<article>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#article09_12_06_060243</id>
	<title>Reducing One Amino Acid Could Increase Lifespan</title>
	<author>timothy</author>
	<datestamp>1260128940000</datestamp>
	<htmltext><a href="mailto:here.is.john@gmail.com" rel="nofollow">John Bryson</a> writes <i>"Eating less of one amino acid might lengthen your life. There have been lots of previous studies showing that many species live long on highly restricted calories, but a lot of this benefit may be possible <a href="http://www.sciencenews.org/view/generic/id/50275/title/Amino\_acid\_recipe\_could\_be\_right\_for\_long\_life">by only restricting one amino acid</a>. Amino acids that have shown this have been tryptophan and methionine. A recent study, published online December 2 in <em>Nature</em>, a highly respected journal, may help explain some of the health benefits of restricted-calorie diets."</i></htmltext>
<tokenext>John Bryson writes " Eating less of one amino acid might lengthen your life .
There have been lots of previous studies showing that many species live long on highly restricted calories , but a lot of this benefit may be possible by only restricting one amino acid .
Amino acids that have shown this have been tryptophan and methionine .
A recent study , published online December 2 in Nature , a highly respected journal , may help explain some of the health benefits of restricted-calorie diets .
"</tokentext>
<sentencetext>John Bryson writes "Eating less of one amino acid might lengthen your life.
There have been lots of previous studies showing that many species live long on highly restricted calories, but a lot of this benefit may be possible by only restricting one amino acid.
Amino acids that have shown this have been tryptophan and methionine.
A recent study, published online December 2 in Nature, a highly respected journal, may help explain some of the health benefits of restricted-calorie diets.
"</sentencetext>
</article>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30353128</id>
	<title>Re:"A highly respected journal"</title>
	<author>Eunuchswear</author>
	<datestamp>1260202140000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><blockquote><div><p>[I] believe global warming is probably a systemic change maybe/maybe not tipped by human activity, and that in any case it's extremely unlikely that it's driven by CO2, or limitable in any meaningful way without genocidal levels of population reduction.</p></div></blockquote><p>"it's extremely unlikely that it's driven by CO2" Why? got some kind of evidence for that extraordinary claim?</p><p>"it's extremely unlikely that it's [...] limitable in any meaningful way", or to put it another way you just like believing things that are convenient for you.</p></div>
	</htmltext>
<tokenext>[ I ] believe global warming is probably a systemic change maybe/maybe not tipped by human activity , and that in any case it 's extremely unlikely that it 's driven by CO2 , or limitable in any meaningful way without genocidal levels of population reduction .
" it 's extremely unlikely that it 's driven by CO2 " Why ?
got some kind of evidence for that extraordinary claim ?
" it 's extremely unlikely that it 's [ ... ] limitable in any meaningful way " , or to put it another way you just like believing things that are convenient for you .</tokentext>
<sentencetext>[I] believe global warming is probably a systemic change maybe/maybe not tipped by human activity, and that in any case it's extremely unlikely that it's driven by CO2, or limitable in any meaningful way without genocidal levels of population reduction.
"it's extremely unlikely that it's driven by CO2" Why?
got some kind of evidence for that extraordinary claim?
"it's extremely unlikely that it's [...] limitable in any meaningful way", or to put it another way you just like believing things that are convenient for you.
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30342978</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30343676</id>
	<title>Aubrey De Grey on CNN</title>
	<author>Fernando Jones</author>
	<datestamp>1260120420000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>I saw this segment on cnn the other day

<a href="http://us.cnn.com/video/?/video/international/2009/11/30/vs.clinic.immortality.cnn" title="cnn.com" rel="nofollow">http://us.cnn.com/video/?/video/international/2009/11/30/vs.clinic.immortality.cnn</a> [cnn.com]</htmltext>
<tokenext>I saw this segment on cnn the other day http : //us.cnn.com/video/ ? /video/international/2009/11/30/vs.clinic.immortality.cnn [ cnn.com ]</tokentext>
<sentencetext>I saw this segment on cnn the other day

http://us.cnn.com/video/?/video/international/2009/11/30/vs.clinic.immortality.cnn [cnn.com]</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30343608</id>
	<title>Re:Yes, but...</title>
	<author>Anonymous</author>
	<datestamp>1260119700000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>I might have taken your post more seriously if you had spelled "serotonin" correctly.</p></htmltext>
<tokenext>I might have taken your post more seriously if you had spelled " serotonin " correctly .</tokentext>
<sentencetext>I might have taken your post more seriously if you had spelled "serotonin" correctly.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30342458</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30343966</id>
	<title>Re:Yes, but...</title>
	<author>Quickening</author>
	<datestamp>1260122760000</datestamp>
	<modclass>Interestin</modclass>
	<modscore>2</modscore>
	<htmltext><p>So they say but not necessarily for all people.   They discovered almost 30 years ago that low tryptophan diets duplicated the effects of caloric restriction (in lab rats).     It's not so difficult to lower tryptophan in a vegetarian diet, for instance, if your primary protein source is yogurt..  This works because tryptophan and phenylalanine compete to cross the blood-brain barrier and you can easily identify which foods have the highest ratio of phe to try.    I made it part of my life extension program decades ago, and heh, it works for me.   The group of Bulgarian centenarians who have eaten large amounts of yogurt their whole lives supports it too.</p></htmltext>
<tokenext>So they say but not necessarily for all people .
They discovered almost 30 years ago that low tryptophan diets duplicated the effects of caloric restriction ( in lab rats ) .
It 's not so difficult to lower tryptophan in a vegetarian diet , for instance , if your primary protein source is yogurt.. This works because tryptophan and phenylalanine compete to cross the blood-brain barrier and you can easily identify which foods have the highest ratio of phe to try .
I made it part of my life extension program decades ago , and heh , it works for me .
The group of Bulgarian centenarians who have eaten large amounts of yogurt their whole lives supports it too .</tokentext>
<sentencetext>So they say but not necessarily for all people.
They discovered almost 30 years ago that low tryptophan diets duplicated the effects of caloric restriction (in lab rats).
It's not so difficult to lower tryptophan in a vegetarian diet, for instance, if your primary protein source is yogurt..  This works because tryptophan and phenylalanine compete to cross the blood-brain barrier and you can easily identify which foods have the highest ratio of phe to try.
I made it part of my life extension program decades ago, and heh, it works for me.
The group of Bulgarian centenarians who have eaten large amounts of yogurt their whole lives supports it too.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30342458</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30342238</id>
	<title>Cysteine?</title>
	<author>jonnat</author>
	<datestamp>1260099060000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>TFA does not mention it and Nature has a paywall, but it would be interesting to know if they supplemented cysteine in these experiments. Cysteine is the only amino acid capable of making disulfide bonds and is only classified as non-essential because it can be converted from methionine. Whether or not they supplemented cysteine may imply that the same benefits could result from reducing the activity of the met-&gt;cys pathway.</htmltext>
<tokenext>TFA does not mention it and Nature has a paywall , but it would be interesting to know if they supplemented cysteine in these experiments .
Cysteine is the only amino acid capable of making disulfide bonds and is only classified as non-essential because it can be converted from methionine .
Whether or not they supplemented cysteine may imply that the same benefits could result from reducing the activity of the met- &gt; cys pathway .</tokentext>
<sentencetext>TFA does not mention it and Nature has a paywall, but it would be interesting to know if they supplemented cysteine in these experiments.
Cysteine is the only amino acid capable of making disulfide bonds and is only classified as non-essential because it can be converted from methionine.
Whether or not they supplemented cysteine may imply that the same benefits could result from reducing the activity of the met-&gt;cys pathway.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30342978</id>
	<title>Re:"A highly respected journal"</title>
	<author>(arg!)Styopa</author>
	<datestamp>1260112500000</datestamp>
	<modclass>Insightful</modclass>
	<modscore>4</modscore>
	<htmltext><p>Neither of the two, actually.<br>Nature is a magazine, edited by humans, who have their own collection of baggage and biases.  In general, these don't interfere with a generally good job of presenting relatively objective information on science.<br>As far as anthropogenic global warming is considered, they're as likely as anyone to fall for the popular hysteria, particularly when it's driven by their own peers.</p><p>Now, you might dismiss this was "ah, he's a denier, he's just parroting his viewpoint" and in a sense I am - a believe global warming is probably a systemic change maybe/maybe not tipped by human activity, and that in any case it's extremely unlikely that it's driven by CO2, or limitable in any meaningful way without genocidal levels of population reduction.  There, that's my bias, all clear and present.</p><p>But I'd look directly at Nature and ask when they've made any such clear statement?  Clearly, they have a non-challenging editorial stance when approaching the laughable 'science facts' in an Inconvenient Truth (not a whisper from Nature as far as I can recall).  Nature IS a respected science journal, that would be a perfect place for the fallacies of the AGW hypothesis to be dissected and the valid conclusions reinforced.  But no, instead they seem to prefer the role of mandarins, defending an established dogma without really every looking at it critically or questioning it honestly.</p></htmltext>
<tokenext>Neither of the two , actually.Nature is a magazine , edited by humans , who have their own collection of baggage and biases .
