<article>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#article10_02_09_1833219</id>
	<title>Re-Engineering the Immune System</title>
	<author>kdawson</author>
	<datestamp>1265704440000</datestamp>
	<htmltext>destinyland notes a microbiology professor describing "Immunity on Demand" (or "Immunity 2.0") and wonders whether we could <a href="http://hplusmagazine.com/articles/bio/re-engineering-human-immune-system">genetically engineer all the antibodies we need.</a> <i>"...there's a good chance this system, or something like it, will actually be in place within decades. Caltech scientists have already engineered stem cells into B cells that produce HIV-fighting antibodies &mdash; and an NIH researcher engineered T cells that recognize tumors which has already had promising clinical trials again skin cancer. Our best hope may be to cut out the middleman. Rather than merely hoping that the vaccine will indirectly lead to the antibody an individual needs, imagine if we could genetically engineer these antibodies and make them available as needed?"</i></htmltext>
<tokenext>destinyland notes a microbiology professor describing " Immunity on Demand " ( or " Immunity 2.0 " ) and wonders whether we could genetically engineer all the antibodies we need .
" ...there 's a good chance this system , or something like it , will actually be in place within decades .
Caltech scientists have already engineered stem cells into B cells that produce HIV-fighting antibodies    and an NIH researcher engineered T cells that recognize tumors which has already had promising clinical trials again skin cancer .
Our best hope may be to cut out the middleman .
Rather than merely hoping that the vaccine will indirectly lead to the antibody an individual needs , imagine if we could genetically engineer these antibodies and make them available as needed ?
"</tokentext>
<sentencetext>destinyland notes a microbiology professor describing "Immunity on Demand" (or "Immunity 2.0") and wonders whether we could genetically engineer all the antibodies we need.
"...there's a good chance this system, or something like it, will actually be in place within decades.
Caltech scientists have already engineered stem cells into B cells that produce HIV-fighting antibodies — and an NIH researcher engineered T cells that recognize tumors which has already had promising clinical trials again skin cancer.
Our best hope may be to cut out the middleman.
Rather than merely hoping that the vaccine will indirectly lead to the antibody an individual needs, imagine if we could genetically engineer these antibodies and make them available as needed?
"</sentencetext>
</article>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31078458</id>
	<title>Sounds useful</title>
	<author>T Murphy</author>
	<datestamp>1265712060000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>I'll take some antibodies for meatloaf, that way Aunt Mary's "specialty" causes an immune response and I can claim to be allergic.</htmltext>
<tokenext>I 'll take some antibodies for meatloaf , that way Aunt Mary 's " specialty " causes an immune response and I can claim to be allergic .</tokentext>
<sentencetext>I'll take some antibodies for meatloaf, that way Aunt Mary's "specialty" causes an immune response and I can claim to be allergic.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077612</id>
	<title>And then when a new disease cones along ...</title>
	<author>maxwell demon</author>
	<datestamp>1265708820000</datestamp>
	<modclass>Informativ</modclass>
	<modscore>2</modscore>
	<htmltext><p>And then when a new disease comes along, our immune system is not properly trained, and we'll die.</p><p>Remember that the native Americans dies from illnesses which were relatively harmless for the Europeans, because they just didn't have all those illnesses there.</p></htmltext>
<tokenext>And then when a new disease comes along , our immune system is not properly trained , and we 'll die.Remember that the native Americans dies from illnesses which were relatively harmless for the Europeans , because they just did n't have all those illnesses there .</tokentext>
<sentencetext>And then when a new disease comes along, our immune system is not properly trained, and we'll die.Remember that the native Americans dies from illnesses which were relatively harmless for the Europeans, because they just didn't have all those illnesses there.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31088102</id>
	<title>Re:And then when a new disease cones along ...</title>
	<author>Chris Burke</author>
	<datestamp>1265050320000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p><i>Remember that the native Americans dies from illnesses which were relatively harmless for the Europeans, because they just didn't have all those illnesses there.</i></p><p>And European explorers, all descendants of survivors of the Black Death, died from tropical diseases at rates far higher than the locals, because they didn't have those diseases in Europe.</p><p>Vaccines are all about "training" our immune system.  But they only work against the disease the vaccine is designed for.</p></htmltext>
<tokenext>Remember that the native Americans dies from illnesses which were relatively harmless for the Europeans , because they just did n't have all those illnesses there.And European explorers , all descendants of survivors of the Black Death , died from tropical diseases at rates far higher than the locals , because they did n't have those diseases in Europe.Vaccines are all about " training " our immune system .
But they only work against the disease the vaccine is designed for .</tokentext>
<sentencetext>Remember that the native Americans dies from illnesses which were relatively harmless for the Europeans, because they just didn't have all those illnesses there.And European explorers, all descendants of survivors of the Black Death, died from tropical diseases at rates far higher than the locals, because they didn't have those diseases in Europe.Vaccines are all about "training" our immune system.
But they only work against the disease the vaccine is designed for.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077612</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077932</id>
	<title>Re:Unintended Consequences?</title>
	<author>Patch86</author>
	<datestamp>1265710200000</datestamp>
	<modclass>Insightful</modclass>
	<modscore>2</modscore>
	<htmltext><p>Move to a country with free healthcare?</p><p>Seriously, paying for medicine is so 19th century.</p></htmltext>
<tokenext>Move to a country with free healthcare ? Seriously , paying for medicine is so 19th century .</tokentext>
<sentencetext>Move to a country with free healthcare?Seriously, paying for medicine is so 19th century.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077568</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31081118</id>
	<title>Re:I was under...</title>
	<author>Anonymous</author>
	<datestamp>1265726880000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>No biologist worth a dollar would ever say virii. It's viruses, damn it!!</p></htmltext>
<tokenext>No biologist worth a dollar would ever say virii .
It 's viruses , damn it !
!</tokentext>
<sentencetext>No biologist worth a dollar would ever say virii.
It's viruses, damn it!
!</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31078332</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31078382</id>
	<title>Ounce/Pound</title>
	<author>overshoot</author>
	<datestamp>1265711760000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><blockquote><div><p> <i>Rather than merely hoping that the vaccine will indirectly lead to the antibody an individual needs, imagine if we could genetically engineer these antibodies and make them available as needed?</i></p></div> </blockquote><p>

Just guessing, mind, but maybe because prevention has advantages over cures?</p></div>
	</htmltext>
<tokenext>Rather than merely hoping that the vaccine will indirectly lead to the antibody an individual needs , imagine if we could genetically engineer these antibodies and make them available as needed ?
Just guessing , mind , but maybe because prevention has advantages over cures ?</tokentext>
<sentencetext> Rather than merely hoping that the vaccine will indirectly lead to the antibody an individual needs, imagine if we could genetically engineer these antibodies and make them available as needed?
Just guessing, mind, but maybe because prevention has advantages over cures?
	</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31078260</id>
	<title>Re:I was under the impression</title>
	<author>Hittite Creosote</author>
	<datestamp>1265711400000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>I assume you're thinking just of optical microscopes, where a standard one can see down to around 200nm. If you include electron microscopes, however, there are plenty that can see down to the size of individual atoms - so definitely enough resolution to see viruses.

There are also a load more visualisation techniques around which can also give info on virus structures.</htmltext>
<tokenext>I assume you 're thinking just of optical microscopes , where a standard one can see down to around 200nm .
If you include electron microscopes , however , there are plenty that can see down to the size of individual atoms - so definitely enough resolution to see viruses .
There are also a load more visualisation techniques around which can also give info on virus structures .</tokentext>
<sentencetext>I assume you're thinking just of optical microscopes, where a standard one can see down to around 200nm.
If you include electron microscopes, however, there are plenty that can see down to the size of individual atoms - so definitely enough resolution to see viruses.
There are also a load more visualisation techniques around which can also give info on virus structures.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077476</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31078014</id>
	<title>Re:I was under the impression</title>
	<author>joocemann</author>
	<datestamp>1265710500000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>We have much more powerful visualization means in science now, I recently watched a video of an HIV virus entering a cell.</p><p>But also I wanted to point out that while this theoretical process being discussed may not be usable for new diseases, there are many disease-causing viruses/microbes that are already identified but still afflict human health.</p><p>MRSA, HIV, HepatitisA/B/C, Herpes, Ghonnorhea, Chlamydia, most cancers... etc etc.  So anyway, the value of the theoretical concept, if it were realized, is its ability to help with the various known problems that we could develop antibodies for and carry out deliberate controlled attacks.</p></htmltext>
<tokenext>We have much more powerful visualization means in science now , I recently watched a video of an HIV virus entering a cell.But also I wanted to point out that while this theoretical process being discussed may not be usable for new diseases , there are many disease-causing viruses/microbes that are already identified but still afflict human health.MRSA , HIV , HepatitisA/B/C , Herpes , Ghonnorhea , Chlamydia , most cancers... etc etc .
So anyway , the value of the theoretical concept , if it were realized , is its ability to help with the various known problems that we could develop antibodies for and carry out deliberate controlled attacks .</tokentext>
<sentencetext>We have much more powerful visualization means in science now, I recently watched a video of an HIV virus entering a cell.But also I wanted to point out that while this theoretical process being discussed may not be usable for new diseases, there are many disease-causing viruses/microbes that are already identified but still afflict human health.MRSA, HIV, HepatitisA/B/C, Herpes, Ghonnorhea, Chlamydia, most cancers... etc etc.
