produce new hiv. You wont be growing wings anytime soon.</p></div><p> <a href="http://en.wikipedia.org/wiki/Transposon" title="wikipedia.org">Transposons</a> [wikipedia.org] would like to disagree! These make up upto <b>50\%</b> of the human genome  (only 2\% are actual Genes)! They are essentially viruses trapped in your cell, they can still duplicate, but they lost their ability to leave the cell. Selfish Genes essentially. Luckily most of them are inactive by now.
</p><p>It is believed that the us Eutheria, i.e. mammals with a placenta, gained the ability to have one common circulatory system for two different organisms by using viral DNA to keep the immune system from going nuts about this.</p></div>
	</htmltext>
<tokenext>you are implying that a virus competely changes your entire genetic make up .
and this is simply not the case .
it changes cellular dna to instructs those infected cells to mass produce new hiv .
You wont be growing wings anytime soon .
Transposons [ wikipedia.org ] would like to disagree !
These make up upto 50 \ % of the human genome ( only 2 \ % are actual Genes ) !
They are essentially viruses trapped in your cell , they can still duplicate , but they lost their ability to leave the cell .
Selfish Genes essentially .
Luckily most of them are inactive by now .
It is believed that the us Eutheria , i.e .
mammals with a placenta , gained the ability to have one common circulatory system for two different organisms by using viral DNA to keep the immune system from going nuts about this .</tokentext>
<sentencetext>you are implying that a virus competely changes your entire genetic make up.
and this is simply not the case.
it changes cellular dna to instructs those infected cells to mass produce new hiv.
You wont be growing wings anytime soon.
Transposons [wikipedia.org] would like to disagree!
These make up upto 50\% of the human genome  (only 2\% are actual Genes)!
They are essentially viruses trapped in your cell, they can still duplicate, but they lost their ability to leave the cell.
Selfish Genes essentially.
Luckily most of them are inactive by now.
It is believed that the us Eutheria, i.e.
mammals with a placenta, gained the ability to have one common circulatory system for two different organisms by using viral DNA to keep the immune system from going nuts about this.
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31408530</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31409070</id>
	<title>Unless...</title>
	<author>Anonymous</author>
	<datestamp>1268061480000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>&gt; Your brain cells, for example, don't appear to be infected and their copies of the genome will not have any HIV DNA in them.</p><p>Unless, of course, the patient got the rarer AIDS strain, the "Zombie" variant -- which keeps saying "Brains! Brains!"</p></htmltext>
<tokenext>&gt; Your brain cells , for example , do n't appear to be infected and their copies of the genome will not have any HIV DNA in them.Unless , of course , the patient got the rarer AIDS strain , the " Zombie " variant -- which keeps saying " Brains !
Brains ! "</tokentext>
<sentencetext>&gt; Your brain cells, for example, don't appear to be infected and their copies of the genome will not have any HIV DNA in them.Unless, of course, the patient got the rarer AIDS strain, the "Zombie" variant -- which keeps saying "Brains!
Brains!"</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31408538</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31409680</id>
	<title>Dentasmile MD</title>
	<author>jallmack</author>
	<datestamp>1268066880000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>Think about this: They drill a hole into your bone and extract some of the insides. If you think the anesthesia will help, then think about the dentist but 50x worse.
<a href="http://www.articlesbase.com/health-articles/denta-smile-md-review-how-effective-dentasmile-md-is-1954951.html" title="articlesbase.com" rel="nofollow">Dentasmile MD</a> [articlesbase.com]</htmltext>
<tokenext>Think about this : They drill a hole into your bone and extract some of the insides .
If you think the anesthesia will help , then think about the dentist but 50x worse .
Dentasmile MD [ articlesbase.com ]</tokentext>
<sentencetext>Think about this: They drill a hole into your bone and extract some of the insides.
If you think the anesthesia will help, then think about the dentist but 50x worse.
Dentasmile MD [articlesbase.com]</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31412396</id>
	<title>oblig.</title>
	<author>Anonymous</author>
	<datestamp>1268144580000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>Yo dawg I heard you have a virus, so we put a virus inside your virus! How do you like that?</p></htmltext>
<tokenext>Yo dawg I heard you have a virus , so we put a virus inside your virus !
How do you like that ?</tokentext>
<sentencetext>Yo dawg I heard you have a virus, so we put a virus inside your virus!
How do you like that?</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31408790</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31408892</id>
	<title>Re:Uh This is a Surprise?</title>
	<author>Anonymous</author>
	<datestamp>1268059980000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>There is actually a drug being researched, Tre Recombinase, that does just that; HIV does not perfectly integrate into human DNA. http://en.wikipedia.org/wiki/Tre\_recombinase</p></htmltext>
<tokenext>There is actually a drug being researched , Tre Recombinase , that does just that ; HIV does not perfectly integrate into human DNA .
http : //en.wikipedia.org/wiki/Tre \ _recombinase</tokentext>
<sentencetext>There is actually a drug being researched, Tre Recombinase, that does just that; HIV does not perfectly integrate into human DNA.
http://en.wikipedia.org/wiki/Tre\_recombinase</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31408428</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31408428</id>
	<title>Uh This is a Surprise?</title>
	<author>phantomcircuit</author>
	<datestamp>1268056560000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>HIV is a retrovirus.  It literally becomes a part of your DNA.  The only way to truly cure HIV is to remove the HIV DNA from your genome, good luck with that.</p></htmltext>
<tokenext>HIV is a retrovirus .
It literally becomes a part of your DNA .
The only way to truly cure HIV is to remove the HIV DNA from your genome , good luck with that .</tokentext>
<sentencetext>HIV is a retrovirus.
It literally becomes a part of your DNA.
The only way to truly cure HIV is to remove the HIV DNA from your genome, good luck with that.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31408530</id>
	<title>Re:Uh This is a Surprise?</title>
	<author>Anonymous</author>
	<datestamp>1268057340000</datestamp>
	<modclass>Informativ</modclass>
	<modscore>5</modscore>
	<htmltext><p>-10 internet points. It becomes part of the dna for a few select cell types, not EVERY cell type, and certainly you cannot spread this 'bad' DNA to offspring by means of DNA in eggs/sperm. you are implying that a virus competely changes your entire genetic make up. and this is simply not the case. it changes cellular dna to instructs those infected cells to mass produce new hiv. You wont be growing wings anytime soon.</p></htmltext>
<tokenext>-10 internet points .
It becomes part of the dna for a few select cell types , not EVERY cell type , and certainly you can not spread this 'bad ' DNA to offspring by means of DNA in eggs/sperm .
you are implying that a virus competely changes your entire genetic make up .
and this is simply not the case .
it changes cellular dna to instructs those infected cells to mass produce new hiv .
You wont be growing wings anytime soon .</tokentext>
<sentencetext>-10 internet points.
It becomes part of the dna for a few select cell types, not EVERY cell type, and certainly you cannot spread this 'bad' DNA to offspring by means of DNA in eggs/sperm.
you are implying that a virus competely changes your entire genetic make up.
and this is simply not the case.
it changes cellular dna to instructs those infected cells to mass produce new hiv.
You wont be growing wings anytime soon.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31408428</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31416706</id>
	<title>Re:And?</title>
	<author>mcgrew</author>
	<datestamp>1268162100000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p><i>light humor, ok folks</i></p><p>VERY light. Here's some light humor --</p><p>How many programmers does it take to change a light bulb?<br>None, that's a hardware problem</p><p>How many blondes does it take to change a lightbulb?<br>None, she'll get a man to change it for her.</p><p>How many engineers does it take to change a light bulb?<br>None, that's a technician's problem.</p><p>How many Irishmen does it take to change a light bulb?<br>Three, one to hold the bulb and two to drink until the room spins.</p><p>How many psychaitrists does it take to change a light bulb?<br>Only one, but the light bulb has to want to change.</p><p>How many emo kids does it take to change a light bulb?<br>None, they can cry in the dark.</p><p>How many feminists does it take to change a light bulb?<br>THAT'S NOT FUNNY YOU GODDAMNED CHAUVINIST ASSHOLE PIG!</p></htmltext>
<tokenext>light humor , ok folksVERY light .
