<article>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#article09_12_26_1826205</id>
	<title>Real-World Synthehol In Development</title>
	<author>timothy</author>
	<datestamp>1261814880000</datestamp>
	<htmltext>Ada\_Rules writes <i>"Researchers at the Imperial College London have announced <a href="http://www.telegraph.co.uk/health/healthnews/6874884/Alcohol-substitute-that-avoids-drunkenness-and-hangovers-in-development.html">development of an alcohol substitute</a> that has many of the same properties as the <a href="http://memory-alpha.org/en/wiki/Synthehol">Synthehol</a> from the series <em>Star Trek</em>, in that one will get a buzz from it but will not end up with a hangover. In addition you will have the option of getting immediately sober if you so desire it. Let's hope this is not the typical vaporware. It is not that I really want a drink of Synthehol, but with its release I assume Romulan Ale won't be far behind."</i></htmltext>
<tokenext>Ada \ _Rules writes " Researchers at the Imperial College London have announced development of an alcohol substitute that has many of the same properties as the Synthehol from the series Star Trek , in that one will get a buzz from it but will not end up with a hangover .
In addition you will have the option of getting immediately sober if you so desire it .
Let 's hope this is not the typical vaporware .
It is not that I really want a drink of Synthehol , but with its release I assume Romulan Ale wo n't be far behind .
"</tokentext>
<sentencetext>Ada\_Rules writes "Researchers at the Imperial College London have announced development of an alcohol substitute that has many of the same properties as the Synthehol from the series Star Trek, in that one will get a buzz from it but will not end up with a hangover.
In addition you will have the option of getting immediately sober if you so desire it.
Let's hope this is not the typical vaporware.
It is not that I really want a drink of Synthehol, but with its release I assume Romulan Ale won't be far behind.
"</sentencetext>
</article>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30568812</id>
	<title>Re:The Puritans won't like this.</title>
	<author>LordLimecat</author>
	<datestamp>1261943520000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>Seems like a lot of people dont like this.  But dont let that stop you from bashing groups you dont like, im sure Microsoft wont like this either. (did I do that right?)</htmltext>
<tokenext>Seems like a lot of people dont like this .
But dont let that stop you from bashing groups you dont like , im sure Microsoft wont like this either .
( did I do that right ?
)</tokentext>
<sentencetext>Seems like a lot of people dont like this.
But dont let that stop you from bashing groups you dont like, im sure Microsoft wont like this either.
(did I do that right?
)</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558322</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558446</id>
	<title>Containers</title>
	<author>Anonymous</author>
	<datestamp>1261822860000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>Don't forget to sell it in Transparent Aluminum cans.</p></htmltext>
<tokenext>Do n't forget to sell it in Transparent Aluminum cans .</tokentext>
<sentencetext>Don't forget to sell it in Transparent Aluminum cans.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30560684</id>
	<title>Re:Headache?</title>
	<author>sjames</author>
	<datestamp>1261848540000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>If your stomach is up to it, regular old aspirin is a much better choice. If your stomach can't handle the aspirin you probably shouldn't be filling it with alcohol either.</p></htmltext>
<tokenext>If your stomach is up to it , regular old aspirin is a much better choice .
If your stomach ca n't handle the aspirin you probably should n't be filling it with alcohol either .</tokentext>
<sentencetext>If your stomach is up to it, regular old aspirin is a much better choice.
If your stomach can't handle the aspirin you probably shouldn't be filling it with alcohol either.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558026</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30560296</id>
	<title>Better Living Through Chemistry.</title>
	<author>KneelBeforeZod</author>
	<datestamp>1261843140000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>I move to add this title as a tag.</p><p>But seriously, I'm curious.  How much of this synthehol can you drink before overdosing?  And what about the effects of mixing it with REAL alcohol?  There isn't anything you can't consume too much of, even water.<br>The alcoholic in me says I'm gonna try some as soon as it comes out.</p></htmltext>
<tokenext>I move to add this title as a tag.But seriously , I 'm curious .
How much of this synthehol can you drink before overdosing ?
And what about the effects of mixing it with REAL alcohol ?
There is n't anything you ca n't consume too much of , even water.The alcoholic in me says I 'm gon na try some as soon as it comes out .</tokentext>
<sentencetext>I move to add this title as a tag.But seriously, I'm curious.
How much of this synthehol can you drink before overdosing?
And what about the effects of mixing it with REAL alcohol?
There isn't anything you can't consume too much of, even water.The alcoholic in me says I'm gonna try some as soon as it comes out.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558664</id>
	<title>So I can bed green women with no ill effects now?</title>
	<author>howardd21</author>
	<datestamp>1261824420000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>Capt Kirk did it, so now I can too.</htmltext>
<tokenext>Capt Kirk did it , so now I can too .</tokentext>
<sentencetext>Capt Kirk did it, so now I can too.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558408</id>
	<title>I'm not alone</title>
	<author>7-Vodka</author>
	<datestamp>1261822500000</datestamp>
	<modclass>Insightful</modclass>
	<modscore>5</modscore>
	<htmltext><p> You know the first thing I'm gonna fucking do, is mix this shit in my rum and cokes while chewing some nicotine gum and smoking a fat joint.<br>
And I know I'm not the only one.</p></htmltext>
<tokenext>You know the first thing I 'm gon na fucking do , is mix this shit in my rum and cokes while chewing some nicotine gum and smoking a fat joint .
And I know I 'm not the only one .</tokentext>
<sentencetext> You know the first thing I'm gonna fucking do, is mix this shit in my rum and cokes while chewing some nicotine gum and smoking a fat joint.
And I know I'm not the only one.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30560404</id>
	<title>Re:Actually, we do have safe alcohol substitute</title>
	<author>Kjella</author>
	<datestamp>1261844580000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>Speaking as one that got very drunk on it tonight, the better question is if alcohol "should" be illegal. On that scale it's high but all things considered, prohibition would be worse. Letting every other drug free would be worse. We're living in a little bubble where we do one unhealthy thing and you put it up as if we'd do alcohol or cannabis or LSD or ecstacy. Truth is there'd probably be a lot of ands in there. Living without stimulants is hard, if you took away coffee most people would freak. I've "picked my poison", and I know it's not ideal. But somehow I don't thing letting every lesser drug free would improve the situation. My 0,02c, YMMV.</p></htmltext>
<tokenext>Speaking as one that got very drunk on it tonight , the better question is if alcohol " should " be illegal .
On that scale it 's high but all things considered , prohibition would be worse .
Letting every other drug free would be worse .
We 're living in a little bubble where we do one unhealthy thing and you put it up as if we 'd do alcohol or cannabis or LSD or ecstacy .
Truth is there 'd probably be a lot of ands in there .
Living without stimulants is hard , if you took away coffee most people would freak .
I 've " picked my poison " , and I know it 's not ideal .
But somehow I do n't thing letting every lesser drug free would improve the situation .
My 0,02c , YMMV .</tokentext>
<sentencetext>Speaking as one that got very drunk on it tonight, the better question is if alcohol "should" be illegal.
On that scale it's high but all things considered, prohibition would be worse.
Letting every other drug free would be worse.
We're living in a little bubble where we do one unhealthy thing and you put it up as if we'd do alcohol or cannabis or LSD or ecstacy.
Truth is there'd probably be a lot of ands in there.
Living without stimulants is hard, if you took away coffee most people would freak.
I've "picked my poison", and I know it's not ideal.
But somehow I don't thing letting every lesser drug free would improve the situation.
My 0,02c, YMMV.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558536</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558434</id>
	<title>Thanks but No Thanks!</title>
	<author>Vinegar Joe</author>
	<datestamp>1261822800000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>I'll just stick with Saurian Brandy.</p></htmltext>
<tokenext>I 'll just stick with Saurian Brandy .</tokentext>
<sentencetext>I'll just stick with Saurian Brandy.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30559278</id>
	<title>Why Bother?</title>
	<author>flajann</author>
	<datestamp>1261829580000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>Why bother with creating synthehol when legalizing marijuana would have the same effect -- plus, we know marijuana won't destroy your body. Who knows what this synthehol will do to you in 10 years?</htmltext>
<tokenext>Why bother with creating synthehol when legalizing marijuana would have the same effect -- plus , we know marijuana wo n't destroy your body .
Who knows what this synthehol will do to you in 10 years ?</tokentext>
<sentencetext>Why bother with creating synthehol when legalizing marijuana would have the same effect -- plus, we know marijuana won't destroy your body.
Who knows what this synthehol will do to you in 10 years?</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30557978</id>
	<title>Headache?</title>
	<author>Anonymous</author>
	<datestamp>1261818960000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>What junk are you drinking? Smirnoff?</p><p>It isn't the alcohol which gives you a headache. It's the alcohol in combination with the rest of the crap in the beverage.</p><p>Either buy decent quality and/or drink a glass of water for each drink and take two paracetamol before you go to bed.<br>
&nbsp;</p></htmltext>
<tokenext>What junk are you drinking ?