So anyway, the value of the theoretical concept, if it were realized, is its ability to help with the various known problems that we could develop antibodies for and carry out deliberate controlled attacks.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077476</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31078630</id>
	<title>Re:I thought we alerady could</title>
	<author>osu-neko</author>
	<datestamp>1265712840000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p><div class="quote"><p>...from a blood transfusion.<nobr> <wbr></nobr>...  So it would seem we already have what the article is talking about.</p></div><p>Really?  How often do people get a transfusion of lab-created, genetically engineered blood?  If the answer is "never", then I fail to see how we already have what the article is talking about.</p></div>
	</htmltext>
<tokenext>...from a blood transfusion .
... So it would seem we already have what the article is talking about.Really ?
How often do people get a transfusion of lab-created , genetically engineered blood ?
If the answer is " never " , then I fail to see how we already have what the article is talking about .</tokentext>
<sentencetext>...from a blood transfusion.
...  So it would seem we already have what the article is talking about.Really?
How often do people get a transfusion of lab-created, genetically engineered blood?
If the answer is "never", then I fail to see how we already have what the article is talking about.
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31078172</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077636</id>
	<title>I for one</title>
	<author>wintercolby</author>
	<datestamp>1265708880000</datestamp>
	<modclass>Funny</modclass>
	<modscore>2</modscore>
	<htmltext>welcome our new <a href="http://www.imdb.com/title/tt0480249/" title="imdb.com" rel="nofollow">zombie overlords</a> [imdb.com].</htmltext>
<tokenext>welcome our new zombie overlords [ imdb.com ] .</tokentext>
<sentencetext>welcome our new zombie overlords [imdb.com].</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31084296</id>
	<title>Neodarwinism</title>
	<author>PeterWone</author>
	<datestamp>1265031000000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>People with enhanced immune systems will run around cheerfully breathing pathogens on people who can't survive them. For once there is a strong and direct correlation between intelligence and chance of survival.</htmltext>
<tokenext>People with enhanced immune systems will run around cheerfully breathing pathogens on people who ca n't survive them .
For once there is a strong and direct correlation between intelligence and chance of survival .</tokentext>
<sentencetext>People with enhanced immune systems will run around cheerfully breathing pathogens on people who can't survive them.
For once there is a strong and direct correlation between intelligence and chance of survival.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077660</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31078198</id>
	<title>They're not all "whack-jobs"...</title>
	<author>MillionthMonkey</author>
	<datestamp>1265711100000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext>Have you ever had a former Playboy Bunny in bed with you? I'd bet you'd go off the rails yourself to keep that going.</htmltext>
<tokenext>Have you ever had a former Playboy Bunny in bed with you ?
I 'd bet you 'd go off the rails yourself to keep that going .</tokentext>
<sentencetext>Have you ever had a former Playboy Bunny in bed with you?
I'd bet you'd go off the rails yourself to keep that going.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077660</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31082128</id>
	<title>Holy Cow!</title>
	<author>Anonymous</author>
	<datestamp>1265737740000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>I read this:</p><p><div class="quote"><p>Rather than merely hoping that the vaccine will indirectly lead to the antibody an individual needs, imagine if we could genetically engineer these antibodies and make them available as needed?</p></div><p>...and immediately went, "Yeah, and can you imagine how much that will cost you to get, let alone develop!"  Let's pray we end these wars and get a public option in the U.S., because otherwise only the rich a-holes like Rush Limbaugh will survive with Keith Richards and the cockroaches!</p></div>
	</htmltext>
<tokenext>I read this : Rather than merely hoping that the vaccine will indirectly lead to the antibody an individual needs , imagine if we could genetically engineer these antibodies and make them available as needed ? ...and immediately went , " Yeah , and can you imagine how much that will cost you to get , let alone develop !
" Let 's pray we end these wars and get a public option in the U.S. , because otherwise only the rich a-holes like Rush Limbaugh will survive with Keith Richards and the cockroaches !</tokentext>
<sentencetext>I read this:Rather than merely hoping that the vaccine will indirectly lead to the antibody an individual needs, imagine if we could genetically engineer these antibodies and make them available as needed?...and immediately went, "Yeah, and can you imagine how much that will cost you to get, let alone develop!
"  Let's pray we end these wars and get a public option in the U.S., because otherwise only the rich a-holes like Rush Limbaugh will survive with Keith Richards and the cockroaches!
	</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077972</id>
	<title>auto immune system response</title>
	<author>MrKaos</author>
	<datestamp>1265710320000</datestamp>
	<modclass>Funny</modclass>
	<modscore>4</modscore>
	<htmltext>Hey wouldn't it be great if our bodies did this automatically...</htmltext>
<tokenext>Hey would n't it be great if our bodies did this automatically.. .</tokentext>
<sentencetext>Hey wouldn't it be great if our bodies did this automatically...</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31078512</id>
	<title>Re:Hey, awesome...</title>
	<author>osu-neko</author>
	<datestamp>1265712300000</datestamp>
	<modclass>Interestin</modclass>
	<modscore>5</modscore>
	<htmltext><p><div class="quote"><p>Lets cure all natural causes of death through the miracle of modern science.
Then starve to death as the world becomes grossly overpopulated.</p></div><p>Problem: All evidence suggests the opposite.  Eliminate all the most egregious morality concerns from a population, and they stop reproducing like rabbits.  In the healthiest parts of the first word, population growth is going negative.</p></div>
	</htmltext>
<tokenext>Lets cure all natural causes of death through the miracle of modern science .
Then starve to death as the world becomes grossly overpopulated.Problem : All evidence suggests the opposite .
Eliminate all the most egregious morality concerns from a population , and they stop reproducing like rabbits .
In the healthiest parts of the first word , population growth is going negative .</tokentext>
<sentencetext>Lets cure all natural causes of death through the miracle of modern science.
Then starve to death as the world becomes grossly overpopulated.Problem: All evidence suggests the opposite.
Eliminate all the most egregious morality concerns from a population, and they stop reproducing like rabbits.
In the healthiest parts of the first word, population growth is going negative.
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077702</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31079984</id>
	<title>Re:I thought we alerady could</title>
	<author>orkysoft</author>
	<datestamp>1265719140000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>Isn't blood filtered before it is transfused?</p></htmltext>
<tokenext>Is n't blood filtered before it is transfused ?</tokentext>
<sentencetext>Isn't blood filtered before it is transfused?</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31078172</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077804</id>
	<title>Too much Sci-fi</title>
	<author>Anonymous</author>
	<datestamp>1265709720000</datestamp>
	<modclass>Funny</modclass>
	<modscore>2</modscore>
	<htmltext>Maybe I have been reading too much sci-fi lately but arent we closer to using nanotech as an immune system than using biological sources?</htmltext>
<tokenext>Maybe I have been reading too much sci-fi lately but arent we closer to using nanotech as an immune system than using biological sources ?</tokentext>
<sentencetext>Maybe I have been reading too much sci-fi lately but arent we closer to using nanotech as an immune system than using biological sources?</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31080630</id>
	<title>Hell, that's what our immune system does already</title>
	<author>NotSoHeavyD3</author>
	<datestamp>1265723160000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>From what I remember in a cell bio class the B-Cells arn't programmed to make any specific antibody at first.(They're naive) When a new molecule shows up in the body some of those cells will edit their DNA to produce a specific antibody to that antigen. The ones that don't really match well die off and the ones that have editted their DNA to produce a good match live on to produce that antibody. If I remember right that process is kind of random so it takes quite a few naive B-Cells before one of them edits their DNA to make a good match. You could skip this step by having someone do the editting of the B-Cell by "hand" so to speak.</htmltext>
<tokenext>From what I remember in a cell bio class the B-Cells ar n't programmed to make any specific antibody at first .
( They 're naive ) When a new molecule shows up in the body some of those cells will edit their DNA to produce a specific antibody to that antigen .
The ones that do n't really match well die off and the ones that have editted their DNA to produce a good match live on to produce that antibody .
If I remember right that process is kind of random so it takes quite a few naive B-Cells before one of them edits their DNA to make a good match .
You could skip this step by having someone do the editting of the B-Cell by " hand " so to speak .</tokentext>
<sentencetext>From what I remember in a cell bio class the B-Cells arn't programmed to make any specific antibody at first.
(They're naive) When a new molecule shows up in the body some of those cells will edit their DNA to produce a specific antibody to that antigen.
The ones that don't really match well die off and the ones that have editted their DNA to produce a good match live on to produce that antibody.
If I remember right that process is kind of random so it takes quite a few naive B-Cells before one of them edits their DNA to make a good match.
You could skip this step by having someone do the editting of the B-Cell by "hand" so to speak.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31078674</id>
	<title>I tha8k you for your time</title>
	<author>Anonymous</author>
	<datestamp>1265712960000</datestamp>
	<modclass>Troll</modclass>
	<modscore>-1</modscore>
	<htmltext>clothes Rorn be a community at</htmltext>
<tokenext>clothes Rorn be a community at</tokentext>
<sentencetext>clothes Rorn be a community at</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31080486</id>
	<title>Re:Dangers of the right thing</title>
	<author>Anonymous</author>
	<datestamp>1265722440000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>This honestly means nothing.</p><p>That viral DNA is, in the vast majority or all of the cases, not being expressed.  So a smarter immune system would not target it.</p><p>And if it is being expressed and making some necessary protein, then a smarter immune system wouldn't target it anyway because that protein would be recognized as self.</p></htmltext>
<tokenext>This honestly means nothing.That viral DNA is , in the vast majority or all of the cases , not being expressed .