Here 's some light humor --How many programmers does it take to change a light bulb ? None , that 's a hardware problemHow many blondes does it take to change a lightbulb ? None , she 'll get a man to change it for her.How many engineers does it take to change a light bulb ? None , that 's a technician 's problem.How many Irishmen does it take to change a light bulb ? Three , one to hold the bulb and two to drink until the room spins.How many psychaitrists does it take to change a light bulb ? Only one , but the light bulb has to want to change.How many emo kids does it take to change a light bulb ? None , they can cry in the dark.How many feminists does it take to change a light bulb ? THAT 'S NOT FUNNY YOU GODDAMNED CHAUVINIST ASSHOLE PIG !</tokentext>
<sentencetext>light humor, ok folksVERY light.
Here's some light humor --How many programmers does it take to change a light bulb?None, that's a hardware problemHow many blondes does it take to change a lightbulb?None, she'll get a man to change it for her.How many engineers does it take to change a light bulb?None, that's a technician's problem.How many Irishmen does it take to change a light bulb?Three, one to hold the bulb and two to drink until the room spins.How many psychaitrists does it take to change a light bulb?Only one, but the light bulb has to want to change.How many emo kids does it take to change a light bulb?None, they can cry in the dark.How many feminists does it take to change a light bulb?THAT'S NOT FUNNY YOU GODDAMNED CHAUVINIST ASSHOLE PIG!</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31408460</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31409346</id>
	<title>Re:The HIV virus...</title>
	<author>Chris Burke</author>
	<datestamp>1268064060000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p><i>Also known as the human immunodeficiency virus virus.</i></p><p>Wait a minute, that gives me an idea... *runs off to lab with microscope*  Yes, yes, it all checks out!  It's so simple, I don't know why we didn't think of it before.</p><p>The Human Immunodeficiency Virus can infect <i>itself</i>!</p><p>My God, this changes everything!  We'll finally be able to defeat this scourge, and we owe it all to Slashdot Pedants.  Here's to you!<nobr> <wbr></nobr>/salute</p></htmltext>
<tokenext>Also known as the human immunodeficiency virus virus.Wait a minute , that gives me an idea... * runs off to lab with microscope * Yes , yes , it all checks out !
It 's so simple , I do n't know why we did n't think of it before.The Human Immunodeficiency Virus can infect itself ! My God , this changes everything !
We 'll finally be able to defeat this scourge , and we owe it all to Slashdot Pedants .
Here 's to you !
/salute</tokentext>
<sentencetext>Also known as the human immunodeficiency virus virus.Wait a minute, that gives me an idea... *runs off to lab with microscope*  Yes, yes, it all checks out!
It's so simple, I don't know why we didn't think of it before.The Human Immunodeficiency Virus can infect itself!My God, this changes everything!
We'll finally be able to defeat this scourge, and we owe it all to Slashdot Pedants.
Here's to you!
/salute</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31408790</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31410666</id>
	<title>Re:Uh This is a Surprise?</title>
	<author>izomiac</author>
	<datestamp>1268077860000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>But transposons aren't viruses.  Viruses are thought to have evolved from transposons (or vice versa, though last I heard that theory was less favored), but there's a pretty fundamental difference between them.  A virus is genetically autonomous, parasitic, and infectious.  A transposon is a part of your genome, and thus you can't think of it like a parasite; "selfish" implies that it has a "self" that isn't the same as the whole organism.  Take maize for example.  Having multicolored kernels is a trait, not a disease or infection.<br> <br>

But the GP's point about not changing your whole genome is still valid, even for tranposons.  It's not like all of your transposons work together to simultaneously jump to the same location in every cell in your body.  Since it's confined to a single cell then it's largely irrelevant for the organism.  In gametes they can be passed on to your offspring, so that's important evolutionarily.  Also, they are mutagens and thus one of the many factors that contribute to cancer and aging.<br> <br>

Now, transposons are very important for the species.  Both transposons and viruses can carry (adjacent) genes with them.  For transposons this creates many duplicates of a gene, which creates "junk DNA".  The duplicates provide redundancy so a mutation in a single copy won't knock-out that gene product, thus it can mutate freely without harming the organism, which is a major benefit to having transposons, and the reason our cells carry so many.  But none of this matters if it doesn't affect a gamete that gives rise to an offspring.</htmltext>
<tokenext>But transposons are n't viruses .
Viruses are thought to have evolved from transposons ( or vice versa , though last I heard that theory was less favored ) , but there 's a pretty fundamental difference between them .
A virus is genetically autonomous , parasitic , and infectious .
A transposon is a part of your genome , and thus you ca n't think of it like a parasite ; " selfish " implies that it has a " self " that is n't the same as the whole organism .
Take maize for example .
Having multicolored kernels is a trait , not a disease or infection .
But the GP 's point about not changing your whole genome is still valid , even for tranposons .
It 's not like all of your transposons work together to simultaneously jump to the same location in every cell in your body .
Since it 's confined to a single cell then it 's largely irrelevant for the organism .
In gametes they can be passed on to your offspring , so that 's important evolutionarily .
Also , they are mutagens and thus one of the many factors that contribute to cancer and aging .
Now , transposons are very important for the species .
Both transposons and viruses can carry ( adjacent ) genes with them .
For transposons this creates many duplicates of a gene , which creates " junk DNA " .
The duplicates provide redundancy so a mutation in a single copy wo n't knock-out that gene product , thus it can mutate freely without harming the organism , which is a major benefit to having transposons , and the reason our cells carry so many .
But none of this matters if it does n't affect a gamete that gives rise to an offspring .</tokentext>
<sentencetext>But transposons aren't viruses.
Viruses are thought to have evolved from transposons (or vice versa, though last I heard that theory was less favored), but there's a pretty fundamental difference between them.
A virus is genetically autonomous, parasitic, and infectious.
A transposon is a part of your genome, and thus you can't think of it like a parasite; "selfish" implies that it has a "self" that isn't the same as the whole organism.
Take maize for example.
Having multicolored kernels is a trait, not a disease or infection.
But the GP's point about not changing your whole genome is still valid, even for tranposons.
It's not like all of your transposons work together to simultaneously jump to the same location in every cell in your body.
Since it's confined to a single cell then it's largely irrelevant for the organism.
In gametes they can be passed on to your offspring, so that's important evolutionarily.
Also, they are mutagens and thus one of the many factors that contribute to cancer and aging.
Now, transposons are very important for the species.
Both transposons and viruses can carry (adjacent) genes with them.
For transposons this creates many duplicates of a gene, which creates "junk DNA".
The duplicates provide redundancy so a mutation in a single copy won't knock-out that gene product, thus it can mutate freely without harming the organism, which is a major benefit to having transposons, and the reason our cells carry so many.
But none of this matters if it doesn't affect a gamete that gives rise to an offspring.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31408752</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31409602</id>
	<title>Re:How about a bone marrow transplant?</title>
	<author>Anonymous</author>
	<datestamp>1268066160000</datestamp>
	<modclass>Insightful</modclass>
	<modscore>1</modscore>
	<htmltext><p>How about blocking the trigger that causes the virus to reactivate? (Provided we can figure it out)</p></htmltext>
<tokenext>How about blocking the trigger that causes the virus to reactivate ?
( Provided we can figure it out )</tokentext>
<sentencetext>How about blocking the trigger that causes the virus to reactivate?
(Provided we can figure it out)</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31408324</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31408562</id>
	<title>Re:Uh This is a Surprise?</title>
	<author>Anonymous</author>
	<datestamp>1268057580000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>The megalomaniac idea would be gene therapy: Inserting another retrovirus with a second strand of DNA into the cell which then fabricates interfering RNA, i.e. RNA which intercepts the other virus' DNA. And that gene can only be activated via some external promoter. And then add a method for apoptosis (cell suicide) that triggers upon binding RNAi (if not all cells are infected).</p><p>
I'm not making any bets how long it will be before this can become reality. Also, I smell Digital Life Management opportunities!</p></htmltext>
<tokenext>The megalomaniac idea would be gene therapy : Inserting another retrovirus with a second strand of DNA into the cell which then fabricates interfering RNA , i.e .
RNA which intercepts the other virus ' DNA .
And that gene can only be activated via some external promoter .
And then add a method for apoptosis ( cell suicide ) that triggers upon binding RNAi ( if not all cells are infected ) .
I 'm not making any bets how long it will be before this can become reality .