In general , these do n't interfere with a generally good job of presenting relatively objective information on science.As far as anthropogenic global warming is considered , they 're as likely as anyone to fall for the popular hysteria , particularly when it 's driven by their own peers.Now , you might dismiss this was " ah , he 's a denier , he 's just parroting his viewpoint " and in a sense I am - a believe global warming is probably a systemic change maybe/maybe not tipped by human activity , and that in any case it 's extremely unlikely that it 's driven by CO2 , or limitable in any meaningful way without genocidal levels of population reduction .
There , that 's my bias , all clear and present.But I 'd look directly at Nature and ask when they 've made any such clear statement ?
Clearly , they have a non-challenging editorial stance when approaching the laughable 'science facts ' in an Inconvenient Truth ( not a whisper from Nature as far as I can recall ) .
Nature IS a respected science journal , that would be a perfect place for the fallacies of the AGW hypothesis to be dissected and the valid conclusions reinforced .
But no , instead they seem to prefer the role of mandarins , defending an established dogma without really every looking at it critically or questioning it honestly .</tokentext>
<sentencetext>Neither of the two, actually.Nature is a magazine, edited by humans, who have their own collection of baggage and biases.
In general, these don't interfere with a generally good job of presenting relatively objective information on science.As far as anthropogenic global warming is considered, they're as likely as anyone to fall for the popular hysteria, particularly when it's driven by their own peers.Now, you might dismiss this was "ah, he's a denier, he's just parroting his viewpoint" and in a sense I am - a believe global warming is probably a systemic change maybe/maybe not tipped by human activity, and that in any case it's extremely unlikely that it's driven by CO2, or limitable in any meaningful way without genocidal levels of population reduction.
There, that's my bias, all clear and present.But I'd look directly at Nature and ask when they've made any such clear statement?
Clearly, they have a non-challenging editorial stance when approaching the laughable 'science facts' in an Inconvenient Truth (not a whisper from Nature as far as I can recall).
Nature IS a respected science journal, that would be a perfect place for the fallacies of the AGW hypothesis to be dissected and the valid conclusions reinforced.
But no, instead they seem to prefer the role of mandarins, defending an established dogma without really every looking at it critically or questioning it honestly.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30342010</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30341976</id>
	<title>Link to actual study</title>
	<author>Anonymous</author>
	<datestamp>1260093840000</datestamp>
	<modclass>Informativ</modclass>
	<modscore>5</modscore>
	<htmltext><p>http://www.nature.com/nature/journal/vaop/ncurrent/full/nature08619.html for the actual study</p></htmltext>
<tokenext>http : //www.nature.com/nature/journal/vaop/ncurrent/full/nature08619.html for the actual study</tokentext>
<sentencetext>http://www.nature.com/nature/journal/vaop/ncurrent/full/nature08619.html for the actual study</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30341952</id>
	<title>Am I reading this right?</title>
	<author>ProfessionalHostage</author>
	<datestamp>1260093120000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>Live long, have lots of sex without worrying about giving babies? By jove! Where can I send my money to?</p></htmltext>
<tokenext>Live long , have lots of sex without worrying about giving babies ?
By jove !
Where can I send my money to ?</tokentext>
<sentencetext>Live long, have lots of sex without worrying about giving babies?
By jove!
Where can I send my money to?</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30342168</id>
	<title>Re:"A highly respected journal"</title>
	<author>Anonymous</author>
	<datestamp>1260097740000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>If nothing else, I imagine the people that work with climate change vs. amino acides are all completely different.</p><p>Not to say nature is disreputable on either, but there is nothing wrong with saying reliable at one thing and maybe not so much in another domain.  its a common enough situation in life.</p></htmltext>
<tokenext>If nothing else , I imagine the people that work with climate change vs. amino acides are all completely different.Not to say nature is disreputable on either , but there is nothing wrong with saying reliable at one thing and maybe not so much in another domain .
its a common enough situation in life .</tokentext>
<sentencetext>If nothing else, I imagine the people that work with climate change vs. amino acides are all completely different.Not to say nature is disreputable on either, but there is nothing wrong with saying reliable at one thing and maybe not so much in another domain.
its a common enough situation in life.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30342010</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30345560</id>
	<title>Re:"A highly respected journal"</title>
	<author>fermion</author>
	<datestamp>1260091620000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>There is a notion in science that any single data point is a guess.  If one takes one measurement, it is a guess.  If one takes several measurement, and then develops a trend, one has something useful.  Journals like Nature have historically contained very interesting science, which is not to say that every conclusion has been exactly true.  What is the case is that many of the articles have been interesting, and the conclusions useful.
<p>
The mistake that many people, who have little understanding of science, make is to judge conclusions on personal beliefs.  For instance, we want to live longer, we want it to be easy, so we want to believe this article.  It sells copy, so it is good mass media.  But all that is hardly the point.  This study is one data point, which may or may not, may or not become, part of a trend.  Just like so much written about on<nobr> <wbr></nobr>/., truth is not the issue.  The issue will be if it becomes a trend, ir it becomes real, or if it does not.
</p><p>
Those who are not scientists will try to cloud the issue by pointing to individual data points that do not fit.  While such is very useful in science, such pointing is used to push science forward not achieve some retrograde state.  It is interesting that those who are not religious do the same thing with religion, for, by instance, saying that because certain arbitrary statement contradict their holy text, science must therefore be invalid.  This always confused me because while science tries to observe creation and thereby understand the creator, these so-called holy text merely impose a human fabricated will upon the creator.</p></htmltext>
<tokenext>There is a notion in science that any single data point is a guess .
If one takes one measurement , it is a guess .
If one takes several measurement , and then develops a trend , one has something useful .
Journals like Nature have historically contained very interesting science , which is not to say that every conclusion has been exactly true .
What is the case is that many of the articles have been interesting , and the conclusions useful .
The mistake that many people , who have little understanding of science , make is to judge conclusions on personal beliefs .
For instance , we want to live longer , we want it to be easy , so we want to believe this article .
It sells copy , so it is good mass media .
But all that is hardly the point .
This study is one data point , which may or may not , may or not become , part of a trend .
Just like so much written about on /. , truth is not the issue .
The issue will be if it becomes a trend , ir it becomes real , or if it does not .
Those who are not scientists will try to cloud the issue by pointing to individual data points that do not fit .
While such is very useful in science , such pointing is used to push science forward not achieve some retrograde state .
It is interesting that those who are not religious do the same thing with religion , for , by instance , saying that because certain arbitrary statement contradict their holy text , science must therefore be invalid .
This always confused me because while science tries to observe creation and thereby understand the creator , these so-called holy text merely impose a human fabricated will upon the creator .</tokentext>
<sentencetext>There is a notion in science that any single data point is a guess.
If one takes one measurement, it is a guess.
If one takes several measurement, and then develops a trend, one has something useful.
Journals like Nature have historically contained very interesting science, which is not to say that every conclusion has been exactly true.
What is the case is that many of the articles have been interesting, and the conclusions useful.
The mistake that many people, who have little understanding of science, make is to judge conclusions on personal beliefs.
For instance, we want to live longer, we want it to be easy, so we want to believe this article.
It sells copy, so it is good mass media.
But all that is hardly the point.
This study is one data point, which may or may not, may or not become, part of a trend.
Just like so much written about on /., truth is not the issue.
The issue will be if it becomes a trend, ir it becomes real, or if it does not.
Those who are not scientists will try to cloud the issue by pointing to individual data points that do not fit.
While such is very useful in science, such pointing is used to push science forward not achieve some retrograde state.
It is interesting that those who are not religious do the same thing with religion, for, by instance, saying that because certain arbitrary statement contradict their holy text, science must therefore be invalid.
This always confused me because while science tries to observe creation and thereby understand the creator, these so-called holy text merely impose a human fabricated will upon the creator.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30342010</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30341854</id>
	<title>So you get old but depressed?</title>
	<author>Anonymous</author>
	<datestamp>1260091200000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>Tryptophan is a major precursor to Serotonin. High tryptophan levels correlate quite strongly with high Serotonin levels,...</p></htmltext>
<tokenext>Tryptophan is a major precursor to Serotonin .
High tryptophan levels correlate quite strongly with high Serotonin levels,.. .</tokentext>
<sentencetext>Tryptophan is a major precursor to Serotonin.
High tryptophan levels correlate quite strongly with high Serotonin levels,...</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30342458</id>
	<title>Re:Yes, but...</title>
	<author>Anonymous</author>
	<datestamp>1260103320000</datestamp>
	<modclass>Informativ</modclass>
	<modscore>5</modscore>
	<htmltext><p>``Ideally, if giving up Trytophan is beneficial with no negative side effects, they'd create a pill that prevents your body from digesting it.''</p><p>Interestingly, there are actually pills that contain tryptophan. Tryptophan is an essential amino acid and is one of the precursors to serotonine. Serotonine is a neurotransmitter, and low serotonine levels are associated with such conditions as depression and anxiety disorders. So people take extra tryptophan (or, more commonly, 5-HTP, the direct precursor to serotonine) to boost serotonine levels.</p></htmltext>
<tokenext>` ` Ideally , if giving up Trytophan is beneficial with no negative side effects , they 'd create a pill that prevents your body from digesting it .