So a smarter immune system would not target it.And if it is being expressed and making some necessary protein , then a smarter immune system would n't target it anyway because that protein would be recognized as self .</tokentext>
<sentencetext>This honestly means nothing.That viral DNA is, in the vast majority or all of the cases, not being expressed.
So a smarter immune system would not target it.And if it is being expressed and making some necessary protein, then a smarter immune system wouldn't target it anyway because that protein would be recognized as self.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077530</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077546</id>
	<title>Someone needs an editor</title>
	<author>wrencherd</author>
	<datestamp>1265708580000</datestamp>
	<modclass>Funny</modclass>
	<modscore>5</modscore>
	<htmltext><p>From TFA:</p><p>"We are not sure when this will all happen, but there&rsquo;s a good chance it will, and perhaps the only question is when."</p><p>Hmmmmm . . .</p></htmltext>
<tokenext>From TFA : " We are not sure when this will all happen , but there    s a good chance it will , and perhaps the only question is when .
" Hmmmmm .
. .</tokentext>
<sentencetext>From TFA:"We are not sure when this will all happen, but there’s a good chance it will, and perhaps the only question is when.
"Hmmmmm .
. .</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31083608</id>
	<title>Pay up or peg out</title>
	<author>dugeen</author>
	<datestamp>1265022840000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>This nightmare is like GM crops, but ten times worse. It's one thing to put agriculture entirely in the hands of US corporations, but giving them control over our immune systems could be described as foolish. I think it would be simpler to cut out the middleman by committing suicide immediately.</htmltext>
<tokenext>This nightmare is like GM crops , but ten times worse .
It 's one thing to put agriculture entirely in the hands of US corporations , but giving them control over our immune systems could be described as foolish .
I think it would be simpler to cut out the middleman by committing suicide immediately .</tokentext>
<sentencetext>This nightmare is like GM crops, but ten times worse.
It's one thing to put agriculture entirely in the hands of US corporations, but giving them control over our immune systems could be described as foolish.
I think it would be simpler to cut out the middleman by committing suicide immediately.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077522</id>
	<title>That's progress for you</title>
	<author>Anonymous</author>
	<datestamp>1265708460000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>What's next, mechanical sperm?</p></htmltext>
<tokenext>What 's next , mechanical sperm ?</tokentext>
<sentencetext>What's next, mechanical sperm?</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31083670</id>
	<title>Hey losertarians and wingnuts</title>
	<author>jhylkema</author>
	<datestamp>1265023680000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>From TFA:</p><blockquote><div><p>Caltech scientists have already engineered stem cells into B cells that produce HIV-fighting antibodies -- and an NIH researcher engineered T cells that recognize tumors which has already had promising clinical trials again skin cancer.</p></div> </blockquote><p>Now, say again please, all after your oh-so-tired anti-government rants?</p></div>
	</htmltext>
<tokenext>From TFA : Caltech scientists have already engineered stem cells into B cells that produce HIV-fighting antibodies -- and an NIH researcher engineered T cells that recognize tumors which has already had promising clinical trials again skin cancer .
Now , say again please , all after your oh-so-tired anti-government rants ?</tokentext>
<sentencetext>From TFA:Caltech scientists have already engineered stem cells into B cells that produce HIV-fighting antibodies -- and an NIH researcher engineered T cells that recognize tumors which has already had promising clinical trials again skin cancer.
Now, say again please, all after your oh-so-tired anti-government rants?
	</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31078172</id>
	<title>I thought we alerady could</title>
	<author>scorp1us</author>
	<datestamp>1265711040000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>As someone who is allergic to nearly everything, I've taken a keen interest in the immune system.</p><p>I read something a while ago that said allergies and even things like nervous tics could be inherited from a blood transfusion. The idea is that along with the blood cells, you get the donor's white blood cells and antibodies, which then teach your own white blood cells how to make the antibodies, so you wind up with their allergies. It also said that some nervous system things like tics could also be inherited the same way. So it would seem we already have what the article is talking about.</p></htmltext>
<tokenext>As someone who is allergic to nearly everything , I 've taken a keen interest in the immune system.I read something a while ago that said allergies and even things like nervous tics could be inherited from a blood transfusion .
The idea is that along with the blood cells , you get the donor 's white blood cells and antibodies , which then teach your own white blood cells how to make the antibodies , so you wind up with their allergies .
It also said that some nervous system things like tics could also be inherited the same way .
So it would seem we already have what the article is talking about .</tokentext>
<sentencetext>As someone who is allergic to nearly everything, I've taken a keen interest in the immune system.I read something a while ago that said allergies and even things like nervous tics could be inherited from a blood transfusion.
The idea is that along with the blood cells, you get the donor's white blood cells and antibodies, which then teach your own white blood cells how to make the antibodies, so you wind up with their allergies.
It also said that some nervous system things like tics could also be inherited the same way.
So it would seem we already have what the article is talking about.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31080476</id>
	<title>Re:Dangers of the right thing</title>
	<author>penguinoid</author>
	<datestamp>1265722380000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>Actually, the very first job of immune cells is to recognize self. After they can recognize self, then they go on to attack non-self. If the immune system were to attack self, you get various autoimmune diseases ranging from diabetes to arthritis. So what I wonder about these, given that they grow in a lab and never recognize you, is whether they will tag our own cells?</p></htmltext>
<tokenext>Actually , the very first job of immune cells is to recognize self .
After they can recognize self , then they go on to attack non-self .
If the immune system were to attack self , you get various autoimmune diseases ranging from diabetes to arthritis .
So what I wonder about these , given that they grow in a lab and never recognize you , is whether they will tag our own cells ?</tokentext>
<sentencetext>Actually, the very first job of immune cells is to recognize self.
After they can recognize self, then they go on to attack non-self.
If the immune system were to attack self, you get various autoimmune diseases ranging from diabetes to arthritis.
So what I wonder about these, given that they grow in a lab and never recognize you, is whether they will tag our own cells?</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077530</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31078408</id>
	<title>Re:I was under the impression</title>
	<author>StellarFury</author>
	<datestamp>1265711880000</datestamp>
	<modclass>Informativ</modclass>
	<modscore>2</modscore>
	<htmltext><p>Your impression was very, very wrong. Not only can we see most disease-causing agents with electron microscopes, we have X-ray and/or NMR crystal structures of a huge number of viruses - meaning we know, down to a "where each individual atom is" level of accuracy, what these things look like.</p></htmltext>
<tokenext>Your impression was very , very wrong .
Not only can we see most disease-causing agents with electron microscopes , we have X-ray and/or NMR crystal structures of a huge number of viruses - meaning we know , down to a " where each individual atom is " level of accuracy , what these things look like .</tokentext>
<sentencetext>Your impression was very, very wrong.
Not only can we see most disease-causing agents with electron microscopes, we have X-ray and/or NMR crystal structures of a huge number of viruses - meaning we know, down to a "where each individual atom is" level of accuracy, what these things look like.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077476</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077802</id>
	<title>Re:I was under the impression</title>
	<author>Anonymous</author>
	<datestamp>1265709660000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>How is it so hard, just put the blood sample in the analyzer, have the microD make a sample, inject said sample hypodermically... hmm, wait what year is it?</p></htmltext>
<tokenext>How is it so hard , just put the blood sample in the analyzer , have the microD make a sample , inject said sample hypodermically... hmm , wait what year is it ?</tokentext>
<sentencetext>How is it so hard, just put the blood sample in the analyzer, have the microD make a sample, inject said sample hypodermically... hmm, wait what year is it?</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077634</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077974</id>
	<title>Re:Hey, awesome...</title>
	<author>fuzzyfuzzyfungus</author>
	<datestamp>1265710380000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>Don't worry; thanks to the work of Norman Borlaug and Mikhail Kalashnikov, there are alternatives to mass starvation...</htmltext>
<tokenext>Do n't worry ; thanks to the work of Norman Borlaug and Mikhail Kalashnikov , there are alternatives to mass starvation.. .</tokentext>
<sentencetext>Don't worry; thanks to the work of Norman Borlaug and Mikhail Kalashnikov, there are alternatives to mass starvation...</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077702</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077526</id>
	<title>What could possibly go wrong?</title>
	<author>SigILL</author>
	<datestamp>1265708460000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>At least let's hope we won't all end up like that guy in TFA's illustration. Looks like he's missing something.</p></htmltext>
<tokenext>At least let 's hope we wo n't all end up like that guy in TFA 's illustration .
Looks like he 's missing something .</tokentext>
<sentencetext>At least let's hope we won't all end up like that guy in TFA's illustration.