Also , I smell Digital Life Management opportunities !</tokentext>
<sentencetext>The megalomaniac idea would be gene therapy: Inserting another retrovirus with a second strand of DNA into the cell which then fabricates interfering RNA, i.e.
RNA which intercepts the other virus' DNA.
And that gene can only be activated via some external promoter.
And then add a method for apoptosis (cell suicide) that triggers upon binding RNAi (if not all cells are infected).
I'm not making any bets how long it will be before this can become reality.
Also, I smell Digital Life Management opportunities!</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31408428</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31410216</id>
	<title>HIV is smart!</title>
	<author>CoffeeDregs</author>
	<datestamp>1268072940000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>I guess that I'm a little bugged by the summary's wording since it makes HIV seem like an intelligent system that chooses to hide itself.  Is that the case or has the latent HIV virus been found in bone marrow?</p><p>From the article, it seems as though HIV is able to infect cells in more areas of the body than previously thought, not that the virus has any particular strategy...  But I suppose a headline that screams "The AIDS is coming!  The AIDS is coming!" probably gets more reads...</p></htmltext>
<tokenext>I guess that I 'm a little bugged by the summary 's wording since it makes HIV seem like an intelligent system that chooses to hide itself .
Is that the case or has the latent HIV virus been found in bone marrow ? From the article , it seems as though HIV is able to infect cells in more areas of the body than previously thought , not that the virus has any particular strategy... But I suppose a headline that screams " The AIDS is coming !
The AIDS is coming !
" probably gets more reads.. .</tokentext>
<sentencetext>I guess that I'm a little bugged by the summary's wording since it makes HIV seem like an intelligent system that chooses to hide itself.
Is that the case or has the latent HIV virus been found in bone marrow?From the article, it seems as though HIV is able to infect cells in more areas of the body than previously thought, not that the virus has any particular strategy...  But I suppose a headline that screams "The AIDS is coming!
The AIDS is coming!
" probably gets more reads...</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31409752</id>
	<title>News at 11</title>
	<author>One\_Minute\_Too\_Late</author>
	<datestamp>1268067780000</datestamp>
	<modclass>Informativ</modclass>
	<modscore>2</modscore>
	<htmltext>While the HIV's preferred target cells are T-cells, macrophages (which tend to be long-lived cells) and microglia (macrophage-like cells that live in the brain) also take up the M-tropic strains of the virus. As these cell types derive ultimately from hematopoietic stem cells, it is not a great surprise to read about this. Sounds like the so-called journalist from AP news was having a slow day. <br> <br>
As for transplants being the great new cure-all for HIV infection: no. Transplantation substitutes one batch of problems for another batch of medical issues. A good HLA match is still required, and finding someone with the right CCR5 or CXCR5 mutation would make the situation doubly difficult. Then, because the engrafted immune system will recognize the host's antigens as foreign (even with HLA typing), the recipient would still require immunosuppression, putting them at risk for the kinds of infections and tumours that HIV patients tend to get. Not to mention the costs of actually doing and maintaining a transplant patient. Can't do that for millions of people, it's hugely expensive. <br> <br>
What this study probably implies is that autologous stem-cell transplantation (capturing the patient's own stem cells, eradicating their immune system, and putting back the stem cells to reconstitute the patient's immune system -- a treatment sometimes used in some lymphomas) would not be feasible as a last-ditch treatment for HIV/AIDS. It wouldn't solve the problem of HIV hiding in 'privileged' sites such as the brain (microglia) anyways, and being a source for viral replication/release even when virions are banished from the blood.</htmltext>
<tokenext>While the HIV 's preferred target cells are T-cells , macrophages ( which tend to be long-lived cells ) and microglia ( macrophage-like cells that live in the brain ) also take up the M-tropic strains of the virus .
As these cell types derive ultimately from hematopoietic stem cells , it is not a great surprise to read about this .
Sounds like the so-called journalist from AP news was having a slow day .
As for transplants being the great new cure-all for HIV infection : no .
Transplantation substitutes one batch of problems for another batch of medical issues .
A good HLA match is still required , and finding someone with the right CCR5 or CXCR5 mutation would make the situation doubly difficult .
Then , because the engrafted immune system will recognize the host 's antigens as foreign ( even with HLA typing ) , the recipient would still require immunosuppression , putting them at risk for the kinds of infections and tumours that HIV patients tend to get .
Not to mention the costs of actually doing and maintaining a transplant patient .
Ca n't do that for millions of people , it 's hugely expensive .
What this study probably implies is that autologous stem-cell transplantation ( capturing the patient 's own stem cells , eradicating their immune system , and putting back the stem cells to reconstitute the patient 's immune system -- a treatment sometimes used in some lymphomas ) would not be feasible as a last-ditch treatment for HIV/AIDS .
It would n't solve the problem of HIV hiding in 'privileged ' sites such as the brain ( microglia ) anyways , and being a source for viral replication/release even when virions are banished from the blood .</tokentext>
<sentencetext>While the HIV's preferred target cells are T-cells, macrophages (which tend to be long-lived cells) and microglia (macrophage-like cells that live in the brain) also take up the M-tropic strains of the virus.
As these cell types derive ultimately from hematopoietic stem cells, it is not a great surprise to read about this.
Sounds like the so-called journalist from AP news was having a slow day.
As for transplants being the great new cure-all for HIV infection: no.
Transplantation substitutes one batch of problems for another batch of medical issues.
A good HLA match is still required, and finding someone with the right CCR5 or CXCR5 mutation would make the situation doubly difficult.
Then, because the engrafted immune system will recognize the host's antigens as foreign (even with HLA typing), the recipient would still require immunosuppression, putting them at risk for the kinds of infections and tumours that HIV patients tend to get.
Not to mention the costs of actually doing and maintaining a transplant patient.
Can't do that for millions of people, it's hugely expensive.
What this study probably implies is that autologous stem-cell transplantation (capturing the patient's own stem cells, eradicating their immune system, and putting back the stem cells to reconstitute the patient's immune system -- a treatment sometimes used in some lymphomas) would not be feasible as a last-ditch treatment for HIV/AIDS.
It wouldn't solve the problem of HIV hiding in 'privileged' sites such as the brain (microglia) anyways, and being a source for viral replication/release even when virions are banished from the blood.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31409028</id>
	<title>Re:Alt Therapies</title>
	<author>Anonymous</author>
	<datestamp>1268061120000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><blockquote><div><p>IIRC, they did a bone marrow transplant between someone with AIDS/HIV and another person who had a natural immunity to the disease.</p></div></blockquote><p>
See: <a href="http://en.wikipedia.org/wiki/CCR5#CCR5-.CE.9432" title="wikipedia.org">CCR5 Delta 32</a> [wikipedia.org] and <a href="http://en.wikipedia.org/wiki/Hematopoietic\_stem\_cell\_transplantation#Transplant\_as\_a\_use\_for\_treatment\_of\_HIV" title="wikipedia.org">how it relates to a BMT</a> [wikipedia.org] <br> <br>
Additionally, if the HIV is limited to the bone marrow, theoretically, a complete myeloablative transplant should eradicate it, regardless of whether or not the donor possesses the CCR5/32 mutation, no?</p></div>
	</htmltext>
<tokenext>IIRC , they did a bone marrow transplant between someone with AIDS/HIV and another person who had a natural immunity to the disease .
See : CCR5 Delta 32 [ wikipedia.org ] and how it relates to a BMT [ wikipedia.org ] Additionally , if the HIV is limited to the bone marrow , theoretically , a complete myeloablative transplant should eradicate it , regardless of whether or not the donor possesses the CCR5/32 mutation , no ?</tokentext>
<sentencetext>IIRC, they did a bone marrow transplant between someone with AIDS/HIV and another person who had a natural immunity to the disease.
See: CCR5 Delta 32 [wikipedia.org] and how it relates to a BMT [wikipedia.org]  
Additionally, if the HIV is limited to the bone marrow, theoretically, a complete myeloablative transplant should eradicate it, regardless of whether or not the donor possesses the CCR5/32 mutation, no?