Smirnoff ? It is n't the alcohol which gives you a headache .
It 's the alcohol in combination with the rest of the crap in the beverage.Either buy decent quality and/or drink a glass of water for each drink and take two paracetamol before you go to bed .
 </tokentext>
<sentencetext>What junk are you drinking?
Smirnoff?It isn't the alcohol which gives you a headache.
It's the alcohol in combination with the rest of the crap in the beverage.Either buy decent quality and/or drink a glass of water for each drink and take two paracetamol before you go to bed.
 </sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558142</id>
	<title>Re:Headache?</title>
	<author>Abcd1234</author>
	<datestamp>1261820160000</datestamp>
	<modclass>Informativ</modclass>
	<modscore>4</modscore>
	<htmltext><p>Uh, no.  Put down the drink, it seems to have damaged your brain.</p><p>The primary cause of most hangover symptoms is very simple:  Dehydration.  The rest are caused by the presence of metabolic by-products of alcohol, which cause, among other things, a decline in available glucose for use by the brain, inhibition of liver function, and vitamin B12 deficiency.</p><p>For more information, wikipedia is <a href="http://en.wikipedia.org/wiki/Hangover" title="wikipedia.org">your friend</a> [wikipedia.org].</p></htmltext>
<tokenext>Uh , no .
Put down the drink , it seems to have damaged your brain.The primary cause of most hangover symptoms is very simple : Dehydration .
The rest are caused by the presence of metabolic by-products of alcohol , which cause , among other things , a decline in available glucose for use by the brain , inhibition of liver function , and vitamin B12 deficiency.For more information , wikipedia is your friend [ wikipedia.org ] .</tokentext>
<sentencetext>Uh, no.
Put down the drink, it seems to have damaged your brain.The primary cause of most hangover symptoms is very simple:  Dehydration.
The rest are caused by the presence of metabolic by-products of alcohol, which cause, among other things, a decline in available glucose for use by the brain, inhibition of liver function, and vitamin B12 deficiency.For more information, wikipedia is your friend [wikipedia.org].</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30557978</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558468</id>
	<title>GHB/GBL</title>
	<author>Anonymous</author>
	<datestamp>1261822980000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>I have always found GHB and/or GBL to be excellent alcohol substitutes. They wear off in a few hours and leave you with no hangover. Unless you mix it with other depressants (alcohol, I'm looking at YOU!) or otherwise overdose you are fine the next day. Not sure about the sobering up-pill though, I don't know enough about the selectivity of their action on GABA. My guess is that it's similar to bensodiazepines.</p></htmltext>
<tokenext>I have always found GHB and/or GBL to be excellent alcohol substitutes .
They wear off in a few hours and leave you with no hangover .
Unless you mix it with other depressants ( alcohol , I 'm looking at YOU !
) or otherwise overdose you are fine the next day .
Not sure about the sobering up-pill though , I do n't know enough about the selectivity of their action on GABA .
My guess is that it 's similar to bensodiazepines .</tokentext>
<sentencetext>I have always found GHB and/or GBL to be excellent alcohol substitutes.
They wear off in a few hours and leave you with no hangover.
Unless you mix it with other depressants (alcohol, I'm looking at YOU!
) or otherwise overdose you are fine the next day.
Not sure about the sobering up-pill though, I don't know enough about the selectivity of their action on GABA.
My guess is that it's similar to bensodiazepines.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558814</id>
	<title>Synthehol?</title>
	<author>Anonymous</author>
	<datestamp>1261825620000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>This many comments, and not a single<nobr> <wbr></nobr>/. nerd has corrected the article's total misunderstanding of Synthehol from Star Trek?</p><p>Synthehol is what Starfleet crews can drink while on duty because it tastes like the real thing but DOESN'T give you a buzz or get you drunk.</p></htmltext>
<tokenext>This many comments , and not a single / .
nerd has corrected the article 's total misunderstanding of Synthehol from Star Trek ? Synthehol is what Starfleet crews can drink while on duty because it tastes like the real thing but DOES N'T give you a buzz or get you drunk .</tokentext>
<sentencetext>This many comments, and not a single /.
nerd has corrected the article's total misunderstanding of Synthehol from Star Trek?Synthehol is what Starfleet crews can drink while on duty because it tastes like the real thing but DOESN'T give you a buzz or get you drunk.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558026</id>
	<title>Re:Headache?</title>
	<author>maxume</author>
	<datestamp>1261819320000</datestamp>
	<modclass>Informativ</modclass>
	<modscore>3</modscore>
	<htmltext><p>Mixing acetaminophen with alcohol is terrible advice.</p></htmltext>
<tokenext>Mixing acetaminophen with alcohol is terrible advice .</tokentext>
<sentencetext>Mixing acetaminophen with alcohol is terrible advice.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30557978</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30569628</id>
	<title>Re:Toxicity</title>
	<author>Anonymous</author>
	<datestamp>1262002560000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>Oral ingestion has little to do with whether the liver metabolizes something...</p><p>However, your concern is valid; these substances are toxic to the liver, although they don't metabolize into a toxic substance like alcohol (which is part of the cause of hangovers).</p><p>I'm not sure whether sufficient doses can even cause acute toxicity (which alcohol doesn't do, but your common analgesics do), which would make this substitute considerably more dangerous than alcohol.  Alcohol is fairly difficult to overdose on, since you tend to pass out first and it's easy to develop tolerance to its effects including the lethal ones, whereas with something else you could develop tolerance to the noticeable effects but not the ones that have the potential to cause death.</p></htmltext>
<tokenext>Oral ingestion has little to do with whether the liver metabolizes something...However , your concern is valid ; these substances are toxic to the liver , although they do n't metabolize into a toxic substance like alcohol ( which is part of the cause of hangovers ) .I 'm not sure whether sufficient doses can even cause acute toxicity ( which alcohol does n't do , but your common analgesics do ) , which would make this substitute considerably more dangerous than alcohol .
Alcohol is fairly difficult to overdose on , since you tend to pass out first and it 's easy to develop tolerance to its effects including the lethal ones , whereas with something else you could develop tolerance to the noticeable effects but not the ones that have the potential to cause death .</tokentext>
<sentencetext>Oral ingestion has little to do with whether the liver metabolizes something...However, your concern is valid; these substances are toxic to the liver, although they don't metabolize into a toxic substance like alcohol (which is part of the cause of hangovers).I'm not sure whether sufficient doses can even cause acute toxicity (which alcohol doesn't do, but your common analgesics do), which would make this substitute considerably more dangerous than alcohol.
Alcohol is fairly difficult to overdose on, since you tend to pass out first and it's easy to develop tolerance to its effects including the lethal ones, whereas with something else you could develop tolerance to the noticeable effects but not the ones that have the potential to cause death.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558244</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558652</id>
	<title>I am not a doctor</title>
	<author>vorlich</author>
	<datestamp>1261824300000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>but I know someone who is. They would advise all slashdotters (and anyone else for that matter) that it is an incredibly bad idea to take any paracetamol when you have been drinking alcohol <a href="http://en.wikipedia.org/wiki/Paracetamol" title="wikipedia.org">http://en.wikipedia.org/wiki/Paracetamol</a> [wikipedia.org]. <br>It is very toxic to your liver. Better to drink responsibly, consume quality products and remember that a reasonable consumption of water only protects you from the effects of hydration but has no real effect on the contaminants that cause the headache and nausea. Wait until the alcohol has been metabolised (2 hours per unit) and then take the lowest dose possible or some other analgesic.</htmltext>
<tokenext>but I know someone who is .
They would advise all slashdotters ( and anyone else for that matter ) that it is an incredibly bad idea to take any paracetamol when you have been drinking alcohol http : //en.wikipedia.org/wiki/Paracetamol [ wikipedia.org ] .
It is very toxic to your liver .
Better to drink responsibly , consume quality products and remember that a reasonable consumption of water only protects you from the effects of hydration but has no real effect on the contaminants that cause the headache and nausea .
Wait until the alcohol has been metabolised ( 2 hours per unit ) and then take the lowest dose possible or some other analgesic .</tokentext>
<sentencetext>but I know someone who is.
They would advise all slashdotters (and anyone else for that matter) that it is an incredibly bad idea to take any paracetamol when you have been drinking alcohol http://en.wikipedia.org/wiki/Paracetamol [wikipedia.org].
It is very toxic to your liver.
Better to drink responsibly, consume quality products and remember that a reasonable consumption of water only protects you from the effects of hydration but has no real effect on the contaminants that cause the headache and nausea.
Wait until the alcohol has been metabolised (2 hours per unit) and then take the lowest dose possible or some other analgesic.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30561062</id>
	<title>Re:The Puritans won't like this.</title>
	<author>Anonymous</author>
	<datestamp>1261854420000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext>One word: faggots.</htmltext>
<tokenext>One word : faggots .</tokentext>
<sentencetext>One word: faggots.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558322</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30559838</id>
	<title>To quote Worf</title>
	<author>gyrogeerloose</author>
	<datestamp>1261835940000</datestamp>
	<modclass>Funny</modclass>
	<modscore>4</modscore>
	<htmltext>"Less talk, more synthehol!"</htmltext>
<tokenext>" Less talk , more synthehol !