Looks like he's missing something.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31078592</id>
	<title>The reminds me of a science-fiction novel</title>
	<author>Anonymous</author>
	<datestamp>1265712660000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>I'll leave it to your imagination how *that* turned out.</p></htmltext>
<tokenext>I 'll leave it to your imagination how * that * turned out .</tokentext>
<sentencetext>I'll leave it to your imagination how *that* turned out.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077488</id>
	<title>Here's hoping...</title>
	<author>Anonymous</author>
	<datestamp>1265708280000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>...I don't die before they invent invincibility... biologically speaking of course<nobr> <wbr></nobr>:)</p><p>stoops.</p></htmltext>
<tokenext>...I do n't die before they invent invincibility... biologically speaking of course : ) stoops .</tokentext>
<sentencetext>...I don't die before they invent invincibility... biologically speaking of course :)stoops.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31090230</id>
	<title>Re:Unintended Consequences?</title>
	<author>Urkki</author>
	<datestamp>1265016480000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p><div class="quote"><p>Move to a country with free healthcare?</p><p>Seriously, paying for medicine is so 19th century.</p></div><p>I fear it may turn out to be very 21st century, as well...<nobr> <wbr></nobr>:-(</p></div>
	</htmltext>
<tokenext>Move to a country with free healthcare ? Seriously , paying for medicine is so 19th century.I fear it may turn out to be very 21st century , as well... : - (</tokentext>
<sentencetext>Move to a country with free healthcare?Seriously, paying for medicine is so 19th century.I fear it may turn out to be very 21st century, as well... :-(
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077932</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31078496</id>
	<title>Re:Unintended Consequences?</title>
	<author>ultranova</author>
	<datestamp>1265712240000</datestamp>
	<modclass>Informativ</modclass>
	<modscore>2</modscore>
	<htmltext><blockquote><div><p>Well, it's been a while since your real immune system has had to work, so the next mutation of a virus comes along and 'oops'.</p></div> </blockquote><p>Your real immune system is working all the time, fighting more simultaneous and endless wars than the United States. Leave a piece of meat on the table and take note how long it takes before all the bacteria, fungi and insects notice it's there. Now remember that <em>you</em> are made of meat.</p><p>You only notice your immune system when something manages to get a foothold, but that doesn't mean that it isn't working at the other times.</p></div>
	</htmltext>
<tokenext>Well , it 's been a while since your real immune system has had to work , so the next mutation of a virus comes along and 'oops' .
Your real immune system is working all the time , fighting more simultaneous and endless wars than the United States .
Leave a piece of meat on the table and take note how long it takes before all the bacteria , fungi and insects notice it 's there .
Now remember that you are made of meat.You only notice your immune system when something manages to get a foothold , but that does n't mean that it is n't working at the other times .</tokentext>
<sentencetext>Well, it's been a while since your real immune system has had to work, so the next mutation of a virus comes along and 'oops'.
Your real immune system is working all the time, fighting more simultaneous and endless wars than the United States.
Leave a piece of meat on the table and take note how long it takes before all the bacteria, fungi and insects notice it's there.
Now remember that you are made of meat.You only notice your immune system when something manages to get a foothold, but that doesn't mean that it isn't working at the other times.
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077568</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31078210</id>
	<title>Re:Unintended Consequences?</title>
	<author>maxume</author>
	<datestamp>1265711160000</datestamp>
	<modclass>Insightful</modclass>
	<modscore>2</modscore>
	<htmltext><p>You need to come up with some better phrasing for that, you are suggesting that back in the 19th century, we had to pay for medicine, rather than having slaves like we do today.</p><p>You should probably use 'universal health care' instead of 'free health care', and speak about not charging for it at the point of delivery.</p></htmltext>
<tokenext>You need to come up with some better phrasing for that , you are suggesting that back in the 19th century , we had to pay for medicine , rather than having slaves like we do today.You should probably use 'universal health care ' instead of 'free health care ' , and speak about not charging for it at the point of delivery .</tokentext>
<sentencetext>You need to come up with some better phrasing for that, you are suggesting that back in the 19th century, we had to pay for medicine, rather than having slaves like we do today.You should probably use 'universal health care' instead of 'free health care', and speak about not charging for it at the point of delivery.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077932</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077788</id>
	<title>Resident Evil</title>
	<author>Anonymous</author>
	<datestamp>1265709600000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>This sounds like the plot to Resident Evil.</p></htmltext>
<tokenext>This sounds like the plot to Resident Evil .</tokentext>
<sentencetext>This sounds like the plot to Resident Evil.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31079794</id>
	<title>Re:Hey, awesome...</title>
	<author>Ghubi</author>
	<datestamp>1265718000000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>I think starvation counts as a natural cause of death.  <a href="http://en.wikipedia.org/wiki/Green\_Revolution" title="wikipedia.org" rel="nofollow">Modern science</a> [wikipedia.org] is working on a "cure" for that too.</htmltext>
<tokenext>I think starvation counts as a natural cause of death .
Modern science [ wikipedia.org ] is working on a " cure " for that too .</tokentext>
<sentencetext>I think starvation counts as a natural cause of death.
Modern science [wikipedia.org] is working on a "cure" for that too.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077702</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31083850</id>
	<title>Re:Unintended Consequences?</title>
	<author>vegiVamp</author>
	<datestamp>1265025840000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>I suspect that, similar to how vaccination works, your own immune system will have picked up the trick and continue fighting on it's own. After all, there'll be a whole lot of dead enemies floating about to see how it's done.</p></htmltext>
<tokenext>I suspect that , similar to how vaccination works , your own immune system will have picked up the trick and continue fighting on it 's own .
After all , there 'll be a whole lot of dead enemies floating about to see how it 's done .</tokentext>
<sentencetext>I suspect that, similar to how vaccination works, your own immune system will have picked up the trick and continue fighting on it's own.
After all, there'll be a whole lot of dead enemies floating about to see how it's done.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077568</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077568</id>
	<title>Unintended Consequences?</title>
	<author>assemblyronin</author>
	<datestamp>1265708640000</datestamp>
	<modclass>Interestin</modclass>
	<modscore>4</modscore>
	<htmltext><p>FTA:</p><p><div class="quote"><p>All this is, of course, a delicate proposition. In some ways, an overactive immune system is as much of a risk as an underactive one: more than a million people worldwide a year die from collateral damage, like septic shock after bacterial infection, and inflammations that may ultimately induce chronic illness such as heart disease and perhaps even cancer.</p></div><p>This is just one possible outcome to programming new antibodies.  I'd also be concerned with how the treatments mitigate any risk to shutting down our own immune system.</p><p>Hypothetical speculation: Say the treatment works well while you're taking regular doses of new Immunity 2.0 shots, but as soon as you can't afford to pay anymore, you're off the Immunity 2.0 shots.  Well, it's been a while since your real immune system has had to work, so the next mutation of a virus comes along and 'oops'.</p><p>Most questions to risk will probably be found in lab research and trials, but it's still something to think about.</p></div>
	</htmltext>
<tokenext>FTA : All this is , of course , a delicate proposition .
In some ways , an overactive immune system is as much of a risk as an underactive one : more than a million people worldwide a year die from collateral damage , like septic shock after bacterial infection , and inflammations that may ultimately induce chronic illness such as heart disease and perhaps even cancer.This is just one possible outcome to programming new antibodies .
I 'd also be concerned with how the treatments mitigate any risk to shutting down our own immune system.Hypothetical speculation : Say the treatment works well while you 're taking regular doses of new Immunity 2.0 shots , but as soon as you ca n't afford to pay anymore , you 're off the Immunity 2.0 shots .
Well , it 's been a while since your real immune system has had to work , so the next mutation of a virus comes along and 'oops'.Most questions to risk will probably be found in lab research and trials , but it 's still something to think about .</tokentext>
<sentencetext>FTA:All this is, of course, a delicate proposition.
In some ways, an overactive immune system is as much of a risk as an underactive one: more than a million people worldwide a year die from collateral damage, like septic shock after bacterial infection, and inflammations that may ultimately induce chronic illness such as heart disease and perhaps even cancer.This is just one possible outcome to programming new antibodies.
I'd also be concerned with how the treatments mitigate any risk to shutting down our own immune system.Hypothetical speculation: Say the treatment works well while you're taking regular doses of new Immunity 2.0 shots, but as soon as you can't afford to pay anymore, you're off the Immunity 2.0 shots.
Well, it's been a while since your real immune system has had to work, so the next mutation of a virus comes along and 'oops'.Most questions to risk will probably be found in lab research and trials, but it's still something to think about.
	</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077530</id>
	<title>Dangers of the right thing</title>
	<author>gmuslera</author>
	<datestamp>1265708460000</datestamp>
	<modclass>Informativ</modclass>
	<modscore>3</modscore>
	<htmltext>Smarting up our immune system could turn to be a dumb idea, as a <a href="http://science.slashdot.org/story/10/01/07/1425242/8-of-Your-DNA-Comes-From-a-Virus" title="slashdot.org">good part of us comes from virus</a> [slashdot.org]</htmltext>
<tokenext>Smarting up our immune system could turn to be a dumb idea , as a good part of us comes from virus [ slashdot.org ]</tokentext>
<sentencetext>Smarting up our immune system could turn to be a dumb idea, as a good part of us comes from virus [slashdot.org]</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077660</id>
	<title>Boy, Howdy!</title>
	<author>overshoot</author>
	<datestamp>1265709000000</datestamp>
	<modclass>Insightful</modclass>
	<modscore>2</modscore>
	<htmltext>If you think that the whack-jobs are ballistic about vaccines, wait they go off the rails for something like this!</htmltext>
<tokenext>If you think that the whack-jobs are ballistic about vaccines , wait they go off the rails for something like this !</tokentext>
<sentencetext>If you think that the whack-jobs are ballistic about vaccines, wait they go off the rails for something like this!</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31078830</id>
	<title>Re:I was under the impression</title>
	<author>jonadab</author>
	<datestamp>1265713620000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>&gt; That we can't actually see a majority of diseases under a microscope<br><br>No, that's wrong.  Well, it could be technically right (depending on how you define "disease"), but not in the way you were probably thinking.<br><br>If the human immune system is making antibodies to fight the disease, then there's a pathogen involved, which we most certainly can see under a microscope.  (These days, microscopes can image amazingly small objects, much smaller than any protein.  Not in color, of course, because we're not talking about light-refracting microscopes here.  But that's really beside the point.  Anyway, I'm not sure what "color" would even mean at the molecular level.)<br><br>The larger issue is that we understand the human immune system about as well as we understand the human brain.  Talking about re-engineering it and making "Immune System 2.0" is pretty arrogant and unrealistic, IMO.  Giving the immune system a sample of what it's supposed to fight and letting it learn to fight that (vaccination, in other words) is one thing.  That's like letting the search dog sniff a scrap of the missing person's clothing so they know who they're supposed to find.  Doing the actual searching is still up to the dog.  Trying to improve on the actual disease-fighting process would be something else quite again.  That's like trying to design a better dog.  Human knowledge of how living systems work is just plain not up to that yet.</htmltext>
<tokenext>&gt; That we ca n't actually see a majority of diseases under a microscopeNo , that 's wrong .