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31408346</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31408992</id>
	<title>Re:Uh This is a Surprise?</title>
	<author>MichaelSmith</author>
	<datestamp>1268060760000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p><a href="http://www.imdb.com/title/tt0083658/quotes" title="imdb.com">I sseem to have heard this before somewhere</a> [imdb.com] </p><p><div class="quote"><p>Tyrell: [Tyrell explains to Roy why he can't extend his lifespan] The facts of life... to make an alteration in the evolvement of an organic life system is fatal. A coding sequence cannot be revised once it's been established.<br>Batty: Why not?<br>Tyrell: Because by the second day of incubation, any cells that have undergone reversion mutation give rise to revertant colonies, like rats leaving a sinking ship; then the ship... sinks.<br>Batty: What about EMS-3 recombination?<br>Tyrell: We've already tried it - ethyl, methane, sulfinate as an alkylating agent and potent mutagen; it created a virus so lethal the subject was dead before it even left the table.<br>Batty: Then a repressor protein, that would block the operating cells.<br>Tyrell: Wouldn't obstruct replication; but it does give rise to an error in replication, so that the newly formed DNA strand carries with it a mutation - and you've got a virus again... but this, all of this is academic. You were made as well as we could make you.<br>Batty: But not to last.<br>Tyrell: The light that burns twice as bright burns for half as long - and you have burned so very, very brightly, Roy. Look at you: you're the Prodigal Son; you're quite a prize!<br>Batty: I've done... questionable things.<br>Tyrell: Also extraordinary things; revel in your time.<br>Batty: Nothing the God of biomechanics wouldn't let you into heaven for.</p></div></div>
	</htmltext>
<tokenext>I sseem to have heard this before somewhere [ imdb.com ] Tyrell : [ Tyrell explains to Roy why he ca n't extend his lifespan ] The facts of life... to make an alteration in the evolvement of an organic life system is fatal .
A coding sequence can not be revised once it 's been established.Batty : Why not ? Tyrell : Because by the second day of incubation , any cells that have undergone reversion mutation give rise to revertant colonies , like rats leaving a sinking ship ; then the ship... sinks.Batty : What about EMS-3 recombination ? Tyrell : We 've already tried it - ethyl , methane , sulfinate as an alkylating agent and potent mutagen ; it created a virus so lethal the subject was dead before it even left the table.Batty : Then a repressor protein , that would block the operating cells.Tyrell : Would n't obstruct replication ; but it does give rise to an error in replication , so that the newly formed DNA strand carries with it a mutation - and you 've got a virus again... but this , all of this is academic .
You were made as well as we could make you.Batty : But not to last.Tyrell : The light that burns twice as bright burns for half as long - and you have burned so very , very brightly , Roy .
Look at you : you 're the Prodigal Son ; you 're quite a prize ! Batty : I 've done... questionable things.Tyrell : Also extraordinary things ; revel in your time.Batty : Nothing the God of biomechanics would n't let you into heaven for .</tokentext>
<sentencetext>I sseem to have heard this before somewhere [imdb.com] Tyrell: [Tyrell explains to Roy why he can't extend his lifespan] The facts of life... to make an alteration in the evolvement of an organic life system is fatal.
A coding sequence cannot be revised once it's been established.Batty: Why not?Tyrell: Because by the second day of incubation, any cells that have undergone reversion mutation give rise to revertant colonies, like rats leaving a sinking ship; then the ship... sinks.Batty: What about EMS-3 recombination?Tyrell: We've already tried it - ethyl, methane, sulfinate as an alkylating agent and potent mutagen; it created a virus so lethal the subject was dead before it even left the table.Batty: Then a repressor protein, that would block the operating cells.Tyrell: Wouldn't obstruct replication; but it does give rise to an error in replication, so that the newly formed DNA strand carries with it a mutation - and you've got a virus again... but this, all of this is academic.
You were made as well as we could make you.Batty: But not to last.Tyrell: The light that burns twice as bright burns for half as long - and you have burned so very, very brightly, Roy.
Look at you: you're the Prodigal Son; you're quite a prize!Batty: I've done... questionable things.Tyrell: Also extraordinary things; revel in your time.Batty: Nothing the God of biomechanics wouldn't let you into heaven for.
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31408562</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31408790</id>
	<title>The HIV virus...</title>
	<author>Pteraspidomorphi</author>
	<datestamp>1268059200000</datestamp>
	<modclass>Funny</modclass>
	<modscore>4</modscore>
	<htmltext><p>Also known as the human immunodeficiency virus virus.</p></htmltext>
<tokenext>Also known as the human immunodeficiency virus virus .</tokentext>
<sentencetext>Also known as the human immunodeficiency virus virus.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31409172</id>
	<title>Re:Uh This is a Surprise?</title>
	<author>icegreentea</author>
	<datestamp>1268062320000</datestamp>
	<modclass>Informativ</modclass>
	<modscore>3</modscore>
	<htmltext>I doubt the GP would deny your point. You're arguing two different things. We've incorporated a ridiculous amount of viral material over the course of human (or any) evolution. That said, when you get infected by HIV or any other retrovirus, it's not like every single cell in your body all gets brand new retroviral goodness injected into the nucleus. All that viral material in our DNA is from viruses infecting gametes that managed to go on and produce a viable reproducing human being (which now has the viral goodness in EVERY cell because the gametes had it too). Over and over and over again over a shit load of generations. Two related... but also completely different things.</htmltext>
<tokenext>I doubt the GP would deny your point .
You 're arguing two different things .
We 've incorporated a ridiculous amount of viral material over the course of human ( or any ) evolution .
That said , when you get infected by HIV or any other retrovirus , it 's not like every single cell in your body all gets brand new retroviral goodness injected into the nucleus .
All that viral material in our DNA is from viruses infecting gametes that managed to go on and produce a viable reproducing human being ( which now has the viral goodness in EVERY cell because the gametes had it too ) .
Over and over and over again over a shit load of generations .
Two related... but also completely different things .</tokentext>
<sentencetext>I doubt the GP would deny your point.
You're arguing two different things.
We've incorporated a ridiculous amount of viral material over the course of human (or any) evolution.
That said, when you get infected by HIV or any other retrovirus, it's not like every single cell in your body all gets brand new retroviral goodness injected into the nucleus.
All that viral material in our DNA is from viruses infecting gametes that managed to go on and produce a viable reproducing human being (which now has the viral goodness in EVERY cell because the gametes had it too).
Over and over and over again over a shit load of generations.
Two related... but also completely different things.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31408752</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31409970</id>
	<title>Alarming!!</title>
	<author>pierceabbey</author>
	<datestamp>1268070540000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>This is an interesting as well as an alarming news!!It means that the fight against Aids is far from over.
<a href="http://www.articlesbase.com/health-articles/colopure-cleanse-review-does-colopure-cleanse-really-work-1955211.html" title="articlesbase.com" rel="nofollow">http://www.articlesbase.com/health-articles/colopure-cleanse-review-does-colopure-cleanse-really-work-1955211.html</a> [articlesbase.com]</htmltext>
<tokenext>This is an interesting as well as an alarming news !
! It means that the fight against Aids is far from over .
http : //www.articlesbase.com/health-articles/colopure-cleanse-review-does-colopure-cleanse-really-work-1955211.html [ articlesbase.com ]</tokentext>
<sentencetext>This is an interesting as well as an alarming news!
!It means that the fight against Aids is far from over.
http://www.articlesbase.com/health-articles/colopure-cleanse-review-does-colopure-cleanse-really-work-1955211.html [articlesbase.com]</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31408434</id>
	<title>Honest Q</title>
	<author>Hatechall</author>
	<datestamp>1268056620000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>Didn't we (the scientific community) know this already?  I could have sworn we did.</htmltext>
<tokenext>Did n't we ( the scientific community ) know this already ?
I could have sworn we did .</tokentext>
<sentencetext>Didn't we (the scientific community) know this already?
I could have sworn we did.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31414950</id>
	<title>Re:What's all this biology?</title>
	<author>mcgrew</author>
	<datestamp>1268155200000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>Read the masthead: Not "news for computer geeks, staff that mutters" but News for NERDS, stuff that matters. Yes, nerds mess with computers and quite a few if not most of us build our own, but nearly all scientists are nerds whether they're astronomers, physicists, or biologists. Isaac Asimov, who if you've not read you're not a nerd, was a biochemist who did research and taught at Boston University. Asimov was a nerd's nerd and wrote over 500 books, both fiction and nonfiction.</p><p>I was a nerd long before I owned a computer (but I'm an old nerd; my first computer was a slide rule).</p><p>Maybe you thought you were at geek.com?</p></htmltext>
<tokenext>Read the masthead : Not " news for computer geeks , staff that mutters " but News for NERDS , stuff that matters .