"</tokentext>
<sentencetext>"Less talk, more synthehol!
"</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30561418</id>
	<title>Metabolizing acetaldehyde</title>
	<author>jones\_supa</author>
	<datestamp>1261946580000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>I actually recently found a quite interesting technique to <a href="http://www.ceri.com/alcohol.htm" title="ceri.com" rel="nofollow">avoid a hangover</a> [ceri.com]. It basically involves taking cysteine with vitamin C to neutralize acetaldehyde, while drinking. I already did some experimenting and I think there might be something to this.</p><p>The guy was a couple of days ago on a <a href="http://www.youtube.com/watch?v=-PA-buwI3q4" title="youtube.com" rel="nofollow">Google Tech Talk</a> [youtube.com] in which he discussed about other nutrients for the mind too.</p></htmltext>
<tokenext>I actually recently found a quite interesting technique to avoid a hangover [ ceri.com ] .
It basically involves taking cysteine with vitamin C to neutralize acetaldehyde , while drinking .
I already did some experimenting and I think there might be something to this.The guy was a couple of days ago on a Google Tech Talk [ youtube.com ] in which he discussed about other nutrients for the mind too .</tokentext>
<sentencetext>I actually recently found a quite interesting technique to avoid a hangover [ceri.com].
It basically involves taking cysteine with vitamin C to neutralize acetaldehyde, while drinking.
I already did some experimenting and I think there might be something to this.The guy was a couple of days ago on a Google Tech Talk [youtube.com] in which he discussed about other nutrients for the mind too.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558326</id>
	<title>The real questions</title>
	<author>mmmmbeer</author>
	<datestamp>1261821660000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>Can I blame my mistakes on my friends and a case of synthehol?  Can I drink a girl pretty with synthehol?  Will this help ugly people get laid?  These are the important questions!</p></htmltext>
<tokenext>Can I blame my mistakes on my friends and a case of synthehol ?
Can I drink a girl pretty with synthehol ?
Will this help ugly people get laid ?
These are the important questions !</tokentext>
<sentencetext>Can I blame my mistakes on my friends and a case of synthehol?
Can I drink a girl pretty with synthehol?
Will this help ugly people get laid?
These are the important questions!</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30559656</id>
	<title>Schedule I, anyone?</title>
	<author>NewWazoo</author>
	<datestamp>1261833600000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>Okay, so let me get this straight:<br><br>it's a chemical,<br>that's meant to be ingested, (and thus a drug)<br>and that has no medical use,<br>and (presumably, like alcohol) is likely to be abused,<br>and that (presumably) can cause damage or death if abused.<br><br>By US law at present, this should be Schedule I and banned immediately.</htmltext>
<tokenext>Okay , so let me get this straight : it 's a chemical,that 's meant to be ingested , ( and thus a drug ) and that has no medical use,and ( presumably , like alcohol ) is likely to be abused,and that ( presumably ) can cause damage or death if abused.By US law at present , this should be Schedule I and banned immediately .</tokentext>
<sentencetext>Okay, so let me get this straight:it's a chemical,that's meant to be ingested, (and thus a drug)and that has no medical use,and (presumably, like alcohol) is likely to be abused,and that (presumably) can cause damage or death if abused.By US law at present, this should be Schedule I and banned immediately.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30559682</id>
	<title>I don't get it ?</title>
	<author>daveime</author>
	<datestamp>1261833960000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>Why is is acceptable for scientists to produce synthetic alcohol, whne in the same week the FDA have just banned another set of synthetic / natural marijuana substitutes ?</p><p>Alcohol is well known to cause aggression and does untold damage to the liver. Whereas most soft drugs make you passive and give you the munchies, yet there is little proven research on the long term effects to the body.</p><p>Could it be that if we actually applied some common sense (i.e. ignored the Americans), there'd be one less "war on [topic]" for them to fuck up ? Prohibition didn't work in the 20's, you'd think they'd have learnt SOMETHING from that ?</p></htmltext>
<tokenext>Why is is acceptable for scientists to produce synthetic alcohol , whne in the same week the FDA have just banned another set of synthetic / natural marijuana substitutes ? Alcohol is well known to cause aggression and does untold damage to the liver .
Whereas most soft drugs make you passive and give you the munchies , yet there is little proven research on the long term effects to the body.Could it be that if we actually applied some common sense ( i.e .
ignored the Americans ) , there 'd be one less " war on [ topic ] " for them to fuck up ?
Prohibition did n't work in the 20 's , you 'd think they 'd have learnt SOMETHING from that ?</tokentext>
<sentencetext>Why is is acceptable for scientists to produce synthetic alcohol, whne in the same week the FDA have just banned another set of synthetic / natural marijuana substitutes ?Alcohol is well known to cause aggression and does untold damage to the liver.
Whereas most soft drugs make you passive and give you the munchies, yet there is little proven research on the long term effects to the body.Could it be that if we actually applied some common sense (i.e.
ignored the Americans), there'd be one less "war on [topic]" for them to fuck up ?
Prohibition didn't work in the 20's, you'd think they'd have learnt SOMETHING from that ?</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558938</id>
	<title>Re:Better Profit Through Pharmaceuticals</title>
	<author>Anonymous</author>
	<datestamp>1261826460000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>Alcohol has the same well-known and deserved reputation for causing addition, tolerance, and withdrawal.  Alcohol withdrawal can kill an addict.  Valium withdrawal is just unpleasant for the user and those around him.</p><p>This is the same crowd that argues so fervently for the legalization of pot because (partly) it's safer.  Why is there such a strong objection to a "safer" alcohol?</p></htmltext>
<tokenext>Alcohol has the same well-known and deserved reputation for causing addition , tolerance , and withdrawal .
Alcohol withdrawal can kill an addict .
Valium withdrawal is just unpleasant for the user and those around him.This is the same crowd that argues so fervently for the legalization of pot because ( partly ) it 's safer .
Why is there such a strong objection to a " safer " alcohol ?</tokentext>
<sentencetext>Alcohol has the same well-known and deserved reputation for causing addition, tolerance, and withdrawal.
Alcohol withdrawal can kill an addict.
Valium withdrawal is just unpleasant for the user and those around him.This is the same crowd that argues so fervently for the legalization of pot because (partly) it's safer.
Why is there such a strong objection to a "safer" alcohol?</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558230</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30562690</id>
	<title>Re:Actually, we do have safe alcohol substitute</title>
	<author>Anonymous</author>
	<datestamp>1261923660000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>Long term use of ecstacy (MDMA) is quite bad for you:</p><p>http://www.drugabuse.gov/nida\_notes/nnvol14n4/Ecstasy.html<br>http://www.mdma.net/toxicity/damage.html<br>http://faculty.washington.edu/chudler/mdma.html</p><p>I'd like to see the report in detail to know why he scored it so low.</p></htmltext>
<tokenext>Long term use of ecstacy ( MDMA ) is quite bad for you : http : //www.drugabuse.gov/nida \ _notes/nnvol14n4/Ecstasy.htmlhttp : //www.mdma.net/toxicity/damage.htmlhttp : //faculty.washington.edu/chudler/mdma.htmlI 'd like to see the report in detail to know why he scored it so low .</tokentext>
<sentencetext>Long term use of ecstacy (MDMA) is quite bad for you:http://www.drugabuse.gov/nida\_notes/nnvol14n4/Ecstasy.htmlhttp://www.mdma.net/toxicity/damage.htmlhttp://faculty.washington.edu/chudler/mdma.htmlI'd like to see the report in detail to know why he scored it so low.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558536</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558772</id>
	<title>Re:Better Profit Through Pharmaceuticals</title>
	<author>Hurricane78</author>
	<datestamp>1261825140000</datestamp>
	<modclass>Interestin</modclass>
	<modscore>2</modscore>
	<htmltext><p>Benzoes? How did a friend say: I tried everything. Even Heroine. But that benzo shit? That&rsquo;s even worse!</p></htmltext>
<tokenext>Benzoes ?
How did a friend say : I tried everything .
Even Heroine .
But that benzo shit ?
That    s even worse !</tokentext>
<sentencetext>Benzoes?
How did a friend say: I tried everything.
Even Heroine.
But that benzo shit?
That’s even worse!</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558230</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30566560</id>
	<title>You shouldn't be getting a headache anyway</title>
	<author>thetoadwarrior</author>
	<datestamp>1261917180000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>Don't drink shit and replace the water you piss out. A pint of water just before bed will stop virtually all headaches.</htmltext>
<tokenext>Do n't drink shit and replace the water you piss out .
A pint of water just before bed will stop virtually all headaches .</tokentext>
<sentencetext>Don't drink shit and replace the water you piss out.