Well , it could be technically right ( depending on how you define " disease " ) , but not in the way you were probably thinking.If the human immune system is making antibodies to fight the disease , then there 's a pathogen involved , which we most certainly can see under a microscope .
( These days , microscopes can image amazingly small objects , much smaller than any protein .
Not in color , of course , because we 're not talking about light-refracting microscopes here .
But that 's really beside the point .
Anyway , I 'm not sure what " color " would even mean at the molecular level .
) The larger issue is that we understand the human immune system about as well as we understand the human brain .
Talking about re-engineering it and making " Immune System 2.0 " is pretty arrogant and unrealistic , IMO .
Giving the immune system a sample of what it 's supposed to fight and letting it learn to fight that ( vaccination , in other words ) is one thing .
That 's like letting the search dog sniff a scrap of the missing person 's clothing so they know who they 're supposed to find .
Doing the actual searching is still up to the dog .
Trying to improve on the actual disease-fighting process would be something else quite again .
That 's like trying to design a better dog .
Human knowledge of how living systems work is just plain not up to that yet .</tokentext>
<sentencetext>&gt; That we can't actually see a majority of diseases under a microscopeNo, that's wrong.
Well, it could be technically right (depending on how you define "disease"), but not in the way you were probably thinking.If the human immune system is making antibodies to fight the disease, then there's a pathogen involved, which we most certainly can see under a microscope.
(These days, microscopes can image amazingly small objects, much smaller than any protein.
Not in color, of course, because we're not talking about light-refracting microscopes here.
But that's really beside the point.
Anyway, I'm not sure what "color" would even mean at the molecular level.
)The larger issue is that we understand the human immune system about as well as we understand the human brain.
Talking about re-engineering it and making "Immune System 2.0" is pretty arrogant and unrealistic, IMO.
Giving the immune system a sample of what it's supposed to fight and letting it learn to fight that (vaccination, in other words) is one thing.
That's like letting the search dog sniff a scrap of the missing person's clothing so they know who they're supposed to find.
Doing the actual searching is still up to the dog.
Trying to improve on the actual disease-fighting process would be something else quite again.
That's like trying to design a better dog.
Human knowledge of how living systems work is just plain not up to that yet.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077476</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31081144</id>
	<title>Re:Unintended Consequences?</title>
	<author>geekoid</author>
	<datestamp>1265727180000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>Just like how you need to keep paying for a polio shot every year.</p><p>No, wait. Maybe the immune system doesn't work like you think it does?</p></htmltext>
<tokenext>Just like how you need to keep paying for a polio shot every year.No , wait .
Maybe the immune system does n't work like you think it does ?</tokentext>
<sentencetext>Just like how you need to keep paying for a polio shot every year.No, wait.
Maybe the immune system doesn't work like you think it does?</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077568</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077486</id>
	<title>I am Will Smith!</title>
	<author>Anonymous</author>
	<datestamp>1265708280000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><i>oh, this ain't gonna end well...</i></htmltext>
<tokenext>oh , this ai n't gon na end well.. .</tokentext>
<sentencetext>oh, this ain't gonna end well...</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077772</id>
	<title>Ah, hubris.</title>
	<author>neurogeneticist</author>
	<datestamp>1265709540000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>So we can't stop our poor dumb natural immune systems from attacking our own bodies, and we're just a few short years away from telling it what to do?</htmltext>
<tokenext>So we ca n't stop our poor dumb natural immune systems from attacking our own bodies , and we 're just a few short years away from telling it what to do ?</tokentext>
<sentencetext>So we can't stop our poor dumb natural immune systems from attacking our own bodies, and we're just a few short years away from telling it what to do?</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31078054</id>
	<title>Re:Hey, awesome...</title>
	<author>Anonymous</author>
	<datestamp>1265710620000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>Ideally we would solve all of our problems eventually, but if it pains you that much to read articles on progress towards solving one or a couple of problems at a time, give me your email and I'll let you know when they publish "All human problems solved!" so you won't have to read through piddly solutions to things like all disease, ever.</p></htmltext>
<tokenext>Ideally we would solve all of our problems eventually , but if it pains you that much to read articles on progress towards solving one or a couple of problems at a time , give me your email and I 'll let you know when they publish " All human problems solved !
" so you wo n't have to read through piddly solutions to things like all disease , ever .</tokentext>
<sentencetext>Ideally we would solve all of our problems eventually, but if it pains you that much to read articles on progress towards solving one or a couple of problems at a time, give me your email and I'll let you know when they publish "All human problems solved!
" so you won't have to read through piddly solutions to things like all disease, ever.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077702</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31080136</id>
	<title>this could be the cure..</title>
	<author>formfeed</author>
	<datestamp>1265720040000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>.. for girl germs!
<br>
Otherwise, I don't know, why it would be posted on<nobr> <wbr></nobr>/.</htmltext>
<tokenext>.. for girl germs !
Otherwise , I do n't know , why it would be posted on / .</tokentext>
<sentencetext>.. for girl germs!
Otherwise, I don't know, why it would be posted on /.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077822</id>
	<title>Within decades?</title>
	<author>MathiasRav</author>
	<datestamp>1265709720000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><a href="http://xkcd.com/678/" title="xkcd.com" rel="nofollow">xkcd:678</a> [xkcd.com]</htmltext>
<tokenext>xkcd : 678 [ xkcd.com ]</tokentext>
<sentencetext>xkcd:678 [xkcd.com]</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077476</id>
	<title>I was under the impression</title>
	<author>Monkeedude1212</author>
	<datestamp>1265708280000</datestamp>
	<modclass>Insightful</modclass>
	<modscore>1</modscore>
	<htmltext><p>That we can't actually see a majority of diseases under a microscope, only the antibodies our bodies produce to fight it off. Has that part been a myth or have we merely technologically advanced past that?</p><p>I find it difficult for us to engineer an antibody to fight against something we haven't actually detected yet.</p></htmltext>
<tokenext>That we ca n't actually see a majority of diseases under a microscope , only the antibodies our bodies produce to fight it off .
Has that part been a myth or have we merely technologically advanced past that ? I find it difficult for us to engineer an antibody to fight against something we have n't actually detected yet .</tokentext>
<sentencetext>That we can't actually see a majority of diseases under a microscope, only the antibodies our bodies produce to fight it off.
Has that part been a myth or have we merely technologically advanced past that?I find it difficult for us to engineer an antibody to fight against something we haven't actually detected yet.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31102868</id>
	<title>Re:Someone needs an editor</title>
	<author>ThatsNotPudding</author>
	<datestamp>1265918340000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>Written by someone who's a big fan of bookends.</htmltext>
<tokenext>Written by someone who 's a big fan of bookends .</tokentext>
<sentencetext>Written by someone who's a big fan of bookends.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077546</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31082888</id>
	<title>Glanding</title>
	<author>FreakyGreenLeaky</author>
	<datestamp>1265057040000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>Reminds me of the folks in <a href="http://en.wikipedia.org/wiki/The\_Culture" title="wikipedia.org" rel="nofollow">The Culture</a> [wikipedia.org], need to stay awake, relieve pain, fall asleep, be happy, be sad, need energy, be calm, get high, get <i>really</i> high, fight disease, etc, simply <i>gland</i> it - a neural implant ("lace") can release whatever chemical you want/need... wonderful stuff.</p></htmltext>
<tokenext>Reminds me of the folks in The Culture [ wikipedia.org ] , need to stay awake , relieve pain , fall asleep , be happy , be sad , need energy , be calm , get high , get really high , fight disease , etc , simply gland it - a neural implant ( " lace " ) can release whatever chemical you want/need... wonderful stuff .</tokentext>
<sentencetext>Reminds me of the folks in The Culture [wikipedia.org], need to stay awake, relieve pain, fall asleep, be happy, be sad, need energy, be calm, get high, get really high, fight disease, etc, simply gland it - a neural implant ("lace") can release whatever chemical you want/need... wonderful stuff.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31079792</id>
	<title>Re:Unintended Consequences?</title>
	<author>Anonymous</author>
	<datestamp>1265718000000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>Nah, it's not actually so bad.  I have eczema which is usually a nuisance but a while back it went nuts and after a few months the doctor prescribed me immune suppressants.  Exactly the same ones people with organ transplants use.  They worked great.  The flare up was my immune system working like mad to kill my skin.  Once my immune system was whipped to submission everything was better.  I actually caught less colds in that time.  So unless they plan on totally turning off the immune system, it'll still be there and capable of doing its job.</p></htmltext>
<tokenext>Nah , it 's not actually so bad .
I have eczema which is usually a nuisance but a while back it went nuts and after a few months the doctor prescribed me immune suppressants .