Yes , nerds mess with computers and quite a few if not most of us build our own , but nearly all scientists are nerds whether they 're astronomers , physicists , or biologists .
Isaac Asimov , who if you 've not read you 're not a nerd , was a biochemist who did research and taught at Boston University .
Asimov was a nerd 's nerd and wrote over 500 books , both fiction and nonfiction.I was a nerd long before I owned a computer ( but I 'm an old nerd ; my first computer was a slide rule ) .Maybe you thought you were at geek.com ?</tokentext>
<sentencetext>Read the masthead: Not "news for computer geeks, staff that mutters" but News for NERDS, stuff that matters.
Yes, nerds mess with computers and quite a few if not most of us build our own, but nearly all scientists are nerds whether they're astronomers, physicists, or biologists.
Isaac Asimov, who if you've not read you're not a nerd, was a biochemist who did research and taught at Boston University.
Asimov was a nerd's nerd and wrote over 500 books, both fiction and nonfiction.I was a nerd long before I owned a computer (but I'm an old nerd; my first computer was a slide rule).Maybe you thought you were at geek.com?</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31408762</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31408324</id>
	<title>How about a bone marrow transplant?</title>
	<author>Anonymous</author>
	<datestamp>1268055960000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>Guess that could get infected again anyway?</htmltext>
<tokenext>Guess that could get infected again anyway ?</tokentext>
<sentencetext>Guess that could get infected again anyway?</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31408496</id>
	<title>Rob Malda's tranny died under mysterious circumsta</title>
	<author>Anonymous</author>
	<datestamp>1268057040000</datestamp>
	<modclass>Offtopic</modclass>
	<modscore>-1</modscore>
	<htmltext><p><b>Rob Malda's tranny died under mysterious circumstances</b></p><p>New details about Rob Malda's past may come out in the divorce proceedings with his wife of 8 years, Kathleen. Page 6 speculates that she may fight the prenup, citing Malda&rsquo;s infidelity with various street trannies.</p><p>In 2007, Malda was caught by Dexter police with a transvestite hooker in his car. He told his wife that he &ldquo;stopped to help a person crying.&rdquo; Several other hookers sold tales of Malda&rsquo;s solicitation to the tabloids, and all of them were convinced to recant, with one exception:<br>Paul Barresi, a private detective who claims he was hired for damage control by Malda when the scandal broke, tells Page Six: &ldquo;I called [Malda attorney] Marty &lsquo;Bull Dog&rsquo; Singer and told him I could round up all the transsexuals alleging sexual dalliances with Malda.&rdquo; And they would all recant their stories.</p><p>&ldquo;In less than 10 days,&rdquo; Barresi says, &ldquo;I got them all to sign sworn, videotaped depositions, stating it wasn&rsquo;t Malda himself, but rather a look-alike, who they&rsquo;d encountered - with the exception of Suiuli.&rdquo; In 2008, she fell to her death from her Dexter roof.</p><p>Atisone Suiuli was the tranny found in Malda&rsquo;s car in 2007. After being caught by police, she had proof that she was with Malda and wouldn&rsquo;t change her story. How convenient for him that she died soon afterwards.</p></htmltext>
<tokenext>Rob Malda 's tranny died under mysterious circumstancesNew details about Rob Malda 's past may come out in the divorce proceedings with his wife of 8 years , Kathleen .
Page 6 speculates that she may fight the prenup , citing Malda    s infidelity with various street trannies.In 2007 , Malda was caught by Dexter police with a transvestite hooker in his car .
He told his wife that he    stopped to help a person crying.    Several other hookers sold tales of Malda    s solicitation to the tabloids , and all of them were convinced to recant , with one exception : Paul Barresi , a private detective who claims he was hired for damage control by Malda when the scandal broke , tells Page Six :    I called [ Malda attorney ] Marty    Bull Dog    Singer and told him I could round up all the transsexuals alleging sexual dalliances with Malda.    And they would all recant their stories.    In less than 10 days ,    Barresi says ,    I got them all to sign sworn , videotaped depositions , stating it wasn    t Malda himself , but rather a look-alike , who they    d encountered - with the exception of Suiuli.    In 2008 , she fell to her death from her Dexter roof.Atisone Suiuli was the tranny found in Malda    s car in 2007 .
After being caught by police , she had proof that she was with Malda and wouldn    t change her story .
How convenient for him that she died soon afterwards .</tokentext>
<sentencetext>Rob Malda's tranny died under mysterious circumstancesNew details about Rob Malda's past may come out in the divorce proceedings with his wife of 8 years, Kathleen.
Page 6 speculates that she may fight the prenup, citing Malda’s infidelity with various street trannies.In 2007, Malda was caught by Dexter police with a transvestite hooker in his car.
He told his wife that he “stopped to help a person crying.” Several other hookers sold tales of Malda’s solicitation to the tabloids, and all of them were convinced to recant, with one exception:Paul Barresi, a private detective who claims he was hired for damage control by Malda when the scandal broke, tells Page Six: “I called [Malda attorney] Marty ‘Bull Dog’ Singer and told him I could round up all the transsexuals alleging sexual dalliances with Malda.” And they would all recant their stories.“In less than 10 days,” Barresi says, “I got them all to sign sworn, videotaped depositions, stating it wasn’t Malda himself, but rather a look-alike, who they’d encountered - with the exception of Suiuli.” In 2008, she fell to her death from her Dexter roof.Atisone Suiuli was the tranny found in Malda’s car in 2007.
After being caught by police, she had proof that she was with Malda and wouldn’t change her story.
How convenient for him that she died soon afterwards.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31408324</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31408350</id>
	<title>Humm</title>
	<author>Wyatt Earp</author>
	<datestamp>1268056140000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>Similar to Acute Lymphoblastic Leukemia then. Interesting.</p></htmltext>
<tokenext>Similar to Acute Lymphoblastic Leukemia then .
Interesting .</tokentext>
<sentencetext>Similar to Acute Lymphoblastic Leukemia then.
Interesting.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31408940</id>
	<title>Re:Uh This is a Surprise?</title>
	<author>Locke2005</author>
	<datestamp>1268060280000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>It is not as easy as you make it appear. We already knew one would have to kill ALL T Cells (which can survive for 70 years) to make sure the virus was gone. Now they are saying you have to kill all the bone marrow cells too! In addition, you would then need to survive without any T Cells long enough to regrow your bone marrow, then you T Cells. So a pessimistic "good luck with that" is probably warranted. What holds better promise is gene therapy, to transfer the immunity possessed by HIV long term nonprogressors to others. Ultimately, I believe we will eventually wipe out this disease in a few generations through vaccination, much like Polio. However, I hold little hope for an actual cure for those that are already infected. Currently, anti-virals are effective in reducing viral load to undetectable levels in almost everyone (or at least everyone that can afford to spend $1000/month on meds). I pray that this continues to be true, so that people that have contracted the virus through no fault of their own (including some close family members of mine) can continue to lead "normal" lives.</htmltext>
<tokenext>It is not as easy as you make it appear .
We already knew one would have to kill ALL T Cells ( which can survive for 70 years ) to make sure the virus was gone .
Now they are saying you have to kill all the bone marrow cells too !
In addition , you would then need to survive without any T Cells long enough to regrow your bone marrow , then you T Cells .
So a pessimistic " good luck with that " is probably warranted .
What holds better promise is gene therapy , to transfer the immunity possessed by HIV long term nonprogressors to others .
Ultimately , I believe we will eventually wipe out this disease in a few generations through vaccination , much like Polio .
However , I hold little hope for an actual cure for those that are already infected .
Currently , anti-virals are effective in reducing viral load to undetectable levels in almost everyone ( or at least everyone that can afford to spend $ 1000/month on meds ) .
I pray that this continues to be true , so that people that have contracted the virus through no fault of their own ( including some close family members of mine ) can continue to lead " normal " lives .</tokentext>
<sentencetext>It is not as easy as you make it appear.
We already knew one would have to kill ALL T Cells (which can survive for 70 years) to make sure the virus was gone.
Now they are saying you have to kill all the bone marrow cells too!