A pint of water just before bed will stop virtually all headaches.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558552</id>
	<title>Re:Headache?</title>
	<author>adamchou</author>
	<datestamp>1261823640000</datestamp>
	<modclass>Informativ</modclass>
	<modscore>3</modscore>
	<htmltext><p>and yet the article in wikipedia clearly says...</p><p>"Hypoglycemia, dehydration, acetaldehyde intoxication, and vitamin B12 deficiency are all <b>theorized</b> causes of hangover symptoms". </p><p>so how can you authoritatively assert what causes a hangover when the scientists, at least according to that article, aren't even sure?</p></htmltext>
<tokenext>and yet the article in wikipedia clearly says... " Hypoglycemia , dehydration , acetaldehyde intoxication , and vitamin B12 deficiency are all theorized causes of hangover symptoms " .
so how can you authoritatively assert what causes a hangover when the scientists , at least according to that article , are n't even sure ?</tokentext>
<sentencetext>and yet the article in wikipedia clearly says..."Hypoglycemia, dehydration, acetaldehyde intoxication, and vitamin B12 deficiency are all theorized causes of hangover symptoms".
so how can you authoritatively assert what causes a hangover when the scientists, at least according to that article, aren't even sure?</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558142</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558384</id>
	<title>From the article...</title>
	<author>Anonymous</author>
	<datestamp>1261822320000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>Professor Nutt got sacked.</p></htmltext>
<tokenext>Professor Nutt got sacked .</tokentext>
<sentencetext>Professor Nutt got sacked.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30557974</id>
	<title>First Postohol</title>
	<author>Anonymous</author>
	<datestamp>1261818900000</datestamp>
	<modclass>None</modclass>
	<modscore>-1</modscore>
	<htmltext><p>This is 100 percent non-synthetic.</p></htmltext>
<tokenext>This is 100 percent non-synthetic .</tokentext>
<sentencetext>This is 100 percent non-synthetic.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30561452</id>
	<title>Hangover Cure: Research in wrong direction?</title>
	<author>w0mprat</author>
	<datestamp>1261947000000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>Wouldn't boosting the function of acetaldehyde dehydrogenase enzyme help mitigate the damaging effects of alcohol and lessen your hangover? As acetaldehyde is theorized to the be the primary cause of a hangover and at least the primary cause of long term harm, this strikes me as an obvious target for harm reduction research. Especially since this would not mess with the metabolism of ethanol directly (alcohol dehydrogenase - which could make you dangerously drunk, or sober and hungover too fast). The final stage, acetic acid is next to harmless, well it's vinegar basically.

To quote wikipedia: <p><div class="quote"><p>Ethanol is converted to acetaldehyde by the enzyme alcohol dehydrogenase, and then from acetaldehyde to acetic acid by the enzyme <b>acetaldehyde dehydrogenase</b>.</p></div></div>
	</htmltext>
<tokenext>Would n't boosting the function of acetaldehyde dehydrogenase enzyme help mitigate the damaging effects of alcohol and lessen your hangover ?
As acetaldehyde is theorized to the be the primary cause of a hangover and at least the primary cause of long term harm , this strikes me as an obvious target for harm reduction research .
Especially since this would not mess with the metabolism of ethanol directly ( alcohol dehydrogenase - which could make you dangerously drunk , or sober and hungover too fast ) .
The final stage , acetic acid is next to harmless , well it 's vinegar basically .
To quote wikipedia : Ethanol is converted to acetaldehyde by the enzyme alcohol dehydrogenase , and then from acetaldehyde to acetic acid by the enzyme acetaldehyde dehydrogenase .</tokentext>
<sentencetext>Wouldn't boosting the function of acetaldehyde dehydrogenase enzyme help mitigate the damaging effects of alcohol and lessen your hangover?
As acetaldehyde is theorized to the be the primary cause of a hangover and at least the primary cause of long term harm, this strikes me as an obvious target for harm reduction research.
Especially since this would not mess with the metabolism of ethanol directly (alcohol dehydrogenase - which could make you dangerously drunk, or sober and hungover too fast).
The final stage, acetic acid is next to harmless, well it's vinegar basically.
To quote wikipedia: Ethanol is converted to acetaldehyde by the enzyme alcohol dehydrogenase, and then from acetaldehyde to acetic acid by the enzyme acetaldehyde dehydrogenase.
	</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30560870</id>
	<title>Re:Headache?</title>
	<author>sjames</author>
	<datestamp>1261851060000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>Ethyl alcohol does not metabolize to methyl alcohol. However, most distilled spirits have some tiny amount of methanol and higher alcohols. Poorly distilled spirits may contain acutely toxic amounts, for example if the distiller doesn't discard the heads. The higher alcohols are from the tails. They also can contribute significantly to a hangover.</p><p>The hangover part of the methanol BTW is that it metabolizes to formaldehyde. Since ethanol competitively inhibits methanol metabolism, if you keep well hydrated, it will wash out before it can cause a problem.</p></htmltext>
<tokenext>Ethyl alcohol does not metabolize to methyl alcohol .
However , most distilled spirits have some tiny amount of methanol and higher alcohols .
Poorly distilled spirits may contain acutely toxic amounts , for example if the distiller does n't discard the heads .
The higher alcohols are from the tails .
They also can contribute significantly to a hangover.The hangover part of the methanol BTW is that it metabolizes to formaldehyde .
Since ethanol competitively inhibits methanol metabolism , if you keep well hydrated , it will wash out before it can cause a problem .</tokentext>
<sentencetext>Ethyl alcohol does not metabolize to methyl alcohol.
However, most distilled spirits have some tiny amount of methanol and higher alcohols.
Poorly distilled spirits may contain acutely toxic amounts, for example if the distiller doesn't discard the heads.
The higher alcohols are from the tails.
They also can contribute significantly to a hangover.The hangover part of the methanol BTW is that it metabolizes to formaldehyde.
Since ethanol competitively inhibits methanol metabolism, if you keep well hydrated, it will wash out before it can cause a problem.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558030</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30559064</id>
	<title>Benzos?</title>
	<author>rodarson2k</author>
	<datestamp>1261827480000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>Somehow, the chemists in my lab have been making benzodiazapines for years without ever once mentioning that they're good for getting drunk off of.</p><p>I suppose its the part where they make about a gram of it in a month that kills the temptation to drink it.</p></htmltext>
<tokenext>Somehow , the chemists in my lab have been making benzodiazapines for years without ever once mentioning that they 're good for getting drunk off of.I suppose its the part where they make about a gram of it in a month that kills the temptation to drink it .</tokentext>
<sentencetext>Somehow, the chemists in my lab have been making benzodiazapines for years without ever once mentioning that they're good for getting drunk off of.I suppose its the part where they make about a gram of it in a month that kills the temptation to drink it.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30559386</id>
	<title>Hangovers and Romulan Ale</title>
	<author>Nitewing98</author>
	<datestamp>1261830600000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>1. Hangover cure - B vitamin complex and 2 aspirin before bed.  Next morning you're good to go.

2. Recipe for Romulan Ale: 2 quarts of Kool-Aid Berry Blue and grain alcohol (or vodka) to your taste.  For hangovers, see item 1.</htmltext>
<tokenext>1 .
Hangover cure - B vitamin complex and 2 aspirin before bed .
Next morning you 're good to go .
2. Recipe for Romulan Ale : 2 quarts of Kool-Aid Berry Blue and grain alcohol ( or vodka ) to your taste .
For hangovers , see item 1 .</tokentext>
<sentencetext>1.
Hangover cure - B vitamin complex and 2 aspirin before bed.
Next morning you're good to go.
2. Recipe for Romulan Ale: 2 quarts of Kool-Aid Berry Blue and grain alcohol (or vodka) to your taste.
For hangovers, see item 1.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558244</id>
	<title>Toxicity</title>
	<author>Anonymous</author>
	<datestamp>1261820880000</datestamp>
	<modclass>Insightful</modclass>
	<modscore>4</modscore>
	<htmltext><p>If it is ingested orally, then it will be metabolized in the liver. What about its toxicity? If it's the same or higher than alcohol, then the illusion of safety may in the end be detrimental to the health of the user.</p></htmltext>
<tokenext>If it is ingested orally , then it will be metabolized in the liver .
What about its toxicity ?
If it 's the same or higher than alcohol , then the illusion of safety may in the end be detrimental to the health of the user .</tokentext>
<sentencetext>If it is ingested orally, then it will be metabolized in the liver.
What about its toxicity?
If it's the same or higher than alcohol, then the illusion of safety may in the end be detrimental to the health of the user.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558036</id>
	<title>Re:Headache?</title>
	<author>Lord Byron II</author>
	<datestamp>1261819380000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p><div class="quote"><p>and take two paracetamol before you go to bed.</p></div><p>That's two Tylenol to us Yankees.</p></div>
	</htmltext>
<tokenext>and take two paracetamol before you go to bed.That 's two Tylenol to us Yankees .</tokentext>
<sentencetext>and take two paracetamol before you go to bed.That's two Tylenol to us Yankees.