''Interestingly , there are actually pills that contain tryptophan .
Tryptophan is an essential amino acid and is one of the precursors to serotonine .
Serotonine is a neurotransmitter , and low serotonine levels are associated with such conditions as depression and anxiety disorders .
So people take extra tryptophan ( or , more commonly , 5-HTP , the direct precursor to serotonine ) to boost serotonine levels .</tokentext>
<sentencetext>``Ideally, if giving up Trytophan is beneficial with no negative side effects, they'd create a pill that prevents your body from digesting it.
''Interestingly, there are actually pills that contain tryptophan.
Tryptophan is an essential amino acid and is one of the precursors to serotonine.
Serotonine is a neurotransmitter, and low serotonine levels are associated with such conditions as depression and anxiety disorders.
So people take extra tryptophan (or, more commonly, 5-HTP, the direct precursor to serotonine) to boost serotonine levels.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30341876</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30341830</id>
	<title>less meat nore veggies- where have we heard this?</title>
	<author>Anonymous</author>
	<datestamp>1260090540000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext>So the conclusion from this study is that people with caloric restriction lifestyles should consider eat more methionine containing foods to regain their mojo.  Those of us on regular diets should cut intake of meat, seeds, and other foods that are high in methionine.</htmltext>
<tokenext>So the conclusion from this study is that people with caloric restriction lifestyles should consider eat more methionine containing foods to regain their mojo .
Those of us on regular diets should cut intake of meat , seeds , and other foods that are high in methionine .</tokentext>
<sentencetext>So the conclusion from this study is that people with caloric restriction lifestyles should consider eat more methionine containing foods to regain their mojo.
Those of us on regular diets should cut intake of meat, seeds, and other foods that are high in methionine.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30342872</id>
	<title>Re:One simple rule</title>
	<author>biryokumaru</author>
	<datestamp>1260111060000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>What rule would that be?</htmltext>
<tokenext>What rule would that be ?</tokentext>
<sentencetext>What rule would that be?</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30341818</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30351736</id>
	<title>Poster should RTFA</title>
	<author>ygor</author>
	<datestamp>1260195480000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>TFA does not mention tryptophan at all.
TFA says lifespan increase is due to reduced calorie diet.
Methionine, says TFA, was added to the diet to reverse lost fertility.
TFA says, "Long life may stem from a proper imbalance of dietary nutrients"
It don't say shit about restricting any amino acids to live longer.  It says add one to be able to reproduce.

What I read says that reduced calorie diet with some yet unknown supplement mix of vitamins and amino acids could extend lifespan.</htmltext>
<tokenext>TFA does not mention tryptophan at all .
TFA says lifespan increase is due to reduced calorie diet .
Methionine , says TFA , was added to the diet to reverse lost fertility .
TFA says , " Long life may stem from a proper imbalance of dietary nutrients " It do n't say shit about restricting any amino acids to live longer .
It says add one to be able to reproduce .
What I read says that reduced calorie diet with some yet unknown supplement mix of vitamins and amino acids could extend lifespan .</tokentext>
<sentencetext>TFA does not mention tryptophan at all.
TFA says lifespan increase is due to reduced calorie diet.
Methionine, says TFA, was added to the diet to reverse lost fertility.
TFA says, "Long life may stem from a proper imbalance of dietary nutrients"
It don't say shit about restricting any amino acids to live longer.
It says add one to be able to reproduce.
What I read says that reduced calorie diet with some yet unknown supplement mix of vitamins and amino acids could extend lifespan.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30344266</id>
	<title>Re:Amino Acids</title>
	<author>structural\_biologist</author>
	<datestamp>1260125340000</datestamp>
	<modclass>Informativ</modclass>
	<modscore>2</modscore>
	<htmltext>You are correct that it is well known that limited diets (i.e. caloric restriction) increase lifespan and also decrease fertility.  Many believe the mechanism involves just what you said: in conditions of limited resources, the body shifts resources away from reproduction.
<br> <br>
The authors of the study set out to test the hypothesis that the decreased fertility from caloric restriction results from a lack of calories.  The authors predicted that if this hypothesis is true, it should not be possible to find nutrient conditions that increase lifespan without decreasing fertility.  However, the authors found that they could restore normal fertility levels while maintaining the increased lifespan in calorie restricted flies by adding methionine to the flies' diet.  Thus, as the authors state in the paper's abstract: "reallocation of nutrients therefore does not explain the responses to dietary restriction."
<br> <br>

Furthermore, they found that it is primarily the lifespan increases in caloric restriction come primarily from restricting amino acids.  Adding carbohydrates or fats to the diets of calorie restricted flies did not reduce the increases in lifespan due to calorie restriction.  So yes, the <b>summary is completely wrong</b>.  Restricting the intake all amino acids except for methionine could increase lifespan (in flies) without harming fertility, not the other way around as the summary implies.
<br> <br>

Of course, it's an open question whether any of this applies to humans or whether this fountain of youth works only for fruit flies.</htmltext>
<tokenext>You are correct that it is well known that limited diets ( i.e .
caloric restriction ) increase lifespan and also decrease fertility .
Many believe the mechanism involves just what you said : in conditions of limited resources , the body shifts resources away from reproduction .
The authors of the study set out to test the hypothesis that the decreased fertility from caloric restriction results from a lack of calories .
The authors predicted that if this hypothesis is true , it should not be possible to find nutrient conditions that increase lifespan without decreasing fertility .
However , the authors found that they could restore normal fertility levels while maintaining the increased lifespan in calorie restricted flies by adding methionine to the flies ' diet .
Thus , as the authors state in the paper 's abstract : " reallocation of nutrients therefore does not explain the responses to dietary restriction .
" Furthermore , they found that it is primarily the lifespan increases in caloric restriction come primarily from restricting amino acids .
Adding carbohydrates or fats to the diets of calorie restricted flies did not reduce the increases in lifespan due to calorie restriction .
So yes , the summary is completely wrong .
Restricting the intake all amino acids except for methionine could increase lifespan ( in flies ) without harming fertility , not the other way around as the summary implies .
Of course , it 's an open question whether any of this applies to humans or whether this fountain of youth works only for fruit flies .</tokentext>
<sentencetext>You are correct that it is well known that limited diets (i.e.
caloric restriction) increase lifespan and also decrease fertility.
Many believe the mechanism involves just what you said: in conditions of limited resources, the body shifts resources away from reproduction.
The authors of the study set out to test the hypothesis that the decreased fertility from caloric restriction results from a lack of calories.
The authors predicted that if this hypothesis is true, it should not be possible to find nutrient conditions that increase lifespan without decreasing fertility.
However, the authors found that they could restore normal fertility levels while maintaining the increased lifespan in calorie restricted flies by adding methionine to the flies' diet.
Thus, as the authors state in the paper's abstract: "reallocation of nutrients therefore does not explain the responses to dietary restriction.
"
 

Furthermore, they found that it is primarily the lifespan increases in caloric restriction come primarily from restricting amino acids.
Adding carbohydrates or fats to the diets of calorie restricted flies did not reduce the increases in lifespan due to calorie restriction.
So yes, the summary is completely wrong.
Restricting the intake all amino acids except for methionine could increase lifespan (in flies) without harming fertility, not the other way around as the summary implies.
Of course, it's an open question whether any of this applies to humans or whether this fountain of youth works only for fruit flies.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30341980</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30342088</id>
	<title>Re:"A highly respected journal"</title>
	<author>Anonymous</author>
	<datestamp>1260096420000</datestamp>
	<modclass>Flamebait</modclass>
	<modscore>-1</modscore>
	<htmltext><p>Liberals in general being bent on destroying America as it is today is not a cabal technically, as it's just like-minded evil, duplicitous, Socialist, Marxist, environmentalists working towards the same goal. But of climate scientists in particular, recent evidence is of exactly that.</p><p>And we'll feel the same about what Nature says about amino acids if leftists start using that too to push a fascist agenda of radical societal and economic transformation.</p></htmltext>
<tokenext>Liberals in general being bent on destroying America as it is today is not a cabal technically , as it 's just like-minded evil , duplicitous , Socialist , Marxist , environmentalists working towards the same goal .
But of climate scientists in particular , recent evidence is of exactly that.And we 'll feel the same about what Nature says about amino acids if leftists start using that too to push a fascist agenda of radical societal and economic transformation .</tokentext>
<sentencetext>Liberals in general being bent on destroying America as it is today is not a cabal technically, as it's just like-minded evil, duplicitous, Socialist, Marxist, environmentalists working towards the same goal.
But of climate scientists in particular, recent evidence is of exactly that.And we'll feel the same about what Nature says about amino acids if leftists start using that too to push a fascist agenda of radical societal and economic transformation.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30342010</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30342016</id>
	<title>O\_N\_L\_Y in a Complex System</title>
	<author>foobsr</author>
	<datestamp>1260094860000</datestamp>
	<modclass>Insightful</modclass>
	<modscore>3</modscore>
	<htmltext>TFA: <i>"&ldquo;The idea that <b>only</b> calories are important is basically falling apart,&rdquo; Fontana says."</i>
<br> <br>
Perhaps one should consider that in complex systems there is no such thing like 'only'.