In addition, you would then need to survive without any T Cells long enough to regrow your bone marrow, then you T Cells.
So a pessimistic "good luck with that" is probably warranted.
What holds better promise is gene therapy, to transfer the immunity possessed by HIV long term nonprogressors to others.
Ultimately, I believe we will eventually wipe out this disease in a few generations through vaccination, much like Polio.
However, I hold little hope for an actual cure for those that are already infected.
Currently, anti-virals are effective in reducing viral load to undetectable levels in almost everyone (or at least everyone that can afford to spend $1000/month on meds).
I pray that this continues to be true, so that people that have contracted the virus through no fault of their own (including some close family members of mine) can continue to lead "normal" lives.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31408538</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31411474</id>
	<title>Re:Uh This is a Surprise?</title>
	<author>Anonymous</author>
	<datestamp>1268133960000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p><div class="quote"><p>It is believed that the us Eutheria, i.e. mammals with a placenta, gained the ability to have one common circulatory system for two different organisms by using viral DNA to keep the immune system from going nuts about this.</p></div><p>This, while being really beneficial, is a pretty bad thing too and probably led to most of the viruses we get today.</p><p>Let us not forget our little friends, the leech- / parasitical-based infections, some of these will just happily live away in the human body till death, screwing around with all kinds of stuff.<br>One can only hope the right one comes long that makes people hyper hungry and hyper violent. Woohooo, near-enough-zombie apocalypse!</p><p>I think i remember seeing some paper a while back that also associated one section of this viral DNA that could be linked to some cancers as well.<br>Wish i could find it again, was a good year or so ago.</p></div>
	</htmltext>
<tokenext>It is believed that the us Eutheria , i.e .
mammals with a placenta , gained the ability to have one common circulatory system for two different organisms by using viral DNA to keep the immune system from going nuts about this.This , while being really beneficial , is a pretty bad thing too and probably led to most of the viruses we get today.Let us not forget our little friends , the leech- / parasitical-based infections , some of these will just happily live away in the human body till death , screwing around with all kinds of stuff.One can only hope the right one comes long that makes people hyper hungry and hyper violent .
Woohooo , near-enough-zombie apocalypse ! I think i remember seeing some paper a while back that also associated one section of this viral DNA that could be linked to some cancers as well.Wish i could find it again , was a good year or so ago .</tokentext>
<sentencetext>It is believed that the us Eutheria, i.e.
mammals with a placenta, gained the ability to have one common circulatory system for two different organisms by using viral DNA to keep the immune system from going nuts about this.This, while being really beneficial, is a pretty bad thing too and probably led to most of the viruses we get today.Let us not forget our little friends, the leech- / parasitical-based infections, some of these will just happily live away in the human body till death, screwing around with all kinds of stuff.One can only hope the right one comes long that makes people hyper hungry and hyper violent.
Woohooo, near-enough-zombie apocalypse!I think i remember seeing some paper a while back that also associated one section of this viral DNA that could be linked to some cancers as well.Wish i could find it again, was a good year or so ago.
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31408752</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31408930</id>
	<title>slashdot got scooped by nbc channel 3</title>
	<author>Anonymous</author>
	<datestamp>1268060220000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>what is happening , slashdot acquired AIDS?</p></htmltext>
<tokenext>what is happening , slashdot acquired AIDS ?</tokentext>
<sentencetext>what is happening , slashdot acquired AIDS?</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31409456</id>
	<title>Re:What's all this biology?</title>
	<author>izomiac</author>
	<datestamp>1268064960000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>It's basically like a virus that not only infects and disables your antivirus scanner, but the very installation media that it came on as well.  Hence why it's a particularly nasty infection that's hard to get rid of.</htmltext>
<tokenext>It 's basically like a virus that not only infects and disables your antivirus scanner , but the very installation media that it came on as well .
Hence why it 's a particularly nasty infection that 's hard to get rid of .</tokentext>
<sentencetext>It's basically like a virus that not only infects and disables your antivirus scanner, but the very installation media that it came on as well.
Hence why it's a particularly nasty infection that's hard to get rid of.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31408762</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31411764</id>
	<title>Re:The HIV virus...</title>
	<author>L4t3r4lu5</author>
	<datestamp>1268137560000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>Someone's suffering from <a href="http://en.wikipedia.org/wiki/RAS\_syndrome" title="wikipedia.org">RAS Syndrome!</a> [wikipedia.org]</htmltext>
<tokenext>Someone 's suffering from RAS Syndrome !
[ wikipedia.org ]</tokentext>
<sentencetext>Someone's suffering from RAS Syndrome!
[wikipedia.org]</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31408790</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31408832</id>
	<title>Oh noews!!</title>
	<author>Anonymous</author>
	<datestamp>1268059440000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext>I gots da aidz in mai bones!</htmltext>
<tokenext>I gots da aidz in mai bones !</tokentext>
<sentencetext>I gots da aidz in mai bones!</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31408592</id>
	<title>lol</title>
	<author>Anonymous</author>
	<datestamp>1268057760000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>Someone I bumped into on the street said the meanest thing to me today:</p><p><div class="quote"><p>I HOPE YOU GET AIDS AND DIE!</p></div><p>Jokes on them. I'm never gonna get laid!</p></div>
	</htmltext>
<tokenext>Someone I bumped into on the street said the meanest thing to me today : I HOPE YOU GET AIDS AND DIE ! Jokes on them .
I 'm never gon na get laid !</tokentext>
<sentencetext>Someone I bumped into on the street said the meanest thing to me today:I HOPE YOU GET AIDS AND DIE!Jokes on them.
I'm never gonna get laid!
	</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31408346</id>
	<title>Alt Therapies</title>
	<author>Anonymous</author>
	<datestamp>1268056140000</datestamp>
	<modclass>Informativ</modclass>
	<modscore>5</modscore>
	<htmltext><p>IIRC, they did a bone marrow transplant between someone with AIDS/HIV and another person who had a natural immunity to the disease.<br>The HIV positive patient was 'cured'<br><a href="http://www.time.com/time/health/article/0,8599,1858843,00.html" title="time.com">http://www.time.com/time/health/article/0,8599,1858843,00.html</a> [time.com] </p><p><div class="quote"><p>Is this a viable cure for HIV? Not by a long shot. Even [Berlin-based hematologist Gero] Huetter says bone-marrow transplants, which kill about a third of patients, are so dangerous that "they can't be justified ethically" in anything other than desperate situations like late-stage leukemia.<br>...<br>But there might be a glimmer of hope in the case. If the transplant does prove to have been a success and can be replicated, researchers say gene therapists might one day be able to re-engineer a patient's cells to change their bone marrow the same way a transplant does, except without the dangers.</p></div></div>
	</htmltext>
<tokenext>IIRC , they did a bone marrow transplant between someone with AIDS/HIV and another person who had a natural immunity to the disease.The HIV positive patient was 'cured'http : //www.time.com/time/health/article/0,8599,1858843,00.html [ time.com ] Is this a viable cure for HIV ?
Not by a long shot .
Even [ Berlin-based hematologist Gero ] Huetter says bone-marrow transplants , which kill about a third of patients , are so dangerous that " they ca n't be justified ethically " in anything other than desperate situations like late-stage leukemia....But there might be a glimmer of hope in the case .
If the transplant does prove to have been a success and can be replicated , researchers say gene therapists might one day be able to re-engineer a patient 's cells to change their bone marrow the same way a transplant does , except without the dangers .</tokentext>
<sentencetext>IIRC, they did a bone marrow transplant between someone with AIDS/HIV and another person who had a natural immunity to the disease.The HIV positive patient was 'cured'http://www.time.com/time/health/article/0,8599,1858843,00.html [time.com] Is this a viable cure for HIV?
Not by a long shot.
Even [Berlin-based hematologist Gero] Huetter says bone-marrow transplants, which kill about a third of patients, are so dangerous that "they can't be justified ethically" in anything other than desperate situations like late-stage leukemia....But there might be a glimmer of hope in the case.
If the transplant does prove to have been a success and can be replicated, researchers say gene therapists might one day be able to re-engineer a patient's cells to change their bone marrow the same way a transplant does, except without the dangers.