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30557978</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30559366</id>
	<title>Saving a life ain't always the smartest thing</title>
	<author>Anonymous</author>
	<datestamp>1261830420000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>When we save lives of people who are on the path to self-implosion, we also preserve the attached mouths that will need feeding and the "private bits" that will need fucking.  Does it actually cure them of self-implosive behavior?  Guess who ultimately loses in the end from that bit of philanthropy?</p></htmltext>
<tokenext>When we save lives of people who are on the path to self-implosion , we also preserve the attached mouths that will need feeding and the " private bits " that will need fucking .
Does it actually cure them of self-implosive behavior ?
Guess who ultimately loses in the end from that bit of philanthropy ?</tokentext>
<sentencetext>When we save lives of people who are on the path to self-implosion, we also preserve the attached mouths that will need feeding and the "private bits" that will need fucking.
Does it actually cure them of self-implosive behavior?
Guess who ultimately loses in the end from that bit of philanthropy?</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30559136</id>
	<title>Re:I'll drink with Scotty...</title>
	<author>BluBrick</author>
	<datestamp>1261828080000</datestamp>
	<modclass>Informativ</modclass>
	<modscore>2</modscore>
	<htmltext><p>No, no you won't.</p><p>If it's Scotch you drink, it's called Whisky.  If it's whiskey you drink, it's no' Scotch!</p></htmltext>
<tokenext>No , no you wo n't.If it 's Scotch you drink , it 's called Whisky .
If it 's whiskey you drink , it 's no ' Scotch !</tokentext>
<sentencetext>No, no you won't.If it's Scotch you drink, it's called Whisky.
If it's whiskey you drink, it's no' Scotch!</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558586</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30563976</id>
	<title>Surprisingly large &amp; small gaps</title>
	<author>swb</author>
	<datestamp>1261938060000</datestamp>
	<modclass>Interestin</modclass>
	<modscore>2</modscore>
	<htmltext><p>I'm surprised that cannabis did only marginally better than alcohol and that the gap between heroin and alcohol was so large.</p><p>I've never known anyone to fight or commit vandalism after smoking pot and while I'd agree its inadvisable, I think stoned drivers are less risky than drunk ones, especially at the low end of drunkenness/stonedness.  Pot also is much easier on your body and does not produce a physical dependence or illness to the same magnitude that alcohol does (even if you factor in high cholesterol from snacking).</p><p>Heroin addiction I can see being destructive, but much of that seems to be a result of legal sanction, not the inherent danger of the drug (interaction with criminal enterprise, impure/uncertain quality, high prices leading to theft, etc).  True it is addictive and many addicts chase the "rush" of injection (as opposed to the high itself) which ends up resulting in overdoses, the opiates are not corrosive to the body and in fact are tolerated very well for long periods of time.</p><p>I suspect these "scores" factor in maleable social and legal circumstances as constant factors and do not weight the actual pharmacological properties enough.<br>
&nbsp;</p></htmltext>
<tokenext>I 'm surprised that cannabis did only marginally better than alcohol and that the gap between heroin and alcohol was so large.I 've never known anyone to fight or commit vandalism after smoking pot and while I 'd agree its inadvisable , I think stoned drivers are less risky than drunk ones , especially at the low end of drunkenness/stonedness .
Pot also is much easier on your body and does not produce a physical dependence or illness to the same magnitude that alcohol does ( even if you factor in high cholesterol from snacking ) .Heroin addiction I can see being destructive , but much of that seems to be a result of legal sanction , not the inherent danger of the drug ( interaction with criminal enterprise , impure/uncertain quality , high prices leading to theft , etc ) .
True it is addictive and many addicts chase the " rush " of injection ( as opposed to the high itself ) which ends up resulting in overdoses , the opiates are not corrosive to the body and in fact are tolerated very well for long periods of time.I suspect these " scores " factor in maleable social and legal circumstances as constant factors and do not weight the actual pharmacological properties enough .
 </tokentext>
<sentencetext>I'm surprised that cannabis did only marginally better than alcohol and that the gap between heroin and alcohol was so large.I've never known anyone to fight or commit vandalism after smoking pot and while I'd agree its inadvisable, I think stoned drivers are less risky than drunk ones, especially at the low end of drunkenness/stonedness.
Pot also is much easier on your body and does not produce a physical dependence or illness to the same magnitude that alcohol does (even if you factor in high cholesterol from snacking).Heroin addiction I can see being destructive, but much of that seems to be a result of legal sanction, not the inherent danger of the drug (interaction with criminal enterprise, impure/uncertain quality, high prices leading to theft, etc).
True it is addictive and many addicts chase the "rush" of injection (as opposed to the high itself) which ends up resulting in overdoses, the opiates are not corrosive to the body and in fact are tolerated very well for long periods of time.I suspect these "scores" factor in maleable social and legal circumstances as constant factors and do not weight the actual pharmacological properties enough.
 </sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558536</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558064</id>
	<title>Re:Headache?</title>
	<author>Anonymous</author>
	<datestamp>1261819680000</datestamp>
	<modclass>Funny</modclass>
	<modscore>1</modscore>
	<htmltext><p>This is the stupidest post I've ever read on<nobr> <wbr></nobr>/.  That's saying something.</p></htmltext>
<tokenext>This is the stupidest post I 've ever read on / .
That 's saying something .</tokentext>
<sentencetext>This is the stupidest post I've ever read on /.
That's saying something.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30557978</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30561378</id>
	<title>Re:Headache?</title>
	<author>w0mprat</author>
	<datestamp>1261946280000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p><div class="quote"><p>"Hypoglycemia, dehydration, acetaldehyde intoxication, and vitamin B12 deficiency are all <b>theorized</b> causes of hangover symptoms". </p><p>so how can you authoritatively assert what causes a hangover when the scientists, at least according to that article, aren't even sure?</p></div><p>Presumably because they don't get invited to the right kind of parties at university to gather data.<br> <br>There is no substitute for field work.</p></div>
	</htmltext>
<tokenext>" Hypoglycemia , dehydration , acetaldehyde intoxication , and vitamin B12 deficiency are all theorized causes of hangover symptoms " .
so how can you authoritatively assert what causes a hangover when the scientists , at least according to that article , are n't even sure ? Presumably because they do n't get invited to the right kind of parties at university to gather data .
There is no substitute for field work .</tokentext>
<sentencetext>"Hypoglycemia, dehydration, acetaldehyde intoxication, and vitamin B12 deficiency are all theorized causes of hangover symptoms".
so how can you authoritatively assert what causes a hangover when the scientists, at least according to that article, aren't even sure?Presumably because they don't get invited to the right kind of parties at university to gather data.
There is no substitute for field work.
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558552</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558322</id>
	<title>The Puritans won't like this.</title>
	<author>Anonymous</author>
	<datestamp>1261821660000</datestamp>
	<modclass>Insightful</modclass>
	<modscore>4</modscore>
	<htmltext><p>Or the Catholics. If you're going to have fun, the punishment must be built-in.</p></htmltext>
<tokenext>Or the Catholics .
If you 're going to have fun , the punishment must be built-in .</tokentext>
<sentencetext>Or the Catholics.
If you're going to have fun, the punishment must be built-in.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30559652</id>
	<title>What is it?</title>
	<author>p51d007</author>
	<datestamp>1261833540000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>It...it...it....it is green!</htmltext>
<tokenext>It...it...it....it is green !</tokentext>
<sentencetext>It...it...it....it is green!</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558668</id>
	<title>The only problem is...</title>
	<author>Hurricane78</author>
	<datestamp>1261824480000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>...that in the <em>real world</em>, alcohol making you drunk is the whole point! We certainly don&rsquo;t drink it because of the bitter, burning taste. ^^</p><p>If this had any chance of being a success, then people would already prefer non-alcoholic cocktails and brews for a looong time.<br>And I don&rsquo;t see that being the case, or ever happening.</p></htmltext>
<tokenext>...that in the real world , alcohol making you drunk is the whole point !
We certainly don    t drink it because of the bitter , burning taste .
^ ^ If this had any chance of being a success , then people would already prefer non-alcoholic cocktails and brews for a looong time.And I don    t see that being the case , or ever happening .</tokentext>
<sentencetext>...that in the real world, alcohol making you drunk is the whole point!
We certainly don’t drink it because of the bitter, burning taste.
^^If this had any chance of being a success, then people would already prefer non-alcoholic cocktails and brews for a looong time.And I don’t see that being the case, or ever happening.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30591922</id>
	<title>Re:Toxicity</title>
	<author>Anonymous</author>
	<datestamp>1259841960000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>I'm sure these guys have considered the possibility, but at the moment all they have is a goal of what they are looking for, and which group of drugs they are hope to find it in.  No doubt they'll look into its safety once they have found a suitable candidate.</p></htmltext>
<tokenext>I 'm sure these guys have considered the possibility , but at the moment all they have is a goal of what they are looking for , and which group of drugs they are hope to find it in .