<br> <br>
CC.</htmltext>
<tokenext>TFA : "    The idea that only calories are important is basically falling apart ,    Fontana says .
" Perhaps one should consider that in complex systems there is no such thing like 'only' .
CC .</tokentext>
<sentencetext>TFA: "“The idea that only calories are important is basically falling apart,” Fontana says.
"
 
Perhaps one should consider that in complex systems there is no such thing like 'only'.
CC.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30341818</id>
	<title>One simple rule</title>
	<author>Anonymous</author>
	<datestamp>1260090360000</datestamp>
	<modclass>Funny</modclass>
	<modscore>5</modscore>
	<htmltext><p>Now I can live longer and get a flat stomach by following ONE simple rule.</p></htmltext>
<tokenext>Now I can live longer and get a flat stomach by following ONE simple rule .</tokentext>
<sentencetext>Now I can live longer and get a flat stomach by following ONE simple rule.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30341876</id>
	<title>Re:Yes, but...</title>
	<author>Anonymous</author>
	<datestamp>1260091560000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>I'd also like to know exactly how much restriction is needed for a significant life benefit.</p><p>Ideally, if giving up Trytophan is beneficial with no negative side effects, they'd create a pill that prevents your body from digesting it. But barring that, if I can just limit the consumption of amino acid X for 100 extra years of life then hey. Maybe I won't get the +105 years of life that guy who completely eliminates tyrophan from his diet does, but 100 is all good by me!</p></htmltext>
<tokenext>I 'd also like to know exactly how much restriction is needed for a significant life benefit.Ideally , if giving up Trytophan is beneficial with no negative side effects , they 'd create a pill that prevents your body from digesting it .
But barring that , if I can just limit the consumption of amino acid X for 100 extra years of life then hey .
Maybe I wo n't get the + 105 years of life that guy who completely eliminates tyrophan from his diet does , but 100 is all good by me !</tokentext>
<sentencetext>I'd also like to know exactly how much restriction is needed for a significant life benefit.Ideally, if giving up Trytophan is beneficial with no negative side effects, they'd create a pill that prevents your body from digesting it.
But barring that, if I can just limit the consumption of amino acid X for 100 extra years of life then hey.
Maybe I won't get the +105 years of life that guy who completely eliminates tyrophan from his diet does, but 100 is all good by me!</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30341774</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30343988</id>
	<title>Re:If that amino acid is delicious, I'm dying earl</title>
	<author>Dogtanian</author>
	<datestamp>1260123120000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p><div class="quote"><p>Salt? Good... what does it matter that too much causes health problems?</p></div><p>Thing about salt is one's taste for what a "normal" level of saltiness is can be changed without a massive amount of hassle. I tend not to normally add salt to my food- granted, there's often a lot still in it- and I find that I notice saltiness in commercially-made foods more.<br> <br>
If it requires a short period of finding less salt on your food slightly bland in order to prolong your life quite a bit, then it's worth it IMHO.</p></div>
	</htmltext>
<tokenext>Salt ?
Good... what does it matter that too much causes health problems ? Thing about salt is one 's taste for what a " normal " level of saltiness is can be changed without a massive amount of hassle .
I tend not to normally add salt to my food- granted , there 's often a lot still in it- and I find that I notice saltiness in commercially-made foods more .
If it requires a short period of finding less salt on your food slightly bland in order to prolong your life quite a bit , then it 's worth it IMHO .</tokentext>
<sentencetext>Salt?
Good... what does it matter that too much causes health problems?Thing about salt is one's taste for what a "normal" level of saltiness is can be changed without a massive amount of hassle.
I tend not to normally add salt to my food- granted, there's often a lot still in it- and I find that I notice saltiness in commercially-made foods more.
If it requires a short period of finding less salt on your food slightly bland in order to prolong your life quite a bit, then it's worth it IMHO.
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30342452</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30341852</id>
	<title>Oh sure.</title>
	<author>Anonymous</author>
	<datestamp>1260091140000</datestamp>
	<modclass>Troll</modclass>
	<modscore>-1</modscore>
	<htmltext><p>Translation: We cut back on everything, then gave them back their protein. Suddenly they got better. IT CANNOT BE! CARBOHYDRATES ARE ESSENTIAL!!!! ITS TEH CALORIES STUPID!</p></htmltext>
<tokenext>Translation : We cut back on everything , then gave them back their protein .
Suddenly they got better .
IT CAN NOT BE !
CARBOHYDRATES ARE ESSENTIAL ! ! ! !
ITS TEH CALORIES STUPID !</tokentext>
<sentencetext>Translation: We cut back on everything, then gave them back their protein.
Suddenly they got better.
IT CANNOT BE!
CARBOHYDRATES ARE ESSENTIAL!!!!
ITS TEH CALORIES STUPID!</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30342600</id>
	<title>Who cares?</title>
	<author>Tibia1</author>
	<datestamp>1260106320000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>I don't know why anyone cares about this kind of information when the best thing you can do to lengthen your life is to do one thing really well:<br>
Sit on your ass, don't get hit by a car, and get your all in 1 survival pill in 15 years.</htmltext>
<tokenext>I do n't know why anyone cares about this kind of information when the best thing you can do to lengthen your life is to do one thing really well : Sit on your ass , do n't get hit by a car , and get your all in 1 survival pill in 15 years .</tokentext>
<sentencetext>I don't know why anyone cares about this kind of information when the best thing you can do to lengthen your life is to do one thing really well:
Sit on your ass, don't get hit by a car, and get your all in 1 survival pill in 15 years.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30342464</id>
	<title>Re:"A highly respected journal"</title>
	<author>MoeDumb</author>
	<datestamp>1260103440000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext>Hey hey hey, let's get back to how I can eat all I want without gaining weight while infinitely extending my lifespan all at the same time!

Now, where'd I put those molecule tweezers...?</htmltext>
<tokenext>Hey hey hey , let 's get back to how I can eat all I want without gaining weight while infinitely extending my lifespan all at the same time !
Now , where 'd I put those molecule tweezers... ?</tokentext>
<sentencetext>Hey hey hey, let's get back to how I can eat all I want without gaining weight while infinitely extending my lifespan all at the same time!
Now, where'd I put those molecule tweezers...?</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30342088</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30349296</id>
	<title>Re:Amino Acids</title>
	<author>Anonymous</author>
	<datestamp>1260121500000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>http://www.sciencedirect.com/science?\_ob=ArticleURL&amp;\_udi=B6T6J-473FRHK-5&amp;\_user=10&amp;\_rdoc=1&amp;\_fmt=&amp;\_orig=search&amp;\_sort=d&amp;\_docanchor=&amp;view=c&amp;\_searchStrId=1124856196&amp;\_rerunOrigin=google&amp;\_acct=C000050221&amp;\_version=1&amp;\_urlVersion=0&amp;\_userid=10&amp;md5=8fdb3a69673c852e7adf0466d2e36687 reports similar finding for rats.</p></htmltext>
<tokenext>http : //www.sciencedirect.com/science ? \ _ob = ArticleURL&amp; \ _udi = B6T6J-473FRHK-5&amp; \ _user = 10&amp; \ _rdoc = 1&amp; \ _fmt = &amp; \ _orig = search&amp; \ _sort = d&amp; \ _docanchor = &amp;view = c&amp; \ _searchStrId = 1124856196&amp; \ _rerunOrigin = google&amp; \ _acct = C000050221&amp; \ _version = 1&amp; \ _urlVersion = 0&amp; \ _userid = 10&amp;md5 = 8fdb3a69673c852e7adf0466d2e36687 reports similar finding for rats .</tokentext>
<sentencetext>http://www.sciencedirect.com/science?\_ob=ArticleURL&amp;\_udi=B6T6J-473FRHK-5&amp;\_user=10&amp;\_rdoc=1&amp;\_fmt=&amp;\_orig=search&amp;\_sort=d&amp;\_docanchor=&amp;view=c&amp;\_searchStrId=1124856196&amp;\_rerunOrigin=google&amp;\_acct=C000050221&amp;\_version=1&amp;\_urlVersion=0&amp;\_userid=10&amp;md5=8fdb3a69673c852e7adf0466d2e36687 reports similar finding for rats.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30341980</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30351478</id>
	<title>Re:Yes, but...</title>
	<author>Anonymous</author>
	<datestamp>1260192660000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>Serotonine generates the *high* when when one eats sugary sweet stuff like chocolate. It has been theorized that serotonine is also an essential signal used by the brain to determine when to eat and not eat. Some studies that I have come across has suggested that eating disorders are linked to problems with the serotonine-base signals to the brain.</p></htmltext>
<tokenext>Serotonine generates the * high * when when one eats sugary sweet stuff like chocolate .
It has been theorized that serotonine is also an essential signal used by the brain to determine when to eat and not eat .
Some studies that I have come across has suggested that eating disorders are linked to problems with the serotonine-base signals to the brain .</tokentext>
<sentencetext>Serotonine generates the *high* when when one eats sugary sweet stuff like chocolate.