Exactly the same ones people with organ transplants use .
They worked great .
The flare up was my immune system working like mad to kill my skin .
Once my immune system was whipped to submission everything was better .
I actually caught less colds in that time .
So unless they plan on totally turning off the immune system , it 'll still be there and capable of doing its job .</tokentext>
<sentencetext>Nah, it's not actually so bad.
I have eczema which is usually a nuisance but a while back it went nuts and after a few months the doctor prescribed me immune suppressants.
Exactly the same ones people with organ transplants use.
They worked great.
The flare up was my immune system working like mad to kill my skin.
Once my immune system was whipped to submission everything was better.
I actually caught less colds in that time.
So unless they plan on totally turning off the immune system, it'll still be there and capable of doing its job.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077568</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077812</id>
	<title>Re:I was under the impression</title>
	<author>Anonymous</author>
	<datestamp>1265709720000</datestamp>
	<modclass>Offtopic</modclass>
	<modscore>-1</modscore>
	<htmltext><p>How's your knowledge of contractions and possessive pronouns? it's means IT IS for crying out loud.</p></htmltext>
<tokenext>How 's your knowledge of contractions and possessive pronouns ?
it 's means IT IS for crying out loud .</tokentext>
<sentencetext>How's your knowledge of contractions and possessive pronouns?
it's means IT IS for crying out loud.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077634</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077616</id>
	<title>Lazy immune system?</title>
	<author>wrencherd</author>
	<datestamp>1265708820000</datestamp>
	<modclass>Insightful</modclass>
	<modscore>2</modscore>
	<htmltext><p>I have to ask, b/c I don't know, but could this lead to lazy-, or even more inept immune systems?</p></htmltext>
<tokenext>I have to ask , b/c I do n't know , but could this lead to lazy- , or even more inept immune systems ?</tokentext>
<sentencetext>I have to ask, b/c I don't know, but could this lead to lazy-, or even more inept immune systems?</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31080924</id>
	<title>Re:Unintended Consequences?</title>
	<author>mindfarms</author>
	<datestamp>1265725560000</datestamp>
	<modclass>Interestin</modclass>
	<modscore>2</modscore>
	<htmltext>That is a very valid point. The creation of Products that "require" continued use in the interest of (so called) continued good health is nothing new to the Pharmaceutical Industries. Read the fine print (really fine print) on the tiny hand-out included with most prescribed drugs and you will see what I mean. Most of them point out dangerous and undesirable results if you DISCONTINUE the medication.

The Internet Marketing Industry grabbed that concept and introduced it as a New Concept... called Forced Continuity, LOL.</htmltext>
<tokenext>That is a very valid point .
The creation of Products that " require " continued use in the interest of ( so called ) continued good health is nothing new to the Pharmaceutical Industries .
Read the fine print ( really fine print ) on the tiny hand-out included with most prescribed drugs and you will see what I mean .
Most of them point out dangerous and undesirable results if you DISCONTINUE the medication .
The Internet Marketing Industry grabbed that concept and introduced it as a New Concept... called Forced Continuity , LOL .</tokentext>
<sentencetext>That is a very valid point.
The creation of Products that "require" continued use in the interest of (so called) continued good health is nothing new to the Pharmaceutical Industries.
Read the fine print (really fine print) on the tiny hand-out included with most prescribed drugs and you will see what I mean.
Most of them point out dangerous and undesirable results if you DISCONTINUE the medication.
The Internet Marketing Industry grabbed that concept and introduced it as a New Concept... called Forced Continuity, LOL.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077568</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077646</id>
	<title>autoimmunity could be a major side-effect</title>
	<author>Anonymous</author>
	<datestamp>1265708940000</datestamp>
	<modclass>Insightful</modclass>
	<modscore>4</modscore>
	<htmltext>If the exogenous antibodies end up hitting the wrong cells in some people, there could be major problems.

<a href="http://en.wikipedia.org/wiki/Autoimmunity" title="wikipedia.org" rel="nofollow">http://en.wikipedia.org/wiki/Autoimmunity</a> [wikipedia.org]

Although I would expect that there would be some sort of pre-compatibility test to avoid major complications - but you can't realistically pre-test every cell type via biopsy.</htmltext>
<tokenext>If the exogenous antibodies end up hitting the wrong cells in some people , there could be major problems .
http : //en.wikipedia.org/wiki/Autoimmunity [ wikipedia.org ] Although I would expect that there would be some sort of pre-compatibility test to avoid major complications - but you ca n't realistically pre-test every cell type via biopsy .</tokentext>
<sentencetext>If the exogenous antibodies end up hitting the wrong cells in some people, there could be major problems.
http://en.wikipedia.org/wiki/Autoimmunity [wikipedia.org]

Although I would expect that there would be some sort of pre-compatibility test to avoid major complications - but you can't realistically pre-test every cell type via biopsy.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31078562</id>
	<title>Aren't there a ton of health problems</title>
	<author>Phizzle</author>
	<datestamp>1265712600000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><b>that are caused by the antibodies?</b></htmltext>
<tokenext>that are caused by the antibodies ?</tokentext>
<sentencetext>that are caused by the antibodies?</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31078362</id>
	<title>There Are No Words</title>
	<author>HTH NE1</author>
	<datestamp>1265711700000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>Just don't make the new immunity cells so aggressive that they escape the body and start to <a href="http://us.imdb.com/title/tt0663079/" title="imdb.com">eat the ink off of the all books in the world</a> [imdb.com].</p></htmltext>
<tokenext>Just do n't make the new immunity cells so aggressive that they escape the body and start to eat the ink off of the all books in the world [ imdb.com ] .</tokentext>
<sentencetext>Just don't make the new immunity cells so aggressive that they escape the body and start to eat the ink off of the all books in the world [imdb.com].</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31078076</id>
	<title>Re:Funny phrasing</title>
	<author>Anonymous</author>
	<datestamp>1265710740000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p><div class="quote"><p><div class="quote"><p>Derya Unutmaz is an Associate Professor of Microbiology and Pathology at N.Y.U. School of Medicine. His current research is focused on understanding the function of human immune system.</p></div><p>I can tell him right now what the function of the human immune system is: to keep us from getting sick.</p><p>I'll take his grant money now.</p></div><p>Please expand your theory into a 100 page paper with several charts and graphs then submit it to the journal Nature. Once accepted by Nature please resubmit your request and tell us how you'd like the grant, in the form of a check or small non-sequential bills in a briefcase?</p></div>
	</htmltext>
<tokenext>Derya Unutmaz is an Associate Professor of Microbiology and Pathology at N.Y.U .
School of Medicine .
His current research is focused on understanding the function of human immune system.I can tell him right now what the function of the human immune system is : to keep us from getting sick.I 'll take his grant money now.Please expand your theory into a 100 page paper with several charts and graphs then submit it to the journal Nature .
Once accepted by Nature please resubmit your request and tell us how you 'd like the grant , in the form of a check or small non-sequential bills in a briefcase ?</tokentext>
<sentencetext>Derya Unutmaz is an Associate Professor of Microbiology and Pathology at N.Y.U.
School of Medicine.
His current research is focused on understanding the function of human immune system.I can tell him right now what the function of the human immune system is: to keep us from getting sick.I'll take his grant money now.Please expand your theory into a 100 page paper with several charts and graphs then submit it to the journal Nature.
Once accepted by Nature please resubmit your request and tell us how you'd like the grant, in the form of a check or small non-sequential bills in a briefcase?
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077564</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077484</id>
	<title>but then...</title>
	<author>Anonymous</author>
	<datestamp>1265708280000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>umbrella corp will have to nuke raccoon city.  MY MOTHER LIVES THERE MAN!</p></htmltext>
<tokenext>umbrella corp will have to nuke raccoon city .
MY MOTHER LIVES THERE MAN !</tokentext>
<sentencetext>umbrella corp will have to nuke raccoon city.
MY MOTHER LIVES THERE MAN!</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31078188</id>
	<title>Re:Hey, awesome...</title>
	<author>mcgrew</author>
	<datestamp>1265711040000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>People aren't starving for lack of food, it's politics that make people go hungry. As far as overpopulation, there's this thing called "birth control" that the Chinese have been pretty good at mandating in their own country. That book "The Population Bomb" is sadly out of date; according to it, we're all supposed to be dead by now.</p><p>Sure is heartwarming that somebody wants people to die so they can have more kids.</p></htmltext>
<tokenext>People are n't starving for lack of food , it 's politics that make people go hungry .
As far as overpopulation , there 's this thing called " birth control " that the Chinese have been pretty good at mandating in their own country .
That book " The Population Bomb " is sadly out of date ; according to it , we 're all supposed to be dead by now.Sure is heartwarming that somebody wants people to die so they can have more kids .</tokentext>
<sentencetext>People aren't starving for lack of food, it's politics that make people go hungry.
As far as overpopulation, there's this thing called "birth control" that the Chinese have been pretty good at mandating in their own country.
That book "The Population Bomb" is sadly out of date; according to it, we're all supposed to be dead by now.Sure is heartwarming that somebody wants people to die so they can have more kids.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077702</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31081132</id>
	<title>Re:Funny phrasing</title>
	<author>geekoid</author>
	<datestamp>1265727000000</datestamp>
	<modclass>Insightful</modclass>
	<modscore>2</modscore>
	<htmltext><p>Incorrect:</p><p>"to keep us from getting sick."</p><p>Correct:<br>"to keep us from getting a sickness, again."</p></htmltext>
<tokenext>Incorrect : " to keep us from getting sick .