No doubt they 'll look into its safety once they have found a suitable candidate .</tokentext>
<sentencetext>I'm sure these guys have considered the possibility, but at the moment all they have is a goal of what they are looking for, and which group of drugs they are hope to find it in.
No doubt they'll look into its safety once they have found a suitable candidate.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558244</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558680</id>
	<title>Do Not Mix With Alcohol?</title>
	<author>Plekto</author>
	<datestamp>1261824540000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>If you read the article, they are using substances that are related to the same family or compounds that you find in Valium and other depressants.  You very well might see them succeed, but I can't imagine drinking beer that has a warning label to not mix with (real)alcohol.</p></htmltext>
<tokenext>If you read the article , they are using substances that are related to the same family or compounds that you find in Valium and other depressants .
You very well might see them succeed , but I ca n't imagine drinking beer that has a warning label to not mix with ( real ) alcohol .</tokentext>
<sentencetext>If you read the article, they are using substances that are related to the same family or compounds that you find in Valium and other depressants.
You very well might see them succeed, but I can't imagine drinking beer that has a warning label to not mix with (real)alcohol.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558030</id>
	<title>Re:Headache?</title>
	<author>Anonymous</author>
	<datestamp>1261819320000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>It is also the metabolites of ethyl alcohol (such as methyl "wood" alcohol) which cause the hangover.</p></htmltext>
<tokenext>It is also the metabolites of ethyl alcohol ( such as methyl " wood " alcohol ) which cause the hangover .</tokentext>
<sentencetext>It is also the metabolites of ethyl alcohol (such as methyl "wood" alcohol) which cause the hangover.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30557978</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558298</id>
	<title>Please tag such stories "Telegraph (UK)."</title>
	<author>Anonymous</author>
	<datestamp>1261821480000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>This would make it clear that the degree of correlation between scientific assertion and journalistic conclusion in the article might not be actually be high enough to support any conclusion of statistical significance, let alone causality.</p></htmltext>
<tokenext>This would make it clear that the degree of correlation between scientific assertion and journalistic conclusion in the article might not be actually be high enough to support any conclusion of statistical significance , let alone causality .</tokentext>
<sentencetext>This would make it clear that the degree of correlation between scientific assertion and journalistic conclusion in the article might not be actually be high enough to support any conclusion of statistical significance, let alone causality.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558438</id>
	<title>Vaporware??</title>
	<author>davidwr</author>
	<datestamp>1261822860000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>It better be <i>vapor</i>ware.</p><p>I love the aroma of a good glass of real wine.  If the synthetic stuff doesn't measure up then what's the point?</p></htmltext>
<tokenext>It better be vaporware.I love the aroma of a good glass of real wine .
If the synthetic stuff does n't measure up then what 's the point ?</tokentext>
<sentencetext>It better be vaporware.I love the aroma of a good glass of real wine.
If the synthetic stuff doesn't measure up then what's the point?</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30559174</id>
	<title>Synthehol is so next century...</title>
	<author>GrahamCox</author>
	<datestamp>1261828320000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>Synthehol is so next century. Wake me up when someone can import real Pan-Galactic Gargle-Blasters to Earth.</htmltext>
<tokenext>Synthehol is so next century .
Wake me up when someone can import real Pan-Galactic Gargle-Blasters to Earth .</tokentext>
<sentencetext>Synthehol is so next century.
Wake me up when someone can import real Pan-Galactic Gargle-Blasters to Earth.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558536</id>
	<title>Actually, we do have safe alcohol substitute</title>
	<author>Anonymous</author>
	<datestamp>1261823520000</datestamp>
	<modclass>Informativ</modclass>
	<modscore>5</modscore>
	<htmltext>We already have alcohol substitutes ( read: recreational drugs ) that are safer than alcohol. Only problem is, they're illegal. <br> <br>
<a href="http://www.boston.com/bostonglobe/ideas/articles/2009/12/13/you\_cant\_handle\_the\_truth/" title="boston.com">You can't handle the truth</a> [boston.com]. Dr. David Nutt, the British government scientist that was recently fired, did an exhaustive study of the real impact of recreational drugs. Herion was 8.32, alcohol 5.54, Cannabis 4.00, LSD 3.68 and Ecstacy 3.27. A higher score is worse.( Many other drugs were in the study).<br> <br>So we already have several safer alternatives to alcohol.</htmltext>
<tokenext>We already have alcohol substitutes ( read : recreational drugs ) that are safer than alcohol .
Only problem is , they 're illegal .
You ca n't handle the truth [ boston.com ] .
Dr. David Nutt , the British government scientist that was recently fired , did an exhaustive study of the real impact of recreational drugs .
Herion was 8.32 , alcohol 5.54 , Cannabis 4.00 , LSD 3.68 and Ecstacy 3.27 .
A higher score is worse .
( Many other drugs were in the study ) .
So we already have several safer alternatives to alcohol .</tokentext>
<sentencetext>We already have alcohol substitutes ( read: recreational drugs ) that are safer than alcohol.
Only problem is, they're illegal.
You can't handle the truth [boston.com].
Dr. David Nutt, the British government scientist that was recently fired, did an exhaustive study of the real impact of recreational drugs.
Herion was 8.32, alcohol 5.54, Cannabis 4.00, LSD 3.68 and Ecstacy 3.27.
A higher score is worse.
( Many other drugs were in the study).
So we already have several safer alternatives to alcohol.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30560952</id>
	<title>Re:Synthehol?</title>
	<author>rantingkitten</author>
	<datestamp>1261852560000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>Uhm, no.  Data said that with synthehol, the "intoxicating effects can be easily dismissed".  That means it <b>does</b> intoxicate you -- it's just that you can shake off the intoxication somehow. <br>
<br>
Plus, Scotty was whining about the lack of any real alcohol.  If a member of the crew was off-duty, why shouldn't he or she be allowed to have a real drink?  Synthehol was a replacement to alcohol. <br>
<br>
<i>Synthehol is what Starfleet crews can drink while on duty because it tastes like the real thing but DOESN'T give you a buzz or get you drunk.</i> <br>
<br>
While on duty?  Pretty sure Starfleet doesn't want their crews drinking anything that could intoxicate them while ON DUTY, even if you can dismiss the effects.</htmltext>
<tokenext>Uhm , no .
Data said that with synthehol , the " intoxicating effects can be easily dismissed " .
That means it does intoxicate you -- it 's just that you can shake off the intoxication somehow .
Plus , Scotty was whining about the lack of any real alcohol .
If a member of the crew was off-duty , why should n't he or she be allowed to have a real drink ?
Synthehol was a replacement to alcohol .
Synthehol is what Starfleet crews can drink while on duty because it tastes like the real thing but DOES N'T give you a buzz or get you drunk .
While on duty ?
Pretty sure Starfleet does n't want their crews drinking anything that could intoxicate them while ON DUTY , even if you can dismiss the effects .</tokentext>
<sentencetext>Uhm, no.
Data said that with synthehol, the "intoxicating effects can be easily dismissed".
That means it does intoxicate you -- it's just that you can shake off the intoxication somehow.
Plus, Scotty was whining about the lack of any real alcohol.
If a member of the crew was off-duty, why shouldn't he or she be allowed to have a real drink?
Synthehol was a replacement to alcohol.
Synthehol is what Starfleet crews can drink while on duty because it tastes like the real thing but DOESN'T give you a buzz or get you drunk.
While on duty?
Pretty sure Starfleet doesn't want their crews drinking anything that could intoxicate them while ON DUTY, even if you can dismiss the effects.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558814</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558232</id>
	<title>Romulan Ale</title>
	<author>feldhaus</author>
	<datestamp>1261820700000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><a href="http://memory-alpha.org/en/wiki/Romulan\_ale" title="memory-alpha.org" rel="nofollow">Romulan Ale</a> [memory-alpha.org] is alcoholic, not sythoholic and a cocktail recipes are available at that link to those with no sense of self-preservation.</htmltext>
<tokenext>Romulan Ale [ memory-alpha.org ] is alcoholic , not sythoholic and a cocktail recipes are available at that link to those with no sense of self-preservation .</tokentext>
<sentencetext>Romulan Ale [memory-alpha.org] is alcoholic, not sythoholic and a cocktail recipes are available at that link to those with no sense of self-preservation.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30560696</id>
	<title>Safe Alcohol wouldn't get licensed</title>
	<author>physburn</author>
	<datestamp>1261848720000</datestamp>
	<modclass>Informativ</modclass>
	<modscore>2</modscore>
	<htmltext>The politics of the world is such that if a drug that mimics alcohol
except for all its bad point was produced, it wouldn't be legalised,
it would just be lumped in with all the illegal recreation drugs, governments
don't have a set safety limit for recreational drug, they are normally
against them on principle, however safe they are.