It has been theorized that serotonine is also an essential signal used by the brain to determine when to eat and not eat.
Some studies that I have come across has suggested that eating disorders are linked to problems with the serotonine-base signals to the brain.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30342458</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30343768</id>
	<title>Met / Trp</title>
	<author>t34g4rd3n</author>
	<datestamp>1260121140000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>The start codon for protein assembly - all proteins, everywhere - specifies that methionine is the first amino acid in the chain.  And as someone else pointed out, Trp is a precursor for serotonin.  These are two pretty important molecules, and toying with their ambient levels doesn't sound like such a great idea to me, the average idiot on the street.</htmltext>
<tokenext>The start codon for protein assembly - all proteins , everywhere - specifies that methionine is the first amino acid in the chain .
And as someone else pointed out , Trp is a precursor for serotonin .
These are two pretty important molecules , and toying with their ambient levels does n't sound like such a great idea to me , the average idiot on the street .</tokentext>
<sentencetext>The start codon for protein assembly - all proteins, everywhere - specifies that methionine is the first amino acid in the chain.
And as someone else pointed out, Trp is a precursor for serotonin.
These are two pretty important molecules, and toying with their ambient levels doesn't sound like such a great idea to me, the average idiot on the street.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30344354</id>
	<title>And Not Or</title>
	<author>DynaSoar</author>
	<datestamp>1260126000000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>Just as the perennial question of 'nature or nurture' is a misstatement of how the world works (neither ever exist or act alone; results are due to the interactions of nature AND nurture) looking into this deeper will almost certainly delve into a wonderfully chaotic collection of interactions, interactions modified by others, interactions that change in strength nonlinearly as the variables change linearly, and more of the stuff that keeps us in income by preventing us on figuring anything out completely. The question won't be whether aminos or calories are more important, but under what conditions which aminos exert significant effects on calories (and vice versa), what second order/third variable interactions are significant, and so forth. I know this seems to fly in the face of parismony, what we call Occam's Razor, but that has to do with relative merits of answers, not questions. The questions are still hairy -- Willem of Ockham had no razor; he had a beard.</p><p>Take tryptophan. Precursor to dopamine. Itself precursor to norepinephrine and epinephrine. The last two are behaviorally activating, the former behaviorally inhibiting. One amino feeds two behavioral tendencies via three neurotransmitters and none of this can be pulled apart. More tryptophan would allow the body to make more of these if needed, but that's not often other than the low level continual need. But reduce tryptophan (but not calories, keeping things clean here) and below a crucial level the animal ceases to orient on salient stimuli (lack of dopamine; it can't stop to smell the roses, or Fruit Loops), including food, as well as slowing its spontaneous movement, meaning its random investigations will bring it in contact with less food, possibly including less variety. Also, lack of orienting means learning is inhibited, so later investigations will be more likely to go over ground already depleted. Further, with its activity slowed, food won't burn as fuel as much and go into fat storage more. It gets fat, so it gets slower, and all these conspire to create a downward spiral.</p><p>Now, that's just from understanding some of the products and giving one possible path. It's probably too simplistic too. Just because we can manipulate one variable and examine certain outcomes doesn't mean other things aren't involved as co-causal, co-result or co-operative.</p><p>Now throw individual differences into the mix. Some do well on low calorie diets. Some suffer. And vice is once again versa. Whatever the reasons, in this situation the organism will seek to reregulate. Also, some are better (more effective, effiecient, or both) at having enough neurotransmitter available for a given amount of precursor. Better creation, better conversion from one to another, less effective mechanisms for removing excess from use, more effective mechanisms for recycling transmitter components to produce more using less precursor, all of these are just a few of the many individual differences that might come into play. And then the array of those differences can change from changing the amount of food/precursor available.</p><p>Oh, and the recycling system for dopamine et al. also works on other transmitters like serotonin, so a neurotransmitter not affected directly by amino or calorie is affected by changing levels in those transmitters that are, and the availability or reregulation of the amount of recycling enzyme (MAO). You can't change one in vivo without affecting the whole system to some extent, while affecting some components more and others less.</p><p>No, it's going to take a lot deeper and wider inestigation to truly make sense of it. A simpler design may produce a result, but unless the design is inclusive, the results won't be generalizable.</p></htmltext>
<tokenext>Just as the perennial question of 'nature or nurture ' is a misstatement of how the world works ( neither ever exist or act alone ; results are due to the interactions of nature AND nurture ) looking into this deeper will almost certainly delve into a wonderfully chaotic collection of interactions , interactions modified by others , interactions that change in strength nonlinearly as the variables change linearly , and more of the stuff that keeps us in income by preventing us on figuring anything out completely .
The question wo n't be whether aminos or calories are more important , but under what conditions which aminos exert significant effects on calories ( and vice versa ) , what second order/third variable interactions are significant , and so forth .
I know this seems to fly in the face of parismony , what we call Occam 's Razor , but that has to do with relative merits of answers , not questions .
The questions are still hairy -- Willem of Ockham had no razor ; he had a beard.Take tryptophan .
Precursor to dopamine .
Itself precursor to norepinephrine and epinephrine .
The last two are behaviorally activating , the former behaviorally inhibiting .
One amino feeds two behavioral tendencies via three neurotransmitters and none of this can be pulled apart .
More tryptophan would allow the body to make more of these if needed , but that 's not often other than the low level continual need .
But reduce tryptophan ( but not calories , keeping things clean here ) and below a crucial level the animal ceases to orient on salient stimuli ( lack of dopamine ; it ca n't stop to smell the roses , or Fruit Loops ) , including food , as well as slowing its spontaneous movement , meaning its random investigations will bring it in contact with less food , possibly including less variety .
Also , lack of orienting means learning is inhibited , so later investigations will be more likely to go over ground already depleted .
Further , with its activity slowed , food wo n't burn as fuel as much and go into fat storage more .
It gets fat , so it gets slower , and all these conspire to create a downward spiral.Now , that 's just from understanding some of the products and giving one possible path .
It 's probably too simplistic too .
Just because we can manipulate one variable and examine certain outcomes does n't mean other things are n't involved as co-causal , co-result or co-operative.Now throw individual differences into the mix .
Some do well on low calorie diets .
Some suffer .
And vice is once again versa .
Whatever the reasons , in this situation the organism will seek to reregulate .
Also , some are better ( more effective , effiecient , or both ) at having enough neurotransmitter available for a given amount of precursor .
Better creation , better conversion from one to another , less effective mechanisms for removing excess from use , more effective mechanisms for recycling transmitter components to produce more using less precursor , all of these are just a few of the many individual differences that might come into play .
And then the array of those differences can change from changing the amount of food/precursor available.Oh , and the recycling system for dopamine et al .
also works on other transmitters like serotonin , so a neurotransmitter not affected directly by amino or calorie is affected by changing levels in those transmitters that are , and the availability or reregulation of the amount of recycling enzyme ( MAO ) .
You ca n't change one in vivo without affecting the whole system to some extent , while affecting some components more and others less.No , it 's going to take a lot deeper and wider inestigation to truly make sense of it .
A simpler design may produce a result , but unless the design is inclusive , the results wo n't be generalizable .</tokentext>
<sentencetext>Just as the perennial question of 'nature or nurture' is a misstatement of how the world works (neither ever exist or act alone; results are due to the interactions of nature AND nurture) looking into this deeper will almost certainly delve into a wonderfully chaotic collection of interactions, interactions modified by others, interactions that change in strength nonlinearly as the variables change linearly, and more of the stuff that keeps us in income by preventing us on figuring anything out completely.
The question won't be whether aminos or calories are more important, but under what conditions which aminos exert significant effects on calories (and vice versa), what second order/third variable interactions are significant, and so forth.
I know this seems to fly in the face of parismony, what we call Occam's Razor, but that has to do with relative merits of answers, not questions.
The questions are still hairy -- Willem of Ockham had no razor; he had a beard.Take tryptophan.
Precursor to dopamine.
Itself precursor to norepinephrine and epinephrine.
The last two are behaviorally activating, the former behaviorally inhibiting.
One amino feeds two behavioral tendencies via three neurotransmitters and none of this can be pulled apart.
More tryptophan would allow the body to make more of these if needed, but that's not often other than the low level continual need.
But reduce tryptophan (but not calories, keeping things clean here) and below a crucial level the animal ceases to orient on salient stimuli (lack of dopamine; it can't stop to smell the roses, or Fruit Loops), including food, as well as slowing its spontaneous movement, meaning its random investigations will bring it in contact with less food, possibly including less variety.
Also, lack of orienting means learning is inhibited, so later investigations will be more likely to go over ground already depleted.
Further, with its activity slowed, food won't burn as fuel as much and go into fat storage more.
It gets fat, so it gets slower, and all these conspire to create a downward spiral.Now, that's just from understanding some of the products and giving one possible path.
It's probably too simplistic too.
Just because we can manipulate one variable and examine certain outcomes doesn't mean other things aren't involved as co-causal, co-result or co-operative.Now throw individual differences into the mix.
Some do well on low calorie diets.
Some suffer.
And vice is once again versa.
Whatever the reasons, in this situation the organism will seek to reregulate.