	</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31409146</id>
	<title>Re:The HIV virus...</title>
	<author>Anonymous</author>
	<datestamp>1268062140000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>You've probably got a problem with typing your PIN number into an ATM machine too, don't you? Ever been to The La Brea Tar Pits? Where would the internet be without the TCP/IP protocol? When you've dealt with human stupidity as long as I have, it becomes no longer remarkable.</htmltext>
<tokenext>You 've probably got a problem with typing your PIN number into an ATM machine too , do n't you ?
Ever been to The La Brea Tar Pits ?
Where would the internet be without the TCP/IP protocol ?
When you 've dealt with human stupidity as long as I have , it becomes no longer remarkable .</tokentext>
<sentencetext>You've probably got a problem with typing your PIN number into an ATM machine too, don't you?
Ever been to The La Brea Tar Pits?
Where would the internet be without the TCP/IP protocol?
When you've dealt with human stupidity as long as I have, it becomes no longer remarkable.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31408790</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31408460</id>
	<title>And?</title>
	<author>Anonymous</author>
	<datestamp>1268056860000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>Cancer is the new AIDS.</p><p>(light humor, ok folks)</p></htmltext>
<tokenext>Cancer is the new AIDS .
( light humor , ok folks )</tokentext>
<sentencetext>Cancer is the new AIDS.
(light humor, ok folks)</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31409486</id>
	<title>Re:Alt Therapies</title>
	<author>Anonymous</author>
	<datestamp>1268065140000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p><i>Even [Berlin-based hematologist Gero] Huetter says bone-marrow transplants, which kill about a third of patients, are so dangerous that "they can't be justified ethically" in anything other than desperate situations like late-stage leukemia.</i></p><p>Yeah, I had a dear family friend who was almost at that stage and the best marrow donor found at that point gave him something like a -- geeze it was years ago but I wanna say -- 20\% chance of survival?  If he'd gone into the acute stage they would have pulled the lever, but they weren't about to do it until they absolutely had to.  That 1/3rd fatality rate is after accounting for the fact that marrow transplants only take place after extensive searches for genetic matches starting with close relatives then working out into the general bone marrow registry (where the odds of a good match are insanely low).  Even an ideal match is pretty sketchy, because after the transplant you have <i>no immune system</i> at all and the mildest cold will kill you.</p><p>So I can see what they're saying when they imply that staying on drugs for the rest of your life is a saner choice than getting a marrow transplant, even if it turns out to be a reliable and complete cure for AIDS.</p><p>But by the same token, my friend lucked out and his relatively rare form of leukemia turned out to be not just treatable but curable with drugs, which at the time were experimental and he was lucky enough to get in on a study.  The results astonished the researchers they were so successful, and they were scrambling to move people from the placebo group to active group without invalidating the study.  Now it's the standard treatment for the disease and the prognosis is overall quite good.</p><p>Here's hoping that this new knowledge can help us find a real cure that isn't as lethal as the disease.</p></htmltext>
<tokenext>Even [ Berlin-based hematologist Gero ] Huetter says bone-marrow transplants , which kill about a third of patients , are so dangerous that " they ca n't be justified ethically " in anything other than desperate situations like late-stage leukemia.Yeah , I had a dear family friend who was almost at that stage and the best marrow donor found at that point gave him something like a -- geeze it was years ago but I wan na say -- 20 \ % chance of survival ?
If he 'd gone into the acute stage they would have pulled the lever , but they were n't about to do it until they absolutely had to .
That 1/3rd fatality rate is after accounting for the fact that marrow transplants only take place after extensive searches for genetic matches starting with close relatives then working out into the general bone marrow registry ( where the odds of a good match are insanely low ) .
Even an ideal match is pretty sketchy , because after the transplant you have no immune system at all and the mildest cold will kill you.So I can see what they 're saying when they imply that staying on drugs for the rest of your life is a saner choice than getting a marrow transplant , even if it turns out to be a reliable and complete cure for AIDS.But by the same token , my friend lucked out and his relatively rare form of leukemia turned out to be not just treatable but curable with drugs , which at the time were experimental and he was lucky enough to get in on a study .
The results astonished the researchers they were so successful , and they were scrambling to move people from the placebo group to active group without invalidating the study .
Now it 's the standard treatment for the disease and the prognosis is overall quite good.Here 's hoping that this new knowledge can help us find a real cure that is n't as lethal as the disease .</tokentext>
<sentencetext>Even [Berlin-based hematologist Gero] Huetter says bone-marrow transplants, which kill about a third of patients, are so dangerous that "they can't be justified ethically" in anything other than desperate situations like late-stage leukemia.Yeah, I had a dear family friend who was almost at that stage and the best marrow donor found at that point gave him something like a -- geeze it was years ago but I wanna say -- 20\% chance of survival?
If he'd gone into the acute stage they would have pulled the lever, but they weren't about to do it until they absolutely had to.
That 1/3rd fatality rate is after accounting for the fact that marrow transplants only take place after extensive searches for genetic matches starting with close relatives then working out into the general bone marrow registry (where the odds of a good match are insanely low).
Even an ideal match is pretty sketchy, because after the transplant you have no immune system at all and the mildest cold will kill you.So I can see what they're saying when they imply that staying on drugs for the rest of your life is a saner choice than getting a marrow transplant, even if it turns out to be a reliable and complete cure for AIDS.But by the same token, my friend lucked out and his relatively rare form of leukemia turned out to be not just treatable but curable with drugs, which at the time were experimental and he was lucky enough to get in on a study.
The results astonished the researchers they were so successful, and they were scrambling to move people from the placebo group to active group without invalidating the study.
Now it's the standard treatment for the disease and the prognosis is overall quite good.Here's hoping that this new knowledge can help us find a real cure that isn't as lethal as the disease.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31408346</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31411416</id>
	<title>Re:this is one nasty little bugger</title>
	<author>Jedi Alec</author>
	<datestamp>1268132880000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>Indeed it is, but then again, considering the limited amount of ways for it to transfer, we might actually be able to bring it down quite a bit in the future.</p><p>Of course that won't help the millions that are already infected...</p></htmltext>
<tokenext>Indeed it is , but then again , considering the limited amount of ways for it to transfer , we might actually be able to bring it down quite a bit in the future.Of course that wo n't help the millions that are already infected.. .</tokentext>
<sentencetext>Indeed it is, but then again, considering the limited amount of ways for it to transfer, we might actually be able to bring it down quite a bit in the future.Of course that won't help the millions that are already infected...</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31408868</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31408914</id>
	<title>Re:Uh This is a Surprise?</title>
	<author>MichaelSmith</author>
	<datestamp>1268060100000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>Fair enough but the point of this article is that you have to kill the bone marrow to kill HIV. My Father in law died of 5FE toxicity last year. The drug killed his bone marrow and from that point on his immune system started to collapse. Before long he was being eaten alive by bacteria. He started to decompose long before he died.</p><p>I don't think we have any good ways to safely reboot the bone marrow with new cells. If we could do that a lot of problems would go away.</p></htmltext>
<tokenext>Fair enough but the point of this article is that you have to kill the bone marrow to kill HIV .
My Father in law died of 5FE toxicity last year .
The drug killed his bone marrow and from that point on his immune system started to collapse .
Before long he was being eaten alive by bacteria .
He started to decompose long before he died.I do n't think we have any good ways to safely reboot the bone marrow with new cells .
If we could do that a lot of problems would go away .</tokentext>
<sentencetext>Fair enough but the point of this article is that you have to kill the bone marrow to kill HIV.
My Father in law died of 5FE toxicity last year.
The drug killed his bone marrow and from that point on his immune system started to collapse.
Before long he was being eaten alive by bacteria.
He started to decompose long before he died.I don't think we have any good ways to safely reboot the bone marrow with new cells.
If we could do that a lot of problems would go away.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31408538</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31408868</id>
	<title>this is one nasty little bugger</title>
	<author>Anonymous</author>
	<datestamp>1268059800000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>well seems the aid virus is a nasty little bugger</p></htmltext>
<tokenext>well seems the aid virus is a nasty little bugger</tokentext>
<sentencetext>well seems the aid virus is a nasty little bugger</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31408640</id>
	<title>Re:Uh This is a Surprise?</title>
	<author>jketch</author>
	<datestamp>1268058060000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>You could, as described by TubeSreak, replace the patient's immune system with another which is not susceptible to HIV.  Sadly, this is not possible in the majority of cases because you need a fairly good match to do successful bone marrow transplant, and HIV-proof people are rare.  Maybe if we ever get the theraputic cloning and genetic engineering down we might be able to make a clone of an individuals immune system with an appropriately modified CD4 receptor (the point of entry for HIV), but a treatment like that is a long way off if its even possible at all.</htmltext>
<tokenext>You could , as described by TubeSreak , replace the patient 's immune system with another which is not susceptible to HIV .