" Correct : " to keep us from getting a sickness , again .
"</tokentext>
<sentencetext>Incorrect:"to keep us from getting sick.
"Correct:"to keep us from getting a sickness, again.
"</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077564</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077634</id>
	<title>Re:I was under the impression</title>
	<author>Anonymous</author>
	<datestamp>1265708880000</datestamp>
	<modclass>Interestin</modclass>
	<modscore>5</modscore>
	<htmltext>For most diseases the antibodies are easier to see because they are more widespread. It only takes a few virally infected cells to set off a massive immune response. The difficulty in engineering an antibody is the same difficulty as engineering any protein. Our knowledge of protein folding is still in it's infancy. So far, we have used evolutionary methods to find new antibodies. Perhaps someday we will be able to build them from the ground up, but not now.</htmltext>
<tokenext>For most diseases the antibodies are easier to see because they are more widespread .
It only takes a few virally infected cells to set off a massive immune response .
The difficulty in engineering an antibody is the same difficulty as engineering any protein .
Our knowledge of protein folding is still in it 's infancy .
So far , we have used evolutionary methods to find new antibodies .
Perhaps someday we will be able to build them from the ground up , but not now .</tokentext>
<sentencetext>For most diseases the antibodies are easier to see because they are more widespread.
It only takes a few virally infected cells to set off a massive immune response.
The difficulty in engineering an antibody is the same difficulty as engineering any protein.
Our knowledge of protein folding is still in it's infancy.
So far, we have used evolutionary methods to find new antibodies.
Perhaps someday we will be able to build them from the ground up, but not now.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077476</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077474</id>
	<title>beating the dead meme</title>
	<author>toastar</author>
	<datestamp>1265708280000</datestamp>
	<modclass>Redundant</modclass>
	<modscore>0</modscore>
	<htmltext><p>I for one welcome our new T cell Overlords</p></htmltext>
<tokenext>I for one welcome our new T cell Overlords</tokentext>
<sentencetext>I for one welcome our new T cell Overlords</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31078332</id>
	<title>Re:I was under...</title>
	<author>Anonymous</author>
	<datestamp>1265711580000</datestamp>
	<modclass>Informativ</modclass>
	<modscore>5</modscore>
	<htmltext>I'm a Biologist, and you're somewhat mistaken.  Antibodies are so infinitesimally tiny that no light microscope can possibly see them, even compared to virii which are also fairly invisible under a microscope.  Antibodies are easy to detect, however, because they have a constant region on their tail end, which we know how to identify.  We have compounds that bind to that constant tail end and as a result tag the antibody and what it is binding to. It's like the antibody is a flag pole, and biologists can run a colorful flag up that pole when we want to see what piece of the ground the flag pole is attached to.<br> <br>
Engineering antibodies is a simple matter, it's the basis of immunization/vaccination. Traditionally, we give chopped up bacteria and virii to a patient and their immune system detects those and creates more antibodies to put into the blood stream to stave off future infection.  With this approach, instead we feed immune cells in a Petri dish an antigen, and they produce antibodies specific to that antigen. We can separate out these antibodies and purify them because they have that constant tail region that we can detect. We can then inject these into a person and these antibodies will cling to whatever thing they've been engineered to detect and attract the native immune system to it.<br> <br>We can also use genetic engineering tricks to produce en masse a single specific kind of antibody. The technology has been there for research labs for decades. Either method will work fairly similarly, but in my opinion the former seems "easier", because we let the cells sort out what specific antibody to make. If we genetically engineer immune cells, we have to know exactly what gene sequence will produce an antibody targetting exactly what we want targetted<nobr> <wbr></nobr>... which is good if we know what the antibody gene sequence is already, but difficult to figure out on our own. Nature is much more efficient (and cost effective) at that kind of thing. Once we let nature figure out what's best, we can just figure out the gene sequence from there to mass produce the antibody.</htmltext>
<tokenext>I 'm a Biologist , and you 're somewhat mistaken .
Antibodies are so infinitesimally tiny that no light microscope can possibly see them , even compared to virii which are also fairly invisible under a microscope .
Antibodies are easy to detect , however , because they have a constant region on their tail end , which we know how to identify .
We have compounds that bind to that constant tail end and as a result tag the antibody and what it is binding to .
It 's like the antibody is a flag pole , and biologists can run a colorful flag up that pole when we want to see what piece of the ground the flag pole is attached to .
Engineering antibodies is a simple matter , it 's the basis of immunization/vaccination .
Traditionally , we give chopped up bacteria and virii to a patient and their immune system detects those and creates more antibodies to put into the blood stream to stave off future infection .
With this approach , instead we feed immune cells in a Petri dish an antigen , and they produce antibodies specific to that antigen .
We can separate out these antibodies and purify them because they have that constant tail region that we can detect .
We can then inject these into a person and these antibodies will cling to whatever thing they 've been engineered to detect and attract the native immune system to it .
We can also use genetic engineering tricks to produce en masse a single specific kind of antibody .
The technology has been there for research labs for decades .
Either method will work fairly similarly , but in my opinion the former seems " easier " , because we let the cells sort out what specific antibody to make .
If we genetically engineer immune cells , we have to know exactly what gene sequence will produce an antibody targetting exactly what we want targetted ... which is good if we know what the antibody gene sequence is already , but difficult to figure out on our own .
Nature is much more efficient ( and cost effective ) at that kind of thing .
Once we let nature figure out what 's best , we can just figure out the gene sequence from there to mass produce the antibody .</tokentext>
<sentencetext>I'm a Biologist, and you're somewhat mistaken.
Antibodies are so infinitesimally tiny that no light microscope can possibly see them, even compared to virii which are also fairly invisible under a microscope.
Antibodies are easy to detect, however, because they have a constant region on their tail end, which we know how to identify.
We have compounds that bind to that constant tail end and as a result tag the antibody and what it is binding to.
It's like the antibody is a flag pole, and biologists can run a colorful flag up that pole when we want to see what piece of the ground the flag pole is attached to.
Engineering antibodies is a simple matter, it's the basis of immunization/vaccination.
Traditionally, we give chopped up bacteria and virii to a patient and their immune system detects those and creates more antibodies to put into the blood stream to stave off future infection.
With this approach, instead we feed immune cells in a Petri dish an antigen, and they produce antibodies specific to that antigen.
We can separate out these antibodies and purify them because they have that constant tail region that we can detect.
We can then inject these into a person and these antibodies will cling to whatever thing they've been engineered to detect and attract the native immune system to it.
We can also use genetic engineering tricks to produce en masse a single specific kind of antibody.
The technology has been there for research labs for decades.
Either method will work fairly similarly, but in my opinion the former seems "easier", because we let the cells sort out what specific antibody to make.
If we genetically engineer immune cells, we have to know exactly what gene sequence will produce an antibody targetting exactly what we want targetted ... which is good if we know what the antibody gene sequence is already, but difficult to figure out on our own.
Nature is much more efficient (and cost effective) at that kind of thing.
Once we let nature figure out what's best, we can just figure out the gene sequence from there to mass produce the antibody.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077476</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077600</id>
	<title>Obligatory tag...</title>
	<author>caladine</author>
	<datestamp>1265708760000</datestamp>
	<modclass>Funny</modclass>
	<modscore>2</modscore>
	<htmltext><p>whatcouldpossiblygowrong</p><p>On a more serious note, this looks promising. I just hope we don't rush into this. The immune system runs a delicate balance, over response is nearly as dangerous as not enough. More research needed.</p></htmltext>
<tokenext>whatcouldpossiblygowrongOn a more serious note , this looks promising .
I just hope we do n't rush into this .
The immune system runs a delicate balance , over response is nearly as dangerous as not enough .
More research needed .</tokentext>
<sentencetext>whatcouldpossiblygowrongOn a more serious note, this looks promising.
I just hope we don't rush into this.
The immune system runs a delicate balance, over response is nearly as dangerous as not enough.
More research needed.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077564</id>
	<title>Funny phrasing</title>
	<author>Anonymous</author>
	<datestamp>1265708640000</datestamp>
	<modclass>Funny</modclass>
	<modscore>3</modscore>
	<htmltext><p><div class="quote"><p>Derya Unutmaz is an Associate Professor of Microbiology and Pathology at N.Y.U. School of Medicine. His current research is focused on understanding the function of human immune system.</p></div><p>I can tell him right now what the function of the human immune system is: to keep us from getting sick.</p><p>I'll take his grant money now.</p></div>
	</htmltext>
<tokenext>Derya Unutmaz is an Associate Professor of Microbiology and Pathology at N.Y.U .
School of Medicine .
His current research is focused on understanding the function of human immune system.I can tell him right now what the function of the human immune system is : to keep us from getting sick.I 'll take his grant money now .</tokentext>
<sentencetext>Derya Unutmaz is an Associate Professor of Microbiology and Pathology at N.Y.U.
School of Medicine.
His current research is focused on understanding the function of human immune system.I can tell him right now what the function of the human immune system is: to keep us from getting sick.I'll take his grant money now.