Also, some are better (more effective, effiecient, or both) at having enough neurotransmitter available for a given amount of precursor.
Better creation, better conversion from one to another, less effective mechanisms for removing excess from use, more effective mechanisms for recycling transmitter components to produce more using less precursor, all of these are just a few of the many individual differences that might come into play.
And then the array of those differences can change from changing the amount of food/precursor available.Oh, and the recycling system for dopamine et al.
also works on other transmitters like serotonin, so a neurotransmitter not affected directly by amino or calorie is affected by changing levels in those transmitters that are, and the availability or reregulation of the amount of recycling enzyme (MAO).
You can't change one in vivo without affecting the whole system to some extent, while affecting some components more and others less.No, it's going to take a lot deeper and wider inestigation to truly make sense of it.
A simpler design may produce a result, but unless the design is inclusive, the results won't be generalizable.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30343466</id>
	<title>Oh effing great</title>
	<author>Opportunist</author>
	<datestamp>1260118320000</datestamp>
	<modclass>Funny</modclass>
	<modscore>5</modscore>
	<htmltext><p>So what this essentially means is that we can choose between shorter lives and not wanting longer ones.</p></htmltext>
<tokenext>So what this essentially means is that we can choose between shorter lives and not wanting longer ones .</tokentext>
<sentencetext>So what this essentially means is that we can choose between shorter lives and not wanting longer ones.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30342458</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30344606</id>
	<title>Redox?</title>
	<author>Anonymous</author>
	<datestamp>1260127680000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>Anyone else read the title as speaking of a decrease of the oxidation state of an amino acid?</p></htmltext>
<tokenext>Anyone else read the title as speaking of a decrease of the oxidation state of an amino acid ?</tokentext>
<sentencetext>Anyone else read the title as speaking of a decrease of the oxidation state of an amino acid?</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30345280</id>
	<title>Re:One simple rule</title>
	<author>Anonymous</author>
	<datestamp>1260132660000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext>obey?</htmltext>
<tokenext>obey ?</tokentext>
<sentencetext>obey?</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30341818</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30342730</id>
	<title>Re:"A highly respected journal"</title>
	<author>selven</author>
	<datestamp>1260109080000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>When talking about computers I'm a respected person of knowledge but when we're talking about hair styles I'm pretty useless.</p></htmltext>
<tokenext>When talking about computers I 'm a respected person of knowledge but when we 're talking about hair styles I 'm pretty useless .</tokentext>
<sentencetext>When talking about computers I'm a respected person of knowledge but when we're talking about hair styles I'm pretty useless.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30342010</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30341774</id>
	<title>Yes, but...</title>
	<author>mano.m</author>
	<datestamp>1260132720000</datestamp>
	<modclass>Interestin</modclass>
	<modscore>2</modscore>
	<htmltext>how do you screen for one amino acid that may keep popping up in a hundred different foodstuff in various amounts? Unless you took a daily dose of something to chelate out that one a.a. from the body. Hmm....</htmltext>
<tokenext>how do you screen for one amino acid that may keep popping up in a hundred different foodstuff in various amounts ?
Unless you took a daily dose of something to chelate out that one a.a. from the body .
Hmm... .</tokentext>
<sentencetext>how do you screen for one amino acid that may keep popping up in a hundred different foodstuff in various amounts?
Unless you took a daily dose of something to chelate out that one a.a. from the body.
Hmm....</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30342108</id>
	<title>Re:"A highly respected journal"</title>
	<author>Anonymous</author>
	<datestamp>1260096720000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>Can someone mod this offtopic? Does everything have to involve this whole global warming clusterfuck?</p></htmltext>
<tokenext>Can someone mod this offtopic ?
Does everything have to involve this whole global warming clusterfuck ?</tokentext>
<sentencetext>Can someone mod this offtopic?
Does everything have to involve this whole global warming clusterfuck?</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30342010</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30344394</id>
	<title>Nice try</title>
	<author>Anonymous</author>
	<datestamp>1260126300000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>You could withhold lysine from the dinosaurs to keep them from reproducing.</p><p>But "life finds a way."</p></htmltext>
<tokenext>You could withhold lysine from the dinosaurs to keep them from reproducing.But " life finds a way .
"</tokentext>
<sentencetext>You could withhold lysine from the dinosaurs to keep them from reproducing.But "life finds a way.
"</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30341864</id>
	<title>tryptophan</title>
	<author>kerrbear</author>
	<datestamp>1260091260000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>&gt; Amino acids that have shown this have been tryptophan</p><p>couldn't they have told us this before thanksgivig?</p></htmltext>
<tokenext>&gt; Amino acids that have shown this have been tryptophancould n't they have told us this before thanksgivig ?</tokentext>
<sentencetext>&gt; Amino acids that have shown this have been tryptophancouldn't they have told us this before thanksgivig?</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30342144</id>
	<title>The aliens worked hard to</title>
	<author>AHuxley</author>
	<datestamp>1260097380000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>keep the herd in stock.  Dont undo their experiments.<br>
Like an admin on holiday, when they get back its personal.</htmltext>
<tokenext>keep the herd in stock .
Dont undo their experiments .
Like an admin on holiday , when they get back its personal .</tokentext>
<sentencetext>keep the herd in stock.
Dont undo their experiments.
Like an admin on holiday, when they get back its personal.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30343474</id>
	<title>Re:Am I reading this right?</title>
	<author>drinkypoo</author>
	<datestamp>1260118380000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p><div class="quote"><p>Live long, have lots of sex without worrying about giving babies? By jove! Where can I send my money to?</p></div><p>You think that's good? You should try reading <a href="http://www.wired.com/wired/archive/10.06/melanotan.html" title="wired.com">Thin! Tan! Hotter Than Hell!</a> [wired.com] You can apparently <a href="http://www.melanotanpeptide.com/product.sc?productId=1" title="melanotanpeptide.com">buy the stuff via web</a> [melanotanpeptide.com] (disclaimer: the above could be a scam, a CIA plant, or a potted plant, I am not affiliated and have not purchased from the prior link) now but I haven't heard one thing about it since reading the above Wired article.</p></div>
	</htmltext>
<tokenext>Live long , have lots of sex without worrying about giving babies ?
By jove !
Where can I send my money to ? You think that 's good ?
You should try reading Thin !
Tan ! Hotter Than Hell !
[ wired.com ] You can apparently buy the stuff via web [ melanotanpeptide.com ] ( disclaimer : the above could be a scam , a CIA plant , or a potted plant , I am not affiliated and have not purchased from the prior link ) now but I have n't heard one thing about it since reading the above Wired article .</tokentext>
<sentencetext>Live long, have lots of sex without worrying about giving babies?
By jove!
Where can I send my money to?You think that's good?
You should try reading Thin!
Tan! Hotter Than Hell!
[wired.com] You can apparently buy the stuff via web [melanotanpeptide.com] (disclaimer: the above could be a scam, a CIA plant, or a potted plant, I am not affiliated and have not purchased from the prior link) now but I haven't heard one thing about it since reading the above Wired article.
	</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30341952</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30342042</id>
	<title>Tryptophan?</title>
	<author>Anonymous</author>
	<datestamp>1260095400000</datestamp>
	<modclass>Informativ</modclass>
	<modscore>2</modscore>
	<htmltext><p>The summary mentions tryptophan but it isn't anywhere in the article. And I wonder if the decreased longevity is due to the excessive methionine itself or a result of its byproducts such as SAM and homocysteine.</p></htmltext>
<tokenext>The summary mentions tryptophan but it is n't anywhere in the article .
And I wonder if the decreased longevity is due to the excessive methionine itself or a result of its byproducts such as SAM and homocysteine .</tokentext>
<sentencetext>The summary mentions tryptophan but it isn't anywhere in the article.
And I wonder if the decreased longevity is due to the excessive methionine itself or a result of its byproducts such as SAM and homocysteine.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30344150</id>
	<title>Turkey</title>
	<author>vxice</author>
	<datestamp>1260124380000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>And I just finished all the thanksgiving leftovers.</htmltext>
<tokenext>And I just finished all the thanksgiving leftovers .</tokentext>
<sentencetext>And I just finished all the thanksgiving leftovers.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30342458</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30341980</id>
	<title>Amino Acids</title>
	<author>LightPhoenix7</author>
	<datestamp>1260094080000</datestamp>
	<modclass>Interestin</modclass>
	<modscore>3</modscore>
	<htmltext><p>So... what they discovered is that limiting diets reduce reproduction at the expense of lifespan?

</p><p>Color me skeptical, but this is not exactly new.  It's well known that limited diets reduce reproductive metabolism in favor of survival.  After all, what good is reproduction if you don't live to do it.

</p><p>Now, I'm not saying this is all bunk.  I don't know.  What I <i>am</i> saying is that all this really proves is that methionine is necessary for egg-laying and lifespan in Drosophila.  That's a <i>far</i> stretch from saying that reducing methionine increases lifespan in well-fed humans.  In fact, what TFA says is that there is a discrepancy in studies.  In fact, TFA doesn't even mention tryptophan, so I don't know where the submitter got that.