<p>
But its also a concern that if synthehol was produced, how would we
know if it was safe of not, it would take usage by milliions over they
adult lifetime, before we genuinely know weather the chemical was
safe.
</p><p>
But good luck to Prof, Knut, who will probably have some very
wild parties testing outs his candiate benzodiazepines.
</p><p>
---
</p><p>
<a href="http://www.feeddistiller.com/blogs/Drug\%20Addiction/feed.html" title="feeddistiller.com">Drug Addiction</a> [feeddistiller.com] Feed @ <a href="http://www.feeddistiller.com/" title="feeddistiller.com">Feed Distiller</a> [feeddistiller.com]</p></htmltext>
<tokenext>The politics of the world is such that if a drug that mimics alcohol except for all its bad point was produced , it would n't be legalised , it would just be lumped in with all the illegal recreation drugs , governments do n't have a set safety limit for recreational drug , they are normally against them on principle , however safe they are .
But its also a concern that if synthehol was produced , how would we know if it was safe of not , it would take usage by milliions over they adult lifetime , before we genuinely know weather the chemical was safe .
But good luck to Prof , Knut , who will probably have some very wild parties testing outs his candiate benzodiazepines .
--- Drug Addiction [ feeddistiller.com ] Feed @ Feed Distiller [ feeddistiller.com ]</tokentext>
<sentencetext>The politics of the world is such that if a drug that mimics alcohol
except for all its bad point was produced, it wouldn't be legalised,
it would just be lumped in with all the illegal recreation drugs, governments
don't have a set safety limit for recreational drug, they are normally
against them on principle, however safe they are.
But its also a concern that if synthehol was produced, how would we
know if it was safe of not, it would take usage by milliions over they
adult lifetime, before we genuinely know weather the chemical was
safe.
But good luck to Prof, Knut, who will probably have some very
wild parties testing outs his candiate benzodiazepines.
---

Drug Addiction [feeddistiller.com] Feed @ Feed Distiller [feeddistiller.com]</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30641434</id>
	<title>Re:What for?</title>
	<author>MightyDrunken</author>
	<datestamp>1231087680000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>It's easy but doesn't work. Even if I hydrate myself with 10 pints of beer I still get a hang over.</htmltext>
<tokenext>It 's easy but does n't work .
Even if I hydrate myself with 10 pints of beer I still get a hang over .</tokentext>
<sentencetext>It's easy but doesn't work.
Even if I hydrate myself with 10 pints of beer I still get a hang over.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558412</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558498</id>
	<title>Like this will be accepted.</title>
	<author>TheRealGrogan</author>
	<datestamp>1261823160000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>Yeah, right. Like society is going to suddenly get over their prejudices about "drugs" and it's going to be acceptable to consume this, take an antidote and drive or go to work or other drinking taboo. In societies where they still criminally prosecute and jail people for the mere possession of marijuana. (which to an established, regular user is relatively harmless)</htmltext>
<tokenext>Yeah , right .
Like society is going to suddenly get over their prejudices about " drugs " and it 's going to be acceptable to consume this , take an antidote and drive or go to work or other drinking taboo .
In societies where they still criminally prosecute and jail people for the mere possession of marijuana .
( which to an established , regular user is relatively harmless )</tokentext>
<sentencetext>Yeah, right.
Like society is going to suddenly get over their prejudices about "drugs" and it's going to be acceptable to consume this, take an antidote and drive or go to work or other drinking taboo.
In societies where they still criminally prosecute and jail people for the mere possession of marijuana.
(which to an established, regular user is relatively harmless)</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558778</id>
	<title>Obligatory Quote</title>
	<author>jonadab</author>
	<datestamp>1261825260000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>What's this stuff?<br><br>It is...  [pause] [sniff]  It is green.</htmltext>
<tokenext>What 's this stuff ? It is... [ pause ] [ sniff ] It is green .</tokentext>
<sentencetext>What's this stuff?It is...  [pause] [sniff]  It is green.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558296</id>
	<title>Alcohol didn't exist more than 3,000 years ago?</title>
	<author>RNLockwood</author>
	<datestamp>1261821420000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>The article says that alcohol has only been around for 3,000 years.  This implies that leavened bread has only been around for that long.  Wonder what the yeasts were producing before and why so many animals have the enzyme alcohol dehydroginase.</p></htmltext>
<tokenext>The article says that alcohol has only been around for 3,000 years .
This implies that leavened bread has only been around for that long .
Wonder what the yeasts were producing before and why so many animals have the enzyme alcohol dehydroginase .</tokentext>
<sentencetext>The article says that alcohol has only been around for 3,000 years.
This implies that leavened bread has only been around for that long.
Wonder what the yeasts were producing before and why so many animals have the enzyme alcohol dehydroginase.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558586</id>
	<title>I'll drink with Scotty...</title>
	<author>thewiz</author>
	<datestamp>1261823940000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>from a bottle of very old Scotch whiskey!</p></htmltext>
<tokenext>from a bottle of very old Scotch whiskey !</tokentext>
<sentencetext>from a bottle of very old Scotch whiskey!</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558412</id>
	<title>What for?</title>
	<author>bistromath007</author>
	<datestamp>1261822560000</datestamp>
	<modclass>Insightful</modclass>
	<modscore>5</modscore>
	<htmltext>To avoid a hangover with the real stuff, just stay hydrated. Not difficult.</htmltext>
<tokenext>To avoid a hangover with the real stuff , just stay hydrated .
Not difficult .</tokentext>
<sentencetext>To avoid a hangover with the real stuff, just stay hydrated.
Not difficult.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558230</id>
	<title>Better Profit Through Pharmaceuticals</title>
	<author>handy\_vandal</author>
	<datestamp>1261820640000</datestamp>
	<modclass>Insightful</modclass>
	<modscore>4</modscore>
	<htmltext><p>"Prof Nutt and his team are concentrating their efforts on benzodiazepines, of which diazepam, the chief ingredient of Valium is one."</p><p>In other words, let's invent another Happy Pill that will make big profit for Big Pharmco. And we'll call it an "alcohol substitute" because alcohol is well-known as the active ingredient in alcoholism, and you're in favor of a cure for alcoholism, right?</p><p>Good thing they're not calling it a "Valium analog", what with <a href="http://en.wikipedia.org/wiki/Valium#Drug\_misuse\_and\_addiction" title="wikipedia.org">Valium's well-known and deserved reputation for causing addiction, tolerance, and withdrawal</a> [wikipedia.org].</p></htmltext>
<tokenext>" Prof Nutt and his team are concentrating their efforts on benzodiazepines , of which diazepam , the chief ingredient of Valium is one .
" In other words , let 's invent another Happy Pill that will make big profit for Big Pharmco .
And we 'll call it an " alcohol substitute " because alcohol is well-known as the active ingredient in alcoholism , and you 're in favor of a cure for alcoholism , right ? Good thing they 're not calling it a " Valium analog " , what with Valium 's well-known and deserved reputation for causing addiction , tolerance , and withdrawal [ wikipedia.org ] .</tokentext>
<sentencetext>"Prof Nutt and his team are concentrating their efforts on benzodiazepines, of which diazepam, the chief ingredient of Valium is one.
"In other words, let's invent another Happy Pill that will make big profit for Big Pharmco.
And we'll call it an "alcohol substitute" because alcohol is well-known as the active ingredient in alcoholism, and you're in favor of a cure for alcoholism, right?Good thing they're not calling it a "Valium analog", what with Valium's well-known and deserved reputation for causing addiction, tolerance, and withdrawal [wikipedia.org].</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30560580</id>
	<title>I read TFA.  There's not much there.</title>
	<author>Harvey Manfrenjenson</author>
	<datestamp>1261847040000</datestamp>
	<modclass>Redundant</modclass>
	<modscore>0</modscore>
	<htmltext><p>Basically, Dr. Nutt is proposing that we legalize one or two benzodiazepenes as a sort of replacement for alcohol (which could then, he suggests, be gradually marginalized and outlawed).  Benzodiazepenes are a class of fast-acting drugs which includes Klonopin, Valium, Xanax, and Ativan (also a number of less-used ones like Librium and Tranxene).</p><p>And the problem with that is it's just not going to work.  Leaving aside the fact that benzos don't feel the quite the same as alcohol (most people would find them overly sedating-- not really the thing you want to take before a night of clubbing), you have the problem that benzos are themselves very addictive.  Ask any doctor.  (They've all had to deal with the benzo-seeking patient who "lost his prescription" for the third time this month).  I guess you could speculate that benzos taken ad libitum might prove to be somewhat *less* addicting than alcohol, relatively speaking, but there's no data to support that happy hypothesis, and good luck trying to design a study to prove it.</p><p>The rest of the article is full of irrelevancy  and hand-waving.  Dr. Nutt states that you can "sober up immediately" from a benzo, I guess by taking flumazenil-- and so what?  Heroin addicts can sober up immediately with Narcan.  That doesn't make heroin particularly safe.</p><p>He also says that his team is going to "identify the closest match to alcohol" from among "thousands" of benzos.  The closest in what sense?  Time of onset?  Half-life?  Xanax is close enough already.  Receptor-binding profile?  Not going to work, since no benzo will duplicate the multiple actions of alcohol on the neuron(which IIRC include effects on membrane fluidity).  Anyway Dr. Nutt says that he wants his drug to be more "focused in its effects" than alcohol, so he wouldn't want a close analog even if he could find one.</p><p>In short: TFA is politically-motivated bullshit which might win Dr. Nutt some publicity and funding but will never produce anything useful.  A previous poster got it right.  If you want a safer alternative to alcohol, legalize pot.  We already fucking *know* it's less addictive (and have the studies to prove it).</p></htmltext>
<tokenext>Basically , Dr. Nutt is proposing that we legalize one or two benzodiazepenes as a sort of replacement for alcohol ( which could then , he suggests , be gradually marginalized and outlawed ) .