	</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31083342</id>
	<title>Re:Too much Sci-fi</title>
	<author>Anonymous</author>
	<datestamp>1265018880000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>Engineering Anti-Bodies for a specific purpose is more or less nanotechnology.</p></htmltext>
<tokenext>Engineering Anti-Bodies for a specific purpose is more or less nanotechnology .</tokentext>
<sentencetext>Engineering Anti-Bodies for a specific purpose is more or less nanotechnology.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077804</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31078716</id>
	<title>Re:Boy, Howdy!</title>
	<author>ultranova</author>
	<datestamp>1265713140000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><blockquote><div><p>If you think that the whack-jobs are ballistic about vaccines, wait they go off the rails for something like this!</p></div> </blockquote><p>So? Then they'll end up dying from illnesses the rest of us are immunized to, which is unfortunate from a humanitarian point of view, but that's their own fault, and at least they'll get some herd protection since everyone around them is unable to pass the disease to them. A pity about their children suffering from their parent's stupidity, but maybe they'll wise up once they grow up.</p><p>Then again, with that ballistic tendency, they might find employment in private spaceflight industry as booster rockets<nobr> <wbr></nobr>;).</p></div>
	</htmltext>
<tokenext>If you think that the whack-jobs are ballistic about vaccines , wait they go off the rails for something like this !
So ? Then they 'll end up dying from illnesses the rest of us are immunized to , which is unfortunate from a humanitarian point of view , but that 's their own fault , and at least they 'll get some herd protection since everyone around them is unable to pass the disease to them .
A pity about their children suffering from their parent 's stupidity , but maybe they 'll wise up once they grow up.Then again , with that ballistic tendency , they might find employment in private spaceflight industry as booster rockets ; ) .</tokentext>
<sentencetext>If you think that the whack-jobs are ballistic about vaccines, wait they go off the rails for something like this!
So? Then they'll end up dying from illnesses the rest of us are immunized to, which is unfortunate from a humanitarian point of view, but that's their own fault, and at least they'll get some herd protection since everyone around them is unable to pass the disease to them.
A pity about their children suffering from their parent's stupidity, but maybe they'll wise up once they grow up.Then again, with that ballistic tendency, they might find employment in private spaceflight industry as booster rockets ;).
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077660</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077862</id>
	<title>Star Trek did it</title>
	<author>Anonymous</author>
	<datestamp>1265709900000</datestamp>
	<modclass>Interestin</modclass>
	<modscore>2</modscore>
	<htmltext>Wasn't there a Star Trek: TNG episode where they did this? Remember how everyone who wasn't engineered was dying?<br> <br>Na, that'll never happen.</htmltext>
<tokenext>Was n't there a Star Trek : TNG episode where they did this ?
Remember how everyone who was n't engineered was dying ?
Na , that 'll never happen .</tokentext>
<sentencetext>Wasn't there a Star Trek: TNG episode where they did this?
Remember how everyone who wasn't engineered was dying?
Na, that'll never happen.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077644</id>
	<title>Re-Engineering?</title>
	<author>Itninja</author>
	<datestamp>1265708940000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>I believe it should be "Re-Randomchanceing the immune system". Remember, something cannot be accidentally engineered. The summary writer is clearly in the pocket of Big I.D.<nobr> <wbr></nobr>/sarcasm</htmltext>
<tokenext>I believe it should be " Re-Randomchanceing the immune system " .
Remember , something can not be accidentally engineered .
The summary writer is clearly in the pocket of Big I.D .
/sarcasm</tokentext>
<sentencetext>I believe it should be "Re-Randomchanceing the immune system".
Remember, something cannot be accidentally engineered.
The summary writer is clearly in the pocket of Big I.D.
/sarcasm</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31080376</id>
	<title>ABs are not everything</title>
	<author>Corson</author>
	<datestamp>1265721780000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>Antibodies are only one and not the most important component of the immune reaction against viruses. T-cells are more important and less easy to... engineer, in this sense.</htmltext>
<tokenext>Antibodies are only one and not the most important component of the immune reaction against viruses .
T-cells are more important and less easy to... engineer , in this sense .</tokentext>
<sentencetext>Antibodies are only one and not the most important component of the immune reaction against viruses.
T-cells are more important and less easy to... engineer, in this sense.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077726</id>
	<title>The Professor Should First Read The  Patent</title>
	<author>Anonymous</author>
	<datestamp>1265709300000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>application for <a href="http://www.google.com/patents/about?id=3M6UAAAAEBAJ&amp;dq=altermune" title="google.com" rel="nofollow">Altermune</a> [google.com] by Kary Mullis (Oct, 29, 2003)</p><p>The professor has been doing too much reading and not enough thinking as Richard Hamming observed.</p><p>Yours In Moscow,<br>Kilgore T.</p></htmltext>
<tokenext>application for Altermune [ google.com ] by Kary Mullis ( Oct , 29 , 2003 ) The professor has been doing too much reading and not enough thinking as Richard Hamming observed.Yours In Moscow,Kilgore T .</tokentext>
<sentencetext>application for Altermune [google.com] by Kary Mullis (Oct, 29, 2003)The professor has been doing too much reading and not enough thinking as Richard Hamming observed.Yours In Moscow,Kilgore T.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31078988</id>
	<title>Re:Boy, Howdy!</title>
	<author>Anonymous</author>
	<datestamp>1265714340000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p><div class="quote"><p>If you think that the whack-jobs are ballistic about vaccines, wait they go off the rails for something like this!</p></div><p>Yeah. Good thing we normal folks are ok with instantly whiping out millions of years of evolution with zero critical thought, because some dude said he's the expert on this stuff.</p></div>
	</htmltext>
<tokenext>If you think that the whack-jobs are ballistic about vaccines , wait they go off the rails for something like this ! Yeah .
Good thing we normal folks are ok with instantly whiping out millions of years of evolution with zero critical thought , because some dude said he 's the expert on this stuff .</tokentext>
<sentencetext>If you think that the whack-jobs are ballistic about vaccines, wait they go off the rails for something like this!Yeah.
Good thing we normal folks are ok with instantly whiping out millions of years of evolution with zero critical thought, because some dude said he's the expert on this stuff.
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077660</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077694</id>
	<title>vaccination 2.0</title>
	<author>Alinabi</author>
	<datestamp>1265709180000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>So this is, like, vaccination 2.0. Is this a ploy to make vaccination more palatable to the freaks who think vaccines cause autism?</htmltext>
<tokenext>So this is , like , vaccination 2.0 .
Is this a ploy to make vaccination more palatable to the freaks who think vaccines cause autism ?</tokentext>
<sentencetext>So this is, like, vaccination 2.0.
Is this a ploy to make vaccination more palatable to the freaks who think vaccines cause autism?</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31078360</id>
	<title>Re:Star Trek did it</title>
	<author>jburroug</author>
	<datestamp>1265711700000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p><a href="http://memory-alpha.org/en/wiki/Unnatural\_Selection\_(episode)" title="memory-alpha.org"> Yes they did </a> [memory-alpha.org] But no one remembers because it was a Dr. Pulaski episode.</p></htmltext>
<tokenext>Yes they did [ memory-alpha.org ] But no one remembers because it was a Dr. Pulaski episode .</tokentext>
<sentencetext> Yes they did  [memory-alpha.org] But no one remembers because it was a Dr. Pulaski episode.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077862</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077702</id>
	<title>Hey, awesome...</title>
	<author>Anonymous</author>
	<datestamp>1265709180000</datestamp>
	<modclass>Insightful</modclass>
	<modscore>1</modscore>
	<htmltext><p>Lets cure all natural causes of death through the miracle of modern science.<br>Then starve to death as the world becomes grossly overpopulated.</p></htmltext>
<tokenext>Lets cure all natural causes of death through the miracle of modern science.Then starve to death as the world becomes grossly overpopulated .</tokentext>
<sentencetext>Lets cure all natural causes of death through the miracle of modern science.Then starve to death as the world becomes grossly overpopulated.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31079464</id>
	<title>Re:Funny phrasing</title>
	<author>Anonymous</author>
	<datestamp>1265716320000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p><div class="quote"><p>I can tell him right now what the function of [my computer] system is: to [read slashdot].</p></div><p>It's fun to simplify and summarize. (And yeah, paraphrasing is mildly entertaining as well).</p></div>
	</htmltext>
<tokenext>I can tell him right now what the function of [ my computer ] system is : to [ read slashdot ] .It 's fun to simplify and summarize .
( And yeah , paraphrasing is mildly entertaining as well ) .</tokentext>
<sentencetext>I can tell him right now what the function of [my computer] system is: to [read slashdot].It's fun to simplify and summarize.
(And yeah, paraphrasing is mildly entertaining as well).
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077564</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31078088</id>
	<title>Re:And then when a new disease cones along ...</title>
	<author>maxume</author>
	<datestamp>1265710740000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>Yeah, and lots of Europeans still died of all sorts of diseases, right up until vaccines and antibiotics were discovered.</p><p>I'd rather have antibiotics and vaccines than be proud of all the exercise my immune system has had. And that is leaving aside the part where no one has ever explained to me why I should view my immune system as a muscle.</p></htmltext>
<tokenext>Yeah , and lots of Europeans still died of all sorts of diseases , right up until vaccines and antibiotics were discovered.I 'd rather have antibiotics and vaccines than be proud of all the exercise my immune system has had .
And that is leaving aside the part where no one has ever explained to me why I should view my immune system as a muscle .</tokentext>
<sentencetext>Yeah, and lots of Europeans still died of all sorts of diseases, right up until vaccines and antibiotics were discovered.I'd rather have antibiotics and vaccines than be proud of all the exercise my immune system has had.
And that is leaving aside the part where no one has ever explained to me why I should view my immune system as a muscle.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment10_02_09_1833219.31077612</parent>
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