Sadly , this is not possible in the majority of cases because you need a fairly good match to do successful bone marrow transplant , and HIV-proof people are rare .
Maybe if we ever get the theraputic cloning and genetic engineering down we might be able to make a clone of an individuals immune system with an appropriately modified CD4 receptor ( the point of entry for HIV ) , but a treatment like that is a long way off if its even possible at all .</tokentext>
<sentencetext>You could, as described by TubeSreak, replace the patient's immune system with another which is not susceptible to HIV.
Sadly, this is not possible in the majority of cases because you need a fairly good match to do successful bone marrow transplant, and HIV-proof people are rare.
Maybe if we ever get the theraputic cloning and genetic engineering down we might be able to make a clone of an individuals immune system with an appropriately modified CD4 receptor (the point of entry for HIV), but a treatment like that is a long way off if its even possible at all.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31408428</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31409620</id>
	<title>Re:Alt Therapies</title>
	<author>quadelirus</author>
	<datestamp>1268066340000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>Is bone marrow transplant as dangerous for the donor (or is it non-live donation)?</htmltext>
<tokenext>Is bone marrow transplant as dangerous for the donor ( or is it non-live donation ) ?</tokentext>
<sentencetext>Is bone marrow transplant as dangerous for the donor (or is it non-live donation)?</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31409486</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31409256</id>
	<title>File under DUH!</title>
	<author>Anonymous</author>
	<datestamp>1268063100000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>Jeeze Louise, this is news WHY?  Everybody who's been paying any attention at all the last 20 years knows this.  AIDS is for life baby.  Wear that condom and stay out of bath houses.</p></htmltext>
<tokenext>Jeeze Louise , this is news WHY ?
Everybody who 's been paying any attention at all the last 20 years knows this .
AIDS is for life baby .
Wear that condom and stay out of bath houses .</tokentext>
<sentencetext>Jeeze Louise, this is news WHY?
Everybody who's been paying any attention at all the last 20 years knows this.
AIDS is for life baby.
Wear that condom and stay out of bath houses.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31408538</id>
	<title>Re:Uh This is a Surprise?</title>
	<author>interkin3tic</author>
	<datestamp>1268057340000</datestamp>
	<modclass>Insightful</modclass>
	<modscore>4</modscore>
	<htmltext><p><div class="quote"><p>HIV is a retrovirus. It literally becomes a part of your DNA. The only way to truly cure HIV is to remove the HIV DNA from your genome, good luck with that.</p></div><p>Sarcasm isn't warranted.  Remember that each cell carries -it's own copy- of the genome.  HIV does not infect every cell in your body.  Kill off the infected cells and you've gotten rid of all the HIV DNA.  Kill off the mature immune system cells and you'll still have this reservoir of stem cells which apperantly produce more virus.  Kill off the fraction of bone marrow cells (ideally without killing the patient) and you'll have gotten rid of the HIV DNA.</p><p>Your brain cells, for example, don't appear to be infected and their copies of the genome will not have any HIV DNA in them.  So it's not nearly as impossible as you've suggested.</p></div>
	</htmltext>
<tokenext>HIV is a retrovirus .
It literally becomes a part of your DNA .
The only way to truly cure HIV is to remove the HIV DNA from your genome , good luck with that.Sarcasm is n't warranted .
Remember that each cell carries -it 's own copy- of the genome .
HIV does not infect every cell in your body .
Kill off the infected cells and you 've gotten rid of all the HIV DNA .
Kill off the mature immune system cells and you 'll still have this reservoir of stem cells which apperantly produce more virus .
Kill off the fraction of bone marrow cells ( ideally without killing the patient ) and you 'll have gotten rid of the HIV DNA.Your brain cells , for example , do n't appear to be infected and their copies of the genome will not have any HIV DNA in them .
So it 's not nearly as impossible as you 've suggested .</tokentext>
<sentencetext>HIV is a retrovirus.
It literally becomes a part of your DNA.
The only way to truly cure HIV is to remove the HIV DNA from your genome, good luck with that.Sarcasm isn't warranted.
Remember that each cell carries -it's own copy- of the genome.
HIV does not infect every cell in your body.
Kill off the infected cells and you've gotten rid of all the HIV DNA.
Kill off the mature immune system cells and you'll still have this reservoir of stem cells which apperantly produce more virus.
Kill off the fraction of bone marrow cells (ideally without killing the patient) and you'll have gotten rid of the HIV DNA.Your brain cells, for example, don't appear to be infected and their copies of the genome will not have any HIV DNA in them.
So it's not nearly as impossible as you've suggested.
	</sentencetext>
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</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31411980</id>
	<title>Re:Uh This is a Surprise?</title>
	<author>mapkinase</author>
	<datestamp>1268140920000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>All that you said is true, except that you said it in reply to a different post or imaginary post:</p><p>"It becomes part of the dna for a few select cell types, not EVERY cell type"</p><p>GP did not claim anything about EVERY DNA, or EVERY cell type.</p><p>"and certainly you cannot spread this 'bad' DNA to offspring by means of DNA in eggs/sperm"</p><p>GP did not say that at all and there is not even a hing of implication in his post.</p><p>"you are implying that a virus completely changes your entire genetic make up. and this is simply not the case"</p><p>Again, GP did not say that. Where are you getting all this stuff, anon?</p><p>"You wont be growing wings anytime soon."</p><p>???</p><p>I am glad that mods at least did not mod down the GP post, which expressed the valid concern as well.</p></htmltext>
<tokenext>All that you said is true , except that you said it in reply to a different post or imaginary post : " It becomes part of the dna for a few select cell types , not EVERY cell type " GP did not claim anything about EVERY DNA , or EVERY cell type .
" and certainly you can not spread this 'bad ' DNA to offspring by means of DNA in eggs/sperm " GP did not say that at all and there is not even a hing of implication in his post .
" you are implying that a virus completely changes your entire genetic make up .
and this is simply not the case " Again , GP did not say that .
Where are you getting all this stuff , anon ?
" You wont be growing wings anytime soon. " ? ?
? I am glad that mods at least did not mod down the GP post , which expressed the valid concern as well .</tokentext>
<sentencetext>All that you said is true, except that you said it in reply to a different post or imaginary post:"It becomes part of the dna for a few select cell types, not EVERY cell type"GP did not claim anything about EVERY DNA, or EVERY cell type.
"and certainly you cannot spread this 'bad' DNA to offspring by means of DNA in eggs/sperm"GP did not say that at all and there is not even a hing of implication in his post.
"you are implying that a virus completely changes your entire genetic make up.
and this is simply not the case"Again, GP did not say that.
Where are you getting all this stuff, anon?
"You wont be growing wings anytime soon."??
?I am glad that mods at least did not mod down the GP post, which expressed the valid concern as well.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31408530</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31408514</id>
	<title>Re:Uh This is a Surprise?</title>
	<author>Anonymous</author>
	<datestamp>1268057280000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>Or kill the infected cells.</p></htmltext>
<tokenext>Or kill the infected cells .</tokentext>
<sentencetext>Or kill the infected cells.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31408428</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_03_08_2354226.31408762</id>
	<title>What's all this biology?</title>
	<author>R3coiler</author>
	<datestamp>1268058960000</datestamp>
	<modclass>Funny</modclass>
	<modscore>4</modscore>
	<htmltext><p>Gosh, doesn't the submitter realize that Slashdotters are computer geeks and not biology geeks?  Use analogies we can understand, like comparing this "hiding" virus to a rootkit or something.</p></htmltext>
<tokenext>Gosh , does n't the submitter realize that Slashdotters are computer geeks and not biology geeks ?
Use analogies we can understand , like comparing this " hiding " virus to a rootkit or something .</tokentext>
<sentencetext>Gosh, doesn't the submitter realize that Slashdotters are computer geeks and not biology geeks?
Use analogies we can understand, like comparing this "hiding" virus to a rootkit or something.</sentencetext>
</comment>
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