Benzodiazepenes are a class of fast-acting drugs which includes Klonopin , Valium , Xanax , and Ativan ( also a number of less-used ones like Librium and Tranxene ) .And the problem with that is it 's just not going to work .
Leaving aside the fact that benzos do n't feel the quite the same as alcohol ( most people would find them overly sedating-- not really the thing you want to take before a night of clubbing ) , you have the problem that benzos are themselves very addictive .
Ask any doctor .
( They 've all had to deal with the benzo-seeking patient who " lost his prescription " for the third time this month ) .
I guess you could speculate that benzos taken ad libitum might prove to be somewhat * less * addicting than alcohol , relatively speaking , but there 's no data to support that happy hypothesis , and good luck trying to design a study to prove it.The rest of the article is full of irrelevancy and hand-waving .
Dr. Nutt states that you can " sober up immediately " from a benzo , I guess by taking flumazenil-- and so what ?
Heroin addicts can sober up immediately with Narcan .
That does n't make heroin particularly safe.He also says that his team is going to " identify the closest match to alcohol " from among " thousands " of benzos .
The closest in what sense ?
Time of onset ?
Half-life ? Xanax is close enough already .
Receptor-binding profile ?
Not going to work , since no benzo will duplicate the multiple actions of alcohol on the neuron ( which IIRC include effects on membrane fluidity ) .
Anyway Dr. Nutt says that he wants his drug to be more " focused in its effects " than alcohol , so he would n't want a close analog even if he could find one.In short : TFA is politically-motivated bullshit which might win Dr. Nutt some publicity and funding but will never produce anything useful .
A previous poster got it right .
If you want a safer alternative to alcohol , legalize pot .
We already fucking * know * it 's less addictive ( and have the studies to prove it ) .</tokentext>
<sentencetext>Basically, Dr. Nutt is proposing that we legalize one or two benzodiazepenes as a sort of replacement for alcohol (which could then, he suggests, be gradually marginalized and outlawed).
Benzodiazepenes are a class of fast-acting drugs which includes Klonopin, Valium, Xanax, and Ativan (also a number of less-used ones like Librium and Tranxene).And the problem with that is it's just not going to work.
Leaving aside the fact that benzos don't feel the quite the same as alcohol (most people would find them overly sedating-- not really the thing you want to take before a night of clubbing), you have the problem that benzos are themselves very addictive.
Ask any doctor.
(They've all had to deal with the benzo-seeking patient who "lost his prescription" for the third time this month).
I guess you could speculate that benzos taken ad libitum might prove to be somewhat *less* addicting than alcohol, relatively speaking, but there's no data to support that happy hypothesis, and good luck trying to design a study to prove it.The rest of the article is full of irrelevancy  and hand-waving.
Dr. Nutt states that you can "sober up immediately" from a benzo, I guess by taking flumazenil-- and so what?
Heroin addicts can sober up immediately with Narcan.
That doesn't make heroin particularly safe.He also says that his team is going to "identify the closest match to alcohol" from among "thousands" of benzos.
The closest in what sense?
Time of onset?
Half-life?  Xanax is close enough already.
Receptor-binding profile?
Not going to work, since no benzo will duplicate the multiple actions of alcohol on the neuron(which IIRC include effects on membrane fluidity).
Anyway Dr. Nutt says that he wants his drug to be more "focused in its effects" than alcohol, so he wouldn't want a close analog even if he could find one.In short: TFA is politically-motivated bullshit which might win Dr. Nutt some publicity and funding but will never produce anything useful.
A previous poster got it right.
If you want a safer alternative to alcohol, legalize pot.
We already fucking *know* it's less addictive (and have the studies to prove it).</sentencetext>
</comment>
<thread>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#thread_09_12_26_1826205_7</id>
	<commentlist>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30560684
http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558026
http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30557978
</commentlist>
</thread>
<thread>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#thread_09_12_26_1826205_0</id>
	<commentlist>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30591922
http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558244
</commentlist>
</thread>
<thread>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#thread_09_12_26_1826205_13</id>
	<commentlist>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30568812
http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558322
</commentlist>
</thread>
<thread>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#thread_09_12_26_1826205_4</id>
	<commentlist>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558938
http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558230
</commentlist>
</thread>
<thread>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#thread_09_12_26_1826205_1</id>
	<commentlist>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30560952
http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558814
</commentlist>
</thread>
<thread>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#thread_09_12_26_1826205_8</id>
	<commentlist>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558772
http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558230
</commentlist>
</thread>
<thread>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#thread_09_12_26_1826205_10</id>
	<commentlist>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30560404
http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558536
</commentlist>
</thread>
<thread>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#thread_09_12_26_1826205_11</id>
	<commentlist>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558064
http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30557978
</commentlist>
</thread>
<thread>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#thread_09_12_26_1826205_15</id>
	<commentlist>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30641434
http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558412
</commentlist>
</thread>
<thread>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#thread_09_12_26_1826205_14</id>
	<commentlist>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30561378
http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558552
http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558142
http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30557978
</commentlist>
</thread>
<thread>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#thread_09_12_26_1826205_2</id>
	<commentlist>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30559136
http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558586
</commentlist>
</thread>
<thread>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#thread_09_12_26_1826205_5</id>
	<commentlist>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558036
http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30557978
</commentlist>
</thread>
<thread>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#thread_09_12_26_1826205_6</id>
	<commentlist>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30562690
http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558536
</commentlist>
</thread>
<thread>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#thread_09_12_26_1826205_9</id>
	<commentlist>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30569628
http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558244
</commentlist>
</thread>
<thread>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#thread_09_12_26_1826205_3</id>
	<commentlist>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30560870
http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558030
http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30557978
</commentlist>
</thread>
<thread>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#thread_09_12_26_1826205_12</id>
	<commentlist>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30561062
http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558322
</commentlist>
</thread>
<thread>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#thread_09_12_26_1826205_16</id>
	<commentlist>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30563976
http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558536
</commentlist>
</thread>
<conversation>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#conversation09_12_26_1826205.6</id>
	<commentlist>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558412
-http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30641434
</commentlist>
</conversation>
<conversation>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#conversation09_12_26_1826205.9</id>
	<commentlist>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30557978
-http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558064
-http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558036
-http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558030
--http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30560870
-http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558142
--http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558552
---http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30561378
-http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558026
--http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30560684
</commentlist>
</conversation>
<conversation>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#conversation09_12_26_1826205.0</id>
	<commentlist>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558296
</commentlist>
</conversation>
<conversation>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#conversation09_12_26_1826205.13</id>
	<commentlist>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558244
-http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30569628
-http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30591922
</commentlist>
</conversation>
<conversation>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#conversation09_12_26_1826205.7</id>
	<commentlist>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558230
-http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558938
-http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558772
</commentlist>
</conversation>
<conversation>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#conversation09_12_26_1826205.11</id>
	<commentlist>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558536
-http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30562690
-http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30560404
-http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30563976
</commentlist>
</conversation>
<conversation>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#conversation09_12_26_1826205.12</id>
	<commentlist>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30557974
</commentlist>
</conversation>
<conversation>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#conversation09_12_26_1826205.4</id>
	<commentlist>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558322
-http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30568812
-http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30561062
</commentlist>
</conversation>
<conversation>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#conversation09_12_26_1826205.2</id>
	<commentlist>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30559174
</commentlist>
</conversation>
<conversation>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#conversation09_12_26_1826205.5</id>
	<commentlist>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30559656
</commentlist>
</conversation>
<conversation>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#conversation09_12_26_1826205.3</id>
	<commentlist>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558814
-http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30560952
</commentlist>
</conversation>
<conversation>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#conversation09_12_26_1826205.1</id>
	<commentlist>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558586
-http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30559136
</commentlist>
</conversation>
<conversation>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#conversation09_12_26_1826205.8</id>
	<commentlist>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30559278
</commentlist>
</conversation>
<conversation>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#conversation09_12_26_1826205.10</id>
	<commentlist>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_26_1826205.30558668
</commentlist>
</conversation>