</p><p>Unfortunately, I can't access the Nature article right now.  However, I'll definitely be taking a look at it tomorrow, because I am extremely skeptical of these claims.</p></htmltext>
<tokenext>So... what they discovered is that limiting diets reduce reproduction at the expense of lifespan ?
Color me skeptical , but this is not exactly new .
It 's well known that limited diets reduce reproductive metabolism in favor of survival .
After all , what good is reproduction if you do n't live to do it .
Now , I 'm not saying this is all bunk .
I do n't know .
What I am saying is that all this really proves is that methionine is necessary for egg-laying and lifespan in Drosophila .
That 's a far stretch from saying that reducing methionine increases lifespan in well-fed humans .
In fact , what TFA says is that there is a discrepancy in studies .
In fact , TFA does n't even mention tryptophan , so I do n't know where the submitter got that .
Unfortunately , I ca n't access the Nature article right now .
However , I 'll definitely be taking a look at it tomorrow , because I am extremely skeptical of these claims .</tokentext>
<sentencetext>So... what they discovered is that limiting diets reduce reproduction at the expense of lifespan?
Color me skeptical, but this is not exactly new.
It's well known that limited diets reduce reproductive metabolism in favor of survival.
After all, what good is reproduction if you don't live to do it.
Now, I'm not saying this is all bunk.
I don't know.
What I am saying is that all this really proves is that methionine is necessary for egg-laying and lifespan in Drosophila.
That's a far stretch from saying that reducing methionine increases lifespan in well-fed humans.
In fact, what TFA says is that there is a discrepancy in studies.
In fact, TFA doesn't even mention tryptophan, so I don't know where the submitter got that.
Unfortunately, I can't access the Nature article right now.
However, I'll definitely be taking a look at it tomorrow, because I am extremely skeptical of these claims.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30342032</id>
	<title>Bad summary</title>
	<author>Mathinker</author>
	<datestamp>1260095100000</datestamp>
	<modclass>Insightful</modclass>
	<modscore>2</modscore>
	<htmltext><p>If anything, TFA says that you should restrict all amino acids <b>except</b> methionine. If you are fruit fly, that is.</p><p>TFA also says nothing about tryptophan in particular.</p><p>Or am I totally confused?</p></htmltext>
<tokenext>If anything , TFA says that you should restrict all amino acids except methionine .
If you are fruit fly , that is.TFA also says nothing about tryptophan in particular.Or am I totally confused ?</tokentext>
<sentencetext>If anything, TFA says that you should restrict all amino acids except methionine.
If you are fruit fly, that is.TFA also says nothing about tryptophan in particular.Or am I totally confused?</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30341994</id>
	<title>All that hunger was for nothing ???</title>
	<author>Anonymous</author>
	<datestamp>1260094320000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext><p>I am on calorie restriction diet for 8 years now. First, this information has made me very upset. Second, I do not believe this !!</p></htmltext>
<tokenext>I am on calorie restriction diet for 8 years now .
First , this information has made me very upset .
Second , I do not believe this !
!</tokentext>
<sentencetext>I am on calorie restriction diet for 8 years now.
First, this information has made me very upset.
Second, I do not believe this !
!</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30341894</id>
	<title>tryptophan</title>
	<author>igotmybfg</author>
	<datestamp>1260091680000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>Couldn't they have told me this one week before I OD'd on tryptophan, not one week after?</htmltext>
<tokenext>Could n't they have told me this one week before I OD 'd on tryptophan , not one week after ?</tokentext>
<sentencetext>Couldn't they have told me this one week before I OD'd on tryptophan, not one week after?</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30342452</id>
	<title>If that amino acid is delicious, I'm dying early</title>
	<author>Anonymous</author>
	<datestamp>1260103260000</datestamp>
	<modclass>Insightful</modclass>
	<modscore>2</modscore>
	<htmltext><p>We all know how this goes.  If it feels good, we do it.  If it feels bad, we don't do it or we avoid whatever causes it.  Salt?  Good... what does it matter that too much causes health problems?  Sugar?  Good... what does it matter that...?  You get the idea.</p></htmltext>
<tokenext>We all know how this goes .
If it feels good , we do it .
If it feels bad , we do n't do it or we avoid whatever causes it .
Salt ? Good... what does it matter that too much causes health problems ?
Sugar ? Good... what does it matter that... ?
You get the idea .</tokentext>
<sentencetext>We all know how this goes.
If it feels good, we do it.
If it feels bad, we don't do it or we avoid whatever causes it.
Salt?  Good... what does it matter that too much causes health problems?
Sugar?  Good... what does it matter that...?
You get the idea.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30342158</id>
	<title>A complete contradiction on health...</title>
	<author>adosch</author>
	<datestamp>1260097500000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>If it's not one study condoning the intake of things like red meat because of known killers like heart disease (which shorten your life), and instead eat the "other" meat, such as fish, turkey, chicken, only to have *this* new study tell me I could live longer if I stay away from foods and specifically meats, such as fish and turkey, that contain amino acids that make me live less?  Who are we kidding?</htmltext>
<tokenext>If it 's not one study condoning the intake of things like red meat because of known killers like heart disease ( which shorten your life ) , and instead eat the " other " meat , such as fish , turkey , chicken , only to have * this * new study tell me I could live longer if I stay away from foods and specifically meats , such as fish and turkey , that contain amino acids that make me live less ?
Who are we kidding ?</tokentext>
<sentencetext>If it's not one study condoning the intake of things like red meat because of known killers like heart disease (which shorten your life), and instead eat the "other" meat, such as fish, turkey, chicken, only to have *this* new study tell me I could live longer if I stay away from foods and specifically meats, such as fish and turkey, that contain amino acids that make me live less?
Who are we kidding?</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30343366</id>
	<title>Reminds me of an old joke</title>
	<author>Opportunist</author>
	<datestamp>1260117300000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>"Doc, I wanna live to a healthy, ripe age."<br>"Hmm... do you drink?"<br>"Nah."<br>"Smoke?"<br>"Nope."<br>"Got frequently changing sexual contacts?"<br>"Not at all."<br>"Then why the heck do you want to get old?"</p><p>We're so afraid of dying that we don't live anymore. We're busy surviving. Personally, I guess I won't see the age of 60. But I'll do my best to have lived every single day 'til.</p></htmltext>
<tokenext>" Doc , I wan na live to a healthy , ripe age. " " Hmm.. .
do you drink ? " " Nah. " " Smoke ? " " Nope .
" " Got frequently changing sexual contacts ?
" " Not at all .
" " Then why the heck do you want to get old ?
" We 're so afraid of dying that we do n't live anymore .
We 're busy surviving .
Personally , I guess I wo n't see the age of 60 .
But I 'll do my best to have lived every single day 'til .</tokentext>
<sentencetext>"Doc, I wanna live to a healthy, ripe age.""Hmm...
do you drink?""Nah.""Smoke?""Nope.
""Got frequently changing sexual contacts?
""Not at all.
""Then why the heck do you want to get old?
"We're so afraid of dying that we don't live anymore.
We're busy surviving.
Personally, I guess I won't see the age of 60.
But I'll do my best to have lived every single day 'til.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30344116</id>
	<title>Nothing more than Propaganda.</title>
	<author>jameskojiro</author>
	<datestamp>1260124080000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>From those damn Visitors, they want to be able to make us amino acid free food so they can tighten their stranglehold on us.</p></htmltext>
<tokenext>From those damn Visitors , they want to be able to make us amino acid free food so they can tighten their stranglehold on us .</tokentext>
<sentencetext>From those damn Visitors, they want to be able to make us amino acid free food so they can tighten their stranglehold on us.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30342312</id>
	<title>With apologies</title>
	<author>BlueParrot</author>
	<datestamp>1260100260000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>Well we all know nature has a liberal bias.<nobr> <wbr></nobr>;-)</p><p>(sorry, couldn't help myself )</p></htmltext>
<tokenext>Well we all know nature has a liberal bias .
; - ) ( sorry , could n't help myself )</tokentext>
<sentencetext>Well we all know nature has a liberal bias.
;-)(sorry, couldn't help myself )</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30342010</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30347694</id>
	<title>Re:Yes, but...</title>
	<author>Anonymous</author>
	<datestamp>1260107100000</datestamp>
	<modclass>None</modclass>
	<modscore>0</modscore>
	<htmltext>5-HTP does not cross the blood-brain barrier like Tryptophan does, therefore it is useless for increasing the amount of serotonin in your system.
<br> <br>
In fact, it's been found in case studies of certain tribes that a high intake of 5-HTP leads to heart disease. So if you're taking 5-HTP, you're not helping your depression AND you're leading to early heart failure... better switch to Tryptophan</htmltext>
<tokenext>5-HTP does not cross the blood-brain barrier like Tryptophan does , therefore it is useless for increasing the amount of serotonin in your system .
In fact , it 's been found in case studies of certain tribes that a high intake of 5-HTP leads to heart disease .
So if you 're taking 5-HTP , you 're not helping your depression AND you 're leading to early heart failure... better switch to Tryptophan</tokentext>
<sentencetext>5-HTP does not cross the blood-brain barrier like Tryptophan does, therefore it is useless for increasing the amount of serotonin in your system.
In fact, it's been found in case studies of certain tribes that a high intake of 5-HTP leads to heart disease.
So if you're taking 5-HTP, you're not helping your depression AND you're leading to early heart failure... better switch to Tryptophan</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30342458</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30342010</id>
	<title>"A highly respected journal"</title>
	<author>Anonymous</author>
	<datestamp>1260094620000</datestamp>
	<modclass>Insightful</modclass>
	<modscore>4</modscore>
	<htmltext><p>As a subscriber to Nature I find it interesting that when we're talking about amino acids Nature is a highly respected international weekly journal of science but.... when we're talking climate science it's the nexus of an evil, duplicitous, Socialist, Marxist, environmentalist cabal bent on destroying the fabric of American society.</p></htmltext>
<tokenext>As a subscriber to Nature I find it interesting that when we 're talking about amino acids Nature is a highly respected international weekly journal of science but.... when we 're talking climate science it 's the nexus of an evil , duplicitous , Socialist , Marxist , environmentalist cabal bent on destroying the fabric of American society .</tokentext>
<sentencetext>As a subscriber to Nature I find it interesting that when we're talking about amino acids Nature is a highly respected international weekly journal of science but.... when we're talking climate science it's the nexus of an evil, duplicitous, Socialist, Marxist, environmentalist cabal bent on destroying the fabric of American society.</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30341794</id>
	<title>Reducing amino acids?</title>
	<author>Anonymous</author>
	<datestamp>1260133080000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>This study may be especially significant for those employed in the nocturnal carnal need satisfaction industry, especially around holiday seasons. It might be the season to be jolly, but think of your health!</htmltext>
<tokenext>This study may be especially significant for those employed in the nocturnal carnal need satisfaction industry , especially around holiday seasons .
It might be the season to be jolly , but think of your health !</tokentext>
<sentencetext>This study may be especially significant for those employed in the nocturnal carnal need satisfaction industry, especially around holiday seasons.
It might be the season to be jolly, but think of your health!</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30343234</id>
	<title>Live longer, or live better?</title>
	<author>CFD339</author>
	<datestamp>1260115800000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>
&nbsp; &nbsp; &nbsp; &nbsp; I, like many people, welcome the idea of living as long as I can be productive and maybe a bit beyond -- but I have no wish to live indefinitely if that life is one of immobility, pain, and humiliating dependence both physically and financially.</p><p>
&nbsp; &nbsp; &nbsp; &nbsp; If this, or any, treatment results in an increased healthy lifespan by somehow allowing my body to repair itself as it did when I was in my twenties or even my early thirties then I'm I'm for it.  Of course, that goes hand in hand with my ability and continued willingness to earn my keep within society.   If, on the other hand, we're talking about a prolonged geriatric dependency and pain cycle than no.  I am not interested in burdening my children and their children with my crotchety, miserable self for the bulk of their adult lives.</p><p>
&nbsp; &nbsp; &nbsp; &nbsp; I'm 42 and while I try to stay in reasonable shape, working out pretty hard on both cardio/aerobics and strength/flexibility with Shotokan Karate two or three times a week, the difference in being over forty is profound in how much harder is is to avoid or recover from injury, to gain back lost strength or fitness, and all manner of other small health details that we completely ignore in our twenties and thirties.</p><p>
&nbsp; &nbsp; &nbsp; &nbsp; So scientist friends; learn to restore the length of tolemeres if that's the magic, or how to rehydrate the collagen and cartilage that loose density and elasticity over time, or how to teach the rest of my organs and joints how to regenerate as my liver does.  Learn to filter the toxins and free radicals that build up over decades and damage my dna, and to repair that dna that gets damaged by radiation and transcription errors.  These things will extend my healthy lifespan and let me contribute to world with youthful energy, a quick mind, and extra decades of learning and wisdom.   If we can do that for people, we'll make the worlds we live in better places.</p><p>
&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; The goal must be living better, longer; not just living longer.</p><blockquote><div><p> <b> I expect to die at 110, shot by a jealous husband. </b> <br>
&nbsp; <i> -- Thurgood Marshall (1908 - 1993)  </i></p></div> </blockquote><p>
&nbsp; &nbsp; &nbsp;</p></div>
	</htmltext>
<tokenext>        I , like many people , welcome the idea of living as long as I can be productive and maybe a bit beyond -- but I have no wish to live indefinitely if that life is one of immobility , pain , and humiliating dependence both physically and financially .
        If this , or any , treatment results in an increased healthy lifespan by somehow allowing my body to repair itself as it did when I was in my twenties or even my early thirties then I 'm I 'm for it .
Of course , that goes hand in hand with my ability and continued willingness to earn my keep within society .
If , on the other hand , we 're talking about a prolonged geriatric dependency and pain cycle than no .
I am not interested in burdening my children and their children with my crotchety , miserable self for the bulk of their adult lives .
        I 'm 42 and while I try to stay in reasonable shape , working out pretty hard on both cardio/aerobics and strength/flexibility with Shotokan Karate two or three times a week , the difference in being over forty is profound in how much harder is is to avoid or recover from injury , to gain back lost strength or fitness , and all manner of other small health details that we completely ignore in our twenties and thirties .
        So scientist friends ; learn to restore the length of tolemeres if that 's the magic , or how to rehydrate the collagen and cartilage that loose density and elasticity over time , or how to teach the rest of my organs and joints how to regenerate as my liver does .
Learn to filter the toxins and free radicals that build up over decades and damage my dna , and to repair that dna that gets damaged by radiation and transcription errors .
These things will extend my healthy lifespan and let me contribute to world with youthful energy , a quick mind , and extra decades of learning and wisdom .
If we can do that for people , we 'll make the worlds we live in better places .
          The goal must be living better , longer ; not just living longer .
I expect to die at 110 , shot by a jealous husband .
  -- Thurgood Marshall ( 1908 - 1993 )      </tokentext>
<sentencetext>
        I, like many people, welcome the idea of living as long as I can be productive and maybe a bit beyond -- but I have no wish to live indefinitely if that life is one of immobility, pain, and humiliating dependence both physically and financially.
        If this, or any, treatment results in an increased healthy lifespan by somehow allowing my body to repair itself as it did when I was in my twenties or even my early thirties then I'm I'm for it.
Of course, that goes hand in hand with my ability and continued willingness to earn my keep within society.
If, on the other hand, we're talking about a prolonged geriatric dependency and pain cycle than no.
I am not interested in burdening my children and their children with my crotchety, miserable self for the bulk of their adult lives.
        I'm 42 and while I try to stay in reasonable shape, working out pretty hard on both cardio/aerobics and strength/flexibility with Shotokan Karate two or three times a week, the difference in being over forty is profound in how much harder is is to avoid or recover from injury, to gain back lost strength or fitness, and all manner of other small health details that we completely ignore in our twenties and thirties.
        So scientist friends; learn to restore the length of tolemeres if that's the magic, or how to rehydrate the collagen and cartilage that loose density and elasticity over time, or how to teach the rest of my organs and joints how to regenerate as my liver does.
Learn to filter the toxins and free radicals that build up over decades and damage my dna, and to repair that dna that gets damaged by radiation and transcription errors.
These things will extend my healthy lifespan and let me contribute to world with youthful energy, a quick mind, and extra decades of learning and wisdom.
If we can do that for people, we'll make the worlds we live in better places.
          The goal must be living better, longer; not just living longer.
I expect to die at 110, shot by a jealous husband.
   -- Thurgood Marshall (1908 - 1993)   
     
	</sentencetext>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30342554</id>
	<title>Re:"A highly respected journal"</title>
	<author>maxume</author>
	<datestamp>1260105660000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext><p>Why is harping on this insightful? There simply isn't any coherent 'we' involved.</p><p>Wow, what a complicated explanation.</p></htmltext>
<tokenext>Why is harping on this insightful ?
There simply is n't any coherent 'we ' involved.Wow , what a complicated explanation .</tokentext>
<sentencetext>Why is harping on this insightful?
There simply isn't any coherent 'we' involved.Wow, what a complicated explanation.</sentencetext>
	<parent>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30342010</parent>
</comment>
<comment>
	<id>http://www.semanticweb.org/ontologies/ConversationInstances.owl#comment09_12_06_060243.30341814</id>
	<title>Prolong life as a what?</title>
	<author>Anonymous</author>
	<datestamp>1260090300000</datestamp>
	<modclass>None</modclass>
	<modscore>1</modscore>
	<htmltext>If you were to RTFA (why yes, I am new around here) you might come to the conclusion that restricting specific amino acids will prolong your life as a fruitfly. <p>
Well, I guess it wouldn't be too bad if you lived in an Apple.</p></htmltext>
<tokenext>If you were to RTFA ( why yes , I am new around here ) you might come to the conclusion that restricting specific amino acids will prolong your life as a fruitfly .
Well , I guess it would n't be too bad if you lived in an Apple .</tokentext>
<sentencetext>If you were to RTFA (why yes, I am new around here) you might come to the conclusion that restricting specific amino acids will prolong your life as a fruitfly.
Well, I guess it wouldn't be too bad if you lived in an Apple.</sentencetext>
</comment>
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